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Recent Longevity News for the seven days ending 12/24/08. You should consult your doctor if you are taking any medications. How Certain Vegetables Combat Cancer - Science Daily, 12/23/08 - "Breast cancer, the second leading cause of cancer deaths in women, can be protected against by eating cruciferous vegetables such as cabbage and near relatives of cabbage such as broccoli and cauliflower ... Our paper focuses on the anti-cancer activity of one of these compounds, called sulforaphane, or SFN ... SFN inhibits the proliferation of human tumor cells by a mechanism similar to the way that the anticancer drugs taxol and vincristine inhibit cell division during mitosis ... SFN, like the more powerful anticancer agents, interferes with microtubule functioning during mitosis in a similar manner to the more powerful anticancer drugs ... SFN may be an effective cancer preventive agent because it inhibits the proliferation and kills precancerous cells" Vitamin D Deficiency Associated With Greater Rates Of Cesarean Sections - Science Daily, 12/23/08 - "pregnant women who are vitamin D deficient are also at an increased risk for delivering a baby by caesarean section as compared to pregnant women who are not vitamin D deficient ... 28 percent of women with serum 25(OH)D less than 37.5 nmol/L had a caesarean section, compared to only 14 percent of women with 25(OH)D greater than 37.5 nmol/L" Go ahead, sleep in — it’s good for the heart - msnbc.com, 12/23/08 - "About 12 percent of the people in the study developed artery calcification during the five-year study period. Among those who had slept less than five hours a night, 27 percent had developed artery calcification ... That dropped to 11 percent among those who slept five to seven hours, and to 6 percent among those who slept more than seven hours a night" Ferritin Levels Linked With Risk of Diabetes, Metabolic Syndrome - Medscape, 12/22/08 - "Elevated circulating ferritin concentrations are independently associated with an increased risk of type 2 diabetes and the metabolic syndrome in middle-aged and elderly Chinese subjects ... Men and women had median ferritin concentrations of 155.7 ng/mL and 111.9 ng/mL, respectively (p < 0.001). Compared to patients in the lowest ferritin quartile, those in the highest quartile had substantially higher odds ratios for metabolic syndrome (2.80) and diabetes (3.26)" - Iron supplements has been controversial for years. I started taking it again because my ferritin was 11.9.
Anthocyanins battle blood vessel degradation: study - Nutra USA, 12/22/08 -
"OPC was found to effectively delay SIPS (stress induced
senescence) caused by exposure to rotenone, a chemical substance that is known
to generate oxidative stress ... The ability of
OPCs to delay senescence was associated with a decrease in the levels of a
marker of DNA damage and DNA terminal ends (gamma-H2AX), suggesting that the
possible molecular mechanism by which OPCs delay senescence in endothelial cells
is through reduction in DNA damage" - See
grape seed extract at Amazon.com Inflamed Gums Linked To Heart Disease - Science Daily, 12/20/08 - "a protein associated with inflammation (called CRP) is elevated in people who are at risk for heart disease. But where's the inflammation coming from? ... infected gums may be one place ... something as simple as taking good care of your teeth and gums can greatly reduce your risk of developing serious diseases" Exercise Suppresses Appetite By Affecting Appetite Hormones - Science Daily, 12/19/08 - "A vigorous 60-minute workout on a treadmill affects the release of two key appetite hormones, ghrelin and peptide YY, while 90 minutes of weight lifting affects the level of only ghrelin" ACE Inhibitors May Protect Diabetics From Cancer, Peptic Ulcer - Medscape, 12/19/08 - "There was a significant association between ACE inhibitor use and the risk for cancer, with an adjusted odds ratio of 0.59 ... The rate of cancer among users of ACE inhibitors was 10% vs 15% for nonusers ... There was also a significant association between ACE inhibitor use and peptic ulcer disease, with an odds ratio of 0.68 ... The rate of peptic ulcer disease among ACE inhibitor users was 12% vs 16% among nonusers" New Anti-cancer Components Of Extra-virgin Olive Oil Revealed - Science Daily, 12/17/08 - "Extra-virgin olive oil is the oil that results from pressing olives without the use of heat or chemical treatments. It contains phytochemicals that are otherwise lost in the refining process. Menendez and colleagues separated the oil into fractions and tested these against breast cancer cells in lab experiments. All the fractions containing the major extra-virgin phytochemical polyphenols (lignans and secoiridoids) were found to effectively inhibit HER2" F.D.A. Approves 2 New Sweeteners - NYTimes.com, 12/17/08 - "Both products use rebiana, an extract from the stevia plant"
Probiotics May Help People Taking Antibiotics - Science Daily, 12/17/08 -
"Up to one in five people on
antibiotics stop taking their full course of
antibiotic therapy due to diarrhea. Physicians
could help patients avoid this problem by prescribing
probiotics" - See
probiotics at Amazon.com Hotel, Restaurant And Carpentry Trades Are Among Professions Posing Highest Risks For Cancer Of The Esophagus - Science Daily, 12/17/08 - "For the squamous cell variety, a significant increase in risk was detected among those who worked in the hotel and restaurant trade, mining (stone cutters) and wood-working workshops. With the adenocarcinoma type, the risk rose among those working as carpenters or animal handlers ...The study revealed a significant risk of squamous cell cancer resulting from exposure to ionising radiation, and for adenocarcinoma from serious exposure to volatile sulphur and lead compounds. Exposure to other substances such as asbestos could also triple the overall risk of oesophageal cancer, depending upon the level of exposure" St. John's Wort for Depression - Clinical Psychology News, 12/08 - "The best available evidence suggests that St. John's wort is better than placebo for treating major depressive disorder, is as effective as some synthetic antidepressants when used in low to moderate dosing ranges, and has fewer side effects than do synthetic antidepressants" Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):
Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term
oral dehydroepiandrosterone treatment in postmenopausal women - Menopause.
2008 Dec 17 - "after prolonged treatment of
postmenopausal women with 25 mg/d of
dehydroepiandrosterone ... Mean baseline androgen levels at day 1 and month
3 in the treated group (seven evaluable women) were the following:
dehydroepiandrosterone, 1.82 and 3.56 ng/mL; dehydroepiandrosterone sulfate,
0.96 and 3.37 mug/mL; 5-androstene-3beta,17beta-diol, 0.32 and 0.66 ng/mL;
androstenedione, 0.50 and 0.86 ng/mL; testosterone, 17.9 and 28.7 ng/dL;
dihydrotestosterone, 6.91 and 17.4 ng/dL; and 3alpha-androstanediol glucuronide,
2.66 and 10.7 ng/mL, respectively; these increases were significant. Small
changes (-6% to 16%) were observed from month 3 to month 6. Nonsignificant
increases were observed in baseline estrone and estradiol levels and in Cmax and
AUC0-24h values for the androgens and estrogens from day 1 to months 3 and 6 of
treatment. Sex hormone-binding globulin levels were unchanged, but free
testosterone increased significantly from day 1 to month 3 ... Changes in
baseline values over time differed significantly between the groups for all
hormones except estrone and estra" - See
DHEA at Amazon.com Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis - Cancer Causes Control. 2008 Dec 16 - "Based on case-control data, the random-effects summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98) per 1,000 mcg/1,000 kcal (I(2): 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI: 0.73-0.98) per 50 mg/1,000 kcal (I(2): 66.1%; p < 0.01); and, for vitamin E: 0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I(2): 0.0%; p: 0.45)" Pioglitazone and heart failure: results from a controlled study in patients with type 2 diabetes mellitus and systolic dysfunction - Congest Heart Fail. 2008 Nov-Dec;14(6):335 - "Pioglitazone was associated with a higher incidence of hospitalization for HF without an increase in cardiovascular mortality or worsening cardiac function (by echocardiography)" Fruit and Vegetable Intakes Are Associated with Lower Risk of Colorectal Adenomas - J Nutr. 2008 Dec 17 - "The odds ratio for upper tertile intake compared with lower was 0.66 (95% CI = 0.51-0.86) for total fruits, 0.64 (95% CI = 0.47-0.87) for berries, 0.72 (95% CI = 0.56-0.92) for fruit juice, and 0.74 (95% CI = 0.58-0.96) for green vegetables. This study provides additional evidence that high total fruit intake and certain fruit and vegetable intakes may be associated with a reduced risk of colorectal adenomas" Vitamin and mineral use and risk of prostate cancer: the case-control surveillance study - Cancer Causes Control. 2008 Dec 18 - "For use of multivitamins that did not contain zinc, the multivariable odds ratios of prostate cancer were 0.6 for 1-4 years, 0.8 for 5-9 years, and 1.2 for 10 years or more, respectively (p for trend = 0.70). Men who used zinc for ten years or more, either in a multivitamin or as a supplement, had an approximately two-fold (OR = 1.9" Plasma homocysteine, folate, and vitamin B12 levels in patients with laryngeal cancer - Arch Otolaryngol Head Neck Surg. 2008 Dec;134(12):1328-33 - "The mean (SD) level of total homocysteine in patients with laryngeal carcinoma was 2.84 (1.62) mg/L vs 0.99 (0.24) mg/L in the control group" Treatment of white coat hypertension with metformin - Int Heart J. 2008 Nov;49(6):671-9 - "White coat hypertension (WCH) is most likely a disorder associated with metabolic syndrome ... Twenty-five cases (14.7%) stopped metformin therapy due to excessive anorexia. At the end of a 6-month period, there were highly significant differences between the two groups with respect to the prevalences of resolved WCH, hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, overweight and obesity, and decreased fasting plasma glucose below 110 mg/dL ... Thus, the management of WCH should not focus solely on the regulation of blood pressure with antihypertensive medications, but rather on the prevention of future excess weight and various associated disorders, and metformin alone is an effective therapeutic option, most likely due to its powerful inhibitory effect on appetite"
Green Tea
Catechin Consumption Enhances Exercise-Induced Abdominal Fat Loss in Overweight
and Obese Adults - J Nutr. 2008 Dec 11 - "percentage
changes in total abdominal fat area [-7.7
(-11.7, -3.8) vs. -0.3 (-4.4, 3.9); P = 0.013], subcutaneous abdominal fat area
[-6.2 (-10.2, -2.2) vs. 0.8 (-3.3, 4.9); P = 0.019], and fasting serum
triglycerides (TG) [-11.2 (-18.8, -3.6) vs. 1.9 (-5.9, 9.7); P = 0.023] were
greater in the catechin group. These findings suggest that
green tea catechin consumption enhances
exercise-induced changes in abdominal fat and serum TG" - See
green tea extract at Amazon.com Sexuality and the management of BPH with alfuzosin (SAMBA) trial - Int J Impot Res. 2008 Dec 11 - "Alfuzosin for the treatment of patients with BPH is effective in improving sexual function, as well as lower urinary tract symptoms (LUTSs) and quality of life, and is well tolerated"
Health Focus (Mold) - I used to think that the people who worried about mold were a bunch of fruit cakes. I spent a year and a half in Vietnam as a helicopter pilot and during the six month monsoons we practically lived in mold. Now I'm not so sure: Alternative News:
Other News:
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