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Recent Longevity News for the seven days ending 3/3/03:

Aspirin May Cut Risk of Throat Cancer - Yahoo, 3/5/03 - "Researchers at the Institute of Pharmacological Research in Milan have now shown that aspirin can slash the risk of mouth and throat cancer by two-thirds"

Aspirin Cuts Intestinal Polyps in At-Risk People - HealthScout News, 3/5/03 - "People who have had colorectal cancer or a history of intestinal polyps can reduce the incidence of those polyps by taking an aspirin a day ... Half took a daily aspirin tablet of standard adult size, 325 milligrams, while the other half took a placebo ... After a year, 17 percent of people in the aspirin group had developed polyps, compared to 27 percent of those in the placebo group" - See Drugstore.com aspirin products.

Folate, Vitamin B6 Reduce Breast Cancer Risk Among Moderate Drinkers - WebMD, 3/4/04 - "They found women with the highest folate levels were 27% less likely to have breast cancer than those with the lowest folate levels. And the reduction in breast cancer risk was much greater among women who drank about one glass of wine or a cocktail per day. These moderate drinkers with high folate levels were 89% less likely to develop breast cancer than those who drank less than one drink per day ... Women with high levels of vitamin B6 also had about a 30% lower risk of breast cancer than those with low levels of this nutrient. Although high levels of vitamin B12 seemed to protect premenopausal women against breast cancer, the effect was not found among postmenopausal women" - See Jarrow brand folic acid at iHerb (5% discount code "qc")

Study Finds Breast Cancer Risk Due to Progestins in HRT - WebMD, 3/5/03 - "Women who take combination hormone replacement therapy for more than four years are at very high risk of breast cancer compared with women who have never used HRT. But estrogen-only HRT is virtually free of breast-cancer risk"

Low-Sugar Diet for Weight Loss - WebMD, 3/4/03 - "Specifically, this is what the UN report says about a healthy diet: Carbohydrates (fruits, vegetables, whole grains, starches) should make up the bulk of total daily calories -- from 55% to 75%. Fat should be 15% -30% total calories (with 10% from saturated fat). Protein should be 10%-15% ... Sugar should be less than 10% of total daily calories ... One hour per day of moderate-intensity activity such as walking, on most days of the week, is needed to maintain a healthy body weight, especially for those people who spend most of their time sitting down"

Vitamins Reduce Rates of Colds and Other Infections for Those With Diabetes - WebMD, 3/3/03 - "Among all participants, 43% of those taking daily supplements reported getting sick during the study, compared with 73% of those getting a placebo. In those with diabetes, 93% taking a placebo got sick, compared with only 17% on the active supplements. However, in those without diabetes, there was no measurable difference between supplement- and placebo-takers ... the diabetics were recruited from an inner-city diabetes clinic, while those without the disease came from a middle-class health clinic and generally ate more nutritiously and were less likely to be obese"

Timing of HRT Key to Heart Disease Prevention - WebMD, 3/3/03 - "taking estrogen around the time of menopause may protect against heart disease, but starting it later in life increases the risk"

Live Longer By Simply Trying to Lose Weight - HealthScout News, 3/3/03 - "The lowest death rates were in people who tried and actually succeeded in losing modest amounts of weight"

Heart Failure Patients Benefit From Exercise - WebMD, 3/3/03 - "Exercise may be the best medicine for even those with the weakest hearts, such as people with heart failure who are awaiting a heart transplant"

Recurrent Major Depression Important Risk Factor For Carotid Plaque In Healthy Middle-Aged Women - Doctor's Guide, 3/3/03 - "Women with a lifetime history of recurrent major depressive episodes were more than twice as likely to have plaque on carotid ultrasonography than women with no history of major depression"

VitaQuiz - Cooper Wellness, 3/03 - "Which of the following appear to help lower C-reactive protein? ... A review of the scientific literature indicates that vitamin E and vitamin B6 both may decrease C-reactive protein. Also, aspirin, exercise, weight reduction, and Cooper Complete vitamins can also help to lower this inflammatory marker"

The Death of Anti-Aging Supplements? - Life Extension Magazine, 3/03 - "During these many trials, researchers routinely found that when taken daily, DHEA supplements effectively reduced depressive episodes and enhanced mood. In fact, according to one major study in the UK, as many as 67% of men and 82% of women reported a noticeable decrease in their depressive symptoms while taking as little as 25 mg/day of DHEA ... DHEA is recognized as one of the major adrenal androgens, and many of its abilities have been well-documented. We have learned through years of research that it enhances the immune system, fights osteoporosis, lowers hyperglycemia (high blood sugar) and may even help to mount a defense against HIV"

Interaction of Dietary Calcium and Protein in Bone Health in Humans - J. Nutr. 133:852S-854S, 3/03 - "Protein has both positive and negative effects on calcium balance, and the net effect of dietary protein on bone mass and fracture risk may be dependent on the dietary calcium intake. In addition to providing substrate for bone matrix, dietary protein stimulates the production of insulin-like growth factor-1 (IGF-1), a factor that promotes osteoblast-mediated bone formation. Protein also increases urinary calcium losses, by several proposed mechanisms. Increasing calcium intake may offset the negative impact of dietary protein on urinary calcium losses, allowing the favorable effect of protein on the IGF-1 axis to dominate"

Alzheimer's Disease and Dementia: Vitamins Can Help Prevent - WebMD, 2/28/03 - "High levels of a substance in the blood called homocysteine tops the list of potentially new risk factors for heart disease, stroke, and now dementia. A new study suggests that high homocysteine levels are linked with mental declines associated with Alzheimer's disease in elderly people ... High homocysteine levels can be treated very easily with vitamins, including folate, niacin, and B-12"

Cardiovascular End Points Reduced With Antioxidant Acetylcysteine In Haemodialysis Patients - Doctor's Guide, 2/28/03 - "They were assigned to receive either acetylcysteine 600 mg twice daily or a placebo ... Primary end point was a composite variable composed of cardiac events that included fatal and non-fatal myocardial infarction, death from cardiovascular disease, necessity for either coronary angioplasty or by-pass surgery, ischaemic stroke, peripheral vascular disease requiring amputation or need for angioplasty ... A primary end point was established in 18 of the 64 [28%] haemodialysed patients who received acetylcysteine, and 33 of 70 [47%] patients undergoing haemodialysis assigned to the control group" - [Medline] - See iHerb (5% discount code "qc") or Vitacost acetyl-l-cysteine products.

Heart Disease: A Woman's Biggest Health Threat - HealthScoutNews, 2/28/03 - "15 percent more women than men die of heart disease ... To prevent heart disease, women and men must address the three largest risk behaviors -- being overweight, lack of physical activity, and smoking ... Exercise and a diet rich in fruits, vegetables, grains and fish are essential. But so is early screening for high cholesterol and blood pressure"

Promising Gains in the Fight Against Heart Disease - HealthScoutNews, 2/28/03 - "as the pacing cells age, they can't supply the heart with enough potassium, preventing the heart's cells from firing ... The gene therapy works by disabling the cellular channel that keeps potassium from reaching heart cells. To date, researchers have only tested the therapy on the heart of a guinea pig"

Inappropriate Advertising of Dietary Supplements - NEJM, 2/27/03 - "We are especially concerned because the promotional e-mails are apparently sending readers to our Web site; the 1990 article by Rudman et al. receives as many "hits" in a week as other 1990 articles do in a year. If people are induced to buy a "human growth hormone releaser" on the basis of research published in the Journal, they are being misled"

Vitamin D Supplementation Every Four Months Cuts Elderly Fracture Risk - Doctor's Guide, 2/27/03 - "The subjects received, every four months by mail, one capsule containing 100,000 IU vitamin D3 (cholecalciferol) or matching placebo. This continued for five years for a total of 15 doses. The subjects also notified the researchers of any fractures or major illness they had experienced in the preceding four months ... Total fracture incidence was reduced by 22%, and fractures in major osteoporotic sites (hip, wrist or forearm, or vertebrae). by 33% ... The relative risk for total mortality in the vitamin D group compared with the placebo group was 0.88" - [WebMD] [Intelihealth] [HealthScoutNews]

Cardiovascular Risk Factors Affected By Diet -  Doctor's Guide, 2/27/03 - "Although patients were advised to maintain an identical energy intake with the different diets, there was significant weight loss on the low glycaemic index diet compared with weight gain on the high sucrose diet"

Treating PMS With the Pill - WebMD, 2/27/03 - "The two-year-old pill, known by the trade name Yasmin, is the first to use the progestin drospirenone, which is believed to have diuretic properties because it is similar in structure to a water pill called spironolactone ... Prior to taking the contraceptive 30% of the women reported that PMS affected their daily activities, but that figure dropped to 16% for those on the pill. The number of women reporting that PMS affected their general well-being also dropped, from 35% prior to taking the birth control pill to 21% while on it"

Is intake of breakfast cereals related to total and cause-specific mortality in men? - AJCN, 3/1/03 - "Compared with men who rarely or never consumed whole-grain cereal, men in the highest category of whole-grain cereal intake ( 1 serving/d) had multivariate-estimated relative risks of total and CVD-specific mortality of 0.83 (95% CI: 0.73, 0.94; P for trend < 0.001) and 0.80"

Dietary factors protecting women from urinary tract infection - AJCN, 3/1/03 - "Frequent consumption of fresh juices, especially berry juices, and fermented milk products containing probiotic bacteria was associated with a decreased risk of recurrence of UTI"

Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes - AJCN, 3/1/03 - "Olive oil induced lower triacylglycerol concentrations and higher HDL-cholesterol concentrations than did butter, without eliciting significant changes in glucose, insulin, or fatty acids" - Olive oil is 76% omega-9.

Whole-grain and fiber intake and the incidence of type 2 diabetes - AJCN, 3/1/03 - "Whole-grain consumption was associated with a reduced risk of type 2 diabetes. The relative risk (adjusted for age, sex, geographic area, smoking status, body mass index, energy intake, and intakes of vegetables, fruit, and berries) between the highest and lowest quartiles of whole-grain consumption was 0.65 (95% CI: 0.36, 1.18; P for trend = 0.02). Cereal fiber intake was also associated with a reduced risk of type 2 diabetes. The relative risk between the extreme quartiles of cereal fiber intake was 0.39" - [WebMD]

Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms - AJCN, 3/1/03 - "ADP-induced platelet aggregation decreased significantly in the mixed tocopherol group but not in the alpha-tocopherol and control groups ... Effects of mixed tocopherols were associated with increased NO release, ecNOS activation, and SOD protein content in platelets, which may contribute to the effect on platelet aggregation"

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