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Recent Longevity News for the seven days ending 8/25/10.  You should consult your doctor if you are taking any medications.

Study compares risk with 2 diabetes drugs - Science Daily, 8/24/10 - "risks of heart disease events and death were no different between patients who took the diabetes drugs rosiglitazone or pioglitazone. In this analysis, approximately 4 percent of patients taking either drug -- sold as Avandia and Actos -- suffered a heart attack, heart failure, both or died over a 33-month period ... Besides its findings that rosiglitazone and pioglitazone have comparable risks, what distinguishes this latest study from other claims-based analyses is its analysis of death records, which include out-of-hospital deaths ... study also followed patients for a longer period of time than some of the earlier research" - So the two drugs have equal risks but what's confusing is how does that 4% risk compare to a placebo?

Oxytocin makes people trusting, but not gullible, study suggests - Science Daily, 8/24/10 - "Oxytocin (OT) is a hormone that plays an important role in social behavior—it has even been nicknamed “the love hormone” and “liquid trust.” Increased levels of OT have been associated with greater caring, generosity, and trust ... volunteers who received the OT nasal spray were more trusting of the computer and the reliable partners—that is, they offered more money to the computer and the reliable partner than did volunteers who received the placebo nasal spray. However, OT did not have an effect when it came to sharing with a seemingly unreliable partner—the volunteers were not generous towards a potentially unreliable partner, regardless of which nasal spray they received. ... These findings suggest that OT fosters trust, but not gullibility: OT may make individuals more trusting, but only in certain situations" - See See Oxytocin 6x5iu tablets at International Antiaging Systems.

Alcohol-based hand disinfectants improve business productivity, study finds - Science Daily, 8/23/10 - "incidences of absenteeism in public administrations due to the common cold, fever and cough are significantly reduced when alcohol-based hand disinfectants are used by employees ... The study also found a reduction in symptoms of illness during times when participants were not absent from work, suggesting that hand disinfectant use can reduce on-the-job-productivity-losses, increase workplace health levels, and therefore improve overall productivity"

Vitamin D found to influence over 200 genes, highlighting links to disease - Science  Daily, 8/23/10 - "The extent to which vitamin D deficiency may increase susceptibility to a wide range of diseases is dramatically highlighted in newly published research ... The researchers found 2,776 binding sites for the vitamin D receptor along the length of the genome. These were unusually concentrated near a number of genes associated with susceptibility to autoimmune conditions such as MS, Crohn's disease, systemic lupus erythematosus (or 'lupus') and rheumatoid arthritis, and to cancers such as chronic lymphocytic leukaemia and colorectal cancer ... vitamin D had a significant effect on the activity of 229 genes including IRF8, previously associated with MS, and PTPN2, associated with Crohn's disease and type 1 diabetes" - See vitamin D at Amazon.com.

Drink water to curb weight gain? Clinical trial confirms effectiveness of simple appetite control method - Science Daily, 8/23/10 - "We found in earlier studies that middle aged and older people who drank two cups of water right before eating a meal ate between 75 and 90 fewer calories during that meal. In this recent study, we found that over the course of 12 weeks, dieters who drank water before meals, three times per day, lost about 5 pounds more than dieters who did not increase their water intake"

Eating berries may activate the brain's natural housekeeper for healthy aging - Science Daily, 8/23/10 - "berries, and possibly walnuts, activate the brain's natural "housekeeper" mechanism, which cleans up and recycles toxic proteins linked to age-related memory loss and other mental decline ... natural compounds called polyphenolics found in fruits, vegetables and nuts have an antioxidant and anti-inflammatory effect that may protect against age-associated decline"

Polyphenol antioxidants inhibit iron absorption - Science Daily, 8/23/10 - "eating certain polyphenols decreased the amount of iron the body absorbs, which can increase the risk of developing an iron deficiency ... People already at risk for iron deficiency increase that risk if they consume high amounts of grape seed extract or EGCG" - See iron supplements at Amazon.com.

Adding Nutritional Supplement to Antidepressant Therapy May Boost Response in Refractory Depression - Medscape, 8/18/10 - "significantly more SAMe-treated than placebo-treated patients (36.1% vs 17.6%) experienced a clinical response on the 17-item Hamilton Depression Rating Scale (HAM-D), which was the primary study outcome. Remission rates (ie, HAM-D score of ≤7) were also higher with SAMe than with placebo (25.8% vs 11.7%)" - See SAM-e at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Pioglitazone attenuates prostatic enlargement in diet-induced insulin-resistant rats by altering lipid distribution and hyperinsulinemia - Br J Pharmacol. 2010 Aug 19 - "Increased incidence of benign prostatic hyperplasia among insulin-resistant individuals suggest a role for hyperinsulinemia in prostatic enlargement ... High fat diet led to the accumulation of fat in non-adipose tissues, insulin resistance, compensatory hyperinsulinemia and prostatic enlargement in rats. Pioglitazone treatment altered fat distribution, improved insulin-sensitivity and normalized lipid and insulin level in rats on the high-fat diet. The improved metabolic parameters led to decreased cellular proliferation and increased apoptosis in the prostate gland. High-fat diet feeding and pioglitazone treatment did not change plasma testosterone levels. However, significant prostatic atrophy was observed in castrated, rats irrespective of dietary intervention" - See pioglitazone at OffshoreRx1.com.  Some doctors think I'm crazy but pioglitazone is one of the drugs I take for anti-aging.  See my Insulin and Aging page.

Isoflavones decrease insomnia in postmenopause - Menopause. 2010 Aug 19 - "Polysomnography revealed a significant increase in sleep efficiency in the isoflavone group (from 77.9% to 83.9%) when compared with the placebo group (from 77.6% to 81.2%). Isoflavones induced a decrease in the intensity and number of hot flashes and the frequency of insomnia: among the women in the placebo group, 94.7% had moderate or intense insomnia at the beginning of the study, compared with 63.2% at the end, whereas in the isoflavone group, these percentages were 89.5% and 36.9%, respectively" - See soy isoflavones at Amazon.com.

Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis - BMJ. 2010 Aug 18;341:c4229 - "greater intake of green leafy vegetables was associated with a 14% (hazard ratio 0.86, 95% confidence interval 0.77 to 0.97) reduction in risk of type 2 diabetes (P=0.01). The summary estimates showed no significant benefits of increasing the consumption of vegetables, fruit, or fruit and vegetables combined"

{gamma}-Tocotrienol but not {gamma}-tocopherol blocks STAT3 cell signaling pathway through induction of protein tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents - J Biol Chem. 2010 Aug 18 - "We found that gamma-T3 but not gamma-tocopherol, the most common saturated form of Vitamin E, inhibited constitutive activation of STAT3 in a dose- and time-dependent manner and this inhibition was not cell type specific. gamma-T3 also inhibited STAT3 DNA binding ... This vitamin also sensitized the tumor cells to the apoptotic effects of thalidomide and bortezomib. Overall, our results suggest that gamma-T3 is a novel blocker of STAT3 activation pathway in both in vitro and in vivo and thus may have potential in prevention and treatment of cancers" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

A Nested Case-Control Study of Midgestation Vitamin D Deficiency and Risk of Severe Preeclampsia - J Clin Endocrinol Metab. 2010 Aug 18 - "Vitamin D may be important in the pathogenesis of severe preeclampsia ... Midgestation maternal 25(OH)D concentration was lower in women who subsequently developed severe preeclampsia compared with controls [median (interquartile range), 75 (47-107) nmol/liter vs. 98 (68-113) nmol/liter; P = 0.01]. Midgestation maternal 25(OH)D of less than 50 nmol/liter was associated with an almost 4-fold odds of severe preeclampsia (unadjusted odds ratio, 3.63; 95% confidence interval, 1.52-8.65) compared with midgestation levels of at least 75 nmol/liter. Adjustment for known confounders strengthened the observed association (adjusted odds ratio, 5.41; 95% confidence interval, 2.02-14.52). Conclusion: Maternal midgestation vitamin D deficiency was associated with increased risk of severe preeclampsia. Vitamin D deficiency may be a modifiable risk factor for severe preeclampsia" - See vitamin D at Amazon.com.

High-Molecular-Weight Adiponectin and the Risk of Type 2 Diabetes in the ARIC Study - J Clin Endocrinol Metab. 2010 Aug 18 - "Adiponectin, synthesized by adipocytes, has been shown to be a predictor of type 2 diabetes ... High-molecular-weight (HMW) adiponectin is thought to be the most biologically active form of adiponectin in terms of glucose homeostasis ... Overall hazard ratios (95% confidence intervals) for developing diabetes for those in the fourth (vs. the first) quartile of total adiponectin, HMW adiponectin, and the ratio of HMW to total were 0.40 (0.25-0.64), 0.38 (0.23-0.63), and 0.65 (0.42-0.99), respectively ... Conclusions: In this community-based sample of U.S. adults, higher total and HMW adiponectin concentrations were similarly associated with a lower incidence of diabetes over 9 yr of follow-up"

Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women - J Nutr. 2010 Aug 19 - "Participants were randomized to consume either a smoothie containing 22.5 g blueberry bioactives (blueberry group, n = 15) or a smoothie of equal nutritional value without added blueberry bioactives (placebo group, n = 17) twice daily for 6 wk. Both groups were instructed to maintain their body weight by reducing ad libitum intake by an amount equal to the energy intake of the smoothies. Participants' body weights were evaluated weekly and 3-d food records were collected at baseline, the middle, and end of the study. The mean change in insulin sensitivity improved more in the blueberry group (1.7 +/- 0.5 mg.kg FFM(-1).min(-1)) than in the placebo group (0.4 +/- 0.4 mg.kg FFM(-1).min(-1)) (P = 0.04). Insulin sensitivity was enhanced in the blueberry group at the end of the study without significant changes in adiposity, energy intake, and inflammatory biomarkers. In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants" - See blueberry extract at Amazon.com.

Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice - Br J Pharmacol. 2010 Sep;161(1):113-26 - "11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome. Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple biological activities ... Emodin is a potent and selective 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively. Single oral administration of emodin inhibited 11beta-HSD1 activity of liver and fat significantly in mice. Emodin reversed prednisone-induced insulin resistance in mice, whereas it did not affect dexamethasone-induced insulin resistance, which confirmed its inhibitory effect on 11beta-HSD1 in vivo. In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism, and lowered blood glucose and hepatic PEPCK, and glucose-6-phosphatase mRNA. CONCLUSIONS AND IMPLICATIONS This study demonstrated a new role for emodin as a potent and selective inhibitor of 11beta-HSD1 and its beneficial effects on metabolic disorders in DIO mice. This highlights the potential value of analogues of emodin as a new class of compounds for the treatment of metabolic syndrome or type 2 diabetes" - Note:  (11beta-HSD1) goes hand in hand with cortisol.  It seems like what came first, the chicken or the egg.  I googled emodin and didn't see any reliable places that sold it.  One article said that it was in some resveratrol products and that the emodin was what caused the stomach problems.

Plasma vitamin D and mortality in older men: a community-based prospective cohort study - Am J Clin Nutr. 2010 Aug 18 - "An approximately 50% higher total mortality rate was observed among men in the lowest 10% (<46 nmol/L) and the highest 5% (>98 nmol/L) of plasma 25(OH)D concentrations compared with intermediate concentrations. Cancer mortality was also higher at low plasma concentrations (multivariable-adjusted HR: 2.20; 95% CI: 1.44, 3.38) and at high concentrations (HR: 2.64; 95% CI: 1.46, 4.78). For cardiovascular death, only low (HR: 1.89; 95% CI: 1.21, 2.96) but not high (HR: 1.33; 95% CI: 0.69, 2.54) concentrations indicated higher risk ... Both high and low concentrations of plasma 25(OH)D are associated with elevated risks of overall and cancer mortality. Low concentrations are associated with cardiovascular mortality" - See vitamin D at Amazon.com.

Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease - Adv Ther. 2010 Aug 16 - "Oral ingestion of probiotics (90 billion colony forming units [CFUs]/day) was well tolerated and safe during the entire trial period at all sites. BUN levels decreased in 29 patients (63%, P<0.05), creatinine levels decreased in 20 patients (43%, no statistical significance), and uric acid levels decreased in 15 patients (33%, no statistical significance). Almost all subjects expressed a perceived substantial overall improvement in QOL (86%, P<0.05)" - See probiotics at Amazon.com.

Resveratrol differentially modulates inflammatory responses of microglia and astrocytes - J Neuroinflammation. 2010 Aug 17;7(1):46 - "These results suggest that murine microglia and astrocytes produce proinflammatory cytokines and NO in response to LPS in a similar pattern with some differences in signaling molecules involved, and further suggest that resveratrol exerts anti-inflammatory effects in microglia and astrocytes by inhibiting different proinflammatory cytokines and key signaling molecules" - See resveratrol products at Amazon.com.

Vitamin D Insufficiency and Prognosis in Non-Hodgkin's Lymphoma - J Clin Oncol. 2010 Aug 16 - "event-free survival (EFS) and overall survival (OS) ... 25(OH)D insufficient patients with diffuse large B-cell lymphoma (DLBCL) had inferior EFS (hazard ratio [HR], 1.41; 95% CI, 0.98 to 2.04) and OS (HR, 1.99; 95% CI, 1.27 to 3.13); 25(OH)D insufficient patients with T-cell lymphoma also had inferior EFS (HR, 1.94; 95% CI, 1.04 to 3.61) and OS (HR, 2.38; 95% CI, 1.04 to 5.41). There were no associations with EFS for the other NHL subtypes. Among patients with DLBCL and T-cell lymphoma, higher 1,25(OH)(2)D levels were associated with better EFS and OS, suggesting that any putative tumor 1-alpha-hydroxylase activity did not explain the 25(OH)D associations. CONCLUSION 25(OH)D insufficiency was associated with inferior EFS and OS in DLBCL and T-cell lymphoma. Whether normalizing vitamin D levels in these patients improves outcomes will require testing in future trials" - See vitamin D at Amazon.com.

Major Dietary Protein Sources and Risk of Coronary Heart Disease in Women - Circulation. 2010 Aug 16 - "26 years of follow-up ... higher intakes of red meat, red meat excluding processed meat, and high-fat dairy were significantly associated with elevated risk of CHD. Higher intakes of poultry, fish, and nuts were significantly associated with lower risk. In a model controlling statistically for energy intake, 1 serving per day of nuts was associated with a 30% (95% confidence interval, 17% to 42%) lower risk of CHD compared with 1 serving per day of red meat. Similarly, compared with 1 serving per day of red meat, a lower risk was associated with 1 serving per day of low-fat dairy (13%; 95% confidence interval, 6% to 19%), poultry (19%; 95% confidence interval, 3% to 33%), and fish (24%; 95% confidence interval, 6% to 39%). Conclusions-These data suggest that high red meat intake increases risk of CHD and that CHD risk may be reduced importantly by shifting sources of protein in the US diet"

Supplement Focus (Vitamin K):

News & Research:

Great mic for $20. At least on my computer it sounds better than my $350 karaoke mics. Maybe it's a compatibility thing. - Ben

Abstracts:

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