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Recent Longevity News for the seven days ending
7/28/10. You should consult your doctor if you are taking any medications.
Relationships improve your odds of survival by 50 percent, research finds -
Science Daily, 7/27/10 - "social connections -- friends,
family, neighbors or colleagues -- improve our odds of survival by 50 percent.
Here is how low social interaction compares to more well-known risk factors: ...
Equivalent to smoking 15 cigarettes a day ... Equivalent to being an alcoholic
... More harmful than not exercising ... Twice as harmful as obesity ...
Relationships provide a level of protection across all ages"
Excessive intake of omega 6 and deficiencies in omega 3 induce obesity down the
generations - Science Daily, 7/26/10 - "Chronic
excess of linoleic acid (omega 6),
coupled with a deficiency in alpha-linoleic acid (omega
3), can increase obesity down the generations
... In the past forty years, there has been a steady rise in obesity over the
generations in Western societies. During the same period, the diet in
industrialized countries has seen a quantitative increase in the calories
ingested (lipids account for 35 to 40% of food intake), high levels of linoleic
acid (omega 6) and low levels of alpha-linoleic acid (omega 3). Indeed, the
amount of omega 6 consumed during the past forty years has rocketed (+250%)
while that of omega 3 has fallen by 40%, thus destabilizing the omega 6/omega 3
ratio when compared with the recommended intakes. While the French Food Safety
Agency (AFSSA) recommends an omega 6/omega 3 ratio of 5/1, actual consumption is
15 omega 6 for 1 omega 3. In the USA, this ratio can even reach 40 omega 6 for 1
omega 3 ... researchers exposed four generations of mice to a Western-style
diet, characterized by these same omega 6/omega 3 ratios. As a result, they saw
a gradual increase in fat mass over several generations"
Preventing heart problems while keeping a cool head: Cause of flushing effect
arising from cholesterol treatment with nicotinic acid - Science Daily,
7/26/10 - "The opposite approach, which involves
increasing the concentration of "good" HDL cholesterol using nicotinic acid, has
proven unpopular among patients up to now. The reason for this is that treatment
with nicotinic acid has an unpleasant but harmless side-effect: the drug makes
patients turn quite red in the face ... the higher an individual's level of HDL
cholesterol, the lower his or her risk of contracting these diseases. For this
reason, the strategy of increasing HDL plasma concentration through medication
has become more prevalent of late. The drug on which most hopes are pinned here
nicotinic acid ... The flushing phenomenon can be
prevented by inhibiting prostaglandin formation or blocking the prostaglandin
receptors in the skin, while the desired effects of the nicotinic acid on lipid
metabolism remain unaffected" - See
niacin at Amazon.com.
time spent sitting linked to higher risk of death; Risk found to be independent
of physical activity level - Science Daily, 7/22/10 -
"more leisure time spent sitting was associated with
higher risk of mortality, particularly in
women. Women who reported more than six hours per day of sitting were 37 percent
more likely to die during the time period studied than those who sat fewer than
3 hours a day. Men who sat more than 6 hours a day were 18 percent more likely
to die than those who sat fewer than 3 hours per day. The association remained
virtually unchanged after adjusting for physical
activity level. Associations were stronger for cardiovascular disease
mortality than for cancer mortality"
needed to help celiacs stave off bone disease, researchers find - Science
Daily, 7/22/10 - "Children with
celiac disease need to include certain must-have
vitamins in their diets to stave off weak bones and osteoporosis ... A study of
43 children and teens from three to 18 years of age diagnosed with celiac
disease showed that they also tended to have low bone density, likely due to
poor intake and absorption of vitamins and minerals. That means they should be
getting more of bone-boosting vitamins such as K and D in their diets"
fat and calories can lower cancer risk in dogs and people - Science Daily,
7/22/10 - "As many as 1 out of 3 cancer deaths in both
humans and dogs could be prevented by reducing
Omega-6 fatty acids and cutting
calories ... Omega-6, such as corn oil, vegetable oil and grain-fed red meat.
Too much Omega-6 fatty acid can lead to
inflammation, which creates an environment conducive to cancer in dogs and
people ... obesity in both dogs and humans limits
the production of adiponectin, a hormone that
has been shown to inhibit cancer cell growth. He
recommended reducing calories, particularly those from sugar, which has the
additional danger of not only causing obesity, but also feeding cancer cells and
encouraging their growth ... the ideal blend of fiber for dog food is about 75
to 80 percent insoluble and 20 to 25 percent soluble. In addition, adding
quality prebiotics to pet foods can enhance their
First human trial backs GS diabetes benefits - Nutra USA, 7/22/10 -
"Their findings recorded an average reduction in fasting
blood glucose from 162 +/- 23 to 119 +/- 17 mg/dL. After eating, blood glucose
levels were found to have reduced from 291 +/-10 to 236 +/-30 mg/dL" -
gymnema sylvestre at Amazon.com.
Nutrient blend improves function of aging brain: rat study - Nutra USA,
7/21/10 - "NT-020 is a combination of blueberry, green
tea extract, carnosine and vitamin D3 ... The NT-020 group demonstrated
increased adult neural stem cell proliferation in the two main stem cell niches
in the brains and improvement in learning and memory" - Note: The
following is from last week's newsletter which didn't explain what NT-020 was.
I feel that many of those proprietary blends most likely designed by their
accountant are a con game to charge three times as much.
substance NT-020 aids aging brains in rats, study finds - Science Daily,
7/20/10 - "Aging has been linked to oxidative
stress, and we have previously shown that natural compounds made from
green tea, and amino acids, such as
carnosine, are high in antioxidants
anti-inflammatory and anti-oxidative
activity .... The combination of these nutrients, called NT-020, creates a
synergistic effect that promotes the proliferation of stem cells in the aged
animals ... NT-020 may have not only a positive effect on the stem cell
niche ... NT-020 may have far-reaching effects on organ function beyond the
replacement of injured cells, as demonstrated by
cognitive improvement in the NT-020 group"
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
Effect of a
high-calcium energy-reduced diet on abdominal obesity and cardiometabolic risk
factors in obese Brazilian subjects - Int J Clin Pract. 2010
Jul;64(8):1076-83 - "(i) a low-calcium
diet (LCD; < 500 mg/day) or (ii) a HCD [1200-1300 mg/day ... 16 weeks of energy
restriction, a significant reduction was observed in all anthropometric
parameters, metabolic variables (except for high-density lipoprotein
cholesterol) and blood pressure levels in both the groups. Insulin was
significantly reduced only in the HCD group. Subjects on the HCD compared with
those on the LCD exhibited a greater reduction in waist circumference (p =
0.002), waist-to-hip ratio (p = 0.0001), diastolic blood pressure (p = 0.04) and
mean blood pressure (p = 0.03). Conclusions: Our study suggests that increased
calcium intake may enhance the beneficial effects of energy restriction on
abdominal obesity and blood pressure"
and placebo therapy both improve weight management and fasting insulin in obese
insulin resistant adolescents: a prospective, placebo-controlled, randomized
study - Eur J Endocrinol. 2010 Jul 16 - "insulin
resistance (HOMA-IR) and the metabolic syndrome (MtS) ... The insulin
sensitivity index, however, only improved in the metformin group. High fasting
insulin is correlated with a subsequent BMI increase irrespective of medication.
MtS remained unchanged"
Neat Tech Stuff / "How To's":
Supplement Focus (Ginseng):
News & Research:
ginseng at Amazon.com
Best Treatment for Erectile Dysfunction? - Dr. Weil, 11/30/09 -
"Ginkgo ... Ashwaganda ... Asian ginseng
Ginseng: Nature's Anti-inflammatory? - Science Daily, 5/13/09 -
"The anti-inflammatory role of ginseng may be due to
the combined effects of these ginsenosides, targeting different levels of
immunological activity, and so contributing to the diverse actions of
ginseng in humans"
Ginseng May Help Treat Schizophrenia - WebMD, 5/8/08 -
"In a small study, patients had fewer negative
symptoms -- such as lack of motivation and a severe reduction in emotional
expression known as "flat affect" -- when they took Panax ginseng than when
they took a placebo ... patients were 50% less likely to have flat affect
when taking the higher, 200-milligram dose of ginseng than when taking
Ginseng May Relieve Cancer Fatigue - WebMD, 6/4/07
Shows Potential To Reduce Cancer-related Fatigue - Science Daily, 6/3/07
- "Of the four treatment arms, patients receiving
the placebo and the lowest dose of ginseng reported very little improvement
in fatigue or other areas of physical or psychological well-being. The
patients receiving the larger doses showed improvements in overall energy
levels, reporting higher vitality levels and less interference with activity
from fatigue. They also reported an improvement in overall mental, physical,
spiritual and emotional well-being"
Ginseng, Ginko Biloba Do Not Interfere With Drug Absorption If Taken At
Recommended Doses - Science Daily, 5/1/07 -
"found daily use of ginseng or ginkgo biloba
supplements at the recommended doses, or the combination of both
supplements, are unlikely to alter the pharmacokinetics - by which drugs are
absorbed, distributed, metabolized, and eliminated by the body - of the
majority of prescription or over-the counter drugs"
Ginseng linked to improved breast cancer outcomes - Nutra USA, 8/17/06
Product Review of Ginseng Supplements - ConsumerLab.com, 5/12/06
Researchers Find Ginseng May Improve Breast Cancer Outcomes - Science
Daily, 3/16/06 - "They also found significant
improvements in both survival and quality of life measures in patients who
Cortisol, Stress, and Health
- Life Extension Magazine, 12/05 -
"Supplements to reduce high
cortisol levels secondary to stress ...
Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3
fatty acids):1-4 gm/day ... Phosphatidylserine:
300-800 mg/day ... Rhodiola rosea:
100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day,
standardized extract ... Ginkgo biloba:
100-200 mg/day, standardized extract ... DHEA:
25-50 mg/day (any hormone supplementation should be monitored by your
Reduce Number and Severity of Colds - New York Times, 11/1/05
Ginseng for Gesundheit? Latest Study on Colds - WebMD, 10/24/05 -
"one in 10 people in the ginseng group reported
having two or more colds that winter, compared with about 23% of those
taking the placebo ... Colds lasted about 11 days for the ginseng group and
16.5 days for the placebo group"
MIT Team Explains Yin-yang Of Ginseng; Work Emphasizes Need For Stronger
Regulations Of Herbal Drugs - Science Daily, 9/1/04
- Ginseng a
No-No for Patients on Coumadin - WebMD, 7/6/04
Herbal Supplement Ginseng Reduces Effects Of Warfarin
- Doctor's Guide, 7/6/04
Natural Sex Boosters Gaining Ground - WebMD, 5/5/04
- Early Pregnancy
Risk With Ginseng - WebMD, 9/24/03
- Ginseng review
- ConsumerLab.com, 8/29/03 -
"A high amount of the pesticide hexachlorobenzene —
a potential human carcinogen — was found in one of five products labeled as
containing "Korean Ginseng." Levels of two other pesticides, quintozene and
lindane — were also above acceptable levels. Another product that failed the
new testing was a liquid "Chinese Ginseng" sold in single-dose bottles.
Despite being labeled "EXTRA STRENGTH" this product contained less than 10%
of the expected ginsenosides"
Ginseng May Improve Glucose Control - Doctor's Guide, 6/18/03
- Ginseng May
Help Treat Diabetes - WebMD, 6/16/03 -
"There are two reasons blood sugar can be out of
control in [people with
diabetes] ... Your body's tissues are not responsive enough to insulin
so they don't process it properly and/or you don't make enough insulin to
begin with ... Ginseng, he said, appears to help the patients both to
secrete more insulin and to process better the insulin they have" -
ginseng at Amazon.com.
- Korean Red Ginseng
Benefits Men with Impotence - New Hope Natural Media, 1/2/03 -
"Men experiencing sexual difficulties due
to inability to achieve erection may be helped by Korean red ginseng (Panax
ginseng), according to a study published in the Journal of Urology ... It is
a problem that affects nearly half of men over age forty worldwide ... Some
60% of participants reported improved erections while receiving ginseng.
Improved sexual desire was also reported during ginseng treatment.
Testosterone levels did not change with treatment, leading the
researchers to conclude that improvements observed with ginseng are not due
to hormonal effects" - See
ginseng at Amazon.com.
Ginseng May Help Regulate Blood Glucose - Natural Foods Merchandiser,
8/02 - "Three new studies, performed jointly by
researchers at the University of Toronto, St. Michael's Hospital in Toronto
and the University of Ottawa, show that American ginseng can lower
blood-sugar levels in diabetic and
nondiabetic patients" - See
ginseng at Amazon.com.
Ginseng's New Powers - HealthScout, 5/24/02
- Ginseng Berry
Shows Promise for Diabetes - WebMD, 5/24/02
Ginseng: Fewer Adverse Events if Used Alone - Clinical Psychiatry News,
Ginseng Helps Regulate Blood Glucose - Nutrition Science News, Spring
'02 - "Three new studies, performed jointly by
researchers at the University of Toronto, St. Michael's Hospital in Toronto,
and the University of Ottawa, show that American ginseng can lower
blood-sugar levels in
diabetic and nondiabetic patients ... They found no significant
differences between the three doses—each lowered postprandial glucose levels
an average of 11.4 percent"
- Some Herbs Boost
Breast Cancer Risk - WebMD, 3/26/02 - "Our
studies show that dong quai and ginseng stimulate the growth of [breast
Notoginseng Cuts Bleeding Time in Half - Nutrition Science News, 12/01
Bright Future For Chinese Mountain Herb - Natural Foods Merchandiser,
Ginseng Lowers Blood Glucose - Nutrition Science News, 7/01
- Not All Ginseng
Supplements Are Alike - WebMD, 6/26/01 - "a new
analysis of 25 commercial ginseng products suggests that the actual
concentration of ginseng is lower than the label says about half the time
and in six products the concentration was only 1%"
Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction,
Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 -
"ArginMax -- a
dietary cocktail consisting of ginseng, ginkgo, B vitamins, calcium, folic
acid, and other vitamins and minerals -- is being heralded as one component
of a lifestyle that improves sexual performance and helps prevent problems
associated with intimacy"
Sustain the Brain - Nutrition Science News, 2/01
Beyond the Label: American Ginseng Protects - Nutrition Science News,
2/01 - "American ginseng has been shown to display
synergistic effects against breast cancer cell growth when combined with
chemotherapy. From the protective perspective, American ginseng displays
potent antioxidant defenses against free radical damage to human LDL
cholesterol, which is reinforced by the vitamin C that inhabits LDL. The
most striking results attributable to this American root are found in its
ability to smooth out post-meal blood-sugar surges and carbohydrate
metabolism in both nondiabetics and type II diabetics."
American Ginseng Protects - Nutrition Science News, 2/01
Ginseng Laced With Pesticides - Nutrition Science News, 9/00
Saving Yourself from AGE - Life Enhancement Magazine, 8/00 - with
American Ginseng, "The researchers found a reduction
in plasma prolactin, a hormone connected with passive "nesting" behavior,
suggesting that this may play a role in the ability of American ginseng to
stimulate sexual activity in the male rat."
Want a love potion? What to know before you try - CNN, 6/15/00 -
"Tissue and animal studies of one form of ginseng,
called panax, give some credence to the root's sexy reputation. A study
published in the May 1995 issue of the journal British Pharmacology, for
instance, concluded that substances in ginseng extract known as ginsenosides
may work in a similar way to Viagra. Viagra enhances the effects of nitric
oxide, which helps relax artery walls, allowing more blood flow into the
penis. Ginsenosides may encourage the release of more nitric oxide."
Ginseng May Enhance Immune Function - WebMD, 6/5/00
Stress: The Hidden Factor For Weight Gain - Nutrition Science News, 4/01
Ergogenics for Endurance Athletes - Nutrition Science News, 3/00
Herbal Aids for Cancer - Nutrition Science News, 3/00
Be All That You Can Be - Life Enhancement Magazine, 7/99
Chinese Herbs Enhance Sexual Vitality - Nutrition Science News, 3/99
Korean Red Ginseng (Panax ginseng C.A. Mayer) and Its Isolated Ginsenosides and
Polysaccharides on Arterial Stiffness in Healthy Individuals - Am J
Hypertens. 2010 Feb 4 - "Although preliminary, this
study is the first to demonstrate that KRG may improve arterial stiffness as
measured by AI"
herbal combination, Etana, for enhancing erectile function: an efficacy and
safety study in animals - Int J Impot Res. 2009 Jun 4 -
"a new herbal combination called Etana that is
composed of five herbal extracts including Panax quinquelotius (Ginseng),
Eurycoma longifolia (Tongkat Ali), Epimedium grandiflorum (Horny goat weed),
Centella asiatica (Gotu Kola) and flower pollen extracts. Most of the
above-mentioned extracts have a long historical and traditional use for
erectile dysfunction (ED) ... penile erection index (PEI) ... At a 7.5 mg
kg(-1) single dose, the percentage of responding rats was 53+/-7 with a PEI
of 337+/-72 compared with 17+/-6 with a PEI of 30+/-10 for control animals.
This PEI was significantly (P<0.001) higher than each single component and
than the sum of any two herbal components of Etana. When compared with
sildenafil citrate, Etana induced more pronounced PEI than 0.36 mg kg(-1),
but similar to 0.71 mg kg(-1) of sildenafil. Furthermore, full acute and
sub-acute toxicity studies showed no toxic effects of Etana. In conclusion,
this study describes a new and safe combination of herbal components that
enhance erectile function in male rats"
of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose
homeostasis in an obese insulin-resistant rat model - Metabolism. 2009
Jan;58(1):8-15 - "We evaluated the antihyperglycemic
and antiobesity effects of ginsam, a component of Panax ginseng produced by
vinegar extraction, which is enriched in the ginsenoside Rg3 ...
Insulin-resistant rats treated with ginsam had lower fasting and
postprandial glucose concentrations compared with vehicle-treated rats.
Importantly, overall glucose excursion during the intraperitoneal 2-hour
glucose tolerance test decreased by 21.5% (P < .01) in the treated rats,
indicating improved glucose tolerance. Plasma insulin concentration was
significantly lower in ginsam-treated rats. These changes may be related to
increased glucose transporter 4 expression in skeletal muscle.
Interestingly, when the data from both ginsam-treated groups were combined,
body weight was 60% lower in the ginsam-treated rats than in the controls (P
< .01). Liver weight and serum alanine aminotransferase concentrations were
also lower in the ginsam-treated rats. These effects were associated with
increased peroxisome proliferator-activated receptor gamma expression and
adenosine monophosphate-activated protein kinase phosphorylation in liver
and muscle. Our data suggest that ginsam has distinct beneficial effects on
glucose metabolism and body weight control in an obese animal model of
insulin resistance by changing the expression of genes involved in glucose
and fatty acid metabolism" - See
ginseng at Amazon.com.
Panax Ginseng Enhances
Cognitive Performance in Alzheimer Disease - Alzheimer Dis Assoc Disord.
2008 Jun 17 - "ginseng group was treated with Panax
ginseng powder (4.5 g/d) for 12 weeks ... After ginseng treatment, the
cognitive subscale of ADAS and the MMSE score began to show improvements and
continued up to 12 weeks (P=0.029 and P=0.009 vs. baseline, respectively).
After discontinuing ginseng, the improved ADAS and MMSE scores declined to
the levels of the control group. These results suggest that Panax ginseng is
clinically effective in the cognitive performance of AD patients" -
ginseng at Amazon.com.
Combined effects of swim training and ginseng supplementation on exercise
performance time, ROS, lymphocyte proliferation, and DNA damage following
exhaustive exercise stress - Int J Vitam Nutr Res. 2007 Jul;77(4):289-96
- "These findings suggest that the combined effect
of swim training and ginseng supplementation sustain lymphocyte function in
the presence of reduced ROS production and DNA damage following acute
Botanical and dietary supplements for mood and anxiety in menopausal women
- Menopause. 2006 Dec 28 - "The one randomized,
controlled trial of ginseng in postmenopausal women reported improvements in
mood and anxiety"
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