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Recent Longevity News for the seven days ending 4/15/09.  You should consult your doctor if you are taking any medications.

Low Glycemic Breakfast May Increase Benefits Of Working Out - Science Daily, 4/15/09 - "Overall, fat oxidation was higher in the LGI treatment than in the HGI treatment (P < 0.05) during the post-breakfast and exercise periods. Following lunch, fullness scores were higher in the LGI trial than in the HGI trial (P < 0.05). The authors concluded that consuming a LGI breakfast increases fat oxidation during subsequent exercise and improved satiety during recovery in sedentary females. As such, individuals trying to shed fat may consider choosing LGI foods eaten prior to when they exercise"

Taking Statins? Five Ways to Boost Your Energy - ABC News, 4/14/09 - "It's a cruel irony that if statins make patients more lethargic, it could impair their ability to exercise or make dietary changes that would help them address their high cholesterol ... some studies have found that patients' energy levels increased while using CoQ10 and statins together ... Try pomegranate juice or a small chunk of dark chocolate, both of which have beneficial antioxidants ... Skimping on sleep has been found to increase calcium deposit build-up in your arteries" - See ubiquinol products at Amazon.com.

Study: No Vision Loss From ED Drugs - WebMD, 4/13/09 - "researchers randomly assigned 244 healthy men age 30 to 65, some with mild erectile dysfunction, to take a daily dose of 5 milligrams of Cialis, 50 milligrams of Viagra, or a placebo for six months ... The results showed no significant differences between those who took the erectile dysfunction drugs or the placebo on ERG, vision function tests, pressure within the eyeball, or assessments of the anatomy of the eye"

Metformin May Have Long-Term Benefits in Patients With Type 2 Diabetes - Medscape, 4/10/09 - "Compared with the placebo group, the metformin group had prevention of weight gain (mean weight gain, −3.07 kg; range, −3.85 to −2.28 kg; P < .001), better glycemic control (mean reduction in glycated hemoglobin level, 0.4%; 95% confidence interval [CI], 0.55 – 0.25; P < .001), and lower insulin requirements (mean reduction, 19.63 U/day; 95% CI, 24.91 – 14.36 U/day; P < .001) ... Add-on metformin improved glycemic control and reduced body weight and insulin requirements"

Omega-3 Fatty Acids May Benefit Cancer Patients Undergoing Major Operations - Science Daily, 4/10/09 - "A randomised controlled trial showed omega-3 fatty acids given as part of an oral nutritional supplement resulted in the preservation of muscle mass in patients undergoing surgery for oesopahageal cancer, a procedure normally associated with significant weight loss and quality of life issues ... Patients given the standard supplement without omega 3 lost a significant amount of weight comprising 100% muscle mass. In fact 68% of patients suffered ‘clinically severe’ weight loss post surgery in the standard group (without omega 3) versus only 8% in the omega 3 group" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Chronic Insomnia With Short Sleep Duration Is Significant Risk Factor For Hypertension - Science Daily, 4/9/09 - "participants with insomnia and an objectively measured, severely short sleep duration of less than five hours had a risk for hypertension that was 500 percent higher than participants without insomnia who slept more than six hours. People with insomnia and a moderately short sleep duration of five to six hours had a risk for hypertension that was 350 percent higher than normal sleepers"

Vitamin D Deficiency Related To Increased Inflammation In Healthy Women - Science Daily, 4/8/09 - "75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri nutritional sciences researcher has found that vitamin D deficiency is associated with inflammation, a negative response of the immune system, in healthy women ... This may explain the vitamin's role in the prevention and treatment of inflammatory diseases, including heart disease, multiple sclerosis and rheumatoid arthritis ... To improve vitamin D status and achieve its related health benefits, most people should get at least 1000 IU of vitamin D per day" - See vitamin D at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Pioglitazone Improves Cardiac Function and Alters Myocardial Substrate Metabolism Without Affecting Cardiac Triglyceride Accumulation and High-Energy Phosphate Metabolism in Patients With Well-Controlled Type 2 Diabetes Mellitus - Circulation. 2009 Apr 6 - "were assigned to pioglitazone (30 mg/d) or metformin (2000 mg/d) and matching placebo for 24 weeks ... No patient developed heart failure. Both therapies similarly improved glycemic control, whole-body insulin sensitivity, and blood pressure. Pioglitazone versus metformin improved the early peak flow rate (P=0.047) and left ventricular compliance. Pioglitazone versus metformin increased myocardial glucose uptake (P<0.001), but pioglitazone-related diastolic improvement was not associated with changes in myocardial substrate metabolism. Metformin did not affect myocardial function but decreased cardiac work relative to pioglitazone (P=0.006), a change that was paralleled by a reduced myocardial glucose uptake and fatty acid oxidation. Neither treatment affected cardiac high-energy phosphate metabolism or triglyceride content. Only pioglitazone reduced hepatic triglyceride content" - I still take pioglitazone even though I don't have diabetes because I feel that higher glucose levels are a major cause of aging.  There doesn't seem to be any evidence that it has the heart rises that rosiglitazone has.  See Pioglitazone at OffshoreRx1.com.

An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals - Eur J Clin Nutr. 2009 Apr 8 - "The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

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