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Recent Longevity News for the seven days ending 6/25/08.  You should consult your doctor if you are taking any medications.

Risk of Dying Linked to Low Vitamin D - WebMD, 6/23/08 - "people with the lowest levels of vitamin D in their blood had the highest chances of dying. Although chances of dying due to heart disease rose with decreasing levels of vitamin D, dying from other causes was more likely, too. Patients with little coronary artery disease were still much more likely to die during follow-up if they had low vitamin D levels" - See vitamin D at Amazon.com.

Common Cooking Spice Found In Curry Shows Promise In Combating Diabetes And Obesity - Science Daily, 6/20/08 - "turmeric-treated mice were less susceptible to developing Type 2 diabetes, based on their blood glucose levels, and glucose and insulin tolerance tests. They also discovered that turmeric-fed obese mice showed significantly reduced inflammation in fat tissue and liver compared to controls. They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these mouse models by dampening the inflammatory response provoked by obesity" - See curcumin products at Amazon.com.

Pine bark extract may ease menstrual pains: study - Nutra USA, 6/20/08 - "Pycnogenol, 60 mg per day ... At the end of the study, Suzuki and co-workers found that, while women in the low pain group showed no benefits from pine bark supplementation, women with dysmenorrhea did significantly benefit. In addition to a reduction in the use of NSAIDs, a reduction in the number of painful days due to dysmenorrhea from 2.1 days before supplementation to 1.3 days during the third and fourth menstrual cycle" - See Pycnogenol at Amazon.com or grape seed extract at Amazon.com (some say the grape seed extract is the same without the patent markup).

Memory Loss Linked To Poor Diet, Study Suggests - Science Daily, 6/19/08 - "Researchers from the Medical University of South Carolina (MUSC) have linked memory loss to a diet high in saturated fat and cholesterol"

Testosterone Gel Improves Insulin Sensitivity, Sexual Function in Hypogonadal Men With Diabetes and Metabolic Syndrome - Doctor's Guide, 6/20/08 - "Among patients with type 2 diabetes with or without metabolic syndrome, insulin resistance as measured by HOMA-IR improved from baseline in the testosterone-treated group compared with placebo at 6 months (testosterone: -0.62, placebo: +0.16; P = .049) and at 12 months (testosterone: -.58 ... Patients receiving testosterone also achieved more than a 5-point improvement over placebo-treated patients on the International Index of Erectile Function (IIEF) at 6 months (P < .05) and more than 6 points over placebo-treated patients at 12 months"

Finasteride and High-Grade Prostate Cancer - Medscape, 6/19/08 - "A new analysis from the national Prostate Cancer Prevention Trial (PCPT) shows that finasteride does not increase the risk for high-grade prostate cancer, as earlier findings appeared to indicate"

Pilot study gives sign of fish oil for insulin sensitivity - Nutra USA, 6/18/08 - "The supplements they were given contained 440mg of DHA and 660mg of EPA ... They saw evidence of increased insulin sensitivity through a reduction in the plasma glucose response, and a mean reduction in serum triglycerides and total cholesterol ... What was significant, however, was the reduction in diastolic blood pressure. Clinically significant reductions in all other biomarkers associated with coronary heart disease risk and mortality" - There's no write-up in the abstract.  See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Failure To Bridle Inflammation Spurs Atherosclerosis - Science Daily, 6/18/08 - "When a person develops a sore or a boil, it erupts, drawing to it immune system cells that fight the infection. Then it resolves and flattens into the skin, often leaving behind a mark or a scar ... A similar scenario plays out in the blood vessels. However, when there is a defect in the resolution response -- the ability of blood vessels to recover from inflammation -- atherosclerosis or hardening of the arteries can result ... Some natural mediators that 'cool' this inflammation are derived from omega-3 polyunsaturated fatty acids" - See See Mega Twin EPA at Amazon.com.  See my inflammation page for other ways to reduce it.

Vitamin D May Up Colon Cancer Survival - WebMD, 6/18/08 - "patients with colon cancer who were among the top 25% in levels of vitamin D before being diagnosed were less likely to die during the study period than those who were among the 25% with the lowest levels of the vitamin" - [Science Daily] - See vitamin D at Amazon.com.  This is getting old.  It's starting to seem like there's nothing that vitamin D doesn't do plus it's cost is next to nothing.  I'm not saying that to sell vitamin D.  The commission on next to nothing is less than next to nothing but I can't believe a lot more people aren't taking it with that many studies supporting it and it's low cost and studies showing that about 40% aren't getting enough.  See my vitamin D page.

Hormone Replacement for Men: Pros, Cons - WebMD, 6/18/08- "The supplemental testosterone reduced total cholesterol, "bad" LDL cholesterol, triglycerides, and body mass index while improving "good" HDL cholesterol. The men lost their pot bellies, Saad says. "What we see after 12 months is a reduction in two or three trouser sizes, three or four inches off the waist. We see a reduction by one-fourth to one-third of their total cholesterol"

High Fructose Corn Syrup Gets Unlikely Ally - WebMD, 6/18/08 - "At a meeting in Chicago, AMA delegates backed a resolution that argues that there's no scientific proof that high fructose corn syrup deserves the blame for obesity more than sugar or other caloric sweeteners. The resolution also nixes putting warning labels on products containing high fructose corn syrup"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome - Int J Clin Pract. 2008 Jun 19 - "treated with metformin 1500 or 2550 mg/day for 8 months ... Mean weight, serum ALT and GGT decreased from 100.3 to 96.6 kg (p < 0.0001), 29.7 to 25.8 U/l (p = 0.012) and 21.4 to 16.9 U/l (p < 0.0001) respectively ... In women with baseline ALT > 29.7 U/l (median), ALT reduction was highly significant (p = 0.005); however in those with baseline ALT < 29.7 U/l, ALT did not change despite similar weight reduction. There was no difference in reductions in ALT and GGT when the two metformin doses were compared" - Why is that important:

  • Elevated ALT Levels Predict Risk of Death From Liver Cancer - Medscape, 11/2/06 - "Upper limits of normal range from 30 IU/L to 60 IU/L, depending on the laboratory. "We want to reset it southward of 30 IU/L," ... ALT levels are a reflection of the general vascular condition ... If the level is above 30, then that person probably has a problem — fatty liver or some vascular disease, including occlusive coronary artery disease"

A Mixture of trans, trans Conjugated Linoleic Acid Induces Apoptosis in MCF-7 Human Breast Cancer Cells with Reciprocal Expression of Bax and Bcl-2 - J Agric Food Chem. 2008 Jun 21 - "These findings suggest that incorporation of t, t CLA in the membrane induces a mitochondria-mediated apoptosis that can enhance the antiproliferative effect of t, t CLA in MCF-7 cells" - See conjugated linoleic acid at Amazon.com.

Cis-9,trans-11-Conjugated Linoleic Acid Inhibits Allergic Sensitization and Airway Inflammation via a PPAR{gamma}-Related Mechanism in Mice - J Nutr. 2008 Jul;138(7):1336-42 - "C9,t11-CLA feeding resulted in significantly reduced IgE production and allergen-induced in vivo airway hyperresponsiveness ... These findings demonstrate that dietary c9,t11-CLA can reduce allergic airway inflammation, most likely via a PPARgamma-related mechanism and by reducing eicosanoid precursors. They give new insights into the fatty acid-mediated mechanism of immunomodulation and may represent a step toward an attractive novel strategy in the dietary prevention and treatment of allergic asthma" - See conjugated linoleic acid at Amazon.com.

Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice - J Nutr. 2008 Jul;138(7):1360-4 - "soy phytochemicals slow the in vivo growth of NSCLC xenografts; the modulation of the Akt-signaling pathway observed in tumors of SSE-treated mice may have a role in the activity observed. Our research provides further support for the concept that consumption of phytoestrogens may be effective in delaying lung cancer progression"

Genistein protects against polycyclic aromatic hydrocarbon-induced oxidative DNA damage in non-cancerous breast cells MCF-10A - Br J Nutr. 2008 Jun 23:1-6 - "These enzymes, in turn, will metabolise the PAH into their ultimate carcinogenic forms. Genistein can significantly suppress the expressions within 5 mum. The comet assay indicated that DMBA introduced DNA damage to these cells, and co-treatment with genistein at 5 or 10 mum could alleviate the damage. In addition to the chelation of DMBA metabolites to DNA, flow cytometry results revealed that oxidation was also a factor of DNA damage. The oxidative DNA damage could be removed by co-treating with 10 mum-genistein. Because no increased oxidative DNA repair was observed, suppression on the cytochrome enzymes appeared to be the underlying mechanism"

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt - J Biol Chem. 2008 Jun 18 - "Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription" - See resveratrol products at Amazon.com.

Genistein reduced the invasive activity of human breast carcinoma cells as a result of decreased tight junction permeability and modulation of tight junction proteins - Cancer Lett. 2008 Jun 14 - "Taken together our results indicate a possible role of genistein as an inhibitor of cancer cell invasion through the tightening of TJs, which may counteract the up-regulation of claudins. In addition, our results indicate that may be beneficial for the inhibition of tumor metastasis"

Neat Tech Stuff :

  • AT&T will start selling the new 3G iPhone on 7/11/08. I applied for their affiliate program then found out that it would not be sold online and cancelled. It’s $199 for the 8 gigs and $299 for 16 gigs. The individual plan is $39.99/month and to add the Internet is another $30/month. I was looking at the old iPhones on Sunday. They are really neat and the newer one is supposed to be a lot better. It’s got the wireless phone, iPod, Internet, GPS, email, photos, video and a lot more all in one. 16 gigs is about 16 movies or a heck of a lot of pictures or songs. My 358 songs is a little over one gigabyte. I’ve got a folder with 330 pictures and it’s less than a twentieth of a gigabyte. The new iPhone also has the iPod plug for your car stereo. It’s also got the advantage that instead of carrying both the iPod and phone when I run I only need the phone. I’ve got a Sony iPod Bluetooth transmitter and headset for the iPod which will work on the iPhone.

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