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Recent Longevity News for the seven days ending
2/3/10. You should consult your doctor if you are taking any medications.
may reduce the risk of psychotic disorders in high-risk individuals -
Science Daily, 2/1/10 - "For 12 weeks, 41 individuals
were assigned to take daily fish oil capsules containing 1.2 grams of
omega-three polyunsaturated fatty acids and
40 were assigned to take placebo; a total of 76 (93.8 percent) completed the
intervention. By the end of the study, two (4.9 percent) in the omega-3 group
and 11 (27.5 percent) in the placebo group had transitioned to psychotic
disorder. The difference between progression to psychosis was 22.6 percent ...
Polyunsaturated fatty acids also significantly reduced symptoms and improved
functioning compared with placebo" - [WebMD]
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Omega-3 may reduce risk of Alzheimer’s: Rat study - Nutra USA, 2/1/10 -
"This study, for the first time, reported […] a clear
correlation between the decrease in acetylcholine release and memory deficit,
E-EPA improves memory by attenuating the
reduction of acetylcholine release and nerve growth factor expression ... In
this study, our findings add further evidence that E-EPA may improve memory by
the modulation of acetylcholineand neurotrophin functions" - [Abstract]
Mega Twin EPA at Amazon.com.
What You Eat After Working Out Matters - WebMD, 1/29/10 -
"A new study shows that eating a low-carbohydrate meal
after aerobic exercise enhances insulin
sensitivity. Increased insulin sensitivity
makes it easier for the body to take up sugar from the bloodstream and store it
in muscles and other tissues where it can be used for fuel ... Impaired insulin
sensitivity, or insulin resistance, increases the risk for type 2 diabetes and
Drinking Tea May Trim Men's Waistlines - WebMD, 1/29/10 -
"In men, the use of sugar in
tea was associated with a nearly 1-inch smaller
waist measurement, but the use of
artificial sweeteners was linked to a nearly
2-inch larger waistline ... Among women, the use of milk in tea was associated
with a two-thirds-of-an-inch smaller waistline. But women who used artificial
sweeteners had an average of nearly an inch larger waistline" - See
green tea extract at Amazon.com. Related
Artificial Sweeteners Linked To Weight Gain - Science Daily, 2/10/08 -
"relative to rats that ate yogurt sweetened with
glucose (a simple sugar with 15 calories/teaspoon, the same as table sugar),
rats given yogurt sweetened with zero-calorie saccharin later consumed more
calories, gained more weight, put on more body fat, and didn't make up for
it by cutting back later, all at levels of statistical significance"
Fats of any kind may boost prostate cancer risk: Study - Nutra USA, 1/29/10
- "Last year, a study from Harvard reported that
increased intakes of trans-fatty acids may increase the risk of non-aggressive
prostate tumors by about 100 per cent ... the
highest blood levels of trans oleic acid and linoleic acids (18:1n-9t and 18:2t)
were associated with a 116 and 97 per cent increase in the risk of
non-aggressive prostate tumors, respectively, compared to the lowest levels. The
study followed almost 15,000 men over 13 years"
Overweight Older People Live Longer - WebMD, 1/28/10 -
"people who met the criteria for being overweight were
17% less likely to die compared to people of normal weight ... In the newly
reported research, overweight study participants in their 70s followed for up to
10 years had a 13% lower risk of death than participants classified as normal
weight ... Obese and normal-weight study participants had a similar risk of
death over the 10 years of follow-up. Underweight study participants had the
highest risk of death, even after the researchers adjusted for the wasting
effects of disease"
Omega-3 may reduce risk of dental disease: Study - Nutra USA, 1/28/10 -
"The average number of dental
disease events was 1.5 times higher in people with low
DHA levels, compared to those with the highest
average levels of DHA" - [Abstract]
Jarrow Max DHA at Amazon.com.
Increased Cancer Risk Seen With Higher Blood Glucose Levels - Medscape,
1/28/10 - "in men, each 1 mmol/L (18 mg/dL) increment in
blood glucose level was associated with a 5% increase in incident cancer risk
and a 15% increase in fatal cancer risk ... In
women, each 1 mmol/L increase in blood glucose level was associated with an 11%
increase in incident cancer risk and a 21% increase in fatal cancer risk ... For
men, there were glucose-related increases in the risks of incident and fatal
cancer of the liver, gallbladder, and respiratory tract; incident thyroid cancer
and multiple myeloma; and fatal rectal and colon cancer .... For women, there
were glucose-related increases in the risks of incident and fatal pancreatic and
stomach cancer; incident urinary bladder cancer and endometrial cancer; and
fatal cervical and uterine corpus cancer. In women, there was also an inverse
association of blood glucose with incident thyroid cancer risk ... For men and
women combined, higher glucose increased the risk of death from oropharyngeal
and esophageal cancers" - See my
Insulin and Aging page.
Vitamin D May Ease Asthma - WebMD, 1/28/10 - "people
with higher vitamin D levels had better lung
function measures than people with lower vitamin D levels. In particular, people
with low vitamin D performed worse on tests of lung function and airway
hyper-responsiveness, two hallmarks of asthma ... researchers say vitamin D
levels were directly related to the participants’ score on the breathing tests:
the lower the vitamin D levels, the worse their performance"
More folate may mean less depression: Study - Nutra USA, 1/27/10 -
"Men with the highest blood levels of
folate were50 per cent less likely to have symptoms of
depression, compared to men with the lowest levels" - [Abstract]
folic acid products at Amazon.com.
D supplements could fight Crohn's disease - Science Daily, 1/27/10 -
"Vitamin D acts
directly on the beta defensin 2 gene, which encodes an antimicrobial peptide,
and the NOD2 gene that alerts cells to the presence of invading microbes. Both
Beta-defensin and NOD2 have been linked to Crohn's
disease. If NOD2 is deficient or defective, it cannot combat invaders in the
intestinal tract ... Siblings of patients with Crohn's disease that haven't yet
developed the disease might be well advised to make sure they're vitamin D
sufficient" - See
vitamin D at Amazon.com.
bacteria keep immune system primed to fight future infections - Science
Daily, 1/27/10 - "The investigators show that
"good" bacteria in the gut keep the
immune system primed to more effectively fight
infection from invading pathogenic bacteria. Altering the intricate dynamic
between resident and foreign bacteria -- via antibiotics, for example --
compromises an animal's immune response, specifically, the function of white
blood cells called neutrophils" - See
probiotics at Amazon.com.
Magnesium May Improve Memory - WebMD, 1/27/10 -
"increasing brain magnesium using a newly developed compound,
magnesium-L-threonate (MgT), improves learning abilities, working memory, and
short- and-long-term memory in rats. The magnesium also helped older rats
perform better on a battery of learning tests ... The researchers cite that only
32% of Americans get the recommended daily allowance of magnesium" - See
magnesium supplements at Amazon.com.
Coffee Break Boosts Memory - WebMD, 1/27/10 -
"Taking a coffee break after class can actually
help you retain that information you just learned"
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
Reductions of acetylcholine release and nerve growth factor expression are
correlated with memory impairment induced by interleukin-1beta administrations:
effects of omega-3 fatty acid EPA treatment - J Neurochem. 2009 Dec 3 -
"E-EPA treatment significantly improved the
memory, which was correlated with normalizing ACh release, and expressions of
NGF and IL-1beta" - See
Mega Twin EPA at Amazon.com.
biloba extract EGb 761((R)) and its main constituent flavonoids and ginkgolides
increase extracellular dopamine levels in the rat prefrontal cortex - Br J
Pharmacol. 2010 Jan 25 - "A single oral dose of
EGb 761 (100 mg.kg(-1)) had no effect on
monoamine levels. However, following chronic (100 mg.kg(-1)/14 days/once daily)
treatment, the same dose significantly increased extracellular
noradrenaline levels, while 5-HT levels were unaffected. Chronic treatment
with EGb 761 showed dose-dependent increases in frontocortical dopamine levels
and, to a lesser extent, in the striatum. The extracellular levels of HVA and
DOPAC were not affected by either acute or repeated doses. Treatment with the
main constituents of EGb 761 revealed that the increase in dopamine levels was
mostly caused by the flavonol glycosides and ginkgolide fractions, whereas
bilobalide treatment was without effect. Conclusions and implications: The
present results demonstrate that chronic but not acute treatment with EGb 761
increased dopaminergic transmission in the PFC. This finding may be one of the
mechanisms underlying the reported effects of G. biloba in improving
Ginkgo biloba at Amazon.com.
Longitudinal relationship between dietary omega-3 fatty acids and periodontal
disease - Nutrition. 2010 Jan 22 - "Low
DHA intake was significantly associated with more
periodontal disease events. The mean number of
periodontal disease events for participants who consumed the lowest tertile of
DHA was approximately 1.5 times larger (lowest tertile, incidence rate ratio
1.49, 95% confidence interval 1.01-2.21) than the reference group (highest
tertile of DHA consumption), after simultaneously adjusting for possible
confounders" - See
Jarrow Max DHA at Amazon.com.
folate and homocysteine and depressive symptoms among Japanese men and women
- Eur J Clin Nutr. 2010 Jan 20 - "The
multivariate-adjusted odds ratios (95% confidence interval) of
depressive symptoms for the lowest to highest
quartiles of serum
folate were 1.00 (reference), 0.53
(0.27-1.03), 0.33 (0.16-0.68) and 0.51 (0.25-1.03), respectively" - See
folic acid products at Amazon.com.
Health Focus (Mediterranean
News & Research:
Linked to Lower Risk for Stomach Cancer - Medscape, 12/29/09 -
"For every 1-unit increase in relative Mediterranean
diet score, the risk for gastric adenocarcinoma decreased by 5% to 7%"
Mediterranean Diet May Fight Depression - WebMD, 10/5/09
Mediterranean Diet May Boost Eye Health - WebMD, 5/11/09 -
"people who ate one serving of fish per week had a
31% lower risk of early signs of AMD. Those who ate one to two servings of
nuts rich in omega-3 fatty acids had a 35% lower risk"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Mediterranean diet may lower blood pressure: Study - Nutra USA, 5/11/09
Mediterranean Diet May Preserve Memory - WebMD, 2/9/09 -
"The Mediterranean diet consists of larger doses of
fish, vegetables, legumes, fruits, cereals, and unsaturated fatty acids; low
amounts of dairy products, meat, and saturated fats; and a moderate amount
of alcohol ... average 4.5 year follow-up period. Those in the top one-third
of Mediterranean diet scores had a 28% lower risk (compared to those in the
bottom third) of developing a cognitive impairment"
Mediterranean Diet Reduces Long-term Risk Of Subsequent Weight Gain And
Obesity Among Adults - Science Daily, 1/22/09 -
"increased fruit and vegetable intake was associated with significantly
lower risk of a medium WG (3,41 kg) over 10 years among adults of a Spanish
Mediterranean population. Dietary strategies to increase fruit and vegetable
intake to prevent and control overweight and obesity should be promoted more
Metabolic Syndrome? Nuts! - WebMD, 12/8/08 - "A
group that was given personalized advice on the Mediterranean diet and about
2 tablespoons of mixed nuts (1/2 walnuts, 1/4 almonds, and 1/4 hazelnuts)
each day ... A year later, nobody lost weight. And about the same number of
people developed newly diagnosed metabolic syndrome in each group ... But
among patients who already had metabolic syndrome, those in the nut group
were 70% more likely to have reversal of metabolic syndrome than those in
the control group"
Accolades for Mediterranean Diet - WebMD, 9/11/08 -
"people who followed a strict Mediterranean diet
were: ... 9% less likely to die from heart disease or other cardiovascular
problems ... 6% less likely to develop cancer or die from it ... 13% less
likely to have Parkinson's or Alzheimer's disease"
Atkins Still Doesn't Beat Low-Fat Diet - Newsweek, 7/16/08 -
"A new study comparing the Atkins diet, a
Mediterranean diet and a low-fat diet published on July 17 in The New
England Journal of Medicine (NEJM), is likely to inspire headlines saying
that the Atkins diet is better for your waistline and your health than a
low-fat diet ... I believe this study is extremely flawed. Here's why: ...
funded in part by the Atkins Foundation ... quality of data in this study
Traditional Mediterranean Diet Protects Against Diabetes, Study Suggests
- Science Daily, 5/30/08 - "A high adherence to the
diet was associated with an 83% relative reduction in the risk of developing
Med diet linked to longer life - study - Nutra USA, 12/12/07 -
"greater adherence to a Med-style diet reduced the
risk of death from cardiovascular disease (CVD) and cancer by 22 and 17 per
cent in men, and 12 per cent for women ... so-called all-cause mortality
(death from all causes) was reduced by 21 per cent among men and 20 per cent
among women with the greatest adherence ... The Mediterranean diet also
includes other important dietary constituents such as fiber and a low
omega-6:omega-3 fatty acid ratio, both of which potentially prevent cancer
initiation and progression" - [Abstract]
Mediterranean Diet May Help Alzheimer's Patients Live Longer - Science
Daily, 9/10/07 - "Alzheimer's patients who adhered
to the diet to a moderate degree lived an average 1.3 years longer than
those people who least adhered to the diet. And those Alzheimer's patients
who followed the diet very religiously lived an average four years longer"
Mediterranean Diet Halves Risk Of Progressive Lung Disease - Science
Diet May Influence Alzheimer's Risk - WebMD, 10/9/06 -
"Long suspected of lowering the risk of heart
disease and diabetes, the Mediterranean diet consists of large amounts of
fruits, vegetables, beans, grains, and nuts. Red meats are eaten only rarely
and poultry, eggs, and dairy products are eaten in moderation. Olive oil and
fatty fish are the main sources of fat in the diet ... People who most
closely adhered to the diet had an Alzheimer's risk that was 40% to 65%
lower than people who were least likely to follow the diet"
Erectile Function in Subjects With the Metabolic Syndrome - Medscape,
7/19/06 - "consumption of a Mediterranean-style diet
in men with the metabolic syndrome and ED at baseline produced significant
improvement of erectile and endothelial functions, together with a
significant reduction of systemic vascular inflammation, as indicated by the
reduced levels of CRP"
Beats Low-Fat Diet - WebMD, 6/5/06 -
"Compared with the low-fat group, the two
Mediterranean diet groups had bigger improvements in blood pressure, insulin
resistance (a problem which accompanies or precedes type 2 diabetes),
markers of inflammation, and levels of cholesterol and other lipids (blood
Mediterranean Diet May Cut Alzheimer's - WebMD, 4/18/06 -
"Scores ranged from 0-9, with higher scores showing
greater adherence to a Mediterranean diet ... those with middle scores were
15% less likely to have been found to have developed Alzheimer's disease,
and those with the highest scores were 40% less likely to have been found to
have Alzheimer's disease"
Olive oil—key to Mediterranean diet's benefits - MSNBC, 3/10/06
Tufts Expert Examines The Cardiovascular Benefits Of A Mediterranean-style
Diet - Science Daily, 2/7/06
The Disease-Preventive Power of the Mediterranean Diet
- Life Extension Magazine, 7/05
Mediterranean Diet Linked to Longer Life - WebMD, 4/7/05 -
"a healthy man of 60 who follows the diet, which is
rich in fruits and vegetables and low in meat and dairy, can expect to live
a year longer than a man of the same age who doesn't follow the diet ... The
Mediterranean diet was nearly vegetarian, with fish and very little meat,
and was rich in green vegetables"
Diet Helps Lower Death Rates - WebMD, 12/9/04 -
"those seniors adhering to the Mediterranean diet
had a 23% lower risk of death from all causes ... seniors who exercised at
least 30 minutes every day lowered their risk of death by 37%. Nonsmoking
seniors reduced their risk by 35%. Seniors who drank alcohol moderately
reduced their risk by 22% ... a senior who adhered to all of these lifestyle
changes reduced his risk of death by 65%"
- More good news about the
Mediterranean diet - MSNBC, 10/29/04 -
"people who ate a mostly Mediterranean diet,
exercised moderately, drank little to moderate amounts of alcohol, and
didn’t smoke had 65 percent fewer deaths than those who followed none or
only one of these healthy habits"
- Is the Mediterranean
Diet Really Healthier? - Dr. Weil, 10/8/04
Mediterranean Diet May Be Effective in Reducing Metabolic Syndrome and
Associated Symptoms - Doctor's Guide, 9/22/04 -
"after 2 years, patients in the Mediterranean diet
intervention group had significant decreases in body weight, blood pressure,
levels of glucose, insulin, total cholesterol, and triglycerides and a
significant increase in levels of high-density lipoprotein cholesterol ...
Serum concentrations of interleukins 6 (IL-6), 7 (IL-7), and 18 (IL-18) and
high-sensitivity C-reactive protein (hs-CRP) were significantly reduced in
patients in the intervention group"
- Mediterranean Diet
Improves Survival in Elderly - Medscape, 9/21/04 -
"Among 70- to 90-year-olds, adherence to a
Mediterranean diet and healthful lifestyle is associated with a more than
50% lower rate of all-cause and cause-specific mortality"
- A Lifestyle
Blueprint for Long Life - WebMD, 9/21/04
- Is It Better to Eat
Like the French? - Dr. Weil, 8/3/04
Diet Fights Heart Disease - WebMD, 11/11/03
- Mediterranean Diet
Lowers C-reactive Protein Levels - Medscape, 11/11/03 -
"For each 10-point increase in diet score, there was
a corresponding 0.22 mg/dL reduction in
C-reactive protein levels, a 0.21 pg/ml reduction in
interleukin-6, a 12.5 mg/dL
decrease in fibrinogen, and a 0.87 mmol/L decrease in
homocysteine levels (P < .05), he said.
Also, white blood cell count decreased significantly"
Mediterranean Diet Independently Lowers Cardiovascular Disease Risk -
Doctor's Guide, 11/10/03
Mediterranean diet evidence - jr2.ox.ac.uk. 8/03
- Mediterranean diet
'extends life' - bbc.co.uk. 8/24/03 -
"The[y] found that quercetin, which is abundant in
olive oil, has a similar effect"
- Mastering the
Mediterranean Diet? - Dr. Weil, 8/14/03
Add 1 lb. of veggies, olive oil - USA Today, 6/25/03 -
"participants were rated on a scale of 0 to 9, based
on how closely they stuck to the traditional Mediterranean diet. The higher
the score, the better the adherence ... A two-point increase in the
adherence score was associated with a 25% reduced risk of death from all
causes, a 33% reduced risk of death from heart disease and a 24% reduced
risk of death from cancer ... People in Greece eat about a pound of
vegetables a day, mostly cooked ... Salads are served with fish, and
vegetables like zucchini and spinach are boiled and seasoned with lemon and
Diet: More Than Olive Oil - WebMD, 6/25/03 -
"In addition to having olive oil with most meals,
the typical Mediterranean diet is very high in vegetables, fruits, legumes,
nuts, and cereals; moderate in fish intake; and has lower amounts of meat
and dairy than the typical American diet. Drinking alcohol is also a
frequently practiced dining ritual"
- Mediterranean Diet Cuts
Risk Of Cancer In Half - Doctor's Guide, 6/16/98
Are there specific treatments for the metabolic syndrome? - Am J Clin
Nutr. 2008 Jan;87(1):8-11 - "Although there is no
"all-inclusive" diet yet, it seems plausible that a Mediterranean-style diet
has most of the desired attributes, including a lower content of refined
carbohydrates, a high content of fiber, a moderate content of fat (mostly
unsaturated), and a moderate-to-high content of vegetable proteins"
Adherence to the Mediterranean Diet Is Inversely Associated With Circulating
Interleukin-6 Among Middle-Aged Men. A Twin Study - Circulation. 2007
Dec 17 - "A 1-unit within-pair absolute difference
in the diet score was associated with a 9% (95% CI, 4.5 to 13.6) lower
Mediterranean Dietary Pattern and Prediction of All-Cause Mortality in a US
Population: Results From the NIH-AARP Diet and Health Study - Arch
Intern Med. 2007 Dec 10;167(22):2461-8 - "The
Mediterranean diet was associated with reduced all-cause and cause-specific
mortality. In men, the multivariate HRs comparing high to low conformity for
all-cause, CVD, and cancer mortality were 0.79 (95% CI, 0.76-0.83), 0.78
(95% CI, 0.69-0.87), and 0.83 (95% CI, 0.76-0.91), respectively. In women,
an inverse association was seen with high conformity with this pattern:
decreased risks that ranged from 12% for cancer mortality to 20% for
all-cause mortality (P = .04 and P < .001, respectively, for the trend)"
Mediterranean Diet, Alzheimer Disease, and Vascular Mediation - Arch
Neurol, 10/9/06 - "Higher adherence to the MeDi was
associated with lower risk for AD (odds ratio, 0.76; 95% confidence
interval, 0.67-0.87; P<.001). Compared with subjects in the lowest MeDi
tertile, subjects in the middle MeDi tertile had an odds ratio of 0.47 (95%
confidence interval, 0.29-0.76) and those at the highest tertile an odds
ratio of 0.32 (95% confidence interval, 0.17-0.59) for AD"
Mediterranean diet improves erectile function in subjects with the metabolic
syndrome - Int J Impot Res. 2006 Jan 5 -
"Mediterranean-style diet rich in whole grain,
fruits, vegetables, legumes, walnut, and olive oil might be effective per se
in reducing the prevalence of ED in men with the metabolic syndrome"
Effect of a mediterranean-style diet on endothelial dysfunction and markers
of vascular inflammation in the metabolic syndrome: a randomized trial
- JAMA. 2004 Sep 22;292(12):1440-6 - "A
Mediterranean-style diet might be effective in reducing the prevalence of
the metabolic syndrome and its associated cardiovascular risk"
Metabolic syndrome: dietary interventions - Curr Opin Cardiol. 2004
"Although there is no "all-inclusive" diet yet, it
seems plausible that a Mediterranean-style diet exhibits most of the desired
Mediterranean diet improves lipid profiles over three months - Asia Pac
J Clin Nutr. 2004;13(Suppl):S138 -
"A Mediterranean diet is effective for weight loss
over three months and has early favourable effect on HDL and Triglyceride
levels and a neutral effect on TC and LDL levels"
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