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Recent Longevity News for the week ending 8/10/22

Waking Up at Night Could Be Your Brain Boosting Your Memory - Medscape, 8/3/22 - "Brief awakenings may be a sign you’ve slept well ... The study, done on mice, found that the stress transmitter noradrenaline wakes up the brain many times a night. These "microarousals" were linked to memory consolidation, meaning they help you remember the previous day's events. In fact, the more "awake" you are during a microarousal, the better the memory boost"

Second coronavirus booster shots for people under 50 on hold amid drive to speed up new vaccine - Washington Post, 7/22/22 - "The retooled boosters will contain components from the omicron subvariants BA.4 and BA.5 as well as the original formula, which was based on the version of the virus that spread globally in early 2020. The hope is that the redesigned boosters will be more effective in dealing with an evolving virus ... But other experts warned that a second dose of the current booster would not provide a big benefit and might do some harm. Paul A. Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia and an outside adviser to the FDA, said recently that repeatedly administering the same vaccine could lead to a phenomenon known as “imprinting,” in which an individual’s immune system develops a highly targeted response to earlier versions of a virus and fails to adapt as that virus evolves"

NMN Shown To Remove Senescent Cells In Aging Eyes - YouTube, Modern Healthspan  - See NMN at Amazon.com.

Rewinding the clock on aging blood vessels - YouTube, Harvard Medical School (Dr. David Sinclair on NMN) - See NMN at Amazon.com.

Abstracts from this week:

Cumulative Coffee Consumption as a Protective Factor for Head and Neck Cancer in Brazil - Nutr Cancer 2022 Aug 8 - "the cumulative consumption of >2 cups of coffee per day is an important protective factor (OR: 0.73, 95% CI: 0.5-0.9) against head and neck cancer. Smoking increased the risk by 22 times (OR: 22.19; 95% CI: 13.7-35.8) in individuals who smoke more than 50 packs per year, and the habit of ingesting more than 155 ml of alcohol per day represented approximately twice as high risk (OR: 2.20; 95% CI: 1.4-3.4). In summary, this study suggests that coffee consumption is associated with a lower chance of head and neck cancer"

Eggs Consumption in Relation to Lower Risk of Cognitive Impairment in Elderly: Findings from a 6-Year Cohort Study - J Nutr Health Aging 2022 - "Compared with non-consumers or less-than-weekly consumers, participants consuming 0.1-2.9 eggs/week and 3.0-5.9 eggs/week had 18% (RR=0.82, 95%CI 0.76-0.89) and 9% (RR=0.91, 95%CI 0.84-0.99) lower risks of cognitive impairment respectively, whereas no association was found in those consuming ≥6.0 eggs/week"

Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE -/- mice - Biochem Biophys Res Commun 2022 Jul 31 - "Cardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Diabetes is a major independent risk factor for the development of atherosclerotic cardiovascular diseases. Diabetic atherosclerosis is characterized by hyperglycemia, hyperinsulinemia, and dyslipidemia. These multiple pathological factors can induce oxidative stress, inflammation, and vascular dysfunction, which can initiate and accelerate atherogenesis ... berberine improved the dysfunction of lipid and glucose metabolism, and inhibited vascular inflammation, which reduced atherogenesis and plaque vulnerability. Mechanistically, berberine stimulated KLF16 and PPARα expression in vivo and in vitro, and activation of PPARα by berberine was through enhancing KLF16 expression and nuclear translocation. Collectively, berberine can attenuate diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα, suggesting that KLF16 is a new target of berberine and enhancing KLF16 by berberine is an efficient strategy for alleviating diabetic atherosclerosis" - See berberine at Amazon.com.

Associations of bioavailable serum testosterone with cognitive function in older men: results from the National Health and Nutrition Examination Survey - J Gerontol A Biol Sci Med Sci 2022 Aug 5 - "with no signs of a plateau effect ... Calculated bioavailable testosterone presented a significant positive association with processing speed, sustained attention and working memory in older men above 60 years of age. Further research is warranted to elucidate the impact of the inevitable age-related decline in testosterone on cognitive function in older men" - Another reason to keep your SHBG under control.

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells - Cancer Lett 2022 Aug 1 - "Oncogenic stress-induced senescence initially inhibits tumor initiation by blocking proliferation and by attracting immune cells to clear potentially harmful cells. If these cells are not eliminated they may resume proliferation upon loss-of-tumor suppressors, and be at risk of transformation. During tumor formation, depending on the sequence of events of gain-of-oncogenes and/or loss-of-tumor suppressors, cancer cells may emerge from senescent cells. Here, we show that these transformed cells after senescence (TS) display more aggressive tumorigenic features, with a greater capacity to migrate and a higher resistance to anti-tumoral drugs than cells having undergone transformation without senescence. Bulk transcriptomic analysis and single cell RNA sequencing revealed a signature unique to TS cells. A score of this signature was then generated and a high score was correlated with decreased survival of patients with lung adenocarcinoma, head-neck squamous cell carcinoma, adrenocortical carcinoma, liver hepatocellular carcinoma, skin cutaneous melanoma and low-grade glioma. Together, these findings strongly support that cancer cells arising from senescent cells are more dangerous, and that a molecular signature of these cells may be of prognostic value for some human cancers"

Application of Angiotensin Receptor-Neprilysin Inhibitor in Chronic Kidney Disease Patients: Chinese Expert Consensus - Front Med (Lausanne) 2022 Jul 19 - "A co-crystal complex of sacubitril, which is a neprilysin inhibitor, and valsartan, which is an angiotensin receptor blockade, has the potential to be widely used against CKD. Sacubitril inhibits neprilysin, which further reduces the degradation of natriuretic peptides and enhances the beneficial effects of the natriuretic peptide system. In contrast, valsartan alone can block the angiotensin II-1 (AT1) receptor and therefore inhibit the renin-angiotensin-aldosterone system. These two components can act synergistically to relax blood vessels, prevent and reverse cardiovascular remodeling, and promote natriuresis. Recent studies have repeatedly confirmed that the first and so far the only angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan can reduce blood pressure more effectively than renin-angiotensin system inhibitors and improve the prognosis of heart failure in patients with CKD"

Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy - J Agric Food Chem 2022 Aug 2 - "KO may prevent DN predominantly by suppressing the TGF-β1 signaling pathway" - See krill oil products at Amazon.com.

The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta-analysis - Phytother Res 2022 Aug 2 - "Quercetin (3,3',4',5,7-pentahydroxyflavone), a flavonoid, is widely found in fruits and vegetables and exerts broad-spectrum pharmacological effects in the liver. Many studies have explored the bioactivity of quercetin in the treatment of liver fibrosis ... The results from the analysis showed that the corresponding liver function indexes, such as the levels of HA and LN, were significantly improved in the quercetin group compared with the model group, and liver function, such as the levels of AST and ALT, were also improved in the quercetin group. The species- and model-based subgroup analyses of AST and ALT revealed that quercetin exerts a significant effect. The therapeutic mechanism of quercetin was shown to be related to multiple pathways involving anti-inflammatory and antioxidant activities and lipid accumulation, including regulation of the TGF-β, α-SMA, ROS, and P-AMPK pathways. The results showed that quercetin exerts an obvious effect on liver fibrosis, and more prominent improvement effects on liver function and liver fibrosis indicators were obtained with a dose of 5-200 mg during a treatment course ranging from 4 to 8 weeks. Quercetin might be a promising therapeutic for liver fibrosis" - See quercetin at Amazon.com.

Is dietary choline intake related to dementia and Alzheimer's disease risk: results from the Framingham Heart Study - Am J Clin Nutr 2022 Aug 2 - "Dietary choline intake showed non-linear relationship with incident dementia and AD. After adjusting for covariates, low choline intake (defined as choline/100 ≤ 2.19 and choline/100 ≤ 2.15 in our sample) was significantly associated with incident dementia or incident AD" - See citicholine at Amazon.com.

MyMD-1 improves health span and prolongs lifespan in old mice: A non-inferiority study to rapamycin - J Gerontol A Biol Sci Med Sci 2022 Aug 2 - "In vivo, a longitudinal cohort of 54 C57BL/6 mice, 19-month-old at the start, was randomized to receive MyMD-1, high-dose (126 ppm) rapamycin, or low-dose (14 ppm) rapamycin plus metformin ... Lifespan was significantly longer in MyMD-1 than rapamycin (P= 0.019 versus high-dose and 0.01 versus low-dose) in a Cox survival model that accounted for sex and serum levels of IL-6, TNF-α, and IL-17A. MyMD-1 also improved several health span characteristics, resulting in milder body weight loss, greater muscle strength, and slower progression to frailty. In vitro, MyMD-1 and rapamycin were compared using a panel of 12 human primary cell systems (BioMAP Diversity PLUS™) where a total of 148 biomarkers are measured. MyMD-1 possessed anti-proliferative, anti-inflammatory, and anti-fibrotic properties. Many were shared with rapamycin, but MyMD-1 was more active in the inhibition of pro-inflammatory and pro-fibrotic biomarkers. Overall, MyMD-1 emerges as a new compound that, even when begun at an advanced age, induces beneficial effects on health and lifespan by modulating inflammation and tissue remodeling" - Note: It's still in trials. See Siromus (rapamycin) at ReliableRXPharmacy.

• MyMD Pharmaceuticals Enrolls First Patient in Phase 2 Clinical Trial of MYMD-1 as a Therapy for Delaying Aging and Extending Healthy Lifespan - businesswire, 2/23/22
• Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty - NIH - "Estimated Study Completion Date : December 31, 2022"

The Efficacy and Safety of Sacubitril-Valsartan for the Treatment of Heart Failure in Adults: A Meta-Analysis - Ann Pharmacother 2022 Aug 2 - "Data of included studies prove the efficacy and safety of SV for curing heart conditions. Therefore, the present evidence shows that SV is effective in the treatment of heart failure, reducing hospitalization and cardiovascular mortality, and that the adverse effects are comparable or fewer than those associated with other drugs used for this indication"

NAD+ to assess health in aging humans - AGING 2022, Vol. 14, Advance - "With NAD+ involved in so many and such diversecellular functions, ranging from DNA repair tocircadian rhythms, redox reactions to cell division, inflammation to epigenetics [1, 2, 8], it could be argued that NAD+ plays a key role in the regulation of almostall biological processes. With NAD+ so convincingly linked to health in preclinical models [1], now demonstrated to reflect health in older humans [4], we ask ourselves the following: For any given intervention to significantly improve healthspan, should it not also serve to maintain NAD+ levels and homeostasis? We suggest that for a range of healthy aging interventions in humans—certainly including exercise—NAD+ abundance may serve as the best molecular marker tounderstand efficacy" - See NAD+ supplements at Amazpn.com.

Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE - Oxid Med Cell Longev 2022 Jul 18 - "retinal pigment epithelium (RPE) ... The protective effects of NMN were demonstrated to rely on undisturbed Sirt1 signaling. Moreover, both the expression of senescence markers of RPE and subretinal inflammatory cell infiltration were decreased by NMN treatment in vivo. Our results indicate that RPE senescence induced by NaIO3 acquired several key features of AMD. More importantly, NMN may potentially be used to treat RPE senescence and senescence-associated pre-AMD changes by restoring the NAD+ levels in cells and tissues." - See NMN at Amazon.com.

Neat Tech Stuff / "How To's":

Dr. John Campbell making a six figure income selling lies and conspiracy theories. I'll never understand why that sells over the truth. He even looks dishonest. I don't know why people can't see it. 700,000 views in four days? What's wrong with people? Campbell is the Alex Jones of the medical community. Alex Jones is said to be worth $260 million. Shows how profitable lies are.

Health Focus (Grains):