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Berberine
Berberine
Specific Recommendations:
News & Research:
Abstracts:
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Berberine and health
outcomes: An umbrella review - Phytother Res 2023 Mar 31 -
"The results revealed that berberine significantly
affects blood glucose levels, insulin resistance, blood lipids, body parameters
and composition, inflammatory markers, colorectal adenomas, and Helicobacter
pylori infections as compared to controls" - See
berberine at Amazon.com.
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Caffeine can alleviate
non-alcoholic fatty liver disease by augmenting LDLR expression via targeting
EGFR - Food Funct 2023 Mar 14 - "Increasing
low-density lipoprotein receptor (LDLR) protein levels represents a key strategy
for the prevention and treatment. Berberine can reportedly alleviate
non-alcoholic fatty liver disease (NAFLD) by increasing the LDLR expression in
an ERK1/2 signaling-dependent manner of NAFLD. Studies have shown that caffeine
can inhibit fat deposition in the livers of mice; however, caffeine has not been
reported to alleviate NAFLD by augmenting the LDLR expression via targeting EGFR
... we found that caffeine could also activate EGFR-ERK1/2 signaling and promote
the LDLR expression in ApoE KO mice. In summary, caffeine can enhance the LDLR
expression by directly binding to EGFR and activating the EGFR-ERK1/2 signaling
pathway. EGFR signaling may represent a novel target for the prevention and
treatment of NAFLD."
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Berberine ameliorates
depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated
neuroinflammation and preventing neuroplasticity disruption - J
Neuroinflammation 2023 Mar 1 - "Neuroinflammation has
been suggested that affects the processing of depression. There is renewed
interest in berberine owing to its anti-inflammatory effects ... The
anti-depressants effects of berberine were accompanied by reduced the
neuroinflammatory response via inhibiting the activation of NLRP3 inflammasome
and rescued the neuronal deterioration via suppression of impairments in
synaptic plasticity and neurogenesis"
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Berberine hydrochloride
alleviates imatinib mesylate - induced cardiotoxicity through the inhibition of
Nrf2-dependent ferroptosis - Food Funct 2023 Jan 3 -
"Imatinib mesylate (IMA) belonging to the selective tyrosine kinase inhibitor
family has been proven to induce cardiotoxic effects along with therapeutic
strategies. Nrf2-dependent ferroptosis has been implicated in the cardiotoxicity
induced by IMA. The present study was designed to investigate the protective
effects of berberine hydrochloride (Ber) on cardiac injuries induced by IMA and
to explore its potential mechanisms ... Our results indicated that Ber increased
cell viability and MMP and decreased cellular ROS and iron levels in comparison
to the IMA group of H9c2 cells. In mice, Ber significantly improved cardiac
status and attenuated the level of ferroptosis biomarkers including
malonaldehyde (MDA) and iron content. Additionally, Ber downregulated the
expression of transferrin receptor (TfR) and P53 and upregulated the expression
of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1),
NAD(P)H quinone oxidoreductase-1 (NQO1), ferritin heavy chain-1 (FTH1), and
glutathione peroxidase 4 (GPX4) in H9c2 cells and mice. The present data
indicated that Ber has the potential to protect against IMA-induced
cardiotoxicity, partly via inhibiting Nrf2-dependent ferroptosis" - See
berberine at Amazon.com.
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Berberine plays a
cardioprotective role by inhibiting macrophage Wnt5a/β-catenin pathway in the
myocardium of mice after myocardial infarction - Phytother Res 2022 Oct 11 -
"Myocardial infarction (MI) is one of the diseases with
high fatality rate. Berberine (BBR) is a monomer compound with various
biological functions. And some studies have confirmed that BBR plays an
important role in alleviating cardiomyocyte injury after MI ... In summary, BBR
effectively improved cardiac function of mice after MI, and the potential
protective mechanism was associated with the regulation of inflammatory
responses and the inhibition of macrophage Wnt5a/β-catenin pathway in the
infarcted heart tissues. Importantly, these findings supported BBR as an
effective cardioprotective drug after MI"
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Berberine ameliorates
depression-like behavior in CUMS mice by activating TPH1 and inhibiting
IDO1-associated with tryptophan metabolism - Phytother Res 2022 Sep 11 -
"Berberine, which is a potential antidepressant,
exhibits definite efficiency in modulating the gut microbiota ... In conclusion,
berberine improves depressive symptoms in CUMS-stimulated mice by targeting both
TPH1 and IDO1, which are involved in tryptophan metabolism"
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Berberine Reduces Renal Cell
Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the
Nrf2-NLRP3-Caspase-1-GSDMD Pathway - Evid Based Complement Alternat Med 2021
Oct 31 - "To observe the effect of berberine (BBR) on
kidney cell pyroptosis in golden hamsters with diabetic nephropathy (DN) and to
explore the molecular mechanism of its renal protection ... DN golden hamster
kidney NLRP3-Caspase-1-GSDMD signalling was enhanced. BBR can reduce oxidative
stress damage by regulating antioxidative Nrf2 and then regulating
NLRP3-Caspase-1-GSDMD signalling to inhibit pyroptosis, antagonizing DN
inflammation-induced damage"
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Berberine inhibits glioma
cell migration and invasion by suppressing TGF-β1/COL11A1 pathway - Biochem
Biophys Res Commun 2022 Jul 31 - "Glioma is a clinically
heterogeneous disease with a poor prognosis. Berberine (BBR), as a multi-target
anti-tumor alkaloid, has the ability to penetrate the blood-brain barrier and
shows cytotoxicity to glioma cells. In previous studies, we demonstrated that
berberine inhibits glioma cell proliferation by inhibiting mutant p53 protein
and promoting mitochondrial damage. In addition, berberine has been shown to
reduce collagen accumulation in pulmonary fibrosis, diabetic nephropathy and
arthritis. However, its effect on collagen in cancer needs to be further
elucidated ... Collectively, berberine that targets COL11A1 to inhibit glioma
migration and invasion, may serve as a promising candidate for the development
of anti-glioma drugs in the future" - See
berberine at Amazon.com.
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Berberine attenuates
diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in
ApoE -/- mice - Biochem Biophys Res Commun 2022 Jul 31 -
"Cardiovascular disease caused by atherosclerosis is a
leading cause of morbidity and mortality worldwide. Diabetes is a major
independent risk factor for the development of atherosclerotic cardiovascular
diseases. Diabetic atherosclerosis is characterized by hyperglycemia,
hyperinsulinemia, and dyslipidemia. These multiple pathological factors can
induce oxidative stress, inflammation, and vascular dysfunction, which can
initiate and accelerate atherogenesis ... berberine improved the dysfunction of
lipid and glucose metabolism, and inhibited vascular inflammation, which reduced
atherogenesis and plaque vulnerability. Mechanistically, berberine stimulated
KLF16 and PPARα expression in vivo and in vitro, and activation of PPARα by
berberine was through enhancing KLF16 expression and nuclear translocation.
Collectively, berberine can attenuate diabetic atherosclerosis via enhancing the
interplay between KLF16 and PPARα, suggesting that KLF16 is a new target of
berberine and enhancing KLF16 by berberine is an efficient strategy for
alleviating diabetic atherosclerosis"
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Successful Treatment of
Bullous Pemphigoid Lesions by Berberine Stamp Therapy: A Case Report and
Literature Review - Front Med (Lausanne) 2022 Jul 1 -
"Bullous pemphigoid (BP) is a life-threatening
autoimmune disease of the skin that is mainly characterized by a large range of
tension blisters and intense itching of the skin. The 1-year mortality rate of
BP was 23.5%. Superinfection caused by skin lesion ulceration is one of the
important causes of disease death. Therefore, it is challenging to control
infection and improve skin wound healing. Here, we report the case of an elderly
woman who presented with BP and involved the oral mucosa. The patient was
successfully treated with hormones combined with topical berberine, and 95% of
the patients' lesions healed completely after 1 month. In addition, we
inductively analyzed the current treatments for BP to provide a reference for BP
clinical treatment"
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Network Pharmacology and
Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of
Ischaemic Stroke - Evid Based Complement Alternat Med 2022 Jun 29 -
"The potential targets and biological effects of
berberine in the treatment of ischaemic stroke were predicted in this study. The
lncRNA H19/EGFR/JNK1/c-Jun signalling pathway may be a key mechanism of
berberine-induced neuroprotection in ischaemic stroke"
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Berberine Alleviates
Gastroesophageal Reflux-Induced Airway Hyperresponsiveness in a Transient
Receptor Potential A1-Dependent Manner - Evid Based Complement Alternat Med
2022 May 9 - "gastroesophageal reflux-induced airway
hyperresponsiveness (GERAHR) ... Berberine, especially at the middle dose tested
(MB, 150 mg/kg), significantly improved lung function, suppressed inflammatory
cell infiltration, and protected inflammation-driven tissue damage in the lung,
trachea, esophagus, and nerve tissues in GERAHR guinea pigs. MB reduced the
expression of TRPA1, SP, and tumor necrosis factor-alpha (TNF-α) in evaluated
organs and tissues. Meanwhile, the MB-mediated protective effects were
attenuated by simultaneous TRPA1 activation ... Mechanistically, berberine was
found to suppress GERAHR-induced upregulation of TRPA1, SP, and TNF-α in many
tissues. Our study has highlighted the potential therapeutic value of berberine
for the treatment of GERAHR"
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Berberine as a Potential
Agent for the Treatment of Colorectal Cancer - Front Med (Lausanne) 2022 Apr
28 - "Numerous studies have shown that berberine (BBR)
is a safe and effective agent presenting significant antitumor effects ... The
review emphasizes several therapeutic effects of BBR and confirms that BBR could
suppress CRC by modulating gene expression, the cell cycle, the inflammatory
response, oxidative stress, and several signaling pathways. In addition, BBR
also displays antitumor effects in CRC by regulating the gut microbiota and
mucosal barrier function" - See berberine at Amazon.com.
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Hydrochloride Berberine
ameliorates alcohol-induced liver injury by regulating inflammation and lipid
metabolism - Biochem Biophys Res Commun 2022 Apr 7 -
"Berberine hydrochloride (BBR) is efficacious in relieving alcoholic liver
injury (ALI) in animal models, but its underlying mechanisms remains largely
unclear ... The results indicated that BBR alleviated alcoholism-induced hepatic
injury by suppressing inflammation (IL-10, TNF-α, LPS, ET and IL-6), and
regulating fatty acids uptake (CD36), lipid synthesis (THRSP, FASN, AMPK-α, ACC,
ACLY) and lipid oxidation (PPARα, CPT1α, ACOX1), and THRSP may be its novel
target"
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Berberine as a natural
modulator of inflammatory signaling pathways in the immune system: Focus on
NF-κB, JAK/STAT, and MAPK signaling pathways - Phytother Res 2022 Feb 10 - "Three
main inflammatory signaling pathways include nuclear factor-κB (NF-κB), Janus
kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and
mitogen-activated protein kinases (MAPKs) play crucial roles in inducing,
promoting, and regulating inflammatory responses in the immune system.
Importantly, the breakdown of mechanisms that tightly regulate inflammatory
signaling pathways can be the underlying cause of uncontrolled inflammatory
responses and be associated with the generation and development of several
inflammatory diseases ... Studies over the past two decades have provided
important information on the polytrophic pharmacological and biochemical
properties of berberine (BBR) as a naturally occurring compound, such as
antioxidant, antitumor, antimicrobial, and antiinflammatory activates.
Interestingly, the modulatory effects of BBR on inflammatory signaling cascades,
which lead to the inhibition of inflammation, have been widely investigated in
several in vitro and in vivo studies. For the first time, herein, this
comprehensive review attempts to put together these studies and provide
important insight into the modulatory effects of BBR on NF-κB, JAKs/STATs, and
MAPKs signaling pathways in vitro in various types of immune cells and in vivo
in several experimental inflammatory diseases. As the second achievement of this
review, we also explore the therapeutic efficacy and antiinflammatory effects of
BBR regarding its modulatory action" - See
berberine at Amazon.com.
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Tree Turmeric: A Super Food
and Contemporary Nutraceutical of 21st Century - A Laconic Review - J Am
Coll Nutr 2021 Nov 10 - "This review illuminates the
therapeutic applications of the plant Berberis aristata, scientific validation
to its traditional uses, role of berberine in the treatment of various diseases
through its different bioactivities, major flaws in berberine treatment, and the
role of nanotechnology in minimizing those flaws and increasing its overall
efficacy. Key teaching pointsPlant Berberis aristata has been used since ancient
times for the treatment of various ailments like jaundice, hepatitis, fever,
bleeding, inflammation, diarrhea, malaria, skin and eye infections, chronic
rheumatism, and urinary disorders.Berberine is the major and most significant
phytochemical among numerous phytochemicals present in plant Berberis
aristata.Berberine has significantly shown many potent effect against emerging
diseases like cancer and diabetes. Besides that, it has also shown antioxidant,
anti-inflamation, antimicrobial, hepatoprotective, and anti-gastrointestinal
disorder properties.Berberine can be very effective in overcoming the demerits
of berberine treatment like poor aqueous solubility, low bioavailability, and
poor absorption in the human body in the treatment of various diseases"
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Effects of Berberine on
Circular RNA Expression Profiles in Human Gastric Cancer Cells - Evid Based
Complement Alternat Med 2021 May 4 - "Our results
demonstrate that berberine has the potential to influence cancer-related
pathways by regulating circRNA expression and their corresponding target genes
in GC cells"
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Berberine modulates crucial
erectogenic biomolecules and alters histological architecture in penile tissues
of diabetic rats - Andrologia 2021 Apr 30 -
"Berberine is an isoquinoline alkaloid, found in several plants. Diabetes
induces erectile dysfunction (ED) via reduction in some hormones and enzymes
implicated in sexual function. This study aimed to investigate the role of
berberine on crucial biomolecules linked to penile function in diabetic rats.
Sixty-three (63) adult male rats were used and distributed into nine groups
(each = 7). Group I-IV normal rats administered with citrate buffer (pH 4.5),
sildenafil citrate (SD, 5.0 mg/kg), 50 and 100 mg/kg of berberine, respectively,
via oral gavage. Rats in groups V-IX were diabetic rat with ED treated with
buffer, SD, 50 and 100 mg/kg of berberine, and acarbose (25 mg/kg ACA)
respectively. The result revealed that histological architecture in penile
tissues were altered in diabetic groups treated with berberine, sildenafil
citrate and acarbose when compared to the diabetic control group. Treatment with
berberine, increased testosterone, luteinizing hormone and follicle-stimulating
hormone in diabetic rat with ED. Also, reduced prolactin level and
acetylcholinesterase, angiotensin-1 converting enzyme, adenosine deaminase and
arginase activities were observed in berberine treated diabetic rat with ED.
Molecular docking analysis revealed that berberine had strong binding affinities
for these enzymes. Thus, berberine could represent a potential therapeutic agent
for diabetes-induced ED." - See berberine at Amazon.com.
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Protective
effects of berberine on senile osteoporosis in mice - J Bone
Miner Metab 2021 Apr 8 - "The present
results suggest that berberine exerts potent bone protective
effects by promoting bone formation, inhibiting marrow fat
accumulation and bone resorption. This effect may be achieved
through cAMP/PKA/CREB signaling pathway" - See
berberine at Amazon.com.
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Berberine-A potent
chemosensitizer and chemoprotector to conventional cancer therapies -
Phytother Res 2021 Feb 8 - "Chemotherapy and
radiotherapy are mainstay treatments for cancer patients. However, their
clinical outcomes are highly limited by the resistance of malignant tumors to
these therapies and the incurrence of serious damages in vital organs. This in
turn necessitates the development of adjunct drugs that overcomes chemo/radioresistance
in refractory cancers and protects vital organs from the cytotoxic effects of
cancer therapies. In recent years, Berberine (BBR), a natural isoquinoline
alkaloid has garnered more attention due to its potent chemosensitizing and
chemoprotective properties. BBR effectively sensitizes refractory cancers to
chemotherapy and radiotherapy by ameliorating the diverse events underlying
therapy resistance. Furthermore, it protects the heart, liver, lungs, and
kidneys from severe damages caused by these therapies. In this review, we
discuss the molecular mechanisms underlying the chemo/radiosensitizing and
chemo/radioprotective potential of BBR during cancer treatment." - See
berberine at Amazon.com.
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A Phase I Trial of
Berberine in Chinese with Ulcerative Colitis - Cancer Prev Res (Phila). 2019
Oct 16 - "The Chinese natural product, berberine, has biological properties
supporting potential efficacy as a colon cancer prevention agent. Its
longstanding use in China to treat gastrointestinal tract and rheumatologic
disorders is generally regarded as safe, supporting initial investigations in an
at-risk population, such as individuals with ulcerative colitis (UC). However,
the safety of berberine in this population is not established. Individuals
living in China with biopsy-proven UC, ≤ grade 2 dysplasia, and with a UC
disease activity index (UCDAI) score ≤ 1 on mesalamine, were randomized 3:1 in a
double-blind phase I trial to berberine 900 mg/day or placebo for 3 months, with
the primary objective of assessing safety ... The combination of berberine and
mesalamine is well tolerated in Chinese with UC, and may enhance mesalamine's
anti-inflammatory effects in colonic tissue"
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Differential effects of
red yeast rice, Berberis aristata and Morus alba extracts on PCSK9 and LDL
uptake - Nutr Metab Cardiovasc Dis. 2019 Jun 14 - "The novel nutraceutical
combination containing red yeast rice (monacolin K 3.3 mg), Berberis aristata
cortex extract (Berberine 531.25 mg) and Morus alba leaves extract
(1-deoxynojirimycin 4 mg) is effective in the management of elevated plasma
low-density lipoprotein cholesterol (LDL-C) levels ... LDL receptor (LDLR)
expression ... B. aristata cortex extract (BCE), red yeast rice (RYR) and M.
alba leaves extract (MLE) ... The positive effect of MLE on PCSK9 supports the
rationale of using the nutraceutical combination of RYR, BCE and MLE to control
hyperlipidemic conditions" - See
red yeast rice at Amazon.com
 ,
berberine at Amazon.com
and
Morus alba at Amazon.com.
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Metabolic
effect of berberine–silymarin association: A meta‐analysis of randomized,
double‐blind, placebo‐controlled clinical trials - Phytotherapy research,
Jan 11, 19 - "Berberine and silymarin combination
treatment exerted a positive effect on TC (mean difference [MD]: −25.3, 95% CI
[−39.2, −11.4] mg/dl; p < 0.001), TG (MD: −28, 95% CI [−35.3, −20.6] mg/dl; p <
0.001), HDL‐C [MD: 6, 95%
CI [3.2, 8.8] mg/dl; p < 0.001), LDL‐C (MD: −29.1, 95% CI [−39.7, −18.6] mg/dl;
p < 0.001), and FPG (MD: −7.5, 95% CI [−13, −1.9] mg/dl; p = 0.008). The present
findings suggest that the coadministration of berberine and silymarin is
associated with an advantageous improvement in lipid and glucose profile,
suggesting the possible use of this nutraceutical combination in order to
promote the cardiometabolic health" - [Nutra
USA] - See silymarin at Amazon.com and
berberine at Amazon.com.
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Berberine alleviates
oxidized low-density lipoprotein-induced macrophage activation by downregulating
galectin-3 via the NF-κB and AMPK signaling pathways - Phytother Res. 2018
Nov 6 - "Macrophage activation plays a central role in neoatherosclerosis and
in-stent restenosis after percutaneous coronary intervention (PCI). Galectin-3,
mainly expressed on macrophages, is an important regulator of inflammation ...
In conclusion, BBR alleviates ox-LDL-induced macrophage activation by
downregulating galectin-3 via the NF-κB and AMPK signaling pathways"
- See
berberine at Amazon.com.
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Berberine Improves
Cognitive Deficiency and Muscular Dysfunction via Activation of the
AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats - J
Nutr Health Aging. 2018;22(6):710-717 - "The manifestations of aging include
cognitive deficits and muscular dysfunction, which are closely linked to
impairment of mitochondrial biogenesis. Berberine, an isoquinoline alkaloid,
presents multiple anti-diabetic pharmacological effects. Evidence has indicated
that insulin resistance and cognitive impairment share the same pathogenesis,
and berberine could reverse glucose metabolism abnormalities and muscle
mitochondrial dysfunction induced by a high-fat diet ... reactive oxygen species
(ROS) ... The results showed that administration of berberine for 6 months
significantly improved cognitive deficits and insulin resistance in naturally
aging rats (p<0.01). Furthermore, berberine treatment helped normalize the
disordered alignment and the decreased number of muscle fibers (p<0.01) in the
skeletal muscle of 24 mo rats. Berberine decreased the levels of ROS in both the
serum and the skeletal muscle of 24 mo rats (p<0.01). Berberine increased the
protein expression of p-AMPK, SIRT1 and PGC-1α and increased the production of
ATP in the skeletal muscle of aging rats"
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Berberine-induced
bioactive metabolites of the gut microbiota improve energy metabolism -
Metabolism. 2017 May;70:72-84 - "Berberine (BBR)
clinically lowers blood lipid and glucose levels via multi-target mechanisms ...
Promotion of butyrate (etc) production in gut microbiota might be one of the
important mechanisms of BBR in regulating energy metabolism"
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Berberine Inhibits
Intestinal Polyps Growth in Apc (min/+) Mice via Regulation of Macrophage
Polarization - Evid Based Complement Alternat Med. 2016;2016:5137505 -
"Antitumor effect of berberine has been reported in a
wide spectrum of cancer ... The total number and size of polyps were reduced
remarkably in berberine group, compared with control group"
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Berberine
improves mesenteric artery insulin sensitivity through up-regulating insulin
receptor-mediated signaling in diabetic rats - Br J Pharmacol. 2016 Feb 23 -
"Berberine improves diabetic vascular insulin
sensitivity and mesenteric vasodilation through upregulating insulin
receptor-mediated signaling in diabetic rats. These findings suggest potential
benefits of berberine in the prevention and adjunctive treatment of diabetic
vascular complications"
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Berberine
attenuates vascular remodeling and inflammation in a rat model of metabolic
syndrome - Biol Pharm Bull. 2015;38(6):862-8 -
"metabolic syndrome (MS) ... our data show that berberine improves vascular
inflammation and remodeling in the MS condition, and this is correlated with the
ability of berberine to inhibit p38 MAPK activation, ATF-2 phosphorylation, and
MMP-2 expression"
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Berberis
aristata combined with Silybum marianum on lipid profile in patients not
tolerating statins at high doses - Atherosclerosis. 2014 Dec 24 -
"To
evaluate the effects of Berberis aristata combined with Silybum marianum in
dyslipidemic patients intolerant to statins at high doses ... B. aristata/S.
marianum reduced fasting plasma glucose (-9 mg/dl), insulin (-0.7 μU/ml), and
HOMA-index (-0.35) levels compared to baseline and also to placebo. Lipid
profile did not significantly change after 6 months since the reduction of
statin dosage and the introduction of B. aristata/S. marianum, while it worsened
in the placebo group both compared to placebo and with active treatment (+23.4
mg/dl for total cholesterol, +19.6 mg/dl for LDL-cholesterol, +23.1 mg/dl for
triglycerides with placebo compared to B. aristata/S. marianum). We did not
record any variations of safety parameters in nether of groups" - See
silymarin at Amazon.com
and
berberine at Amazon.com.
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Nutraceutical pill containing berberine versus ezetimibe on plasma lipid
pattern in hypercholesterolemic subjects and its additive effect in patients
with familial hypercholesterolemia on stable cholesterol-lowering treatment
- Lipids Health Dis. 2012 Sep 22;11(1):123 -
"Although statins (STs) are drugs of first choice in hypercholesterolemic
patients, especially in those at high cardiovascular risk, some of them are
intolerant to STs or refuse treatment with these drugs. In view of this, we
have evaluated the lipid-lowering effect of a nutraceutical pill containing
berberine (BBR) and of ezetimibe, as alternative treatments, in monotherapy
or in combination, in 228 subjects with primary hypercholesterolemia (HCH),
with history of STs intolerance or refusing STs treatment ... In HCH
subjects the nutraceutical pill resulted more effective than EZE in lowering
LDL cholesterol (-31.7% vs -25.4%, P < 0.001) and better tolerated. On
treatment, LDL-C level below 3.36 mmol/L (<=130 mg/dl) was observed in 28.9%
of subjects treated with the nutraceutical pill and 11.8% of those treated
with EZE (P <0.007). In the group treated with EZE the subjects carrying the
G allele of the g.1679 C > G silent polymorphism of NPC1L1 gene showed a
higher response to EZE than homozygous for the common allele (GG + CG: LDL-C
-29.4+/-5.0%, CC -23.6+/-6.5%, P <0.001). Combined treatment with these
drugs was as effective as STs in moderate doses (LDL cholesterol -37%,
triglycerides -23%). In HeFH patients the addition of BBR resulted in LDL
cholesterol reductions inversely related to those induced by the stable
therapy (r = -0.617, P <0.0001), with mean 10.5% further decrease"
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Berberine inhibits human colon cancer cell migration via AMP-activated
protein kinase-mediated downregulation of integrin β1 signaling -
Biochem Biophys Res Commun. 2012 Aug 25
-
Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol)
in elderly hypercholesterolemic patients - Adv Ther. 2011 Nov 21 -
"containing berberine 500 mg, policosanol 10 mg, red
yeast rice 200 mg, folic acid 0.2 mg, coenzyme Q10 2.0 mg, and astaxanthin
0.5 mg) or placebo ... There was a statistically significant reduction in
total cholesterolemia (-20%), LDL-C (-31%), and insulin resistance (-10%)
with nutraceutical treatment. No significant changes were detected for
plasma high-density lipoprotein cholesterol (HDL-C). Furthermore, no
statistical differences were found between baseline and end-study safety
parameters. Medication compliance and tolerability were high" - Note:
I’m been promoting synergy and talking lower doses of everything proven in
specific areas like this for some time.
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