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Recent Longevity News for the week ending 8/8/18

Proton Pump Inhibitor and Histamine–2 Receptor Antagonist Use and Risk of Liver Cancer in Two Population–Based Studies - Medscape, 8/2/18 - "ever use of PPIs was associated with increased liver cancer risk (adjusted OR 1.80, 95% CI 1.34, 2.41 and adjusted HR 1.99, 95% CI 1.34, 2.94 respectively)"

Even low levels of air pollution linked with serious changes in the heart, according to new UK research - Science Daily, 8/3/18 - "The team found a clear association between those who lived near loud, busy roads, and were exposed to nitrogen dioxide (NO2) or PM2.5 -- small particles of air pollution -- and the development of larger right and left ventricles in the heart. The ventricles are important pumping chambers in the heart and, although these participants were healthy and had no symptoms, similar heart remodeling is seen in the early stages of heart failure "

Low plasma levels of omega-3 fatty acids associated with preterm birth - Science Daily, 8/3/18 - "Analysis of the blood samples showed that women who were in the lowest quintile of EPA+DHA serum levels -- with EPA+DHA levels of 1.6% or less of total plasma fatty acids -- had a 10 times higher risk of early preterm birth when compared with women in the three highest quintiles, whose EPA+DHA levels were 1.8% or higher. Women in the second lowest quintile had a 2.7 times higher risk compared with women in the three highest quintiles" - See omega-3 supplements at Amazon.com.

Low Acetyl-L-Carnitine a New Biomarker for Major Depression? - Medscape, 8/2/18 - "In addition, secondary exploratory analyses "showed that the degree of LAC deficiency reflected both the severity and age of onset of MDD ... Interestingly, LAC supplementation administered intravenously or orally to the rats who had depression-like traits led to "rapid and lasting antidepressant-like effects."" - See acetyl l-carnitine products at Amazon.com.

pH imbalance in brain cells may contribute to Alzheimer's disease - Science Daily, 8/2/18 - "one root of Alzheimer's disease may be a simple imbalance in acid-alkaline -- or pH -- chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells ... the scientists gave drugs called histone deacetylase (HDAC) inhibitors to pH-imbalanced mice cells engineered with a common Alzheimer's gene variant. The experiment successfully reversed the pH problem and improved the capacity for amyloid beta clearance ... mouse cell lines containing the Alzheimer's disease gene variant had more acidic endosomes (average of 5.37 pH) than cell lines without the gene variant (average of 6.21 pH)"

Measure of belly fat in older adults is linked with cognitive impairment - Science Daily, 8/1/18 - "a higher waist:hip ratio was associated with reduced cognitive function. This could be explained by an increased secretion of inflammatory markers by belly fat, which has been previously associated with a higher risk of impaired cognition. On the contrary, body mass index (BMI) was found to protect cognitive function. BMI is a crude measure of body fat and cannot differentiate between fat and fat-free mass (muscle), thus it is proposed that the fat-free mass component is likely to be the protective factor"

Diabetes drugs act as powerful curb for immune cells in controlling inflammation - Science Daily, 7/28/18 - "Keeping macrophages from going overboard on the job may inhibit the onset of obesity and diabetes following tissue inflammation ... Lazar's team found that the TZDs, working through PPAR gamma, promote the metabolism of an amino acid called glutamine, a protein building block necessary for macrophage activation. The team found that macrophages lacking PPAR gamma are unable to use glutamine as an energy source and therefore are more susceptible to inflammatory stimulation"

HDL-C: Is It Time to Stop Calling It the 'Good' Cholesterol? - Medscape, 7/17/18 - "Recent data from two population-based cohorts in Copenhagen of over 100,000 people showed that all-cause mortality rates increased significantly for men with HDL-C levels above 97 mg/dL and for women above 135 mg/dL.[6] This mirrored findings from a Canadian big data cohort of more than 630,000 individuals that saw higher risk for noncardiovascular death at fasting levels above 70 mg/dL for men and 90 mg/dL for women.[7] The researchers hypothesized that extremely high levels may reflect dysfunctional HDL-C"

What Is Narcan and Why Was It Used When Demi Lovato Overdosed? - People, 7/24/18 - "Narcan isn’t a solution to addiction by any means, but it is a solution to death ... in some cases, it does not work with the first injection. The patient may require CPR, and an additional dose. It is not possible to overdose on naloxone" - https://people.com/health/demi-lovato-overdose-narcan/

Pregnant women took generic Viagra in a clinical drug trial. Eleven babies died - Washington Post, 6/25/18 - "Sildenafil, a generic version of the erectile dysfunction drug Viagra, was given to 93 pregnant women; another 90 were given an inert placebo ... Then the babies started dying  ... After they were born, 11 of the babies whose mothers had been given sildenafil developed a form of high blood pressure in the lungs, which killed them, the researchers said. Six babies in that group also suffered the complication but survived ... In the placebo group, three developed the disorder, but all of them survived"

Omega-3s help keep kids out of trouble - Science Daily, 7/24/18 - "Giving children omega-3 fatty acid supplements reduces disruptive behavior, which in turn had a positive effect on their parents, making them less likely to argue with each other and engage in other verbal abuse ... That work takes Portnoy into the heart of the "nature versus nurture" debate -- whether people who commit crimes have something in their physiological makeup that predisposes them to doing so or if social factors like abusive family situations lead them to it" - See omega-3 supplements at Amazon.com.

Turmeric-derived eye drops could treat glaucoma: study - Science Daily, 7/24/18 - "The research team found the eye drops can reduce the loss of retinal cells in rats, which is known to be an early sign of glaucoma ... Curcumin is an exciting compound that has shown promise at detecting and treating the neurodegeneration implicated in numerous eye and brain conditions from glaucoma to Alzheimer's disease, so being able to administer it easily in eye drops may end up helping millions of people ... After twice-daily use of eye drops in the rats for three weeks, retinal ganglion cell loss was significantly reduced compared to matched controls, and the treatment was found to be well-tolerated with no signs of eye irritation or inflammation"

Abstracts from this week:

Association of dietary sodium:potassium ratio with the metabolic syndrome in Chinese adults - Br J Nutr. 2018 Aug 2:1-7 - "higher dietary Na:K ratio significantly increased the risk of the MetS in Chinese adults" - See potassium citrate at Amazon.com.

The association between dietary intake of magnesium and psychiatric disorders among Iranian adults: a cross-sectional study - Br J Nutr. 2018 Aug 2:1-10 - "dietary intake of Mg was inversely associated with depression and anxiety" - See magnesium supplements at Amazon.com.

Iron deficiency in patients with heart failure with preserved ejection fraction and its association with reduced exercise capacity, muscle strength and quality of life - Clin Res Cardiol. 2018 Jul 26 - "heart failure with preserved ejection fraction (HFpEF) ... ID is a frequent co-morbidity in HFpEF and is associated with reduced exercise capacity and QoL. Its prevalence increases with increasing severity of diastolic dysfunction" - See iron supplements at Amazon.com.

Protective antioxidant effects of N-acetylcysteine against impairment of spermatogenesis caused by paranonylphenol - Andrologia. 2018 Aug 1:e13114 - "The findings of this study indicate that NAC as a potent antioxidant be able to compensate the adverse effects of p-NP in spermatogenesis, testis and levels of testosterone and MDA in the p-NP + NAC group significantly compared to the p-NP group" - See n-acetyl cysteine at Amazon.com.

A Review on the Protective Effects of Honey against Metabolic Syndrome - Nutrients. 2018 Aug 2;10(8) - "Honey is a nutritional food low in glycemic index. Honey intake reduces blood sugar levels and prevents excessive weight gain. It also improves lipid metabolism by reducing total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL), which leads to decreased risk of atherogenesis. In addition, honey enhances insulin sensitivity that further stabilizes blood glucose levels and protects the pancreas from overstimulation brought on by insulin resistance. Furthermore, antioxidative properties of honey help in reducing oxidative stress, which is one of the central mechanisms in MetS. Lastly, honey protects the vasculature from endothelial dysfunction and remodelling. Therefore, there is a strong potential for honey supplementation to be integrated into the management of MetS, both as preventive as well as adjunct therapeutic agents" - See Manuka Honey at Amazon.com.

  • What is UMF - "The UMF grading system appraises the natural markers found in manuka honey and assures purity and quality ... The higher the UMF grade the greater the presence of the unique manuka honey attributes ... Low Grade: UMF5 to UMF9 ... Medium Grade: UMF10 to UMF15 ... Superior High Grade: UMF16+"

Pioglitazone's beneficial effects on erectile function preservation after cavernosal nerve injury in the rat are negated by inhibition of the insulin-like growth factor-1 receptor: a preclinical study - Int J Impot Res. 2018 Aug 2 - "Pio improves erectile function in rats undergoing BCNI via an IGF-1-mediated pathway"

Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind placebo-controlled trial - Nutri, Jul 2018 - "After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4±34.4 vs 220.6±37.4, p=0.04) and triglyceride (133.4±55.3 vs 166.7±68.5, p=0.04) concentrations compared with the placebo group, without significant statistical differences for HDL-C and LDL-C levels" - [Nutra USA] - See resveratrol products at Amazon.com..

Whole blood n-3 fatty acids are associated with executive function in 2-6-year-old Northern Ghanaian children - J Nutr Biochem. 2018 Jul;57:287-293 - "A total of 307, 2-to-6-year-old children attempted the dimensional change card sort (DCCS) task to assess executive function, and dried blood spot samples were collected and analyzed for FA content. Significant differences in mean % total whole-blood fatty acids were observed between children who could not follow directions on the DCCS test (49.8% of the sample) and those who could (50.2% of the sample). Positive associations with DCCS performance were observed for DHA (β=0.25, P=.06), total n-3 (β=0.17, P=.06) and dihomo-gamma-linolenic acid (DGLA; β=0.60, P=.06). Children with the highest levels of total n-3 and DHA were three and four times, respectively, more likely to pass at least one condition of the DCCS test of executive function than those with the lowest DHA levels" - [Nutra USA] - See omega-3 supplements at Amazon.com.

The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind, randomized, placebo controlled trial - J Int Soc Sports Nutr. 2018 Jul 31;15(1):37 - "betaine (2.5 g/day ... Significant interactions were found for changes in body fat percentage and fat mass: body fat percentage and fat mass decreased significantly more in betaine (- 3.3 ± 1.7%; - 2.0 ± 1.1 kg) compared to placebo (- 1.7 ± 1.6%; - 0.8 ± 1.3 kg), respectively" - [Nutra USA] - See trimethylglycine at Amazon.com.

Blood pressure level associated with lowest cardiovascular event in hypertensive diabetic patients - J Hypertens. 2018 Jul 13 - "A mean BP of less than 140/80 mmHg was associated with further reduction in the risk of all-cause mortality, cardiovascular mortality, and nonfatal cardiovascular events in diabetic hypertensive patients"

Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study - J Gerontol A Biol Sci Med Sci. 2018 Jul 19 - "The present study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months ... Paired Associate Learning (PAL), a visuospatial learning and episodic memory test. Secondary outcomes included verbal episodic and recognition memory (VRM) and working memory (SSP) ... There was no significant effect of PEGB on the PAL on the whole cohort. Yet, PEGB supplementation improved VRM free recall. Stratifying the cohort in quartiles based on PAL at baseline revealed a subgroup with advanced cognitive decline (decliners) who responded positively to the PEGB. In this group, PEGB consumption was also associated with a better VRM delayed recognition. In addition to a lower polyphenol consumption, the urine metabolomic profile of decliners revealed that they excreted more metabolites. Urinary concentrations of specific flavan-3-ols metabolites were associated, at the end of the intervention, with the memory improvements. Our study demonstrates that PEGB improves age-related episodic memory decline in individuals with the highest cognitive impairments" - [Nutra USA] - See blueberry extract at Amazon.com and grape seed extract at Amazon.com..

Health Focus (C-reactive protein):