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Recent Longevity News for the seven days ending 7/25/12.  You should consult your doctor if you are taking any medications.

High dietary antioxidant intake might cut pancreatic cancer risk - Science Daily, 7/23/12 - "Increasing dietary intake of the antioxidant vitamins C, E, and selenium could help cut the risk of developing pancreatic cancer by up to two thirds ... The disease has the worst prognosis of any cancer, with just 3% of people surviving beyond five years ... weekly intake of selenium in the top 25% of consumption roughly halved their risk of developing pancreatic cancer compared with those whose intake was in the bottom 25% ... those whose vitamins C, E, and selenium intake was in the top 25% of consumption were 67% less likely to develop pancreatic cancer than those who were in the bottom 25%"

Medical Food Linked to Memory Improvement in Mild Alzheimer's - Medscape, 7/23/12 - "Administration of a medical food designed to improve synaptic dysfunction is associated with continuous memory improvement in patients with mild Alzheimer's disease (AD) ... The once-a-day drink contains a patented nutrient combination with the following ingredients: Eicospentaenoic acid, 300 mg ... Docosahexaenoic acid, 1200 mg ... Phospholipids 106 mg ... Choline, 400 mg ... Uridine monophosphate, 625 mg ... Vitamin E (alpha-tocopherol equivalents), 40 mg ... Selenium, 60 µg ... Vitamin B12, 3 µg ... Vitamin B6, 1 µg ... Folic acid, 400 µg" - Note:  I've already been taking all of that for years except for the uridine. See uridine at Amazon.com.

Shortened Telomeres Linked to Dementia, Mortality - Medscape, 7/23/12 - "Shortening of leukocyte telomeres, the extreme ends of chromosomal DNA, is associated with risks for dementia and mortality, and may be a marker of biological aging ... After controlling for age, sex, ethnicity, education, and APOE status, the risk of mortality for those with the shortest TL compared with the longest was 1.72 (95% CI, 1.40 - 2.11; P < .001). This association might indicate that shortened TL causes processes that lead to earlier mortality, that other biological processes or preclinical disorders cause TL shortening, or that some environmental or genetic influences cause shortening of TL and increase mortality"

Vitamin D may protect lung function in smokers - Science Daily, 7/20/12 - "We found that vitamin D sufficiency (defined as serum vitamin D levels of >20 ng/ml) had a protective effect on lung function and the rate of lung function decline in smokers" - See vitamin D at Amazon.com.

Testosterone Has Benefits for Metabolism, Weight Loss - Medscape, 7/18/12 - "All these patients presented [to a urologist] because of erectile dysfunction ... They received 4 years of testosterone therapy without interruption. To our surprise, we saw that they lost weight, and this was neither intended nor expected ... Specifically, they found that the mean weight decrease from baseline to the last patient visit was 14.3 kg [31.5 pounds], with 2 patients losing 40 kg [88 pounds] or more. The mean percentage weight loss was 13.0%, body mass index (BMI) decreased by a mean of 4.5 points, and the mean decline in waist circumference was 11 cm [4.3 inches]"

Sleep Quality Now May Affect Cognition Later - Medscape, 7/17/12 - "The first, which examined data from more than 15,000 participants in the Nurses' Health Study, showed that women who regularly slept 5 hours or less a night or 9 hours or more a night had an increased risk for cognitive decline compared with the women who regularly slept for the common goal of 7 hours per night ... A second study ... showed that a significantly increased risk for MCI/dementia at the 5-year study point was found for the women with sleep disordered breathing at baseline compared with those who did not have the condition (adjusted odds ratio [OR], 2.33; 95% confidence interval [CI], 1.28 - 4.25)"

Vitamin B12 May Boost Hep C Treatment - WebMD, 7/17/12 - "In the newly reported Italian study, previously untreated patients with hepatitis C virus (HCV) who received vitamin B12 along with the drugs pegylated interferon and ribavirin were more likely to have undetectable levels of virus at 24 weeks after stopping treatment compared to patients who did not receive vitamin B12" - See vitamin B12 at Amazon.com.

Vitamin E may lower liver cancer risk - Science Daily, 7/17/12 - "China who were enrolled in the Shanghai Women's Health Study (SWHS) from 1997-2000 or the Shanghai Men's Health Study (SMHS) from 2002-2006, two population-based cohort studies jointly conducted by the Shanghai Cancer Institute and Vanderbilt University. Using validated food-frequency questionnaires, the researchers conducted in-person interviews to gather data on study participants' dietary habits. They compared liver cancer risk among participants who had high intake of vitamin E with those with low intake ... Vitamin E intake from diet and vitamin E supplement use were both associated with a lower risk of liver cancer. This association was consistent among participants with and without self-reported liver disease or a family history of liver cancer" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Marijuana use prior to pregnancy doubles risk of premature birth - Science Daily, 7/17/12 - "Preterm or premature birth -- at least three weeks before a baby's due date -- can result in serious and life-threatening health problems for the baby, and an increased risk of health problems in later life, such as heart disease and diabetes ... A study of more than 3000 pregnant women in Adelaide, Australia and Auckland, New Zealand has detailed the most common risk factors for preterm birth"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effect of pioglitazone on testosterone in eugonadal men with type 2 diabetes mellitus: A randomized double blind placebo-controlled study - Clin Endocrinol (Oxf). 2012 Jul 20 - "randomly assigned to receive pioglitazone 30 mg per day or placebo along with existing glimepiride and metformin therapy ... As compared to placebo, six months of pioglitazone therapy in patients with T2DM resulted in significant reduction in mean total testosterone level (16.1 to 14.9 vs 17.1 to 17.0 nmol/L; p = 0.031), calculated free testosterone (p = 0.001) and bioavailable testosterone (p = 0.000) despite significant increase in sex hormone binding globulin (p = 0.000). Plasma androstenedione (∆(4) ) level increased (1.5 to 1.9 ng/ml; p = 0.051) following pioglitazone therapy"

Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats - Atherosclerosis. 2012 Jun 26 - "red wine (RW) ... resveratrol RS ... RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 +/- 1.2, RW 38.7 +/- 1.7, LRS 38.5 +/- 1.6, HRS 38.3 +/- 1.8 mlO(2) min(-1) kg(-1)), and RW or LRS also improved time of exercise tolerance vs. C (p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 +/- 30 days, p = NS" - See resveratrol products at Amazon.com.

Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic Patients - Adv Ther. 2012 Jul 20 - "patients with type 2 diabetes and hypertension with poor control of blood pressure by 40 mg/day telmisartan were randomly assigned into the telmisartan 80 mg/day (Tel80) group (dose increase from 40 to 80 mg/day) or the telmisartan 40 mg + amlodipine 5 mg (Tel40 + Aml5) group ... Although the antihypertensive effects of the two doses of telmisartan were similar, a significant increase in HMW adiponectin levels was noted only in the Tel80 group" - See telmisartan at OffshoreRx1.com.

Mitochondrial effects of Ginkgo biloba extract - Int Psychogeriatr. 2012 Aug;24 Suppl 1:S18-20 - "The flavonoids, bilobalide and some of the ginkgolides (B and J) had a high protective capacity, indicating that a combination of several compounds within standardized Gingko biloba extracts contribute disproportionately for these protective effects" - See Ginkgo biloba at Amazon.com.

Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761® - Int Psychogeriatr. 2012 Aug;24 Suppl 1:S25-34 - "As seen for isorhamnetin, the effect on neurotransmitter levels seems not to be a general effect of flavonols but rather to be a specific action of acylated flavonol glycosides which are present in EGb 761®. The direct involvement of these two flavonol derivatives in the increase of dopaminergic and cholinergic neurotransmission in the prefrontal cortex may be one of the underlying mechanisms behind the reported effects of EGb 761® on the improvement of cognitive function" - See Ginkgo biloba at Amazon.com.

Gingko biloba extract EGb 761®: clinical data in dementia - Int Psychogeriatr. 2012 Aug;24 Suppl 1:S35-40 - "Research into Gingko biloba extract EGb 761® has been ongoing for many years. Early studies showed that the extract was superior to placebo in improving symptoms of dementia, and this has been confirmed by more recent research. The GINDEM-NP, GOTADAY and GOT-IT! studies showed that 240 mg/day EGb 761® improved cognitive function, neuropsychiatric symptoms, activities of daily living, and quality of life in patients with mild to moderate dementia compared with placebo, with results reproducible in independent trials. The strength of the effect in terms of improvements in neurosensory symptoms associated with old age and dementia was strong enough to be detected by caregivers and independent clinicians. A combination of 240 mg/day EGb 761® and 10 mg/day (initially 5 mg/day) donepezil was also more effective than either drug alone. Regarding the improvement of neuropsychiatric symptoms, a cross-comparison of studies with different antidementia agents suggests that EGb 761® is at least as effective as memantine, galantamine, and donepezil. Safety data revealed no important safety concerns with EGb 761®" - See Ginkgo biloba at Amazon.com.

Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome - J Nutr. 2012 Jul 18 - "We evaluated the effects of grape polyphenols in individuals classified with metabolic syndrome (MetS). Men (n = 24) aged 30-70 y were randomly assigned to consume either a freeze-dried grape polyphenol powder (GRAPE) or a placebo for 30 d in a double-blind, crossover design, separated by a 3-wk washout period ... These results suggest that GRAPE polyphenols may potentiate vasorelaxation and reduce BP and circulating cell adhesion molecules, resulting in improvements in vascular function" - See Jarrow Formulas, OPCs + 95 at Amazon.com.

Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats - J Diabetes Complications. 2012 Jul 16 - "Diabetes was induced by feeding rats with an HFD for 2weeks followed by an intraperitoneal injection of STZ (35mg/kg body weight). An oral dose of 50mg/kg hesperidin or naringin was daily given for 4weeks after diabetes induction ... At the end of the experimental period, blood was obtained from jugular vein and livers were rapidly excised and homogenized for biochemical assays. In the diabetic control group, levels of glucose, glycosylated hemoglobin (HbA1c%), MDA, NO, TNF-α and IL-6 were significantly increased, while serum insulin, GSH, vitamin C, and vitamin E levels were decreased. Both hesperidin and naringin administration significantly reversed these alterations. Moreover, supplementation with either compound significantly ameliorated serum and liver MDA, NO and glutathione, and liver antioxidant enzymes" - See hesperidin at Amazon.com.

Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trial - Nutr J. 2012 Jul 17;11(1):47 - "KRG supplementation may attenuate lymphocyte DNA damage and LDL oxidation by upregulating antioxidant enzyme activity" - See ginseng at Amazon.com.

Lower lifetime dietary fiber intake is associated with carotid artery stiffness: the Amsterdam Growth and Health Longitudinal Study - Am J Clin Nutr. 2012 Jul;96(1):14-23 - "This was a longitudinal cohort study among 373 participants in whom dietary intake was assessed between the ages of 13 to 36 y (2-8 repeated measures, median of 5), and arterial stiffness estimates of 3 large arteries (ultrasonography) were ascertained at age 36 y ... After adjustment for sex, height, total energy intake, and other lifestyle variables, subjects with stiffer carotid arteries consumed less fiber (in g/d) during the 24-y study than did those with less stiff carotid arteries, as defined on the basis of the highest compared with the lowest sex-specific tertiles of the distensibility and compliance coefficients (reversed) and Young's elastic modulus: -1.9 (95% CI: -3.1, -0.7), -2.3 (-3.5, -1.1), and -1.3 (-2.5, -0.0), respectively. Furthermore, subjects with stiffer carotid arteries were characterized by a lower lifetime consumption of fruit, vegetables, and whole grains-deleterious associations that could be explained, to a great extent, by related low fiber intake"

Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus - Lipids Health Dis. 2012 Feb 22;11:29 - "A randomized, double-blind, placebo-controlled study was conducted on twenty volunteers (ten for placebo group and ten for symbiotic group), aged 50 to 60 years ... Over a total test period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of 200 mL of a symbiotic shake containing 10(8) UFC/mL Lactobacillus acidophilus, 10(8) UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other volunteers (the placebo group) drank daily the same amount of a shake that did not contain any symbiotic bacteria ... The results of the symbiotic group showed a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a significant increase (P < 0.05) in HDL cholesterol and a significant reduction (P < 0.05) in fasting glycemia. No significant changes were observed in the placebo group"

Rethinking the Association of High Blood Pressure With Mortality in Elderly Adults: The Impact of Frailty - Arch Intern Med. 2012 Jul 16:1-7 - "The association between BP and mortality varied by walking speed. Among faster walkers, those with elevated systolic BP (≥140 mm Hg) had a greater adjusted risk of mortality compared with those without (hazard ratio [HR], 1.35; 95% CI, 1.03-1.77). Among slower walkers, neither elevated systolic nor diastolic BP (≥90 mm Hg) was associated with mortality. In participants who did not complete the walk test, elevated BP was strongly and independently associated with a lower risk of death: HR, 0.38; 95% CI, 0.23-0.62 (systolic); and HR, 0.10; 95% CI, 0.01-0.81 (diastolic)"

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