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Home > Anti-aging Research > Uridine monophosphate

Uridine monophosphate

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  • Dietary treatment shows potential in mouse model of Alzheimer's disease - Science Daily, 1/24/14 - "The study used transgenic female mice carrying APP and PS1 mutations linked with familial Alzheimer's disease, and wild-type mice ... some of the APP/PS1 mice were fed three experimental chows enriched with fish oil and having a similar fat content as the control chow: fish oil supplement only, plant sterol supplement or Fortasyn supplement, which contains uridine-monophosphate, phospholipids, B- vitamins, and antioxidants ... Among transgenic mice on the experimental diets, the mice on the Fortasyn diet performed equally well as the wild-type mice, whereas other dietary treatments showed no improvement. However, all test diets reversed the memory deficit of the APP/PS1 mice in the odour recognition task. The levels of accumulated amyloid-β protein in the brain were examined at the end of the study. A significant reduction in the amyloid-β levels was observed in the plant sterol group while other experimental diets showed no effect. However, why was a substantial reduction in brain amyloid-β levels not accompanied by a positive memory effect in the spatial task in the plant sterol group? One explanation is that the plant sterol diet increased formation of reactive oxygen species in the hippocampus, whereas the Fortasyn diet, which yielded the best results in the spatial memory task, tended to have an opposite effect" - See uridine at Amazon.com.
  • Medical Food Linked to Memory Improvement in Mild Alzheimer's - Medscape, 7/23/12 - "Administration of a medical food designed to improve synaptic dysfunction is associated with continuous memory improvement in patients with mild Alzheimer's disease (AD) ... The once-a-day drink contains a patented nutrient combination with the following ingredients: Eicospentaenoic acid, 300 mg ... Docosahexaenoic acid, 1200 mg ... Phospholipids 106 mg ... Choline, 400 mg ... Uridine monophosphate, 625 mg ... Vitamin E (alpha-tocopherol equivalents), 40 mg ... Selenium, 60 µg ... Vitamin B12, 3 µg ... Vitamin B6, 1 µg ... Folic acid, 400 µg"
  • Nutrient mixture improves memory in patients with early Alzheimer's - Science Daily, 7/10/12 - "Wurtman came up with a mixture of three naturally occurring dietary compounds: choline, uridine and the omega-3 fatty acid DHA ... These nutrients are precursors to the lipid molecules that, along with specific proteins, make up brain-cell membranes, which form synapses. To be effective, all three precursors must be administered together ... In animal studies, he showed that his dietary cocktail boosted the number of dendritic spines, or small outcroppings of neural membranes, found in brain cells. These spines are necessary to form new synapses between neurons ... 40 percent of patients who consumed the drink improved in a test of verbal memory, while 24 percent of patients who received the control drink improved their performance ... Patients, whether taking Souvenaid or a placebo, improved their verbal-memory performance for the first three months, but the placebo patients deteriorated during the following three months, while the Souvenaid patients continued to improve ... as the trial went on, the brains of patients receiving the supplements started to shift from patterns typical of dementia to more normal patterns. Because EEG patterns reflect synaptic activity, this suggests that synaptic function increased following treatment, the researchers say" - Avoid the patent mark-up.  See citicholine at Amazon.com, uridine at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Antidepressant Foods - Forbes.com, 2/10/05 - "The Omega-3 diet showed results after one month, and uridinewas effective as long as the rats were fed enough of it. But when given both together, within ten days the rats who were eating the good foods behaved as well as those on medications ... Uridine fuels mitochondria, and paired with the lubricating effect of the Omega-3s, helps them make more energy more efficiently"
  • Nutrient cocktail may boost memory and learning: study - Nutra USA, 7/10/08 - "It may be possible to use this [combination] to partially restore brain function in people with diseases that decrease the number of brain neurons, including, for example, Alzheimer's disease, Parkinson's, strokes and brain injuries. Of course, such speculations have to be tested in double-blind, placebo-controlled clinical trials ... supplemented the diets of gerbils with uridine (in its monophosphate form, 0.5 per cent) and choline (0.1 per cent), and docosahexaenoic acid (DHA, 300 mg/kg/day) for four weeks ... At the end of the study, significant increases in phospholipid levels in the brain were observed when the compounds were given together, while administration of only DHA or UMP or UMP plus choline produced smaller increases" - [Abstract]


  • A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats - Neurobiol Aging. 2014 Jul 24 - "Fortasyn Connect (FC) is a specific nutrient combination designed to target synaptic dysfunction in Alzheimer's disease by providing neuronal membrane precursors and other supportive nutrients ... the FC diet enhances hippocampal cholinergic neurotransmission in aged rats and suggest that this effect is mediated by enhanced synaptic membrane formation. These data provide further insight into cellular and molecular mechanisms by which FC may support memory processes in Alzheimer's disease"
    • Souvenaid - Wikipedia - "Souvenaid was developed by Advanced Medical Nutrition division of Nutricia and contains a patented combination of nutrients, referred to under the trademark Fortasyn Connect™.[4] Souvenaid was designed to support synapse formation and function[1] in early Alzheimer’s disease ... Composition ... Eicospentaenoic acid, 300 mg ... Docosahexaenoic acid, 1200 mg ... Phospholipids 106 mg ... Choline, 400 mg ... Uridine monophosphate, 625 mg ... Vitamin E (alpha-tocopherol equivalents), 40 mg ... Selenium, 60 µg ... Vitamin B12, 3 µg ... Vitamin B6, 1 mg ... Folic acid, 400 µg" - See uridine at Amazon.com.  Most health conscious people are probably already taking the other incredients.
  • A Nutrient Combination that Can Affect Synapse Formation - Nutrients. 2014 Apr 23;6(4):1701-10 - "Brain neurons form synapses throughout the life span. This process is initiated by neuronal depolarization, however the numbers of synapses thus formed depend on brain levels of three key nutrients-uridine, the omega-3 fatty acid DHA, and choline ... In Alzheimer's disease (AD) the need for extra quantities of the three nutrients is enhanced, both because their basal plasma levels may be subnormal (reflecting impaired hepatic synthesis), and because especially high brain levels are needed for correcting the disease-related deficiencies in synaptic membrane and synapses" - See uridine at Amazon.com, docosahexaenoic acid at Amazon.com and citicholine at Amazon.com.