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Anti-aging Research > Uridine monophosphate
Uridine monophosphate
Specific Recommendations:
News & Research:
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Dietary treatment shows potential in mouse model of Alzheimer's disease - Science
Daily, 1/24/14 - "The study used transgenic female mice
carrying APP and PS1 mutations linked with familial Alzheimer's disease, and
wild-type mice ... some of the APP/PS1 mice were fed three experimental
chows enriched with fish oil and having a similar fat content as the control
chow: fish oil supplement only, plant sterol supplement or Fortasyn
supplement, which contains uridine-monophosphate, phospholipids, B-
vitamins, and antioxidants ... Among transgenic mice on the experimental
diets, the mice on the Fortasyn diet performed equally well as the wild-type
mice, whereas other dietary treatments showed no improvement. However, all
test diets reversed the memory deficit of the APP/PS1 mice in the odour
recognition task. The levels of accumulated amyloid-β protein in the brain
were examined at the end of the study. A significant reduction in the
amyloid-β levels was observed in the plant sterol group while other
experimental diets showed no effect. However, why was a substantial
reduction in brain amyloid-β levels not accompanied by a positive memory
effect in the spatial task in the plant sterol group? One explanation is
that the plant sterol diet increased formation of reactive oxygen species in
the hippocampus, whereas the Fortasyn diet, which yielded the best results
in the spatial memory task, tended to have an opposite effect" - See
uridine at Amazon.com
 .
- Medical
Food Linked to Memory Improvement in Mild Alzheimer's - Medscape,
7/23/12 - "Administration of a medical food designed
to improve synaptic dysfunction is associated with continuous memory
improvement in patients with mild Alzheimer's
disease (AD) ... The once-a-day drink contains a patented nutrient
combination with the following ingredients: Eicospentaenoic acid, 300 mg ...
Docosahexaenoic acid, 1200 mg ... Phospholipids 106 mg ... Choline, 400 mg
... Uridine monophosphate, 625 mg ... Vitamin E (alpha-tocopherol
equivalents), 40 mg ... Selenium, 60 µg ... Vitamin B12, 3 µg ... Vitamin
B6, 1 µg ... Folic acid, 400 µg"
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Nutrient
mixture improves memory in patients with early Alzheimer's - Science Daily,
7/10/12 - "Wurtman came up with a mixture of three
naturally occurring dietary compounds: choline, uridine and the omega-3 fatty
acid DHA ... These nutrients are precursors to the lipid molecules that, along
with specific proteins, make up brain-cell membranes, which form synapses. To be
effective, all three precursors must be administered together ... In animal
studies, he showed that his dietary cocktail boosted the number of dendritic
spines, or small outcroppings of neural membranes, found in brain cells. These
spines are necessary to form new synapses between neurons ... 40 percent of
patients who consumed the drink improved in a test of verbal memory, while 24
percent of patients who received the control drink improved their performance
... Patients, whether taking Souvenaid or a placebo, improved their
verbal-memory performance for the first three months, but the placebo patients
deteriorated during the following three months, while the Souvenaid patients
continued to improve ... as the trial went on, the brains of patients receiving
the supplements started to shift from patterns typical of dementia to more
normal patterns. Because EEG patterns reflect synaptic activity, this suggests
that synaptic function increased following treatment, the researchers say"
- Avoid the patent mark-up. See
citicholine at Amazon.com,
uridine at Amazon.com and
Jarrow Max DHA at Amazon.com.
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Antidepressant Foods - Forbes.com, 2/10/05 - "The
Omega-3 diet showed results after one month, and uridinewas effective as long as
the rats were fed enough of it. But when given both together, within ten days
the rats who were eating the good foods behaved as well as those on medications
... Uridine fuels mitochondria, and paired with the lubricating effect of the
Omega-3s, helps them make more energy more efficiently"
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Nutrient cocktail may boost memory and learning: study - Nutra USA, 7/10/08
- "It may be possible to use this [combination] to
partially restore brain function in people with diseases that decrease the
number of brain neurons, including, for example, Alzheimer's disease,
Parkinson's, strokes and brain injuries. Of course, such speculations have to be
tested in double-blind, placebo-controlled clinical trials ... supplemented the
diets of gerbils with uridine (in its monophosphate form, 0.5 per cent) and
choline (0.1 per cent), and docosahexaenoic acid (DHA, 300 mg/kg/day) for four
weeks ... At the end of the study, significant increases in phospholipid levels
in the brain were observed when the compounds were given together, while
administration of only DHA or UMP or UMP plus choline produced smaller
increases" - [Abstract]
Abstracts:
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A specific
multi-nutrient enriched diet enhances hippocampal cholinergic transmission in
aged rats - Neurobiol Aging. 2014 Jul 24 - "Fortasyn
Connect (FC) is a specific nutrient combination designed to target synaptic
dysfunction in Alzheimer's disease by providing neuronal membrane precursors and
other supportive nutrients ... the FC diet enhances hippocampal cholinergic
neurotransmission in aged rats and suggest that this effect is mediated by
enhanced synaptic membrane formation. These data provide further insight into
cellular and molecular mechanisms by which FC may support memory processes in
Alzheimer's disease"
- Souvenaid -
Wikipedia - "Souvenaid was developed by Advanced
Medical Nutrition division of Nutricia and contains a patented combination
of nutrients, referred to under the trademark Fortasyn Connect™.[4]
Souvenaid was designed to support synapse formation and function[1] in early
Alzheimer’s disease ... Composition ... Eicospentaenoic acid, 300 mg ...
Docosahexaenoic acid, 1200 mg ... Phospholipids 106 mg ... Choline, 400 mg
... Uridine monophosphate, 625 mg ... Vitamin E (alpha-tocopherol
equivalents), 40 mg ... Selenium, 60 µg ... Vitamin B12, 3 µg ... Vitamin
B6, 1 mg ... Folic acid, 400 µg" - See
uridine at Amazon.com.
Most health conscious people are probably already taking the other
incredients.
- A
Nutrient Combination that Can Affect Synapse Formation - Nutrients. 2014
Apr 23;6(4):1701-10 - "Brain neurons form synapses
throughout the life span. This process is initiated by neuronal
depolarization, however the numbers of synapses thus formed depend on brain
levels of three key nutrients-uridine, the omega-3 fatty acid DHA, and
choline ... In Alzheimer's disease (AD) the need for extra quantities of the
three nutrients is enhanced, both because their basal plasma levels may be
subnormal (reflecting impaired hepatic synthesis), and because especially
high brain levels are needed for correcting the disease-related deficiencies
in synaptic membrane and synapses" - See
uridine at Amazon.com,
docosahexaenoic acid at Amazon.com
and
citicholine at Amazon.com.
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