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Recent Longevity News for the week ending 1/21/15
Vitamin D Linked to Lower Colorectal Cancer Risk - WebMD, 1/16/15 -
"people with high amounts of
25-hydroxy vitamin D had a lower risk of
getting colorectal tumors that have a large number of immune cells. The authors
say this suggests there’s an interaction between vitamin D and the immune system
that may work to prevent colorectal cancer"
- See
vitamin D at Amazon.com Flu Vaccine Barely Working This Year, CDC Says - today.com, 1/15/15 - "The flu vaccine is barely protecting people this year – reducing the risk of serious disease by just 23 percent ... the CDC’s been reminding people that there are three antiviral drugs on the market that can help you recover more quickly from flu. Tamiflu is the pill most widely prescribed, and there are injectable and inhalable drugs, too ... Unlike with antibiotics, there is not a big downside to taking a flu drug without being sure you have influenza ... And it’s even OK to just call your symptoms in to your doctor so you can fill the prescription right away – because time is of the essence in treating flu" Abstracts from this week:
Polyunsaturated fatty acids in relation to incident mobility disability and
decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study
- Eur J Clin Nutr. 2015 Jan 14 - "In women, but not men,
every s.d. increment increase of total n-3 PUFAs
and docosahexaenoic acid (DHA) was associated with
lower mobility disability risk, odds ratio 0.48 (0.25; 0.93) and odds ratio 0.45
(0.24; 0.83), respectively. There was no association between n-6 PUFAs and the
risk of incident mobility disability or gait speed decline ... Higher
concentrations of n-3 PUFAs and, particularly, DHA may protect women from
impaired mobility but does not appear to have such an effect in men" -
See
fish oil supplements at Amazon.com
Antidepressant-like effects of cordycepin in a mice model of chronic
unpredictable mild stress - Evid Based Complement Alternat Med.
2014;2014:438506 - "This study is attempted to
investigate whether cordycepin (COR) possesses
beneficial effects on chronic unpredictable mild stress- (CUMS-) induced
behavioral deficits (depression-like behaviors) and explore the possible
mechanisms ... COR remarkably improved depression-like
behavior in CUMS mice and its antidepressant activity is mediated, at least in
part, by the upregulating BDNF and downregulating 5-HT2AR levels and
inflammation in hippocampus" - See
cordyceps at Amazon.com
Vaccinium
myrtillus extract prevents or delays the onset of diabetes--induced
blood-retinal barrier breakdown - Int J Food Sci Nutr. 2015 Jan 13 -
"bilberries (Vaccinium
myrtillus) ... V. myrtillus extract ... VME may prevent or delay the onset of
early diabetic retinopathy. These findings
have important implications for prevention of diabetic retinopathy using a
dietary bilberry supplement" - See
bilberry at Amazon.com
Effects of vitamin D
supplementation and circuit training on indices of obesity and insulin
resistance in T2D and vitamin D deficient elderly women - J Exerc Nutrition
Biochem. 2014 Sep;18 - "It was concluded that the 12
weeks of vitamin D supplementation and circuit
training would have positive effects on abdominal
fat and blood lipid profiles in T2D and vitamin D deficient elderly women.
Vitamin D supplementation was especially effective when it was complemented with
exercise training" - [Nutra
USA] - See
vitamin D at Amazon.com
Vitamin E
and risk of age-related cataract: a meta-analysis - Public Health Nutr. 2015
Jan 16 - "age-related
cataract (ARC) ... Dietary vitamin E intake, dietary and supplemental
vitamin E intake, and high serum tocopherol levels were significantly associated
with decreased risk of ARC, the pooled relative risk was 0.73 (95 % CI 0.58,
0.92), 0.86 (95 % CI 0.75, 0.99) and 0.77 (95 % CI 0.66, 0.91), respectively.
Supplemental vitamin E intake was non-significantly associated with ARC risk
(relative risk=0.92; 95 % CI 0.78, 1.07). The findings from dose-response
analysis showed evidence of a non-linear association between dietary vitamin E
intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7
mg/d (relative risk=0.94; 95 % CI 0.90, 0.97)" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com Dietary patterns and colorectal cancer: results from a Canadian population-based study - Nutr J. 2015 Jan 15;14(1):8 - "Three major dietary patterns were derived using factor analysis, namely a Meat-diet pattern, a Plant-based diet pattern and a Sugary-diet pattern. In combination the three dietary patterns explained 74% of the total variance in food intake. Results suggest that the Meat-diet and the Sugary-diet increased the risk of CRC with corresponding odds ratios (ORs) of 1.84 (95% CI: 1.19-2.86) and 2.26 (95% CI: 1.39-3.66) for people in the highest intake quintile compared to those in the lowest. Whereas plant-based diet pattern decreases the risk of CRC with a corresponding OR of 0.55 (95% CI: 0.35-0.87)"
Low serum
tryptophan predicts higher mortality in cardiovascular disease - Eur J Clin
Invest. 2015 Jan 13 - "After adjustments for
cardiovascular risk factors and other possible confounders, the hazard ratio
(with 95% CI) in the first tryptophan
quartile of the study population was 1.51 (1.19-1.90; p=0.0006) for total
mortality, 1.41 (1.05-1.89; p=0.0224) for cardiovascular and 1.79 (1.20-2.67;
p=0.0042) for non-cardiovascular mortality, respectively, thus indicating a
significantly higher risk of death in patients with tryptophan concentrations
<34 μmol/L ... Low serum tryptophan in CAD patients is associated with immune
activation and indicates reduced life expectancy" - See
L-tryptophan at Amazon.com
The
Association Between Vitamin B12 Deficiency and Long-Term Use of Acid Lowering
Agents: A Systematic Review and Meta-Analysis - Intern Med J. 2015 Jan 13 -
"Chronic use of ALAs
is a risk factor for developing vitamin B12
deficiency. Judicious prescribing of ALAs and regular monitoring of vitamin
B12 in patients who are inevitably on long-term ALA therapy are recommended"
- See
vitamin B12 at Amazon.com
The effect of
supplementation with alkaline potassium salts on bone metabolism: a
meta-analysis - Osteoporos Int. 2015 Jan 9 - "The
objective of this study was, therefore, to conduct a meta-analysis to assess the
effects of supplemental potassium bicarbonate
(KHCO3) and potassium citrate (KCitr) on urinary calcium and
acid excretion, markers of
bone turnover and bone mineral density (BMD)
and to compare their effects with that of potassium chloride (KCl) ... Urinary
calcium excretion was lowered by intervention with both KHCO3 (P = 0.04) and
KCitr (P = 0.01), as was net acid excretion (NAE) (P = 0.002 for KHCO3 and
P = 0.0008 for KCitr). Both salts significantly lowered the bone resorption
marker NTX (P < 0.00001). There was no effect on bone formation markers or BMD.
KHCO3 and KCitr lowered calcium excretion to a greater extent than did KCl"
- [Nutra
USA] - Note: I take 1100 mg of potassium citrate per day with food to
raise my acidic urine PH closer to neutral. You shouldn't take that much
with being under the supervision of a doctor though. See
potassium citrate at Amazon.com
Berberis
aristata combined with Silybum marianum on lipid profile in patients not
tolerating statins at high doses - Atherosclerosis. 2014 Dec 24 -
"To
evaluate the effects of Berberis aristata combined with
Silybum marianum in
dyslipidemic patients intolerant to statins at high doses ... B. aristata/S.
marianum reduced fasting plasma glucose (-9 mg/dl), insulin (-0.7 μU/ml), and
HOMA-index (-0.35) levels compared to baseline and also to placebo. Lipid
profile did not significantly change after 6 months since the reduction of
statin dosage and the introduction of B. aristata/S. marianum, while it worsened
in the placebo group both compared to placebo and with active treatment (+23.4
mg/dl for total cholesterol, +19.6 mg/dl for LDL-cholesterol, +23.1 mg/dl for
triglycerides with placebo compared to B. aristata/S. marianum). We did not
record any variations of safety parameters in nether of groups" - See
silymarin at Amazon.com
Effect of
Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major
Surgery: Systematic Review and Meta-Analysis - Nutrients. 2015 Jan
9;7(1):481-499 - "GLN supplementation did not affect
overall morbidity (RR = 0.84, 95% CI 0.51 to 1.36; p = 0.473) and infectious
morbidity (RR = 0.64; 95% CI = 0.38 to 1.07; p = 0.087). Patients treated with
glutamine had a significant reduction in length of hospital stay (WMD = -2.67;
95% CI = -3.83 to -1.50; p < 0.0001)" - Note: I don't understand
why they're saying that it had no affect on overall morbidity and infection
morbidity with a relative risk of 0.84 and 0.64 respectively. See
glutamine at Amazon.com Meat subtypes and their association with colorectal cancer: systematic review and meta-analysis - Int J Cancer. 2015 Jan 12 - "Comparing highest versus lowest intake, beef consumption was associated with an increased risk of CRC (RR=1.11, 95% CI=1.01 to 1.22) and colon cancer (RR=1.24, 95% CI=1.07 to 1.44), but no association was found with rectal cancer (RR=0.95, 95% CI=0.78 to 1.16). Higher consumption of lamb was also associated with increased risk of CRC (RR=1.24, 95% CI=1.08 to 1.44). No association was observed for pork (RR=1.07, 95% CI=0.90 to 1.27), but some between study heterogeneity was observed. No association was observed for poultry consumption and risk of colorectal adenomas or cancer"
Omega-3
polyunsaturated fatty acids and chronic obstructive pulmonary disease - Curr
Opin Clin Nutr Metab Care. 2015 Jan 8 - "Observational
data support the hypothesis that omega-3 PUFAs
may provide a therapeutic strategy for managing COPD"
- See
fish oil supplements at Amazon.com Appliance Science: The hot physics of induction cooktops - CNET, 1/19/15 - "Induction cooktops are also more efficient than other types of cooking methods. Because the heat is generated inside the base of the pan, they use less electricity than conventional electric cooktops, and can heat things quicker. They are also easier to clean, because the flat glass or ceramic surface has no gaps or grills to collect spilled food, and the food doesn't get burned onto the surface. If you spill something, one quick swipe with a damp cloth will clean it up. They are also quicker to control and more precise, again because the heat is generated inside the cookware, and so react quicker when you turn the dial up or down ... So why aren't they more common? It's partly a comfort thing; most US consumers don't like them because they grew up on gas rings"
I bought an induction cooktop and was surprised how fast it heats the pan and the accuracy of the settings. I tried a couple fast and easy Chinese dishes. I used the simmer setting at 400 degrees for the meat then set it aside then the simmer 375 degrees setting for the vegetables then threw in the meat and added the sauce packet. In the morning I use it for eggs. I set it at simmer, 175 degrees and set the timer for two minutes. It shuts off at two minutes and I just flip the eggs and wait about another minutes. Even though it's none stick I use cooking spray. The stir fry vegetables were available in the produce department at the commissary where I shop. Here's the setup:
How to set up Chrome Remote Desktop for iOS - CNET, 1/19/15 - Note: Chrome Remote Desktop works on Android, iPhone, iPad and PC to PC plus it's free. Health Focus (Hypertension):
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