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Recent Longevity News for the week ending 1/21/15

Vitamin D Linked to Lower Colorectal Cancer Risk - WebMD, 1/16/15 - "people with high amounts of 25-hydroxy vitamin D had a lower risk of getting colorectal tumors that have a large number of immune cells. The authors say this suggests there’s an interaction between vitamin D and the immune system that may work to prevent colorectal cancer" - See vitamin D at Amazon.com.

Flu Vaccine Barely Working This Year, CDC Says - today.com, 1/15/15 - "The flu vaccine is barely protecting people this year – reducing the risk of serious disease by just 23 percent ... the CDC’s been reminding people that there are three antiviral drugs on the market that can help you recover more quickly from flu. Tamiflu is the pill most widely prescribed, and there are injectable and inhalable drugs, too ... Unlike with antibiotics, there is not a big downside to taking a flu drug without being sure you have influenza ... And it’s even OK to just call your symptoms in to your doctor so you can fill the prescription right away – because time is of the essence in treating flu"

Abstracts from this week:

Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study - Eur J Clin Nutr. 2015 Jan 14 - "In women, but not men, every s.d. increment increase of total n-3 PUFAs and docosahexaenoic acid (DHA) was associated with lower mobility disability risk, odds ratio 0.48 (0.25; 0.93) and odds ratio 0.45 (0.24; 0.83), respectively. There was no association between n-6 PUFAs and the risk of incident mobility disability or gait speed decline ... Higher concentrations of n-3 PUFAs and, particularly, DHA may protect women from impaired mobility but does not appear to have such an effect in men" - See fish oil supplements at Amazon.com and docosahexaenoic acid at Amazon.com.

Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress - Evid Based Complement Alternat Med. 2014;2014:438506 - "This study is attempted to investigate whether cordycepin (COR) possesses beneficial effects on chronic unpredictable mild stress- (CUMS-) induced behavioral deficits (depression-like behaviors) and explore the possible mechanisms ... COR remarkably improved depression-like behavior in CUMS mice and its antidepressant activity is mediated, at least in part, by the upregulating BDNF and downregulating 5-HT2AR levels and inflammation in hippocampus" - See cordyceps at Amazon.com.

Vaccinium myrtillus extract prevents or delays the onset of diabetes--induced blood-retinal barrier breakdown - Int J Food Sci Nutr. 2015 Jan 13 - "bilberries (Vaccinium myrtillus) ... V. myrtillus extract ... VME may prevent or delay the onset of early diabetic retinopathy. These findings have important implications for prevention of diabetic retinopathy using a dietary bilberry supplement" - See bilberry at Amazon.com.

Effects of vitamin D supplementation and circuit training on indices of obesity and insulin resistance in T2D and vitamin D deficient elderly women - J Exerc Nutrition Biochem. 2014 Sep;18 - "It was concluded that the 12 weeks of vitamin D supplementation and circuit training would have positive effects on abdominal fat and blood lipid profiles in T2D and vitamin D deficient elderly women. Vitamin D supplementation was especially effective when it was complemented with exercise training" - [Nutra USA] - See vitamin D at Amazon.com.

Vitamin E and risk of age-related cataract: a meta-analysis - Public Health Nutr. 2015 Jan 16 - "age-related cataract (ARC) ... Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0.73 (95 % CI 0.58, 0.92), 0.86 (95 % CI 0.75, 0.99) and 0.77 (95 % CI 0.66, 0.91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0.92; 95 % CI 0.78, 1.07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0.94; 95 % CI 0.90, 0.97)" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Dietary patterns and colorectal cancer: results from a Canadian population-based study - Nutr J. 2015 Jan 15;14(1):8 - "Three major dietary patterns were derived using factor analysis, namely a Meat-diet pattern, a Plant-based diet pattern and a Sugary-diet pattern. In combination the three dietary patterns explained 74% of the total variance in food intake. Results suggest that the Meat-diet and the Sugary-diet increased the risk of CRC with corresponding odds ratios (ORs) of 1.84 (95% CI: 1.19-2.86) and 2.26 (95% CI: 1.39-3.66) for people in the highest intake quintile compared to those in the lowest. Whereas plant-based diet pattern decreases the risk of CRC with a corresponding OR of 0.55 (95% CI: 0.35-0.87)"

Low serum tryptophan predicts higher mortality in cardiovascular disease - Eur J Clin Invest. 2015 Jan 13 - "After adjustments for cardiovascular risk factors and other possible confounders, the hazard ratio (with 95% CI) in the first tryptophan quartile of the study population was 1.51 (1.19-1.90; p=0.0006) for total mortality, 1.41 (1.05-1.89; p=0.0224) for cardiovascular and 1.79 (1.20-2.67; p=0.0042) for non-cardiovascular mortality, respectively, thus indicating a significantly higher risk of death in patients with tryptophan concentrations <34 μmol/L ... Low serum tryptophan in CAD patients is associated with immune activation and indicates reduced life expectancy" - See L-tryptophan at Amazon.com.

The Association Between Vitamin B12 Deficiency and Long-Term Use of Acid Lowering Agents: A Systematic Review and Meta-Analysis - Intern Med J. 2015 Jan 13 - "Chronic use of ALAs is a risk factor for developing vitamin B12 deficiency. Judicious prescribing of ALAs and regular monitoring of vitamin B12 in patients who are inevitably on long-term ALA therapy are recommended" - See vitamin B12 at Amazon.com.

The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis - Osteoporos Int. 2015 Jan 9 - "The objective of this study was, therefore, to conduct a meta-analysis to assess the effects of supplemental potassium bicarbonate (KHCO3) and potassium citrate (KCitr) on urinary calcium and acid excretion, markers of bone turnover and bone mineral density (BMD) and to compare their effects with that of potassium chloride (KCl) ... Urinary calcium excretion was lowered by intervention with both KHCO3 (P = 0.04) and KCitr (P = 0.01), as was net acid excretion (NAE) (P = 0.002 for KHCO3 and P = 0.0008 for KCitr). Both salts significantly lowered the bone resorption marker NTX (P < 0.00001). There was no effect on bone formation markers or BMD. KHCO3 and KCitr lowered calcium excretion to a greater extent than did KCl" - [Nutra USA] - Note:  I take 1100 mg of potassium citrate per day with food to raise my acidic urine PH closer to neutral.  You shouldn't take that much with being under the supervision of a doctor though.  See potassium citrate at Amazon.com.

Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses - Atherosclerosis. 2014 Dec 24 - "To evaluate the effects of Berberis aristata combined with Silybum marianum in dyslipidemic patients intolerant to statins at high doses ... B. aristata/S. marianum reduced fasting plasma glucose (-9 mg/dl), insulin (-0.7 μU/ml), and HOMA-index (-0.35) levels compared to baseline and also to placebo. Lipid profile did not significantly change after 6 months since the reduction of statin dosage and the introduction of B. aristata/S. marianum, while it worsened in the placebo group both compared to placebo and with active treatment (+23.4 mg/dl for total cholesterol, +19.6 mg/dl for LDL-cholesterol, +23.1 mg/dl for triglycerides with placebo compared to B. aristata/S. marianum). We did not record any variations of safety parameters in nether of groups" - See silymarin at Amazon.com and berberine at Amazon.com.

  • Silybum marianum -  Wikipedia - "Silybum marianum has other common names include cardus marianus, milk thistle, blessed milk thistle, Marian Thistle, Mary Thistle, Saint Mary's Thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle"
  •  Berberis aristata - Wikipedia - "The root bark contains berberine, quaternary ammonium salt of isoquinoline alkaloid. Berberine has antibacterial, antifungal, antiviral and antioxidant properties"

Effect of Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major Surgery: Systematic Review and Meta-Analysis - Nutrients. 2015 Jan 9;7(1):481-499 - "GLN supplementation did not affect overall morbidity (RR = 0.84, 95% CI 0.51 to 1.36; p = 0.473) and infectious morbidity (RR = 0.64; 95% CI = 0.38 to 1.07; p = 0.087). Patients treated with glutamine had a significant reduction in length of hospital stay (WMD = -2.67; 95% CI = -3.83 to -1.50; p < 0.0001)" - Note:  I don't understand why they're saying that it had no affect on overall morbidity and infection morbidity with a relative risk of 0.84 and 0.64 respectively.  See glutamine at Amazon.com.

Meat subtypes and their association with colorectal cancer: systematic review and meta-analysis - Int J Cancer. 2015 Jan 12 - "Comparing highest versus lowest intake, beef consumption was associated with an increased risk of CRC (RR=1.11, 95% CI=1.01 to 1.22) and colon cancer (RR=1.24, 95% CI=1.07 to 1.44), but no association was found with rectal cancer (RR=0.95, 95% CI=0.78 to 1.16). Higher consumption of lamb was also associated with increased risk of CRC (RR=1.24, 95% CI=1.08 to 1.44). No association was observed for pork (RR=1.07, 95% CI=0.90 to 1.27), but some between study heterogeneity was observed. No association was observed for poultry consumption and risk of colorectal adenomas or cancer"

Omega-3 polyunsaturated fatty acids and chronic obstructive pulmonary disease - Curr Opin Clin Nutr Metab Care. 2015 Jan 8 - "Observational data support the hypothesis that omega-3 PUFAs may provide a therapeutic strategy for managing COPD" - See fish oil supplements at Amazon.com.

Neat Tech Stuff / "How To's":

Appliance Science: The hot physics of induction cooktops - CNET, 1/19/15 - "Induction cooktops are also more efficient than other types of cooking methods. Because the heat is generated inside the base of the pan, they use less electricity than conventional electric cooktops, and can heat things quicker. They are also easier to clean, because the flat glass or ceramic surface has no gaps or grills to collect spilled food, and the food doesn't get burned onto the surface. If you spill something, one quick swipe with a damp cloth will clean it up. They are also quicker to control and more precise, again because the heat is generated inside the cookware, and so react quicker when you turn the dial up or down ... So why aren't they more common? It's partly a comfort thing; most US consumers don't like them because they grew up on gas rings"

  • Induction cooking - Wikipedia - "The energy efficiencies for cooking given above (84% for induction and 40% for gas) are in terms of site energies at the customer's meters. The (US averaged) efficiencies recalculated relative to source fuels energies are hence 25% for induction cooking surfaces using grid electricity, 84% for induction cooking surfaces using on-Site Solar, and 38% for gas burners"

I bought an induction cooktop and was surprised how fast it heats the pan and the accuracy of the settings.  I tried a couple fast and easy Chinese dishes.  I used the simmer setting at 400 degrees for the meat then set it aside then the simmer 375 degrees setting for the vegetables then threw in the meat and added the sauce packet.  In the morning I use it for eggs.  I set it at simmer, 175 degrees and set the timer for two minutes.  It shuts off at two minutes and I just flip the eggs and wait about another minutes.  Even though it's none stick I use cooking spray.  The stir fry vegetables were available in the produce department at the commissary where I shop.  Here's the setup:

How to set up Chrome Remote Desktop for iOS - CNET, 1/19/15 - Note:  Chrome Remote Desktop works on Android, iPhone, iPad and PC to PC plus it's free.

Health Focus (Hypertension):