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Home > Anti-aging Research > l-tryptophan


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  • Effects of dietary tryptophan on muscle growth, protein synthesis, and antioxidant capacity in hybrid catfish Pelteobagrus vachelli♀ × Leiocassis longirostris - Br J Nutr 2021 Jul 29 - "Trp improved muscle growth, protein synthesis as well as antioxidant capacity, which might be partly related to myogenic regulatory factors (MRFs), IGFs/PIK3Ca/AKT/TOR, and Keap1/Nrf2 signaling pathways" - See l-tryptophan at Amazon.com.
  • The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression - Nutr Rev 2021 May 3 - "Results from the study suggested that Trp supplementation can shorten wake after sleep onset (-81.03 min/g, P = 0.017; SMD, -1.08 min [95%CI, -1.89 to -0.28]). In addition, the group receiving ≥1 g Trp supplementation had a shorter wake after sleep onset than the group with Trp < 1g supplementation (Trp <1 g vs Trp ≥1 g: 56.55 vs 28.91 min; P = 0.001) ... Conclusion: Trp supplementation, especially at ≥1 g can help improve sleep quality"
  • Dietary intake of tryptophan tied emotion-related impulsivity in humans - Int J Vitam Nutr Res. 2019 Oct 4:1-8 - "Three Factor Impulsivity Index, TFI ... Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r = -.502, p < .010, and (lack-of) Follow-Through scores, r = -.407, p < .050. ... Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits. It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder"
  • Low serum tryptophan predicts higher mortality in cardiovascular disease - Eur J Clin Invest. 2015 Jan 13 - "After adjustments for cardiovascular risk factors and other possible confounders, the hazard ratio (with 95% CI) in the first tryptophan quartile of the study population was 1.51 (1.19-1.90; p=0.0006) for total mortality, 1.41 (1.05-1.89; p=0.0224) for cardiovascular and 1.79 (1.20-2.67; p=0.0042) for non-cardiovascular mortality, respectively, thus indicating a significantly higher risk of death in patients with tryptophan concentrations <34 μmol/L ... Low serum tryptophan in CAD patients is associated with immune activation and indicates reduced life expectancy"