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Recent Longevity News for the week ending 4/19/23

EVOO as Main Dietary Fat Diet Improved Biomarkers - Medscape, 4/17/23 - "Switching dietary fat intake from common processed OO to EVOO rich in oleocanthal and oleacein improved markers of oxidative stress and inflammation ... After one month of EVOO use, study participants had a significantly greater decrease in the inflammatory cytokine interferon-gamma compared with when they used OO ... EVOO use also significantly linked with greater increases in total antioxidants and greater decreases in lipid and organic hydroperoxides compared with the period of OO use ... EVOO use also linked with significant reductions in weight, BMI, and blood glucose levels compared with baseline levels, but not when compared with the period of OO use. Weight decreased by a significant average 0.92 kg compared with baseline on EVOO, and by a nonsignificant average 0.62 kg on OO compared with baseline." - See olive leaf extract at Amazon.com.

Bad Sleep Cuts Years Off Your Life, but Exercise Can Save You - WebMD, 4/11/23 - "Plenty of research points to sleep and physical activity as crucial factors impacting life expectancy. Regular exercise can lengthen life, while too little or too much sleep may cut it short ... But evidence is growing that exercise may counteract the negative effects of poor sleep"

Survival Gains After Surgery for Small Pancreatic NETs? Medscape, 4/11/23 - "surgical resection was associated with longer overall survival for patients with tumors of 1.1–2.0 cm (hazard ratio [HR], 0.58) but not 1 cm or smaller (HR, 0.68; P = .12)."

Abstracts from this week:

Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12-years of follow-up among adults in the Framingham Heart Study - Am J Clin Nutr 2023 Apr 13 - "Mean age was 58.4 years (SD ± 8.3, n=1,701; 55.5% women). Mean total flavonoid intake was 309 mg/day (SD ± 266). After 12.4 (SD ± 0.8) years, 224 (13.2%) individuals developed frailty. While total flavonoid intake was not statistically associated with frailty onset [adjusted OR-1.00; 95%CI: 0.99-1.01], each 10 mg/day of flavonols intake was linked with 20% lower odds of frailty onset [OR-0.80; 95%CI: 0.67-0.96]. Other subclasses showed no association (p-values range: 0.12-0.99), but every 10 mg/day of quercetin intake was associated with 35% lower odds of frailty onset [OR-0.65; 95%CI: 0.48-0.88]" - See quercetin at Amazon.com.

The synergistic effect of epigallocatechin-3-gallate and quercetin co-loaded hydrogel beads on inflammatory bowel disease - Food Funct 2023 Apr 17 - "The synergistic effect of epigallocatechin-3-gallate (E) and quercetin (Q) enhances the therapeutic efficacy on related diseases; however, the instability and lower bioavailability of E and Q limited their application. Therefore, E and Q were co-encapsulated in hydrogel beads (H) with sodium alginate (SA) and soybean protein isolate (SPI) to improve their stability and bioavailability ... This study provides a theoretical basis for the application of E and Q in IBD" - See green tea extract at Amazon.com and quercetin at Amazon.com.

Dietary flavonoid intake is associated with a lower risk of diabetic nephropathy in US adults: data from NHANES 2007-2008, 2009-2010, and 2017-2018 - Food Funct 2023 Apr 17 - "Weighted logistic regression models demonstrated that the total flavonoid intake in the second (OR: 0.642; 95% CI: 0.456-0.906), third (OR: 0.665; 95% CI: 0.447-0.988), and the highest (OR: 0.551; 95% CI: 0.382-0.796) quantiles (versus the lowest) were associated with the decreased risk of DN. Restricted cubic spline (RCS) analyses showed that the total flavonoid intake had a negative linear association with DN (p-value for non-linearity was 0.003). Weighted quantile sum (WQS) regression analyses revealed that flavan-3-ols, flavones, and anthocyanidins were the main contributors for the combined effects of six flavonoid subclasses. Our findings suggested that higher dietary flavonoid intake was associated with a decreased risk of DN, with the greatest influence coming from flavan-3-ols, flavones, and anthocyanidins" - See anthocyanins at Amazon.com and blueberry extract at Amazon.com.

Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk - Nutrients 2023 Apr 4 - "Several studies have reported that vitamin D deficiency may be a relevant risk factor for depression, and vitamin D supplementation has shown promising effects in the adjunctive treatment of this mood disorder. Among the beneficial mechanisms of vitamin D, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide" - See vitamin D at Amazon.com.

Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours - Nutrients 2023 Apr 4 - "One of the approaches to reduce or avoid chemotherapy-associated complications is to restore the gut microbiota. Gut microbiota is essential for the healthy functioning of the immune system, metabolism, and the regulation of other molecular responses in the body. Chemotherapy erodes the mucosal layer of the gastrointestinal tract and results in the loss of gut microbiota. One of the ways to restore the gut microbiota is through the use of probiotics. Probiotics are the 'good' bacteria that may provide health benefits if consumed in appropriate amounts. Some studies have highlighted that the consumption of probiotics in combination with prebiotics, known as synbiotics, may provide better health benefits when compared to probiotics alone" - See synbiotic supplements at Amazon.com.

Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non-small cell lung cancer - Phytother Res 2023 Apr - "Lung cancer is the leading cause of cancer-related death. In particular, non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. Due to tumor resistance and the toxicity of chemotherapeutic agents, it is increasingly critical to discover novel, potent antitumorigenic drugs for treating NSCLC. Lutein, a carotenoid, has been reported to exert toxic effects on cells in several tumor types ... Mechanistically, lutein exerted antitumorigenic effects by inducing DNA damage and subsequently activating the ATR/Chk1/p53 signaling pathway in A549 cells. In vivo, lutein impeded tumor growth in mice and prolonged their survival. In conclusion, our findings demonstrate the antitumorigenic potential of lutein and reveal its molecular mechanism of action, suggesting that lutein is a promising candidate for clinical NSCLC treatment" - See lutein at Amazon.com.

Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis - Phytother Res 2023 Apr 10 - "Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being a crucial factor in its pathogenesis. Pterostilbene is a well-known natural stilbene derivative that has excellent anti-inflammatory activity, suggesting its potential medicinal advantages for treating DCI ... Pharmacological evaluation showed pterostilbene could ameliorate cognitive dysfunction, regulate glycolipid metabolism disorders, improve neuronal damage, and reduce the accumulation of β-amyloid in DCI mice. Pterostilbene alleviated neuroinflammation by suppressing oxidative stress and carbonyl stress damage, astrocyte and microglia activation, and dopaminergic neuronal loss. Further investigations showed that pterostilbene reduced the level of lipopolysaccharide, modulated colon and brain TLR4/NF-κB signaling pathways, and decreased the release of inflammatory factors, which in turn inhibited intestinal inflammation and neuroinflammation. Furthermore, pterostilbene could also improve the homeostasis of intestinal microbiota, increase the levels of short-chain fatty acids and their receptors, and suppress the loss of intestinal tight junction proteins. In addition, the results of plasma non-targeted metabolomics revealed that pterostilbene could modulate differential metabolites and metabolic pathways associated with inflammation, thereby suppressing systemic inflammation in DCI mice. Collectively, our study found for the first time that pterostilbene could alleviate diabetic cognitive dysfunction by inhibiting the TLR4/NF-κB pathway through the microbiota-gut-brain axis, which may be one of the potential mechanisms for its neuroprotective effects" - See pterostilbene at Amazon.com.

Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial - Hypertens Res 2023 Feb 28 - "Resveratrol (RES) has been demonstrated to be protective in the cardiovascular system in animal studies, but the evidence is limited in humans ... After 6 months, the RES group had smaller left atrial, lower E/e', higher left ventricular global longitudinal strain and lower biomarkers indicating cardiac fibrosis (expressed by decreases in procollagen type I C-peptide and galectin-3) compared to the control group. However, there was no significant difference in left ventricular structure between the two groups. Although the RES group showed a significant decrease in brachial-ankle pulse wave velocity compared to the pre-intervention value, the difference between the RES and the control groups was not obvious. What's more, compared with the control group, the serum levels of sirtuin3, superoxide dismutase and klotho were significantly increased in the RES group. In conclusion, RES supplementation can alleviate left atrial remodeling, improve left ventricular diastolic function and may alleviate cardiac fibrosis in hypertensive patients, and could be used as an adjunct to conventional therapies of hypertensive heart disease" - See resveratrol products at Amazon.com.

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