Recent Longevity News for the seven days ending 11/26/08.  You should consult your doctor if you are taking any medications.

I started sending 50 of these per week via my RoadRunner account because of numerous complaints that people haven't been receiving my QualityCounts.com Newsletter.  Last May RoadRunner started limiting customers to 100 emails per week so I had to start sending my newsletter via a mailing list from my web hoster. Some spam filters recognize those as spam.  If you believe that is happening, you might try to add ben@qualitycounts.com to your spam white list or add http://www.qualitycounts.com/rss.xml to your RSS feed.  If you want your RSS feed via email, I recommend http://www.newsgator.com/Individuals/NewsGatorInbox/.

'Let The Sunshine In' To Protect Your Heart This Winter - Science Daily, 11/26/08 - "The temperature might not be the only thing plummeting this winter. Many people also will experience a decrease in their vitamin D levels ... Chronic vitamin D deficiency may be a culprit in heart disease, high blood pressure and metabolic syndrome" - See vitamin D at Amazon.com.

Oily fish may boost prostate cancer survival rate: Study - Nutra USA, 11/24/08 - "The prospective cohort study with 20,167 men also found that men who ate five portions of fish per week had a 48 per cent improved survival rate from the disease than men who consumed only one portion per week" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Older patients face higher mortality, CHF hospitalizations with rosiglitazone over pioglitazone - theheart.org, 11/24/08 - "In the study's primary analysis, which assumed that patients were exposed to the drug for just 60 days after the date of their most recently filled prescription (and adjusted for patient characteristics), diabetic patients initially treated with rosiglitazone had a 15% higher mortality rate than patients on pioglitazone. Rates of first hospitalization for congestive heart failure—a known side effect of TZDs—were 13% higher in the rosiglitazone group than in the pioglitazone group. In contrast to recent studies pointing to a risk of ischemic events with rosiglitazone, rates of MI and stroke were no different between the groups"

New Gout Drug Gets FDA Panel Nod - WebMD, 11/24/08 - "Uloric should be the first new gout drug to be approved in over 40 years ... Unlike allopurinol, very little Uloric is excreted through the urine, making Uloric safe for patients with kidney problems"

Potassium Loss From Blood Pressure Drugs May Explain Higher Risk Of Adult Diabetes - Science Daily, 11/24/08 - "a drop in blood potassium levels caused by diuretics commonly prescribed for high blood pressure could be the reason why people on those drugs are at risk for developing type 2 diabetes" - See potassium citrate at Amazon.com.

How Red Wine Compounds Fight Alzheimer's Disease - Science Daily, 11/23/08 - "Teplow's lab has been studying how amyloid beta (Aß) is involved in causing Alzheimer's. In this work, researchers monitored how Aß40 and Aß42 proteins folded up and stuck to each other to produce aggregates that killed nerve cells in mice. They then treated the proteins with a polyphenol compound extracted from grape seeds. They discovered that polyphenols carried a one-two punch: They blocked the formation of the toxic aggregates of Aß and also decreased toxicity when they were combined with Aß before it was added to brain cells" - See grape seed extract at Amazon.com.

Bad Cholesterol Inhibits The Breakdown Of Peripheral Fat - Science Daily, 11/20/08 - "LDL cholesterol slows the rate of fat breakdown (i.e. lipolysis) in adipocytes, the peripheral cells responsible for fat storage"

Ginkgo biloba has no benefits against dementia: Study - Nutra USA, 11/19/08 - "The GEM Study involved 3,069 community volunteers with an average age of 79.1 ... Commenting on the study, Dr Fabricant said the study had two major limitations: “One, it looks exclusively at people almost 80 years old who are far more likely to have Alzheimer’s, while ignoring those in middle ages, where the risk for developing the disease rises quickly and prevention could best be analyzed,” ... Two, it excludes completely any consideration of the strong and established role that family history plays with Alzheimer’s. You can’t do a study on the weather without looking at wind and rain.”"

Physical Exercise Keeps Brain Young - WebMD, 11/19/08 - "The brain-boosting effects of exercise diminish rapidly after early middle age ... mice that worked out every day grew 2.5 times more new brain cells than couch potato mice. And in the exercising mice, far more of these new neurons survived, grew, and integrated into existing brain networks"

Most ginkgo products fail quality testing - Nutra USA, 11/18/08 - "Some companies put less of it in their products than they claim or use ingredient that has been adulterated with inexpensive material that can fool non-specific tests ... companies continued to make products with little to no ginkgo in them, leading Consumerlab to suggest “ginkgo is among the most adulterated herbs.”" - That's why I stay with the top brand names.  They have more to loose with bad  press.  I also think that's why some studies show benefits with certain supplement while other studies don't.  I've been taking Nature's Way, Ginkgold.  I get the paid version of Consumerlab and I thought it was strange that they didn't test that brand. - Ben

Ginkgo Biloba Does Not Reduce Dementia Risk, Study Shows - Science Daily, 11/18/08 - "The researchers found no statistical difference in dementia or Alzheimer's disease rates between the groups. Among those taking G. biloba, 277 developed dementia. Among those in the placebo group, 246 developed dementia. Mortality rates also were similar" - I read this after the above article and comments but like I said.

Broccoli May Help Smokers' Lungs - WebMD, 11/18/08 - "asked 948 lung cancer patients and 1,743 people without lung cancer about their smoking history and consumption of fruits, cruciferous vegetables, and other vegetables ... Among smokers -- and especially among former smokers -- higher intake of cruciferous vegetables was linked to lower risk of lung cancer"

Canola Oil May Affect Breast Cancer Risk - WebMD, 11/18/08 - "Could the type of oil a woman consumes during pregnancy influence her daughter's breast cancer risk years later? ... pregnant women may be better off choosing canola oil over most other vegetable oils ... Corn oil has 50% omega-6 and almost no omega-3, while canola oil has 20% omega-6 and 10% omega-3,""

St. John's Wort Holds Its Own in Meta-Analysis - Clinical Psychology News, 11/08 - "St. John's wort was more effective than placebo and just as effective as standard antidepressants in treating depression, a Cochrane analysis of 29 studies of almost 5,500 adults with major depression shows" - See St. John's wort at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Why Iron Deficiency Is Important in Infant Development - J Nutr. 2008 Dec;138(12):2534-2536 - "Rodent studies also show effects of iron deficiency during gestation and lactation that persist into adulthood despite restoration of iron status at weaning. These studies indicate that gestation and early lactation are likely critical periods when iron deficiency will result in long-lasting damage"

A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality - Am J Clin Nutr. 2008 Nov;88(5):1297-303 - "Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish >or=5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05]. A similar association was found between seafood n-3 fatty acid intake and prostate cancer mortality (RR(Q5 versus Q1) = 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Docosahexaenoic Acid and the Aging Brain - J Nutr. 2008 Dec;138(12):2510-2514 - "Deficits in DHA or its peroxidation appear to contribute to inflammatory signaling, apoptosis, and neuronal dysfunction in Alzheimer disease (AD), a common and progressive age-related neurological disorder unique to structures and processes of the human brain" - See Jarrow Max DHA at Amazon.com.

The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial - J Hum Hypertens. 2008 Nov 20 - "Over 4 months, subjects in the intervention group received 2.5 g of MgCl(2) (50 ml of a solution containing 50 g of MgCl(2) per 1000 ml of solution) equivalent to 450 mg of elemental magnesium, and control subjects inert placebo ... SBP (-20.4+/-15.9 versus -4.7 +/- 12.7 mm Hg, P=0.03) and DBP (-8.7+/-16.3 versus -1.2+/-12.6 mm Hg, P=0.02) showed significant decreases, and high-density lipoprotein-cholesterol (0.1+/-0.6 versus -0.1+/-0.7 mmol l(-1), P=0.04) a significant increase in the magnesium group compared to the placebo group. The adjusted odds ratio between serum magnesium and BP was 2.8 (95%CI: 1.4-6.9). Oral magnesium supplementation with MgCl(2) significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia" - See magnesium supplements at Amazon.com.

Coenzyme Q(10) An Independent Predictor of Mortality in Chronic Heart Failure - J Am Coll Cardiol. 2008 Oct 28;52(18):1435-1441 - "Plasma CoQ(10) concentration was an independent predictor of mortality in this cohort. The CoQ(10) deficiency might be detrimental to the long-term prognosis of CHF, and there is a rationale for controlled intervention studies with CoQ(10)" - See ubiquinol products at Amazon.com.

Effects of Garlic on Blood Pressure in Patients With and Without Systolic Hypertension: A Meta-Analysis (December) - Ann Pharmacother. 2008 Nov 18 - "Garlic reduced SBP by 16.3 mm Hg (95% CI 6.2 to 26.5) and DBP by 9.3 mmHg (95% CI 5.3 to 13.3) compared with placebo in patients with elevated SBP" - See garlic supplements at Amazon.com.

Cushing's Syndrome Induced by Misuse of Moderate- to High-Potency Topical Corticosteroids (December) - Ann Pharmacother. 2008 Nov 18 - "Continuous use of moderate- to high-potency topical corticosteroids over several months can contribute to Cushing's syndrome"

Neat Tech Stuff :

• Brazen Nuke Facility Raid An Inside Job?, Eyewitness Talks To 60 Minutes About Brazen Assault On South African Nuclear Facility - CBS News, 11/23/08 - "It was a daring break-in at a heavily guarded nuclear plant that holds enough weapons grade uranium to build a dozen atomic bombs" - Not really "Neat Tech Stuff" but something to worry about.
• LA 2008: Toyota Camry CNG Hybrid Concept gets early reveal - AutoblogGreen, 11/19/08

Supplement Focus (Magnesium):

Magnesium News & Research:

• Why you need to go with a supplement with the right calcium, magnesium, zinc, copper ratio such as Body Wise Essential Calcium
  • Magnesium--A Forgotten Mineral - Health & Nutrition Breakthroughs, 9/97 - "Excess calcium and phosphate also interfere with magnesium absorption. (Thus, taking calcium supplements without adding magnesium could result in magnesium deficiency.)"
  • Inhibitory effects of zinc on magnesium balance and magnesium absorption in magnesium absorption in man - J Am Coll Nutr. 1994 Oct;13(5):479-84 - "the overall effect of the high Zn intake of the three groups combined, regardless of the Ca intake, was a highly significant decrease of Mg absorption and of the Mg balance"
  • Zinc -- The Immune System's Missing Link? - Health & Nutrition Breakthroughs, 12/97 - "Supplementing with zinc is quite safe--its only significant side effect is lowered copper levels in the body tissues, since the two minerals compete for absorption. Considering zinc's safety, people should consider taking zinc supplements, especially as they age--being sure to include copper in the proper balance. Most practitioners who supplement their patients' diets with zinc also recommend taking copper at a ratio of 10 mg to 15 mg zinc for each milligram of copper."
  • Calcium, Keep What You Take - Life Extension Magazine, 3/99 - "The final study was a two-year, placebo controlled trial on 225 postmenopausal women. One group received calcium supplements only, the second group zinc, manganese and copper, the third group received calcium plus zinc, manganese and copper, while the fourth group received a placebo. After two years, the only group who experienced an improvement in bone mineral density was the group taking calcium plus zinc, manganese and copper" - [Abstract]
  • Magnesium: The Multi-Purpose Mineral - Think Muscle Newsletter - "If you take high amounts of calcium daily, you may have a magnesium deficiency. Most experts suggest that your calcium: magnesium ration should be 2:1. In other words, if you take 1500 mg of calcium daily through diet and supplementation, you should try to consume at least 750 mg of magnesium daily as well"

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• magnesium supplements at Amazon.com
• Magnesium - The Natural Pharmacist
• Calcium May Only Protect Against Colorectal Cancer In Presence Of Magnesium - Science Daily, 11/16/08 - "supplementation of calcium only reduced the risk of adenoma recurrence if the ratio of calcium to magnesium was low and remained low during treatment. "The risk of colorectal cancer adenoma recurrence was reduced by 32 percent among those with baseline calcium to magnesium ratio below the median in comparison to no reduction for those above the median"
• Magnesium linked to fewer gallstones - Nutra USA, 2/26/08 - "After adjusting the results to account for age differences, which may affect the results, Tsai and co-workers calculated that men with the highest levels of magnesium intake (454 mg/d) were 28 per cent less likely to develop gallstones, compared to men with the lowest average intake (262 mg/d)" - [Abstract]
• Magnesium Supplements review - ConsumerLab.com, 10/31/07
• Magnesium Intake May Cut Risk of Gallstones - Medscape, 2/22/08 - "Magnesium deficiency is known to cause elevated triglyceride levels and decreased HDL cholesterol levels, both of which may raise the risk of gallstones ... Compared with the lowest quintile of total magnesium intake (median 262 mg/day), the highest quintile of intake (454 mg/day) reduced the risk of gallstone disease by 33%"
• Migraine Patients May Benefit From Magnesium or CoQ10 - Clinical Psychiatry News, 8/07 - "The most important supplement, according to Dr. Mauskop, is magnesium. “It's known that up to 50% of people with acute migraine have a magnesium deficiency. … It is much more effective to treat them with a product they're deficient in rather than using drugs,” ... Research has found that, for migraine, CoQ10 at 300 mg/day is effective, and that for Parkinson's disease 1,200 mg/day is effective"
• Grain Fiber And Magnesium Intake Associated With Lower Risk For Diabetes - Science Daily, 5/14/07 - "those who consumed the most cereal fiber had a 33 percent lower risk of developing diabetes than those who took in the least, while those who consumed the most magnesium had a 23 percent lower risk than those who consumed the least. There was no association between fruit or vegetable fiber and diabetes risk"
• Dietary Magnesium May Reduce Risk for Diabetes in Black Women - Medscape, 10/9/06 - "41,186 women enrolled in the Black Women's Health Study ... Higher magnesium intakes in the highest vs the lowest quintile were associated with lower incidence of diabetes mellitus with an adjusted HR of 0.69"
• Magnesium supplements could help asthmatics, says study - Nutra USA, 7/5/06
• Need More Magnesium? - Dr. Weil, 6/29/06 - "a diet rich in magnesium appears to protect against metabolic syndrome, a combination of risk factors that can lead to diabetes and heart disease"
• Magnesium Lowers Heart, Diabetes Risks - WebMD, 3/27/06 - "people in the study who consumed the most magnesium had a 31% lower risk of developing metabolic syndrome, compared with people who ate the least"
• Magnesium Prevents Osteoporosis - Healthwell, 2/9/06 - "a higher magnesium intake was associated with greater whole-body bone mineral density, after adjusting for calcium and vitamin D intake, level of exercise, use of estrogen medication, and other factors known to be related to bone health"
• More support for magnesium against colon cancer - Nutra USA, 1/31/06 - "The hazard ratio, a measure of the risk, was statistically 25 per cent lower for the volunteers with the highest intake of magnesium (more than 356 mg per day)"
• Magnesium In Your Diet Could Lead To Stronger Bones - Science Daily, 12/22/05
• Dietary Magnesium Could Lead to Stronger Bones - Doctor's Guide, 12/21/05 - "For every 100 milligram per day increase in magnesium intake, data showed a 1% increase in bone density ... this link was only true for the older white men and women"
• Magnesium could reduce osteoporosis risk - Nutra USA, 12/8/05 - "Higher Mg intake through diet and supplements was positively associated with total-body [bone mineral density] BMD in older white men and women. For every 100 mg per day increase in Mg, there was an approximate 2 per cent increase in whole-body BMD"
• Magnesium Intake and Bone Mineral Density - Medscape, 11/8/05 - "The mean intakes of Mg by race-sex subgroup are listed in Table 2 . Less than 26% of the cohort met the RDA for Mg ... twenty-five percent of the cohort took a Mg-containing supplement; the mean dose was 83 mg ... RDA of 420 mg/d" - See iHerb or Vitacost magnesium products.
• Magnesium Deficiency in Obese Children May Be Linked to Insulin Resistance - Medscape, 5/9/05 - "Magnesium deficiency in obese children is associated with the development of insulin resistance"
• Focus on Magnesium - Dr. Murray's Natural Facts, 3/3/05 - "Double-blind studies in people with CFS have shown magnesium supplementation significantly improved energy levels, better emotional state, and less pain"
• MIT: Magnesium May Reverse Middle-age Memory Loss - Science Daily, 12/27/04 - "In the cover story of the Dec. 2 issue of Neuron, MIT researchers report a possible new role for magnesium: helping maintain memory function in middle age and beyond ... magnesium helps regulate a key brain receptor important for learning and memory"
• What to take to keep diabetes at bay - Delicious Living, 12/04 - "Recent research suggests that magnesium keeps blood sugars from rising too high, thus staving off diabetes"
• Magnesium in Hypertension Prevention and Control - Life Extension Magazine, 9/04 - "Magnesium is one of the body’s most important minerals. ... Magnesium is a major factor in relaxing the smooth muscles within the blood vessels, thereby reducing peripheral vascular resistance and blood pressure.11-13 In addition, magnesium reduces nerve and muscle excitability, stabilizes cardiac conductivity, and influences neurochemical transmission.11,13,14 Magnesium also affects circulating levels of norepinephrine and the synthesis of serotonin and nitric oxide"
• Americans Need More Magnesium in Diet - WebMD, 7/23/04 - "nearly two-thirds of us may not be getting enough magnesium ... Adult men need 400-420 mg/day while adult women need 310-320 mg /day"
• Lack Energy? Maybe It's Your Magnesium Level - Science Daily, 5/10/04 - "inadequate magnesium is associated with a need for increased oxygen during exercise. They found that during moderate activity, those with low magnesium levels in muscle are likely to use more energy—and therefore to tire more quickly—than those with adequate levels"  - See iHerb or Vitacost magnesium products.
• Magnesium may reduce risk of diabetes - MSNBC, 5/7/04 - "The conclusions of these three studies are generally supported by earlier large population studies. Laboratory studies suggest that magnesium influences the action of insulin in the body. A lack of magnesium may worsen insulin resistance, triggering the onset of diabetes" - See iHerb or Vitacost magnesium products.
• Magnesium Helps Prevent Arrhythmia After Cardiac Surgery - Doctor's Guide, 3/10/04
• Low Magnesium Intake May be Associated with Increased Risk for Type 2 Diabetes - Doctor's Guide, 1/6/04 - "Statistical analyses revealed a significant inverse association between magnesium intake and risk of type 2 diabetes"
• Magnesium Lowers Type 2 Diabetes Risk - WebMD, 12/23/03
• Dietary Magnesium May Help Prevent Development of Type 2 Diabetes - Medscape, 12/23/03 - "Magnesium-containing foods can prevent development of type 2 diabetes in both men and women ... Comparing the highest with the lowest quintile of total magnesium intake ... was 0.66 ... in women and 0.67 in men"
• Does taking extra magnesium help prevent heart disease? - Natural Foods Merchandiser, 11/03
• Magnesium Deficiency Associated with Insulin-Resistance Syndrome - New Hope Natural Media, 6/12/03
• Magnesium Beneficial for Urinary Urge Incontinence - New Hope Natural Media, 3/20/03
• Magnesium Plus Albuterol More Effective Than Albuterol Alone in Asthma - Medscape, 10/21/02
• Low Dietary Magnesium Changes Cardiac Rhythm - Doctor's Guide, 3/4/02 - "Low intakes of dietary magnesium may increase supraventricular ectopy ... people who live in areas with soft water, who use diuretics, or who are predisposed to magnesium loss may need to take in more dietary magnesium than others ... Magnesium is central to a variety of cellular mechanisms that control activity of muscle and nerve cells. Cardiac muscle seems to have been more sensitive to this intake than was skeletal muscle ... They point out some women may habitually eat a diet similar to the one in this study and for long periods of time"
• Magnesium Abnormalities Key In Dermatomyositis? - Doctor's Guide, 2/27/02
• Adequate Magnesium Intake Reduces Risk For Cardiovascular Disease Type 1 Diabetics - Doctor's Guide, 1/18/02
• Magnesium Shows Promise for Thrombolysis-ineligible Cardiac Patients - Doctor's Guide, 11/14/01
• Got Magnesium? Those With Heart Disease Should - WebMD, 11/9/00 - "Similar magnesium supplements are available over-the-counter in the U.S., but they might not provide similar benefits. "The product we used is from Germany, where supplements of this kind are regulated and quality is monitored," Merz says. "Because that is not the case in the U.S., it is impossible to know what you are getting in a supplement, or even whether it contains any magnesium at all.""
• More Than Half of All Women Report: 'We're Stressed!', Experts Say Diet, Supplements May Be the Answer - WebMD, 6/2/00 - ""Stress affects nutrient needs by reducing absorption, increasing excretion, [and] altering how the body uses -- or increasing the daily requirements for -- certain nutrients," she says. For example, the body releases stress hormones, such as cortisol, during stressful times, and these stress hormones deplete your body's supply of magnesium -- an element that plays a role the body's use of energy."
• Low Magnesium Levels May Strongly Foreshadow Diabetes Development in Whites - WebMD, 10/18/99
• Potassium-Magnesium Citrate Effective In Correcting Thiazide-Induced Side Effects - Doctor's Guide, 11/13/98

Magnesium Abstracts:

• The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial - J Hum Hypertens. 2008 Nov 20 - "Over 4 months, subjects in the intervention group received 2.5 g of MgCl(2) (50 ml of a solution containing 50 g of MgCl(2) per 1000 ml of solution) equivalent to 450 mg of elemental magnesium, and control subjects inert placebo ... SBP (-20.4+/-15.9 versus -4.7 +/- 12.7 mm Hg, P=0.03) and DBP (-8.7+/-16.3 versus -1.2+/-12.6 mm Hg, P=0.02) showed significant decreases, and high-density lipoprotein-cholesterol (0.1+/-0.6 versus -0.1+/-0.7 mmol l(-1), P=0.04) a significant increase in the magnesium group compared to the placebo group. The adjusted odds ratio between serum magnesium and BP was 2.8 (95%CI: 1.4-6.9). Oral magnesium supplementation with MgCl(2) significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia"
• Long-term effect of magnesium consumption on the risk of symptomatic gallstone disease among men - Am J Gastroenterol. 2008 Feb;103(2):375-82 - "The age-adjusted relative risks (RRs) for men with total magnesium intake and dietary magnesium, when the highest and lowest quintiles were compared, were 0.67 (95% confidence interval [CI] 0.59-0.77, P for trend <0.0001) and 0.67 (CI 0.59-0.76, P for trend <0.0001), respectively. After adjusting for multiple potential confounding variables, when extreme quintiles were compared, the multivariate RR of total magnesium intake (RR 0.72, CI 0.61-0.86, P for trend = 0.006) and dietary magnesium (RR 0.68, CI 0.57-0.82, P for trend = 0.0006) remained significant with a dose-response relationship ... Our findings suggest a protective role of magnesium consumption in the prevention of symptomatic gallstone disease among men"
• Long-Term Effect of Magnesium Consumption on the Risk of Symptomatic Gallstone Disease Among Men - Am J Gastroenterol. 2007 Dec 12 - "Our findings suggest a protective role of magnesium consumption in the prevention of symptomatic gallstone disease among men"
• Magnesium intake and risk of type 2 diabetes: a meta-analysis - J Intern Med. 2007 Aug;262(2):208-14 - "The overall relative risk for a 100 mg day(-1) increase in magnesium intake was 0.85"
• Fiber and Magnesium Intake and Incidence of Type 2 Diabetes: A Prospective Study and Meta-analysis - Arch Intern Med. 2007 May 14;167(9):956-65 - "Higher cereal fiber and magnesium intakes may decrease diabetes risk"
• Rapid recovery from major depression using magnesium treatment - Med Hypotheses. 2006 Mar 14 - "Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use"
• Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study - Br J Cancer. 2007 Feb 12;96(3):510-3 - "Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake"
• A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls - J Clin Endocrinol Metab. 2006 Oct 3 - "Magnesium (300 mg elemental Mg per day in 2 divided doses) or placebo, given orally, for 12 months ... Significantly increased accrual (P = 0.05) in integrated hip BMC occurred in the Mg-supplemented vs. placebo group"
• Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension - Clin Exp Hypertens. 2006 Jul;28(5):489-97 - "magnesium, 70.8 mg/d; potassium, 217.2 mg/d ... On K+ and Mg2+ supplementation, systolic and diastolic BP decreased 7.83 +/- 1.87 mm Hg and 3.67 +/- 1.03 mm Hg"
• Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial - Eur J Clin Nutr. 2006 Jun 21 - "Oral magnesium supplementation helped to reduce bronchial reactivity to methacholine, to diminish their allergen-induced skin responses and to provide better symptom control in pediatric patients with moderate persistent asthma treated with inhaled fluticasone"
• Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects - J Am Geriatr Soc. 2005 Nov;53(11):1875-80 - "Greater magnesium intake was significantly related to higher BMD in white women and men"
• Magnesium Intake, C-Reactive Protein, and the Prevalence of Metabolic Syndrome in Middle-Aged and Older U.S. Women - Diabetes Care. 2005 Jun;28(6):1438-1444 - "women in the highest quintile of magnesium intake had 27% lower risk of the metabolic syndrome ... compared with those in the lowest quintile of intake"
• Magnesium intake in relation to risk of colorectal cancer in women - JAMA. 2005 Jan 5;293(1):86-9 - "a high magnesium intake may reduce the occurrence of colorectal cancer in women"
• Magnesium Intake and Risk of Type 2 Diabetes in Men and Women - Diabetes Care. 2004 Jan;27(1):134-140 - "Our findings suggest a significant inverse association between magnesium intake and diabetes risk. This study supports the dietary recommendation to increase consumption of major food sources of magnesium, such as whole grains, nuts, and green leafy vegetables"
• Dietary magnesium intake and the future risk of coronary heart disease (The Honolulu Heart Program) - Am J Cardiol. 2003 Sep 15;92(6):665-9 - "When adjustments were made for age and other nutrients (singly or combined), there was a 1.7- to 2.1-fold excess in the risk of CHD in the lowest versus highest quintiles ... We conclude that the intake of dietary Mg is associated with a reduced risk of CHD"
• Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects: A randomized double-blind controlled trial - Diabetes Care 2003 Apr;26(4):1147-52 - "At the end of the study, subjects who received magnesium supplementation showed ... fasting glucose levels (8.0 +/- 2.4 vs. 10.3 +/- 2.1 mmol/l ... Oral supplementation with MgCl(2) solution restores serum magnesium levels, improving insulin sensitivity and metabolic control in type 2 diabetic patients with decreased serum magnesium levels"