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Home >
Health Conditions > Hypertension >
diuretics
Diuretics
Click here for why I feel
that Micardis® (telmisartan) should be the first line treatment for
hypertension.
Related Topics:
Alternative News:
- Oral magnesium
supplementation improves endothelial function and attenuates subclinical
atherosclerosis in thiazide-treated hypertensive women - J Hypertens.
2016 Oct 18 - "Diuretics commonly cause
hypomagneseamia ... Hypertensive women (40-65 years) on hydrochlorothiazide
and mean 24-h BP at least 130/80 mmHg were divided into placebo and
supplementation (magnesium chelate 600 mg/day) groups ... The magnesium
group had a significant reduction in SBP (144 ± 17 vs. 134 ± 14 mmHg,
P = 0.036) and DBP (88 ± 9 vs. 81 ± 8 mmHg, P = 0.005) at 6 months, without
effect on plasma glucose, lipids, or arterial stiffness parameters. The
placebo group showed a significant increase in carotid intima-media
thickness (0.78 ± 0.13 vs. 0.89 ± 0.14 mm, P = 0.033) without change in the
magnesium group (0.79 ± 0.16 vs. 0.79 ± 0.19 mm, P = 0.716) after 6 months.
The magnesium group demonstrated a significant increase in variation of FMD
vs. the placebo group (+3.7 ± 2.1 vs. 2.4 ± 1.2%" - See
magnesium chelate at Amazon.com.
I'm sticking with the Magtein form to kill more birds with the same stone.
See
Jarrow Formulas, MagMind at Amazon.com
 .
-
Potassium Loss From Blood Pressure Drugs May Explain Higher Risk Of Adult
Diabetes - Science Daily, 11/24/08 - "a drop in
blood potassium levels caused by diuretics commonly prescribed for high
blood pressure could be the reason why people on those drugs are at risk for
developing type 2 diabetes" - See
potassium citrate at Amazon.com.
-
DASH Diet Acts Through Diuretic Effect To Lower Blood Pressure -
Doctor's Guide, 5/20/03
- DASH Diet Works
Like Hypertension Drug - WebMD, 5/19/03 -
"the DASH diet --
created to fight
high blood pressure -- works just like
water pills ... If people eat the DASH diet with low salt intake --
especially older people -- their blood pressure goes down 15 points"
- Fighting Fluid Retention?
- Dr. Weil, 9/20/02
News & Research:
-
Widely Used BP Meds May Raise Skin Cancer Risk - WebMD. 4/12/21 -
"The findings showed that certain types of high
blood pressure drugs — known as thiazide diuretics — were associated with
higher rates of keratinocyte skin cancers, including basal cell carcinoma,
squamous cell carcinoma, advanced keratinocyte carcinoma and melanoma ...
Four other blood pressure medications — angiotensin-converting enzyme (ACE)
inhibitors, beta blockers, angiotensin II receptor blockers (ARBs) and
calcium channel blockers — did not show an association with skin cancer risk
... Previous studies had shown increased risk of skin cancer among people
taking the drug, also known as hydrochlorothiazide ... If you're on these
medications for just a few years, it doesn't have a major impact on your
cancer risk. But for someone who has been on, let's say, 25 milligrams a day
of hydrochlorothiazide for 10 years, in our study that person would have a
40% increased risk of keratinocyte carcinoma ... If they were on that same
dose for 20 years, the increased relative risk compared to somebody who had
not taken hydrochlorothiazide is a 75% increased risk"
- Hydrochlorothiazide
and Skin Cancer: Raise the Red Flag - Medscape, 5/4/18 -
"The antihypertensive drug hydrochlorothiazide
(HCTZ) is a potent photosensitizer, associated with phototoxic and
photoallergic skin reactions as well as drug-induced lupus.[4] HCTZ has also
been shown to enhance UVA-induced DNA damage in an experimental model[5] and
to increase the incidence of SCC of the lip up to sevenfold in a recent
Danish case-control study"
-
Common blood pressure medication may pose risk to older adults - Science
Daily, 6/16/14 - "During a nine month period, 14
percent of older adults prescribed a thiazide diuretic developed a metabolic
adverse event, compared with 6 percent of adults not prescribed a thiazide
diuretic. For every 12 adults who were newly prescribed a thiazide diuretic,
one developed a metabolic adverse event that he or she would not otherwise
have had ... The three metabolic adverse events that researchers assessed
were hyponatremia (low sodium levels in the blood), hypokalemia (low
potassium levels in the blood), and acute kidney injury (a 25 percent
decrease in kidney function from the baseline value before the thiazide
diuretic was started)"
-
Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation
of Memory Study - Neurology. 2013 Aug 2 -
"Secondary longitudinal data analysis of the Ginkgo Evaluation of Memory
Study in older adults at least 75 years of age with normal cognition (n =
1,928) or MCI (n = 320) over a median 6.1-year period ... Hazard ratio for
incident AD dementia among participants with normal cognition was 0.51 in
diuretic (95% confidence interval [CI] 0.31-0.82), 0.31 in ARB (95% CI
0.14-0.68), 0.50 in ACE-I (95% CI 0.29-0.83), 0.62 in CCB (95% CI
0.35-1.09), and 0.58 in BB (95% CI 0.36-0.93) users and was not
significantly altered when mean systolic blood pressure was above 140 mm Hg"
- Note: Sounds like the ARB's left the others in the dust. See my
telmisartan as a first line treatment page.
- More Evidence That
ARBs Have Cognitive Benefits - Medscape, 3/23/12 -
"After stopping their antihypertensive medications,
the patients were randomly assigned to the ARB candesartan (n = 20), the
angiotensin-converting enzyme inhibitor (ACEI) lisinopril (n = 18), or the
diuretic hydrochlorothiazide (n = 15) ... After adjustment for age and
baseline score on the Mini-Mental State Examination, patients taking
candesartan showed the greatest improvements on tests assessing executive
function ... Our findings further support observational data showing that
ARB use is associated with lower risk of dementia and Alzheimer disease
compared with the use of ACEIs or other antihypertensives ... As reported
previously by Medscape Medical News, Dr. Kehoe and colleagues recently
published a study showing a 53% lower risk for Alzheimer's disease in older
adults prescribed an ARB compared with those prescribed other
antihypertensive agents"
-
Diuretics Associated With Bone Loss In Older Men - Science Daily, 4/14/08 -
"After adjusting for other related factors, the average
annual rate of decline in total hip bone mineral density was -0.33 percent in
non-users, -0.58 percent in intermittent users and -0.78 percent among
continuous users"
-
2-drug
Blood Pressure Therapy Dramatically Lowers Cardiovascular Risk - Science
Daily, 3/31/08 - "One group received a tablet containing
benazepril, which is a type of drug called an ACE inhibitor, and amlodipine,
which belongs to a class of drugs known as calcium channel blockers or CCBs. The
other pill combined benazepril and hydrochloro-thiazide, a type of diuretic or
"water pill." The 20 percent reduction in cardiovascular events was observed
with the ACE/CCB combination tablet"
-
Impaired Glycemic Control
Reversible When Switching Off Diuretic-Based Therapy - Medscape, 5/25/07 -
"The risk of new-onset diabetes is also dose dependent, he said, such that at
25-mg hydrochlorothiazide (HCTZ) there is substantial risk of impairing the
glucose response"
-
Valsartan Cuts C-Reactive Protein Levels in Prediabetics - Doctor's Guide,
5/22/07 - "In diabetic patients with abdominal obesity,
after 16 weeks of hydrochlorothiazide therapy, median hsCRP values were
increased 16% (4.9 vs 3.7 mg/L at baseline, P <.05) but decreased 9% in patients
on valsartan (3.7 vs 4.1 mg/L at baseline, P <.05) and 5% in patients on
combination therapy"
-
Thiazide and
Beta-Blocker Use Linked With Increased Risk for Incident Diabetes -
Medscape, 5/8/07 - "the relative risk of incident
diabetes for those taking a thiazide diuretic compared with those not taking a
thiazide was 1.20 (95% confidence interval [CI], 1.08 - 1.33) in older women;
1.45 (95% CI, 1.17 - 1.79) in younger women; and 1.36 (95% CI, 1.17 - 1.58) in
men ... the risk for incident diabetes was also increased in patients taking
beta-blockers relative to those who were not: 1.32 (95% CI, 1.20 - 1.46) in
older women and 1.20 (95% CI, 1.05 -1.38) in men. In younger women, a category
of "other antihypertensives" was used that included beta-blockers, and their use
was associated with an increased risk for 1.46"
-
FDA Panel Favors First-Line
Use of Irbesartan/HCTZ Combo - Medscape, 4/19/07 -
"The US FDA Cardiovascular and Renal Drugs Advisory
Committee recommended extended use of the combination product irbesartan plus
hydrochlorothiazide (Avalide, Bristol-Myers Squibb) for the first-line treatment
of hypertension" - Yeah, if you can get by the side effects of
hydrochlorothiazide plus the increased chance of diabetes. Irbesartan is a
ARB and hydrochlorothiazide is a diuretic. I'm not a doctor and here I am
criticizing those who are but I still feel that telmisartan (a ARB)/ramipril (a
ACE inhibitor) should be the first time treatment.
Click here for the research. Some doctors claim you can't mix a ARB with
an ACE inhibitor but I couldn't find any evidence of that.
-
Fasting Glucose Increases
in Older Adults With Hypertension Regardless of Treatment Type
- Medscape, 11/16/06 - "randomized to receive treatment
with chlorthalidone, amlodipine, or lisinopril to reduce blood pressure to less
than 140/90 mm Hg ... During the first 2 years, the mean increase is serum
glucose levels was 8.5, 5.5, and 3.5 mg/dL among the chlorthalidone, amlodipine,
and lisinopril groups, respectively"
-
Fasting glucose levels and incident diabetes mellitus in older nondiabetic
adults randomized to receive 3 different classes of antihypertensive treatment:
a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart
Attack Trial (ALLHAT) - Arch Intern Med. 2006 Nov 13;166(20):2191-201 -
"Mean FG levels increased during follow-up in all
treatment groups. At year 2, those randomized to the chlorthalidone group had
the greatest increase (+8.5 mg/dL [0.47 mmol/L] vs +5.5 mg/dL [0.31 mmol/L] for
amlodipine and +3.5 mg/dL [0.19 mmol/L] for lisinopril)"
-
Diuretics: A modern day treatment option? (Review Article) - Nephrology
(Carlton). 2006 Oct;11(5):419-27 - "The main area of
doubt lies in relation to the risk of renal outcomes and of metabolic outcomes,
such as new onset diabetes - where the evidence suggests that drugs that inhibit
the renin-angiotensin system may be more protective than all other drug classes"
-
Thiazide Diuretics, Potassium, and the Development of Diabetes. A Quantitative
Review - Hypertension. 2006 Jun 26 -
"thiazide-induced
hypokalemia is associated with increased blood glucose"
-
Thiazide and Beta-Blocker
Use Linked With Increased Risk for Incident Diabetes - Medscape, 5/8/06 -
"The multivariate risk ratios of developing diabetes associated with taking
thiazide diuretics were 1.20, 1.51, and 1.31 in the NHS I, NHS II, and HPFS,
respectively"
-
Use of Potassium-Sparing Diuretics Cuts AD Risks - Clinical Psychiatry
News, 4/06 - "The risk of developing AD was
significantly smaller in those who took antihypertensive medications than in
those who did not (adjusted hazard ratio [aHR] 0.64). When the results were
broken down by drug class, diuretics showed the greatest protective effect
against AD"
-
Diuretics Reduce Risk of Death From Congestive Heart Failure - Doctor's
Guide, 2/13/06
-
One in Five Patients on Commonly Prescribed Diuretics Have Abnormal Sodium
and Potassium Levels - Doctor's Guide, 1/11/06 -
"In milder cases they can make people feel below
par, cause general weakness and tiredness and sometimes interfere with the
normal rhythm of the heart ... Severe loss of sodium can make it difficult
for people to maintain their blood pressure at a normal level, causing
dizziness, confusion and an increased risk of falls in older people"
-
Increased Serum Creatinine More Likely when Nesiritide is Combined with
High-Dose Diuretics - Doctor's Guide, 11/16/05
-
'Water Pills' May Cut Heart Risks in Diabetes - WebMD, 6/27/05
-
Patients Who Fail Anti-Hypertensive Monotherapy Respond to Fixed-Dose
Combination of Irbesartan/Hydrochlorothiazide - Doctor's Guide, 5/19/05
-
High-Dose Hydrochlorothiazide Gets Hard-to-Treat Hypertensive Patients to
Blood Pressure Goal - Doctor's Guide, 5/18/05
-
Combo Drug Controls Hypertension In Hard-to-treat Patients - Science
Daily, 5/18/05 - "the combination pill of irbesartan
(an angiotensin II receptor blocker) and a diuretic, hydrochlorothiazide ...
the participants' systolic blood pressure (the top number) dropped an
average of 21.5 points, from 154.4 to 132.9 points. Their diastolic blood
pressure (the bottom number) fell an average of 10.4 points, from 91.3 to
80.9" - Yeah, but what about impotence from the diuretic?
-
Blood Pressure
Linked to Erectile Dysfunction - WebMD, 5/16/05 -
"Men on older high blood pressure medications
(diuretics, beta-blockers) had higher rates and more severe erectile
dysfunction than men on newer medications (calcium antagonists, ACE
inhibitors, angiotensin II receptor blockers)"
-
Diuretics Best Initial Therapy in Treating High Blood Pressure -
Doctor's Guide, 4/7/05
-
Water Pill Works Best for High Blood Pressure - WebMD, 4/5/05 -
"thiazide-type diuretics, known as water pills,
which cost just pennies a pill, are a better choice for the initial
treatment of high blood pressure than the newer drugs, known as ACE
inhibitors and calcium-channel blockers"
-
Diuretic Not Suited for Everyone With Heart Failure - HealthDay, 8/4/04
-
Telmisartan 40 or 80 mg/Hydrochlorothiazide 12.5 mg Fixed –Dose Combinations
Can Thwart Early Morning Blood Pressure Surge - Doctor's Guide, 6/15/04
-
Diuretics May Be Underused as First Line Treatment for Patients With
Hypertension - Doctor's Guide, 4/5/04
-
Chronic Diuretic Use in Heart Failure Patients Called Into Question -
Doctor's Guide, 3/9/04
- Diuretics Linked to
Increased Mortality in Heart Failure - Medscape, 3/9/04
-
Diuretics Appear To Reduce Pulse Pressure Effectively In Older Hypertensive
Patients - Doctor's Guide, 11/21/03
-
Spironolactone Reduces Blood Pressure in Patients with Resistant
Hypertension - Doctor's Guide, 11/4/03
-
Hypertension Drug Also Cuts Bone Loss - HealthDay, 9/15/03
- Millions Wasted
on High Blood Pressure Medications - WebMD, 9/8/03 - Yeah, but what
about the fact the diuretics have to
worst compliance! - Ben
-
Perindopril/Indapamide Therapy May Help Reduce Dementia Risk In Patients
With Cerebrovascular Disease - Doctor's Guide, 6/16/03
-
FDA Grants Marketing Approval for Benicar HCT (Olmesartan
Medoxomil-Hydrochlorothiazide) Treatment For Hypertension - Doctor's
Guide, 6/9/03
-
Low-Dose Diuretics Most Effective Way To Treat Hypertension - Doctor's
Guide, 5/21/03
- Diuretic Use Linked
to End-Stage Renal Disease [ESRD] - Medscape, 5/16/03 -
"We're concerned that there could be a long time lag
between use of thiazide diuretics and
ESRD, even as long as 10 to 15 years"
-
Maternal Diuretics In Pregnancy May Be Linked To Schizophrenia In Offspring
- Doctor's Guide, 3/14/03
-
Which Blood Pressure Drug Is Best? - HealthDay, 2/12/03 -
"The differing results could have been due to the
difference in the ethnic makeup of the two trials, Reid says. "Thirty
percent of the ALLHAT subjects were black Americans, who are known not to
respond to ACE inhibitors," ... Almost
all the 6,083 people in the Australian trial were white. Blood pressure
reduction was the same in those who took a diuretic and those who took an
ACE inhibitor. The incidence of stroke was the same in both groups, but the
number of deaths from cardiovascular disease was 11 percent lower in the ACE
inhibitor group ... There is general agreement that almost all people with
high blood pressure need to take to more than one drug"
- Blood Pressure
Control -- Timing Matters - WebMD, 1/24/03 -
"Researchers found that the diuretic and
calcium-channel blocker were effective around the clock. The
beta-blocker was the least effective of the four drugs overall and it
had no effect on blood pressure during the night or in the early morning
hours. ACE inhibitors actually worked
best while the study participants were sleeping, but had little effect on
blood pressure during the day"
-
Spironolactone Augments Angiotensin-Converting Enzyme Inhibitors, Benefits
Left Ventricular Function - Doctor's Guide, 1/6/03
-
Thiazide Diuretics Less Damaging to Bone Than Loop Diuretics - Doctor's
Guide, 1/2/03
-
BP Lowering May Halt Descent Into Dementia - Clinical Psychiatry News,
12/02 -
"Dr. Hansson served as cochair of SCOPE, a 15-nation
study in which 4,937 mildly hypertensive
patients aged 70-89 were randomized to the
angiotensin-receptor blocker candesartan or diuretic-based therapy.
Serial Mini-Mental Status Exams (MMSEs) conducted during more than 18,000
patient-years of follow-up demonstrated that among individuals with a
baseline MMSE of 24-28—indicative of normal to slightly impaired
cognitive function—those in the candesartan arm had a mean 0.5-point
decline in MMSE scores during follow-up, compared with a 6-point drop in
those on a diuretic. The cognitive benefit was even more pronounced in
patients over age 85"
- Diuretics Best
for High Blood Pressure - WebMD, 12/17/02 -
"diuretics should be the top choice for combating
high blood pressure" - Yeah, but what about impotence and other
quality of life issues. If people don't take them because of the side
effects, they aren't doing much good. See:
-
Reproducibility Of Responses To Hydrochlorothiazide Variable For Individuals
- Doctor's Guide, 12/11/02
-
Diuretics Associated with Increased Mortality Risk in Acute Renal Failure
- Doctor's Guide, 11/27/02
-
Low Dietary Or Serum Potassium Risk Factor For Stroke - Doctor's Guide,
8/27/02 -
"Diuretic users had an increased risk for
stroke which was associated with lower serum
potassium (relative risk 2.5;P<0.0001). People who did not use diuretics
had an increased risk for stroke if they had low dietary potassium intake
(relative risk 1.5;P<0.005)"
-
Patient Compliance with Antihypertensive Therapy Appears Longer for Those
Taking Angiotensin II Antagonists - Doctor's Guide, 7/18/02 -
"The researchers found that the class of drug had a statistically
significant effect on the patients' persistence of compliance. Angiotensin
II antagonists had the highest rate of persistence followed by ACE
inhibitors, calcium channel blockers, beta-blockers, and diuretics"
-
Losartan Plus Hydrochlorothiazide Reduces Essential Hypertension -
Doctor's Guide, 6/26/02
-
Telmisartan/Hydrochlorothiazide Combination Superior To Telmisartan Alone
For Hypertension - Doctor's Guide, 5/13/02
- Blood Pressure
Combo [ACE inhibitor & diuretic] Lowers Risk of Stroke - WebMD, 9/27/01
- ACE Inhibitor Plus
Diuretic Combo Best for American Indians - Doctor's Guide, 7/11/01
- Low-Dose
Perindopril/Indapamide Combination More Effective Than Irbesartan Alone
- Doctor's Guide, 6/21/01
- ACE Inhibitor/Diuretic
Combination Treatment Protects Against Second Stroke - Doctor's Guide,
6/18/01
-
Blood Pressure Drugs Cut Stroke Risk - Intelihealth, 6/17/01 -
"giving stroke patients blood pressure pills and
diuretics could halve the chance of their suffering another stroke"
- Telmisartan With
Hydrochlorithiazide Controls Hypertension - Doctor's Guide, 5/18/01 -
"after eight weeks on the FDC, both SBP/DBP dropped
by 7.4/3.5 mmHg, compared with the telmisartan 40 mg monotherapy"
- Black Hypertensive
Patients Benefit From Combined Angiotensin II Antagonist + Thiazide -
Doctor's Guide, 4/6/01 -
"The combination gave a mean reduction from baseline
of 13.3 mmHg, compared with only 4.6 mmHg for telmisartan 80 mg alone and
5.2 mmHg for HCTZ alone (p<0.01). The active treatments produced no more
side-effects than placebo did"
- A Water Pill a
Day Can Keep a Stroke Away, Study: People With High Blood Pressure Need to
Be on a Diuretic - WebMD, 1/8/01 -
""If I had high blood pressure, I would take a
diuretic as a first-line treatment drug," says study author Bruce M. Psaty,
MD, PhD. He is a professor of medicine and epidemiology at the University of
Washington in Seattle."
-
Study: Diuretics Help Stop Strokes - Intelihealth, 1/8/01
- FDA Approves Micardis HCT
(Telmisartan/Hydrochlorothiazide) For Hypertension - Doctor's Guide,
11/21/00 (Micardis is and ARB, hydrochlorothiazine
is a diuretic)
-
Nutrient Depletion Checklist: Thiazide Diuretics - Nutrition Science
News, 11/00
- Atacand HCT (Candesartan
Cilexetil-Hydrochlorothiazide), Anti-Hypertensive, Now Available In US -
Doctor's Guide, 10/26/00
- Chlorthalidone Superior To
Doxazosin As First-Line Antihypertensive - Doctor's Guide, 4/4/00
- ACC Issues Clinical Alert
On Use Of Cardura (Doxazosin) For Hypertension - Doctor's Guide, 3/16/00
- Potassium-Magnesium Citrate
Effective In Correcting Thiazide-Induced Side Effects - Doctor's Guide,
11/13/98
- FDA-Approved Diovan HCT
Combines Two Hypertension Drug Classes - Doctor's Guide, 3/10/98
- Diuretic Withdrawal Can Do
More Harm Than Good- Doctor's Guide, 8/22/97
- Diuretics Significantly
Lower Risk Of Heart Failure - Doctor's Guide, 7/15/97
Related Searches:
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