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Recent Longevity News for the week ending 10/12/16

Urinary Citrate Positively Associated With Bone Strength, Health - Medscape, 10/11/16 - "Slight shifts of acid-base status toward a more acidic direction adversely affect bone status. A more alkaline diet rich in fruits and vegetables appears to counteract these shifts and has a long-term preventive medical importance for bone health"

Blood pressure meds could raise your depression risk - CNN, 10/10/16 - "people taking one of two classes of drugs, known beta blockers or calcium channel antagonists, had twice the risk of being admitted into the hospital with a mood disorder, such as severe depression. However, people taking a class of drugs known as angiotensin blockers -- ACE inhibitors -- had a lower risk of developing severe mood disorders, even compared with healthy control groups with no history of hypertension or depression" - Note: It doesn't mention ARB's.  I think they're talking about ACE inhibitors and ARB's as interchangeable with regards to mood.  If you Google 'angiotensin blockers' it brings up ARB's.

UPDATE:  Someone sent me this which does include ARB's for mood: Common high blood pressure meds affect mood disorders - American Heart Association, 10/10/16

Abstracts from this week:

Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial - Nutrients. 2016 Sep 28;8(10) - "A total of 100 patients with slow transit constipation were randomized to receive either a synbiotic or placebo twice daily for 12 weeks ... Over 12 weeks, 64.6% of the patients who received the synbiotic experienced clinical improvement, compared to 29.2% of the patients in the placebo group (p < 0.01). During the intervention period, patients who were treated with the synbiotic exhibited increased stool frequency, improved stool consistency, decreased CTT, and improved constipation-related symptoms" - [Nutra USA] - See synbiotic products at Amazon.com, probiotic products at Amazon.com and inulin at Amazon.com.

Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention - J Am Coll Cardiol. 2016 Oct 11;68(15):1609-1617 - "There was a direct linear association between average sodium intake and mortality, with an HR of 0.75, 0.95, and 1.00 (references) and 1.07 (p trend = 0.30) for <2,300, 2,300 to <3,600, 3,600 to <4,800, and ≥4,800 mg/24 h, respectively; and with an HR of 1.12 per 1,000 mg/24 h (95% CI: 1.00 to 1.26; p = 0.05). There was no evidence of a J-shaped or nonlinear relationship. The HR per unit increase in sodium/potassium ratio was 1.13 (95% CI: 1.01 to 1.27; p = 0.04) ... We found an increased risk of mortality for high-sodium intake and a direct relationship with total mortality, even at the lowest levels of sodium intake. These results are consistent with a benefit of reduced sodium and sodium/potassium intake on total mortality over a 20-year period" - Note:  One way to decrease the sodium/potassium ratio is through potassium citrate.  See potassium citrate at Amazon.com.

Vitamin C Supplementation, APOE4 Genotype and Cognitive Functioning in a Rural-Dwelling Cohort - J Nutr Health Aging. 2016;20(8):841-844 - "Overall, Vitamin C supplementation was associated with significantly better immediate memory (p=0.04), visuospatial skills (p=0.002), language (p=0.01), and global cognitive functioning (p=0.006). Among APOE4 non-carriers, vitamin C supplementation was positively associated with immediate memory (F[1,392] =6.7, p=0.01), visuospatial skills (F[1,391]=10.6, p=0.001), language (F[1,392]=13.0, p<0.001), attention (F[1,386]=7.9, p=0.005, and global cognition (F[1,382]=11.0, p=0.001. However, there was no significant link between vitamin C supplementation and cognition among APOE4 carriers" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.

A Study on Neuroprotective Effects of Curcumin on the Diabetic Rat Brain - J Nutr Health Aging. 2016;20(8):835-840 - "Taking all these data together, the curcumin found to be effective against oxidative stress and glutamate neurotoxicity in the male albino rats" - See curcumin products at Amazon.com.

The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial - J Am Coll Nutr. 2016 Oct 6:1-7 - "Five hundred milligrams per day quercetin supplementation for 8 weeks resulted in significant improvements in clinical symptoms, disease activity, hs-TNFα, and HAQ in women with RA" - See quercetin at Amazon.com.

Meta-analysis of Egg Consumption and Risk of Coronary Heart Disease and Stroke - J Am Coll Nutr. 2016 Oct 6:1-13 - "A 12% decreased risk (SRRE = 0.88, 95% confidence interval [CI], 0.81-0.97) of stroke was observed in the meta-analysis of 7 studies of egg intake (high vs low; generally 1/d vs <2/wk) ... A nonstatistically significant SRRE of 0.97 (95% CI, 0.88-1.07, p-H = 0.67, I2 = 0.00) was observed in the meta-analysis of 7 studies of egg consumption and CHD ... Based on the results of this meta-analysis, consumption of up to one egg daily may contribute to a decreased risk of total stroke, and daily egg intake does not appear to be associated with risk of CHD"

Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline - Ann Pharmacother. 2016 Oct 4 - "Data from the Canadian Study of Health and Aging (1991-2002), a cohort study of dementia including 3 evaluation waves at 5-yearly intervals, were used ... Compared with those not taking vitamin supplements, the age-, sex-, and education-adjusted hazard ratios of CIND, AD, and all-cause dementia were, respectively, 0.77 (95% CI = 0.60-0.98), 0.60 (95% CI = 0.42-0.86), and 0.62 (95% CI = 0.46-0.83) for those taking vitamin E and/or C supplements ... This analysis suggests that the use of vitamin E and C supplements is associated with a reduced risk of cognitive decline" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com and American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com

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