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Recent Longevity News for the week ending 5/18/16

Exercise Lowers Risk for These 13 Cancer Types - NBC News, 5/16/16 - "Those who exercised the most had: A 26 percent lower risk of lung cancer ... A 23 percent lower risk of kidney cancer ... A 22 percent lower risk of stomach cancer ... A 21 percent lower risk of endometrial cancer ... A 20 percent lower risk of myeloid leukemia ... A 17 percent lower risk of myeloma ... A 16 percent lower risk of colon cancer... A 15 percent lower risk of head and neck cancer ... A 13 percent lower risk of rectal cancer...A 13 percent lower risk of bladder cancer ... A 10 percent lower risk of breast cancer"

Omega-3 lowers childhood aggression in short term - Science Daily, 5/14/16 - "In a randomized control trial, one group received omega-3 supplements for six months, the other didn't. Those taking the fish oil saw a reduction in aggressive and antisocial behavior ... The Philadelphia randomized control study placed 290 11- and 12-year-olds with a history of violence into four groups: The first received omega-3 in the form of juice, as well as multivitamins and calcium for three months. For that same duration, a second group participated in cognitive behavioral therapy, or CBT, which included meeting weekly for an hour, with time split between the child, the parent and with both together ... A third group in the study took the supplements and participated in CBT, and a fourth received resources and information targeted at reducing aggressive behavior ... immediately after three months of the nutritional intervention rich in omega-3s, we found a decrease in the children's reporting of their aggressive behavior" - See fish oil supplements at Amazon.com.

This popular painkiller also kills kindness - Washington Post, 5/12/16 - "Acetaminophen, the most common drug ingredient in the United States, can reduce a person's capacity to empathize with another person's pain, whether that pain is physical or emotional"

Vinegar and Diabetes: Dos and Don'ts - Medscape, 5/12/16 - "The limited available research suggests that vinegar taken before a meal may lower blood glucose from 20% to 33%.[10,12] The response may depend on the type of glucose load—that is, a more pronounced response with a high-glycemic vs low-glycemic meal or glucose-containing beverage ... Patients should limit consumption to a maximum of 1-2 tablespoons of vinegar diluted with water twice daily ... Patients should limit consumption to a maximum of 1-2 tablespoons of vinegar diluted with water twice daily" - See apple cider vinegar at Amazon.com - 1 Source Natural 500 mg tablet equals 2 teaspoons of vinegar.  4.5 tablets equals about 3 tablespoons by my calculations.

Vitamin B12 May Slow Brain Aging - Medscape, 5/11/16 - "researchers examined data on 501 participants aged 60 years and older ... total brain tissue (TBT) ... increased baseline levels of vitamin B12 and holotranscobalamin (the biologically active fraction of B12) were associated with a decreased rate of TBT volume loss, at respective beta values of 0.048 (P < .001) and 0.040 (P = .002) for each standard deviation increase" - See vitamin B12 at Amazon.com.

Driving while high on marijuana causing spike in fatal accidents - today.com, 5/10/16 - "A new report by the American Auto Association (AAA) has found that the percentage of drivers who are high on pot during fatal accidents in Washington State more than doubled between 2013 and 2014"

Abstracts from this week:

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta-analysis - Int J Cancer. 2016 May 13 - "In a meta-analysis of 10 studies, statin use was associated with improved recurrence-free survival (RFS) (HR 0.64; 95% CI 0.53- 0.79, I2 = 44%). Furthermore, this RFS benefit appeared to be confined to use of lipophilic statins (HR 0.72; 95% CI 0.59- 0.89) as hydrophilic statin use was not associated with improvement in RFS (HR 0.80; 95% CI 0.44- 1.46). Statin users similarly showed improved overall survival in a meta-analysis with substantial heterogeneity (8 studies, HR 0.66; 95% CI 0.44-0.99, I2 = 89%). Statin users also had improved cancer-specific survival, although this relationship was measured with less precision (6 studies, HR 0.70"

  • Which Statin Is Right for My Patient? - Medscape, 8/28/07 - "Atorvastatin, lovastatin, and simvastatin are lipophilic, whereas pravastatin, rosuvastatin, and fluvastatin are more hydrophilic"

A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters - J Diet Suppl. 2016 May 10:1-15 - "Using a two-part approach in humans, the impact of theacrine (TeaCrine®, TC) was used to examine subjective dose-response, daily changes in cognitive and psychometric parameters, and changes in gas exchange and vital signs. ... visual analog scale (VAS) ... Energy, focus, and concentration increased from baseline values in both doses with no dose-response effect. VAS responses in the 200 mg for willingness to exercise, anxiety, motivation to train and libido increased across the measurement period while no such change was seen with the 400 mg dose. After consuming a single 200 mg dose, significant group × time interaction effects were seen for energy, fatigue, and concentration. No changes in resting heart rate, gas exchange, systemic hemodynamics or side effect profiles were noted" - See TeaCrine® at Amazon.com.

Calcium intake and breast cancer risk: meta-analysis of prospective cohort studies - Br J Nutr. 2016 May 12:1-9 - "The overall RR of breast cancer for high v. low intake of Ca was 0.92 (95 % CI 0.85, 0.99), with moderate heterogeneity (P=0.026, I 2=44.2 %). In the subgroup analysis, the inverse association appeared stronger for premenopausal breast cancer (RR 0.75; 95 % CI 0.59, 0.96) than for postmenopausal breast cancer (RR 0.94; 95 % CI 0.87, 1.01). Dose-response analysis revealed that each 300 mg/d increase in Ca intake was associated with 2 % (RR 0.98; 95 % CI 0.96, 0.99), 8 % (RR 0.92; 95 % CI 0.87, 0.98) and 2 % (RR 0.98; 95 % CI 0.97, 0.99) reduction in the risk of total, premenopausal and postmenopausal breast cancer, respectively. Our findings suggest an inverse dose-response association between Ca intake and risk of breast cancer"

The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats - Phytother Res. 2016 May 11 - "Pycnogenol® (PYC) belongs to strong antioxidants that may interfere with different pathways playing an important role in diseases associated with oxidative stress. Metformin (MET), commonly used antidiabetic drug, has cardio-protective effects via activation of AMP kinase (AMPK). In our study, we examined the effects of PYC as add-on drug to metformin therapy in streptozotocin (STZ)-induced diabetic rats. Our results revealed that both used agents, PYC and MET, showed improvement of blood glucose levels, vascular reactivity, left ventricular hypertrophy, expression of AMPK, glucose transporter 4 (GLUT4) and calcium/calmodulin-dependent protein kinase II (CaMKII) in left ventricle of the hearts. However, the combination of these interventions has failed to possess higher efficacy" - See Pycnogenol at Amazon.com.

Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study - Eur J Clin Nutr. 2016 Apr 13 - "We found statistically significant associations between serum EPA+DPA+DHA and better performance in the Trail Making Test and the Verbal Fluency Test. The individual associations with EPA and DHA were similar with the findings with EPA+DPA+DHA, although the associations with DHA were stronger. No associations were observed with serum DPA. Pubic hair mercury content was associated only with a worse performance in the Trail Making Test, and mercury had only little impact on the associations between the serum PUFAs and cognitive performance" - [Nutra USA] - See fish oil supplements at Amazon.com.

Vitamin D Status and Mortality: Meta-Analysis of Individual Participant Data Confirms Strong Association - Int J Vitam Nutr Res. 2016 May 10:1-4 - "Scientists and physicians have suggested that poor vitamin D intake can result in increased cardio-vascular mortality. Also total mortality appears to be increased with poor vitamin D status. A research team of the German Cancer Research Center in Heidelberg (DKFZ) headed by Ben Schöttker was able to demonstrate this association in a meta-analysis of 8 European and US-based cohort studies" - See vitamin D at Amazon.com.

Are Supplementation of Omega-3 and Ascorbic Acid Effective in Reducing Oxidative Stress and Depression among Depressed Shift Workers? - Int J Vitam Nutr Res. 2016 May 10:1-12 - "Beck Depression Inventory (BDI) ... Among the participants, 33 received omega-3 fatty acid soft gel (1000 mg twice daily) with vitamin C (250 mg twice daily) (group 1), 31 took omega-3 fatty acid supplements and vitamin C placebo (group 2), 30 took omega-3 fatty acid supplement placebo and vitamin C (group 3), and 32 received omega-3 fatty acid supplement placebo and vitamin C placebo (group 4) for 2 months ... the BDI score was reduced significantly in all 4 groups, however, the level of decrease was more in the omega-3 fatty acid (alone) supplementation group (mean 6.29 score decrease) (p < 0.001)" - See fish oil supplements at Amazon.com.

3,3',5-triiodothyroxine inhibits apoptosis and oxidative stress by the PKM2/PKM1 ratio during oxygen-glucose deprivation/reperfusion AC16 and HCM-a cells - Biochem Biophys Res Commun. 2016 May 6 - "Oxidative stress (OS) plays a crucial role in the development of myocardial disease, which can induce the dysfunction of cardiac muscle cells ... The present study aimed to reveal the key effects of T3 on protecting human myocardial cell lines from oxidative stress and the downstream molecular mechanism ... The effects of T4 were not notable. T3 also protected OGDR cells from apoptosis and upregulated the PKM2/PKM1 ratio" - See T3 at International Anti-aging Systems.

Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with Type 2 diabetes - Diabetes Metab Res Rev. 2016 May 7 - "Vitamin D deficiency (VDD) was reported to be associated with diabetic peripheral neuropathy (DPN) ... After adjusting for all potential confounders, VDD was still linked with increased risk of DPN [odds ratio (OR) 2.59" - See vitamin D at Amazon.com.

l-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight men - Br J Nutr. 2016 May 10:1-7 - "Combined isometric exercise or metaboreflex activation (post-exercise muscle ischaemia (PEMI)) and cold pressor test (CPT) increase cardiac afterload, which may lead to adverse cardiovascular events. l-Citrulline supplementation (l-CIT) reduces systemic arterial stiffness (brachial-ankle pulse wave velocity (baPWV)) at rest and aortic haemodynamic responses to CPT ... placebo or l-CIT (6 g/d) for 14 d in a cross-over design. Brachial and aortic systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP), aortic augmented pressure (AP), augmentation index (AIx), baPWV, reflection timing (Tr) and heart rate (HR) were evaluated at rest and during isometric handgrip exercise (IHG), PEMI and PEMI+CPT at baseline and after 14 d. No significant effects were evident after l-CIT at rest. l-CIT attenuated the increases in aortic SBP and wave reflection (AP and AIx) during IHG, aortic DBP, MAP and AIx during PEMI, and aortic SBP, DBP, MAP, AP, AIx and baPWV during PEMI+CPT compared with placebo. HR and Tr were unaffected by l-CIT in all conditions. Our findings demonstrate that l-CIT attenuates aortic blood pressure and wave reflection responses to exercise-related metabolites. Moreover, l-CIT attenuates the exaggerated arterial stiffness response to combined metaboreflex activation and cold exposure, suggesting a protective effect against increased cardiac afterload during physical stress" - See BulkSupplements Pure L-Citrulline Powder.

Sex steroids, sex hormone-binding globulin and cardiovascular health in men and postmenopausal women: the Rotterdam Study - J Clin Endocrinol Metab. 2016 May 10 - "estradiol (E2), testosterone (T), sex hormone-binding globulin (SHBG), and free androgen index (FAI) ... optimal cardiovascular health (OCH ... After adjustment for confounders, OCH was associated with lower T [OR (95%CI): 0.69 (0.48-1.00)] and lower FAI [0.43 (0.32-0.57)] and higher levels of SHBG [4.55 (2.99-6.94)] among women and with higher levels of SHBG [2.56 (1.45-4.49)] in men" 

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