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Recent Longevity News for the week ending 10/7/15

Flu Vaccine May Also Protect Against Pneumonia - WebMD, 10/5/15 - "We estimate that approximately 57 percent of hospitalizations due to influenza pneumonia could be prevented by influenza vaccination ... The leading cause of these hospitalizations and deaths is not flu itself, but pneumonia, which is a common complication of flu ... The flu is a great enabler ... It enables heart disease, pneumonia, appendicitis, sore throats and earaches ... And pneumonia is the number one cause of hospitalization and death"

Glutamate: Essential food for the brain - Science Daily, 10/4/15 - "Devoid of the energy supplied by cerebral glutamate, the brain sends signals to the liver to requisition a compensatory proportion of glucose, at the expense of the rest of the body. This is why the transgenic mice also showed a growth deficit and muscle atrophy. "This clearly shows how the brain works in a just-in-time manner and that each percent of energy resources is essential for its proper functioning," highlights Professor Pierre Maechler. "If a part of this energy disappears, the brain serves itself first and the rest of the body suffers. The liver must then make more glucose by drawing upon muscle protein, resulting in loss of muscle mass. Knowing that the brain uses glutamate as an energy resource allows us to reflect on other ways to overcome a potential shortfall" - See l-glutamic acid at Amazon.com.

Omega-3 Fatty Acids for Breast Cancer Prevention and Survivorship - Medscape, 10/1/15 - "Women with evidence of high intake ratios of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to the omega-6 arachidonic acid have been found to have a reduced risk of breast cancer compared with those with low ratios in some but not all case–control and cohort studies. If increasing EPA and DHA relative to arachidonic acid is effective in reducing breast cancer risk, likely mechanisms include reduction in proinflammatory lipid derivatives, inhibition of nuclear factor-κB-induced cytokine production, and decreased growth factor receptor signaling as a result of alteration in membrane lipid rafts ... The inflammation-resolving properties and favorable effects of EPA and DHA on oncogenic proteins, as well as on the cardiovascular, bone, and central nervous system, make them excellent candidates for primary and secondary breast cancer prevention trials for individuals at increased risk as well as breast cancer survivors" - See fish oil supplements at Amazon.com.

Calcium From Supplements or Dairy Doesn't Strengthen Bones, Study Finds - NBC News, 9/29/15 - "taking calcium supplements is not just a waste of time, but it could be harmful. The extra calcium doesn't go to strengthen bones but instead can build up in the arteries, causing heart disease, or in the kidneys, causing kidney stones"

Abstracts from this week:

A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension - J Alzheimers Dis. 2015 Sep 4 - "Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline performance in CLOX-1. The placebo cohort did not improve in DRS and declined in CLOX-1, but during the open-label extension improved in DRS and ceased declining in CLOX-1" - [Nutra USA]

A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations - Clin Nutr. 2015 Sep 25 - "This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C" - See Spirulina at Amazon.com.

Dairy consumption and risk of metabolic syndrome: a meta-analysis - Diabet Med. 2015 Oct 3 - "In the meta-analysis of prospective cohort studies, the pooled relative risk of incidence of metabolic syndrome for the highest vs. the lowest category of dairy consumption was 0.85 (95% CI 0.73-0.98), and for a 1-serving/day increment of dairy consumption, the pooled relative risk was 0.88 (95% CI 0.82-0.95). In the meta-analysis of cross-sectional studies, the pooled relative risk of prevalence of metabolic syndrome for the highest vs. the lowest category of dairy consumption was 0.73 (95% CI 0.63-0.86)"

Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice - Clin Nutr. 2015 Sep 25 - "GLY treated mice lost more whole-body fat mass (14%, p < 0.05) and epididymal fat mass (26%, P < 0.05), less lean mass (27%, P < 0.05), and had better preserved quadriceps muscle mass (4%, P < 0.01) than ALA treated mice after 20 d CR ... Taken together, these findings suggest that glycine supplementation during CR may be beneficial for preserving muscle mass and stimulating loss of adipose tissue" - See glycine products at Amazon.com.

Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behavior and reduces oxidative stress in brain and pancreas - Diabetes Metab Res Rev. 2015 Oct 3 - "This study aimed to evaluate the effects of antioxidants n-acetylcysteine (NAC) and deferoxamine (DFX) on behavior and oxidative stress parameters in diabetic rats. To this aim, after induction of diabetes by a single dose of alloxan, Wistar rats were treated with NAC or DFX for 14 days and then depressive-like behavior was evaluated ... Diabetic rats displayed depressive-like behavior and treatment with NAC reversed this alteration. Carbonyl protein levels were increased in the PFC, hippocampus, and pancreas of diabetic rats, and both NAC and DFX reversed these alterations. Lipid damage was increased in the PFC, hippocampus, amygdala, and pancreas, however treatment with NAC or DFX reversed lipid damage only in the hippocampus and pancreas" - See n-acetyl cysteine at Amazon.com.

Effects of Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial - J Am Coll Nutr. 2015 Oct 2:1-6 - "Nonalcoholic fatty liver disease (NAFLD) is a condition defined by exceeding triglycerides accumulation in the liver. The condition can develop into fibrosis, cirrhosis, and hepatocellular carcinoma ... Subjects in the intervention and control groups consumed 2 capsules/day probiotic or placebo, respectively, for 8 weeks. Fasting blood sugar (FBS) ... Means of FBS, insulin, insulin resistance, and IL-6 were significantly different between groups after intervention (p < 0.05), whereas TNF-α was not significantly modified (p > 0.05). In the probiotic group, insulin, insulin resistance, TNF-α, and IL-6 decreased significantly at the end of the study compared to the beginning of study" - See probiotic products at Amazon.com.

Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population - J Atheroscler Thromb. 2015 Oct 1 - "Multivariate-adjusted logistic regression analysis showed that high FT3 levels were associated with low prevalent elevated C-IMT. The adjusted odds ratio for elevated C-IMT was 0.71 (95% confidence interval, 0.52-0.99, P=0.04) when comparing the highest with the lowest quartile of FT3" - See T3 at International Anti-aging Systems.

Mente Activa® Improves Impaired Spatial Memory in Aging Rats - J Nutr Health Aging. 2015;19(8):819-27 - "Our data indicate that supplemented rats showed less escape latency, distance swum, higher use of spatial search strategies, and crossed the former platform location with higher frequency than control rats. These effects were specific of the treatment, indicating that this nutritional supplement has a beneficial effect on spatial memory" - Note:  The following is what the Google Chrome translate option translates the ingredients too.  It sounds like the main active ingredients are the DHA and the phospatidylserine:

  • ACTIVE MIND CEREGUMIL Softgels 30 caps - ceregumil.com - "Composition ... Fish oil 50% DHA / 10% EPA source phosphatidylserine (100 mg), 70% sunflower oil ALA, vitamin C (calcium ascorbate), iron (ferrous sulfate 1-hydrate), zinc (zinc sulfate 1-hydrate soy ), vitamin E (DL-alpha tocopherol acetate), taurine, vitamin A (vitamin A palmitate), vitamin B12 (cyanocobalamin), selenium (sodium selenite). Excipients: Glyceryl monostearate (emulsifier E471), soya lecithin (emulsifier E322), essential oils of mint and lemon. Capsule: Sorbitol (humectant E420) gelling (fish gelatin), wetting agent (glycerol), coloring E171, E172, E141"

Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women - Br J Nutr. 2015 Sep 30 - "Recent evidence suggests that Ca supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain ... We randomised 100 post-menopausal women to 1 g/d of Ca or a placebo containing no Ca ... Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The reduction in systolic blood pressure was smaller in the Ca group compared with the control group by >5 mmHg between 2 and 6 h (P≤0.02), and the reduction in diastolic blood pressure was smaller at 2 h (between-groups difference 4.5 mmHg, P=0.004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the calcium citrate and control groups. At 4 h, the increase in the coagulation index was greater in the calcium citrate group compared with the control group (P=0.03), which appeared to be due to a greater reduction in the time to clot initiation"

The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials - J Cosmet Dermatol. 2015 Sep 12 - "Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration ... Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects" - [Nutra USA] - See Protein Essentials Hydrolyzed Collagen Protein Powder with Peptan® (16oz) at Amazon.com. It's the Rousselot Peptan collagen brand talked about in the Nutra USA article.  See the Rousselot Peptan collagen website.

Neat Tech Stuff / "How To's":

This is a neat gadget.  It’s a LCD arm.  Not only does it put my monitor in the perfect place but it makes cleaning my desk a lot easier.  It’s got 5 stars with 537 reviews at Amazon, something you rarely see.  See: http://amzn.to/1VpmKbP .  After I bought it I noticed that Amazon has what looks like the same thing under their brand for $30 less: http://amzn.to/1RhLTPY .  Also there’s a wall mounted model: http://amzn.to/1LSiA6k

Health Focus (Atherosclerosis):