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Home > Anti-aging Research > Glycine

Glycine

Specific Recommendations:

News & Research:

  • COVID-19 patients have severely increased levels of oxidative stress and oxidant damage, and glutathione deficiency, study finds - Science Daily, 1/3/22 - "Compared to healthy age-matched individuals whose samples were taken before the pandemic started in 2019, patients hospitalized with COVID-19 had significantly increased levels of oxidative stress and oxidant damage, and markedly reduced levels of glutathione ... GlyNAC, a combination of glutathione precursors previously shown to reduce oxidative stress and oxidant damage and increase glutathione as well as improve health indicators such as inflammation, might be beneficial to COVID-19 patients. However, GlyNAC supplementation has not as yet been studied in association with COVID-19 ... Increased oxidative stress and reduced glutathione levels are associated with a number of conditions including aging, diabetes, HIV infection, neurodegenerative disorders, cardiovascular disorders, neurometabolic diseases, obesity and others ... supplementing GlyNAC, a combination of glutathione precursors, improved these defects in all these populations" - Note: NAC has been know for years to increase glutathione. Taking glutathione doesn't work. Amazon and several others have stopped selling NAC. See the article below. I bought about a three year supply from iHerb.  See glycine products at Amazon.com and NAC at iHerb.
    • GlyNAC improves multiple defects in aging to boost strength and cognition in older humans - Science Daily, 3/29/21 - "supplementation with GlyNAC -- a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione -- could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging ... older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. The benefits declined after stopping supplementation for 12 weeks. GlyNAC supplementation was well tolerated during the study period ... Mitochondria generate energy needed for supporting cellular functions by burning fat and sugar from foods, therefore mitochondrial health is critically important for life. Sekhar believes that improving the health of malfunctioning mitochondria in aging is the key ... I am particularly encouraged by the improvements in cognition and muscle strength ... Alzheimer's disease and mild cognitive impairment (MCI) are serious medical conditions affecting memory in older people and leading to dementia, and there are no effective solutions for these disorders. We are exploring the possibility that GlyNAC could help with these conditions by conducting two pilot randomized clinical trials to test whether GlyNAC supplementation could improve defects linked to cognitive decline in Alzheimer's disease and in MCI, and possibly improve cognitive function."
    • GLYNAC (NAC & GLYCINE) 60 x 500mg capsules - youthandearth - "GLYNAC is a powerful precursor to Glutathione consisting of two amino acids NAC (N-acetylcysteine) and Glycine ... Supplementation with GLYNAC has been shown to raise Glutathione levels"
    • FDA Requests Information Relevant to the Use of NAC as a Dietary Supplement - fda.gov - "The FDA is asking interested parties to submit such information by January 25, 2022, while the agency continues to evaluate both citizen petitions. The agency will use the information submitted for our analysis and provide a final response to both petitioners directly once we complete our review."
    • Ask the Pharmacist: NAC supplements going away soon - marconews.com, 5/17/21 - "Cysteine is a natural compound and N acetyl cysteine (NAC) is a dietary supplement. That’s how you can find it in health food stores, as “NAC.” But you won’t find it for long, so if you want NAC, you should buy it now. It’s already virtually gone from Amazon! ... There’s a disagreement between the Food and Drug Administration and the dietary supplement industry over how legal it is for dietary supplements to put this amino acid into their supplements. The NAC is also available by prescription. It is forcing Amazon and other selling platforms to take sides on the issue."
  • GlyNAC improves multiple defects in aging to boost strength and cognition in older humans - Science Daily, 3/29/21 - "supplementation with GlyNAC -- a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione -- could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging ... older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. The benefits declined after stopping supplementation for 12 weeks. GlyNAC supplementation was well tolerated during the study period ... Mitochondria generate energy needed for supporting cellular functions by burning fat and sugar from foods, therefore mitochondrial health is critically important for life. Sekhar believes that improving the health of malfunctioning mitochondria in aging is the key ... I am particularly encouraged by the improvements in cognition and muscle strength ... Alzheimer's disease and mild cognitive impairment (MCI) are serious medical conditions affecting memory in older people and leading to dementia, and there are no effective solutions for these disorders. We are exploring the possibility that GlyNAC could help with these conditions by conducting two pilot randomized clinical trials to test whether GlyNAC supplementation could improve defects linked to cognitive decline in Alzheimer's disease and in MCI, and possibly improve cognitive function." - See glycine products at Amazon.com and n-acetyl cysteine at Amazon.com.
  • How Did Glycine Significantly Decrease Liver Injury? - Science Daily, 10/31/08 - "Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplantation"
  • Glycine Reduces Negative And Cognitive Symptoms in Schizophrenic Patients Taking Olanzapine Or Risperidone - Doctor's Guide, 3/16/04
  • Green Tea, Glycine May Slow Tumor Growth - WebMD, 11/2/01 - "high levels of glycine reduced breast tumor growth rates by 15% in rats by blocking the growth of new tumor-feeding blood vessels. The special diet also reduced wound-healing by 30% ... Tumors and wounds have one very important thing in common -- they both produce new blood vessels through the same mechanism, known as angiogenesis ... If you can block one response, you can block the other"

Abstracts: