Recent Longevity News for the seven days ending 12/2/09.  You should consult your doctor if you are taking any medications.

Continuous Aspirin May Lower Mortality Despite Increased Risk for Recurrent Peptic Ulcer Bleeding - Medscape, 12/1/09 - "Continuous low-dose aspirin therapy may increase the risk for recurrent peptic ulcer bleeding but potentially lowers mortality rates ... Compared with patients who received placebo, patients who received aspirin had lower all-cause mortality rates (1.3% vs 12.9%; difference, 11.6 percentage points; 95% CI, 3.7 - 19.5 percentage points). In addition, patients in the aspirin group had lower mortality rates resulting from cardiovascular, cerebrovascular, or gastrointestinal tract complications vs patients in the placebo group (1.3% vs 10.3%; difference, 9 percentage points; 95% CI, 1.7 - 16.3 percentage points)"

Molecular Proof: Exercise Keeps You Young - WebMD, 12/1/09 - "Compared to people who did not exercise, elite runners in the study had cells that looked much younger under a microscope ... Just as the plastic tips on the ends of shoelaces keep the laces from fraying, telomeres protect the chromosomes that carry genes during cell division ... Each time a cell divides, telomeres get shorter. When telomeres get too short, cells can no longer divide and they die ... Researchers now believe telomere shortening is critical to aging, making people more vulnerable to diseases such as heart disease, diabetes, and cancer ... That study suggested exercise might trump genes when it comes to keeping people young" - [U.S. News & World Report]

Dutasteride Reduces Risk for Biopsy-Detectable Prostate Cancer in Men at Increased Risk - Doctor's Guide, 12/1/09 - "Compared with placebo, active treatment also showed significantly lower risks for (respectively) HG-PIN (5.4% vs 3.5%; RRR, 34%; P = .0053), ASAP (5.1% vs 3.6%; RRR, 28%; P = .0274), AUR (7.1% vs 1.4%; RRR, 80.4%; P < .0001), BPH-related surgery (5.7% vs 1.4%; RRR 75.6%; P < .0001), and UTI (9.6% vs 5.8%; RRR, 40.8%; P < .0001) ... Similarly, there were significant reductions for mean prostate volume (18.7% increase vs 16.9% decrease; P < .0001) and IPSS (+1.14 vs -0.6; P < .0001), and slightly fewer high-grade tumours (Gleason score, 7-10) in the dutasteride group (7.5% vs 7.0%) ... These benefits were accompanied by significantly more frequent dutasteride-related adverse events (12% vs 19%; P < .0001), with dutasteride treatment showing increased frequencies of decreased libido (2.8% vs 5.5%), impotence (7.7% vs 10.9%), ejaculation disorders (0.5% vs 2.4%), and breast disorders (1.9% vs 3.5%)" - See Dutasteride (Avodart) 30 x 0.5mg capsules at International Antiaging Systems or .

Surgeons offering new procedure for acid reflux, GERD - Science Daily, 12/1/09 - "Using the new procedure known as EsophyX TIF (Transoral Incisionless Fundaplication), surgeons can repair or reconstruct the valve between the esophagus and stomach, effectively stopping GERD. BMC is the only hospital in New England offering this new treatment"

Cardiovascular Fitness May Sharpen Mind - WebMD, 11/30/09 - "A large new study links cardiovascular fitness in early adulthood to increased intelligence, better performance on cognitive tests, and higher educational achievement later in life ... When researchers looked at twins, they found that environmental factors rather than genetics appeared to play the largest role in these associations. Non-shared environmental influences accounted for 80% or more of differences in academic achievement, whereas genetics accounted for less than 15% of these differences"

Too much physical activity may lead to arthritis - Science Daily, 11/30/09 - "Middle-aged men and women who engage in high levels of physical activity may be unknowingly causing damage to their knees and increasing their risk for osteoarthritis"

Best Treatment for Erectile Dysfunction? - Dr. Weil, 11/30/09 - "Ginkgo ... Ashwaganda ... Asian ginseng"

Hand sanitizer: How it protects you - CNN, 11/27/09 - "up to 80 percent of all infections get spread by hands ... Hand sanitizers are effective against both bacteria and viruses ... The sanitizer works on contact, meaning it's only effective on the parts of your hands that it touches. That means if you miss a spot between your fingers, there could still be viruses or bacteria in that place" - Click here for Purell dispensers.

High salt intake directly linked to stroke and cardiovascular disease - Science Daily, 11/24/09 - "analyzed the results of 13 published studies involving over 170,000 people that directly assessed the relationship between levels of habitual salt intake and rates of stroke and cardiovascular disease ... Their analysis shows unequivocally that a difference of 5 g a day in habitual salt intake is associated with a 23% difference in the rate of stroke and a 17% difference in the rate of total cardiovascular disease"

Really? - The Claim - Vinegar Can Help Lower Blood Sugar Levels - NYTimes.com, 11/23/09 - "THE BOTTOM LINE Studies suggest that adding vinegar to a meal may reduce its impact on blood sugar" - See apple cider vinegar at Amazon.com - 1 Source Natural 500 mg tablet equals 2 tsb of vinegar.  4.5 tablets equals about 3 tablespoons by my calculations.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effects of magnesium on postprandial serum lipid responses in healthy human subjects - Br J Nutr. 2009 Nov 27:1-4 - "The present study indicated that Mg supplementation could inhibit fat absorption and improve postprandial hyperlipidaemia in healthy subjects" - See magnesium supplements at Amazon.com.

Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure - Am J Hypertens. 2009 Nov 26 - "Resveratrol treatment significantly prevented the development of concentric hypertrophy, and systolic and diastolic dysfunction in SHR without lowering blood pressure. Resveratrol also significantly reduced the oxidative stress levels of cardiac tissue in SHR.ConclusionsResveratrol treatment was beneficial in preventing the development of concentric hypertrophy and cardiac dysfunction in SHR. The cardioprotective effect of resveratrol in SHR may be partially mediated by a reduction in oxidative stress. Thus, resveratrol may have potential in preventing cardiac impairment in patients with essential hypertension" - See resveratrol products at Amazon.com.

25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services - Neurology. 2009 Nov 25 - "Vitamin D insufficiency and deficiency was associated with all-cause dementia, Alzheimer disease, stroke (with and without dementia symptoms), and MRI indicators of cerebrovascular disease. These findings suggest a potential vasculoprotective role of vitamin D" - See vitamin D at Amazon.com.

Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 - "Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases" - See resveratrol products at Amazon.com.

Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of gamma-Interferon-Induced JAK-PKC-delta-STAT1 Signaling in Human Oral Cancer Cells - J Agric Food Chem. 2009 Nov 24 - "In this study, (-)-epigallocatechin-3-gallate (EGCG), the major constituent of green tea, is found to significantly inhibit the expression of IDO in human oral cancer cell lines ... This study indicates that EGCG is a potential drug for immune and target therapy to enhance cancer therapy by increasing antitumor immunity" - See green tea extract at Amazon.com.

Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome - Diabetes Care. 2009 Nov 23 - "Metformin exerts a slight but significant deleterious effect on serum Hcy levels in patients with PCOS, and supplementation with folate is useful to increase the beneficial effect of metformin on the vascular endothelium"

Health Focus (Deprenyl/Selegiline):

Related Topics:

• dopamine / Monoamine Oxidase (MAO) Inhibitors / antidepressants / Parkinson's Disease / depression / attention deficient hyperactive disorder

Where to purchase:

• Deprenyl at International Anti-aging Systems

News & Research:

• Deprenyl - Life Extension Foundation
• Deprenyl - extending lifespan - article by James South - "At normally used clinical dosages (10-15 mg/day), deprenyl is a selective MAO-B inhibitor, so it doesn’t prevent intestinal MAO-A from digesting dietary tyramine. (1) In addition, deprenyl has the unique ability to prevent tyramine from getting into noradrenalin-using nerve calls, and it’s only when tyramine enters noradrenalin nerve cells that control arterial blood pressure that it triggers the “cheese effect.”"
• Deprenyl- A multi-functional anti-aging drug - Ward Dean MD - "In addition to its potential as a life-extending drug, Deprenyl also appears to have a number of other beneficial effects. One of the most significant is its libido promoting/aphrodisiac effects, in both men and women. . . . Deprenyl has also been found to protect neurons from toxic substances, act as an anti-oxidant, and as an inducer of the anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT)"
• Deprenyl - International Antiaging Systems
• Deprenyl: A Universal Anti-Aging Strategy - CERI
• The Responsible Parent's Guide to Healthy Mood-Boosters for all the Family - BLTC Research
• Study Will Test Antidepressant Patch That May Help Smokers Kick The Habit - Science Daily, 1/8/07
• Valeant Pharmaceuticals Announces Availability of Zelapar(R) for Parkinson's Disease Patients - Doctor's Guide, 7/21/06
• Patch Approval: ‘Big Moment’ in Psychopharm: Resistant depression patients may benefit - Clinical Psychiatry News, 4/06 - "Probably 30% of people who present with depressive complaints have an MAO-inhibitor responsive condition that will not respond well or not at all to [selective serotonin reuptake inhibitors, selective norepinephrine reuptake inhibitors, or tricyclics]"
• FDA Approves Emsam (selegiline transdermal system), the First Transdermal Patch for the Treatment of Major Depressive Disorder - Doctor's Guide, 2/28/06 - "the U.S. Food and Drug Administration (FDA) approved Emsam® (selegiline transdermal system), the first transdermal patch for the treatment of major depressive disorder (MDD) in adults"
• FDA OKs Patch to Treat Depression - WebMD, 2/28/06 - "At its lowest strength, Emsam can be used without the dietary restrictions that are needed for all oral MAO inhibitors that are approved for treating major depression"
• FDA Panel Backs Selegiline Patch For Depression: Majority view 20-mg formulation as safe - Clinical Psychiatry News, 12/05 - "Unlike the transdermal formulation, the oral formulation does not achieve antidepressant levels in the central nervous system"
• Fast-dissolving Selegiline (Zelapar Zydis) Reduces "Off-Time" in Up to 4 Years of Follow-Up - Doctor's Guide, 10/3/05
• Parkinson's Drug May Be Safer Than Thought - WebMD, 8/12/04
• Transdermal Selegiline Can Prevent Depression Relapse - Clinical Psychiatry News Online, 11/03
• Transdermal MAO Inhibitor Patch Effective for ADHD - Clinical Psychiatry News, 6/03 - "A transdermal patch containing the selective monoamine oxidase inhibitor selegiline applied daily appeared effective and well tolerated in a pilot study of children and adolescents with attention-deficit hyperactivity disorder ... Selegiline is a specific monoamine oxidase (MAO) type B inhibitor, so it “is essentially devoid of the tyramine-cheese effect we think about with MAO [type A] inhibitors"
• Selegiline Transdermal System Shows Modest But Significant Antidepressant Effect - Doctor's Guide, 3/19/03 - "Use of a selegiline transdermal system offers modest but statistically significant antidepressant benefit in outpatients with major depressive disorder"
• Zelapar (Selegiline) Receives Approvable Letter From FDA - Doctor's Guide, 2/18/03
• Parkinson's Drug May Help Smokers Quit - WebMD, 1/24/03
• Selegiline Helps Smokers Quit - Medscape, 1/23/03 - "Its effect was about half that of buproprion but comparable to that of nicotine replacement ... selegiline doses greater than 10 mg/day are associated with increased risk of hypertensive crises"
• Selegiline Might Aid Smoking Cessation - Doctor's Guide, 9/12/02
• Transdermal MAO Inhibitor Appears Safe Without Dietary Restrictions - Clinical Psychiatry News, 9/01 - "Selegiline is a MAO-B inhibitor that has been shown to have a significant antidepressant effect at oral doses of 30-60 mg/day. But at this level, the drug also inhibits MAO-A and requires the restriction of dietary tyramine and sympathomimetic amines"
• Deprenyl May Result In AD/HD Symptom Improvements - Doctor's Guide, 10/26/99 - "Ten children (ages six to 13) with AD/HD participated in the study. These children had very severe AD/HD and presented many co-morbid problems. Placebo and deprenyl tablets (5 mg) were given twice a day for one month each ... Results showed that three tasks were significantly improved (paired-associate learning, math computation and Beery shape copying) with deprenyl treatment as determined by a two-tailed statistical test. This pilot study indicates that deprenyl may have some benefits for the task performance and classroom behavior of some children with AD/HD."
• A Good Dose of Deprenyl How Much is Too Much? - Life Extension Magazine, 8/99
• Selegiline - BLTC Research
• Youthful Brain, Youthful Body - Life Extension Magazine, 5/98
• Effect Of Long-Term Deprenyl Treatment On Age-Dependent Changes In The Rat Brain - Life Extension Magazine, 9/96
• Top Ten Life Extension Drugs - Life Extension Magazine, 9/95
• Eldepryl Shows Encouraging Results In Alzheimer's Study - Doctor's Guide, 4/24/97
• Report: Vitamin E, Parkinson's drug slow Alzheimer's disease - CNN, 4/23/97

Abstracts:

• Selegiline transdermal system: a novel treatment option for major depressive disorder - Expert Opin Pharmacother. 2009 Jul;10(10):1665-73 - "Selegiline transdermal system is safe and effective in treating major depressive disorder at the dose range of 6 - 12 mg/24 h, without the need for dietary precautions at the 6 mg/24 h dose. No cases of hypertensive crisis were reported in clinical trials, even without dietary restrictions"
• Transdermal Selegiline in Major Depression: A Double-Blind, Placebo-Controlled, Parallel-Group Study in Outpatients - Am J Psychiatry, 11/02 - "Transdermal selegiline (20 mg applied once daily by means of a 20-cm2 patch) administered for 6 weeks was an effective and well-tolerated treatment for adult outpatients with major depression. The typical side effects commonly seen with traditional monoamine oxidase inhibitor antidepressants were not observed"
• MAO inhibitors and oxidant stress in aging brain tissue - Eur Neuropsychopharmacol. 1999 Mar;9(3):247-52 - "By reducing the oxidant stress observed in aging brain, MAO inhibitors, especially deprenyl, may contribute to the control of the aging process."
• Current status of antioxidant therapy for Alzheimer's Disease - J Am Geriatr Soc. 1998 Dec;46(12):1566-72 - "High dose vitamin E, ginkgo biloba, and selegiline are three putative antioxidants that have been tested in randomized multicenter trial conditions in the US"
• The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl - Mech Ageing Dev. 1988 Dec;46(1-3):237-62
• Integrated medicine and the prevention and reversal of memory loss - Altern Ther Health Med. 1998 Nov;4(6):38-43 - "The program includes a diet consisting of 15% fat and supplementation with brain-specific nutrients such as vitamin B complex, vitamin E, ubiquinone, ginkgo biloba, and phosphatidylserine. In addition, stress-relieving meditation, mind-body and cognitive exercise, antiaging drugs like L-deprenyl citrate, as well as hormones such as dehydroepiandrosterone and pregnenolone complete the program"
• Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors - Cancer Lett. 1998 Jan 30;123(2):177-83 - "These results suggest that the administration of deprenyl blocked the development of mammary tumors . . ."

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