Recent Longevity News for the seven days ending 10/21/09.  You should consult your doctor if you are taking any medications.

Alzheimer's Researchers Find High Protein Diet Shrinks Brain - Science Daily, 10/20/09 - "mice fed a high protein/low carbohydrate diet had brains five percent lighter that all the others, and regions of their hippocampus were less developed"

Olive oil component could avert Alzheimer’s - Nutra USA, 10/20/09 - "ADDLs bind within the neural synapses of the brains of Alzheimer's patients and are believed to directly disrupt nerve cell function, eventually leading to memory loss, cell death and global disruption of brain function ... incubation with oleocanthal changed the structure of ADDLs by increasing the protein's size" - [Abstract] - See olive leaf extract at Amazon.com.

H1N1 Swine Flu Deadly to the Young - WebMD, 10/20/09 - "In a normal flu season, 90% of deaths are in elderly people. Since September, 90% of deaths have been in people under age 65 -- with almost a quarter of the deaths in young people under age 25" - Note: The article doesn't say but I believe the reason is what I was saying several weeks ago, that being that the older people have previously been exposed to a similar virus or vaccine in the past. After I wrote the previous sentence they were saying the same thing on the news.

Antioxidant OPCs may boost memory: Animal study - Nutra USA, 10/16/09 - "The results showed that OPC-consuming animals had “improved spatial and object recognition impairment”" - [Abstract] - See grape seed extract at Amazon.com.

Men who consumed more than 0.39 grams of PUFAs per day had an associated risk of ACS 27 per cent lower than men who consumed less than 0.39 grams per day - Nutra USA, 10/16/09 - "Men who consumed more than 0.39 grams of PUFAs per day had an associated risk of ACS 27 per cent lower than men who consumed less than 0.39 grams per day" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Be Overweight And Live Longer, German Study Suggests - Science Daily, 10/16/09 - "overweight does not increase death rates, although obesity does increase them by 20%. As people grow older, obesity makes less and less difference ... For coronary heart disease, overweight increases risk by about 20% and obesity increases it by about 50%. On the other hand, a larger BMI is associated with a lower risk of bone and hip fracture"

CoQ10 may protect against obesity problems: Study - Nutra USA, 10/15/09 - "We propose, in view of our study, that CoQ10, when given orally, is able to target the liver tissue, and to lessen inflammatory stress associated with obesity in mice in this tissue, independent on any action on lipid peroxidation" - [Abstract] - See ubiquinol products at Amazon.com.

Bosses Who Feel Inadequate Are More Likely To Bully - Science Daily, 10/15/09 - "Incompetence alone doesn't lead to aggression ... It's the combination of having a high-power role and fearing that one is not up to the task that causes power holders to lash out. And our data suggest it's ultimately about self-worth"

Nuts, Vegetables, Fish Cut Alzheimer's Risk - WebMD, 10/14/09 - "we discovered an Alzheimer's-disease-protective dietary pattern that was characterized by a high consumption of nuts, fish, salad dressing, poultry, tomatoes, cruciferous, dark, and green leafy vegetables and fruits, and low in high-fat dairy, red meat, organ meat, and butter"

'Beneficial' Effects Of Alcohol? - Science Daily, 10/14/09 - "During a follow-up time of six and a half years, the researchers found that participants consuming moderate levels of alcohol had the lowest incidence of mobility limitation and disability. After adjusting for demographic characteristics, moderate alcohol intake was still associated with reduced risk compared to never or occasional consumption, but adjusting for life-style related variables substantially reduced the strength of the associations. Adjustment for diseases and health status indicators did not affect the strength of the associations, which led the authors to conclude that life-style is the most important factor in confounding this relationship ... Globally taken, these results suggest that the reported protective effect of moderate alcohol intake on physical performance may be only apparent, because life-style related characteristics seem to be the real determinant of the reported association, suggesting caution in attributing a direct benefit of moderate alcohol intake on functional ability"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal - Toxicol Appl Pharmacol. 2009 Oct 15;240(2):189-97 - "results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics" - See olive leaf extract at Amazon.com.

Curcumin synergizes with resveratrol to inhibit colon cancer - Nutr Cancer. 2009;61(4):544-53 - "the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Analysis by Calcusyn software showed synergism between curcumin and resveratrol. The inhibition of tumors in response to curcumin and/or resveratrol was associated with the reduction in proliferation and stimulation of apoptosis accompanied by attenuation of NF-kappaB activity. In vitro studies have further demonstrated that the combinatorial treatment caused a greater inhibition of constitutive activation of EGFR and its family members as well as IGF-1R. Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer"

Effects of Dietary Fiber, Fats, and Meat Intakes on the Risk of Barrett's Esophagus - Nutr Cancer. 2009;61(5):607-16 - "Higher intakes of omega-3-fatty-acids [cases vs. population controls; OR = 0.46, 95% CI = 0.22-0.97, 4th vs. 1st quartiles of intake], polyunsaturated fat, total fiber (OR = 0.34, 95% CI = 0.15-0.76), and fiber from fruits and vegetables (OR = 0.47 95% CI = 0.25-0.88) were associated with a lower risk of Barrett's esophagus. Higher meat intakes were associated with a lower risk of long-segment Barrett's esophagus (OR = 0.25, 95% CI = 0.09-0.72). In contrast, higher trans-fat intakes were associated with increased risk (OR = 1.11; 95% CI = 1.03-1.21 per g/day). Total fat intake, barbecued foods, and fiber intake from sources other than fruits and vegetables were not associated with Barrett's esophagus"

Folate intake and prostate cancer risk: a case-control study - Nutr Cancer. 2009;61(5):617-28 - "Folate deficiency has been implicated in the carcinogenesis of several tumor types ... Dietary folate intake was inversely associated with overall risk of prostate cancer as compared to clinic controls (P for a linear trend = 0.003). When stratified by disease severity, dietary folate and folate from natural sources were associated with reduced risk of high-grade cancer as compared to both clinic controls (P for a linear trend = 0.0009 and 0.02, respectively) and biopsy negative controls (P for a linear trend = 0.03 and 0.05, respectively) ... These analyses support an inverse association between dietary folate intake and prostate cancer risk and primarily risk of high-grade prostate cancer"

Gamma Tocopherol Upregulates the Expression of 15-S-HETE and Induces Growth Arrest Through a PPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells - Nutr Cancer. 2009;61(5):649-62 - "These data demonstrate that the growth arrest mediated by gamma-tocopherol follows a PPAR-gamma-dependent mechanism" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Fish Oil Supplementation Inhibits NNK-Induced Lung Carcinogenesis in the A/J Mouse - Nutr Cancer. 2009;61(5):663-9 - "fish oil supplementation was able to decrease lung tumor prevalence by 78% and 80% compared to groups receiving soybean oil and corn oil supplementation, respectively" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study - Br J Nutr. 2009 Oct 14:1-6 - "Men in the four highest quintiles of n-3 PUFA intake (>0.39 g n-3 PUFA per d) had a lower incidence of ACS compared with men in the lowest quintile. The hazard ratio was 0.83 (95 % CI 0.67, 1.03) when we compared men in the second lowest and lowest quintile of n-3 PUFA intake" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Oligomeric proanthocyanidins improve memory and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8 - Br J Nutr. 2009 Oct 13:1-11 - "This indicates that oligomers result in an increase in the densities of axons, dendrites and synapses. To investigate the protective mechanisms of oligomers against brain dysfunction with ageing, we carried out a receptor tyrosine kinase phosphorylation antibody array, and clarified that the administration of oligomers led to an increase in the phosphorylation of vascular endothelial growth factor receptor (VEGFR)-2, suggesting the neuroprotective role of oligomers. The phosphorylation of VEGFR-2 was more greatly increased in the hypothalamus and choroid plexus than in other brain regions of SAMP8. Memory in oligomer-treated mice was impaired by SU1498, a VEGFR-2-specific antagonist. Elucidating the relationship between memory impairment with ageing and VEGFR-2 signalling may provide new suggestions for protection against memory deficit in the ageing brain" - See grape seed extract at Amazon.com.

Green tea consumption is associated with depressive symptoms in the elderly - Am J Clin Nutr. 2009 Oct 14 - "A more frequent consumption of green tea was associated with a lower prevalence of depressive symptoms in the community-dwelling older population" - See green tea extract at Amazon.com.

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice - Biochem Pharmacol. 2009 Dec 1;78(11):1391-400 - "CoQ10 supplementation decreased the global hepatic mRNA expression of inflammatory and metabolic stresses markers without changing obesity and tissue lipid peroxides compared to HFF mice" - See ubiquinol products at Amazon.com.

Health Focus (Interleukin 6 (IL-6)):

Related Topics:

• inflammation / C-reactive protein / cytokines

Alternative News:

• Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis - Hypertens Res. 2009 Apr 17 - "Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol" - See resveratrol products at Amazon.com.
• Omega-3 DHA boost for heart health in high-risk men: Study - Nutra USA, 3/6/09 - "supplementation with DHA for 45 days resulted in decreased levels of the number of circulating white blood cells (neutrophils) by 11.7 per cent, and these reductions were maintained until the end of the 90-day study (10.5 per cent reduction) ... levels of C-reactive protein (CRP) had decreased by 15 per cent, and IL-6 had decreased by 23 per cent ... Furthermore, levels of the anti-inflammatory matrix metalloproteinase-2 rose by 7 per cent ... In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - [Abstract] - See Jarrow Max DHA at Amazon.com.
• DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men - J Nutr. 2009 Jan 21 - "DHA supplementation for 45 and 91 d decreased the number of circulating neutrophils by 11.7 and 10.5%, respectively (P < 0.05). It did not alter the circulating concentrations of other inflammatory markers tested within 45 d, but at 91 d it reduced (P < 0.05) concentrations of C-reactive protein (CRP) by 15%, interleukin-6 by 23%, and granulocyte monocyte-colony stimulating factor by 21% and DHA increased the concentration of antiinflammatory matrix metalloproteinase-2 by 7%. The number of circulating neutrophils was positively associated with the weight percent (wt %) of 20:4(n-6) in RBC lipids, and negatively to the wt % of 20:5(n-3) and 22:6(n-3). Concentrations of CRP and serum amyloid A were positively associated with the sum of SFA and negatively with the wt % of 18:1(n-9) and 17:0 in RBC lipids; CRP was also positively associated with the wt % of 20:2(n-6). The mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - See Jarrow Max DHA at Amazon.com.
• Vitamin E Shows Possible Promise In Easing Chronic Inflammation - Science Daily, 12/4/08 - "the larger take-home message of the study, published in the December issue of the journal Experimental Physiology, is that Vitamin E “may be beneficial in individuals with chronic inflammation, such as the elderly or patients with type II diabetes or chronic heart failure" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
• Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals - Atherosclerosis. 2008 Sep 27 - "The combination of n-3 PUFA and plant sterols reduced several inflammatory markers. High sensitivity C-reactive protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha (TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009), leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by 29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in the combination group. CONCLUSION: We have demonstrated, for the first time that dietary intervention with n-3 PUFA and plant sterols reduces systemic inflammation in hyperlipidemic individuals. Furthermore, our results suggest that reducing inflammation provides a potential mechanism by which the combination of n-3 PUFA and plant sterols are cardioprotective" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Red Wine's Resveratrol May Help Battle Obesity - Science Daily, 6/16/08 - "resveratrol inhibited the pre-fat cells from increasing and prevented them from converting into mature fat cells. Also, resveratrol hindered fat storage. Most interesting, according to Fischer-Posovszky, was that resveratrol reduced production of certain cytokines (interleukins 6 and 8), substances that may be linked to the development of obesity-related disorders, such as diabetes and clogged coronary arteries. Also, resveratrol stimulated formation of a protein known to decrease the risk of heart attack. Obesity decreases this substance, called adiponectin" - See resveratrol products at Amazon.com.
• Probiotics may offer hay fever hope - Nutra USA, 6/3/08 - "Hayfever is an allergic reaction to pollen or fungal spores, most commonly grass pollen. The immune system mistakes the spores for harmful invaders and white blood cells - T-helper type 2 (Th2) lymphocytes - produce protein-like cytokines, such as interleukin-4 (IL-4), IL-5 and IL-6, which in turn promote the synthesis of the immune chemicals immunoglobulins (Ig) to bind to the pollen and fight them off ... However, supplementation with the probiotic led to reduced production of IL-5 and IL-6, as well as decreased in the production of IgE ... The probiotic-supplemented volunteers had significantly reduced levels of IL-5 and IL-6" - [Abstract] - See probiotics at Amazon.com.
• Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis - Clin Exp Allergy. 2008 May 28 - "Lactobacillus casei Shirota (LcS) ... Volunteers treated with LcS showed a significant reduction in levels of antigen-induced IL-5, IL-6 and IFN-gamma production compared with volunteers supplemented with placebo. Meanwhile, levels of specific IgG increased and IgE decreased in the probiotic group" - See probiotics at Amazon.com.
• Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 - Proc Natl Acad Sci U S A. 2008 May 19 - "Luteolin consumption reduced LPS-induced IL-6 in plasma 4 h after injection. Furthermore, luteolin decreased the induction of IL-6 mRNA by LPS in hippocampus but not in the cortex or cerebellum. Taken together, these data suggest luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia. Thus, luteolin may be useful for mitigating neuroinflammation" - See luteolin products at iHerb.
• Plant Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In The Brain - Science Daily, 5/20/08 - "The new study looked at luteolin (LOO-tee-OH-lin), a plant flavonoid known to impede the inflammatory response in several types of cells outside the central nervous system ... Those cells that were also exposed to luteolin showed a significantly diminished inflammatory response. Jang showed that luteolin was shutting down production of a key cytokine in the inflammatory pathway, interleukin-6 (IL-6). The effects of luteolin exposure were dramatic, resulting in as much as a 90 percent drop in IL-6 production in the LPS-treated cells ... Inflammatory cytokines such as interleukin-6 are very well known to inhibit certain types of learning and memory that are under the control of the hippocampus, and the hippocampus is also very vulnerable to the insults of aging ... If you had the potential to decrease the production of inflammatory cytokines in the brain you could potentially limit the cognitive deficits that result" - See luteolin at Amazon.com.
• Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study - Am J Clin Nutr. 2008 Feb;87(2):424-30 - "Compared with the lowest tertile of choline intake (<250 mg/d), participants who consumed >310 mg/d had, on average, 22% lower concentrations of C-reactive protein (P < 0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower concentrations of tumor necrosis factor-alpha" - See citicholine at Amazon.com.
• Adherence to the Mediterranean Diet Is Inversely Associated With Circulating Interleukin-6 Among Middle-Aged Men. A Twin Study - Circulation. 2007 Dec 17 - "A 1-unit within-pair absolute difference in the diet score was associated with a 9% (95% CI, 4.5 to 13.6) lower interleukin-6 level"
• Study gives vitamin K anti-inflammation boost - Nutra USA, 12/3/07 - "Limited in vitro data support the inverse association between vitamin K and interleukin-6, and this may influence the association between vitamin K and other cytokines, such as osteoprotegerin" - [Abstract] - See vitamin K at Amazon.com.
• Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study - Am J Epidemiol. 2007 Nov 15 - "Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers" - See vitamin K at Amazon.com.
• Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients - J Ren Nutr. 2007 Sep;17(5):296-304 - "gamma tocopherol (308 mg) and DHA (800 mg) ... In the treatment group, but not in the placebo group, there were significant decreases in IL-6 (21.4 +/- 3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9 +/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4 +/- 0.3 10(3)/microL), at P < .05 for all"
• Clinical Update on Benefits of DHEA - A4M, 4/6/04 - "Recently, researchers discovered important anti-inflammatory properties of DHEA. It was known that DHEA can lower the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha)" - See iHerb or Vitacost DHEA products.
• Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers - Atherosclerosis. 2003 Oct;170(2):261-7 - "short term administration of vitamins C (2 g/day) and E (800 IU/day) reduces serum levels of IL-1b, IL-6, sVCAM-1 and sICAM-1, and improves forearm vasodilatory response to reactive hyperemia in healthy young smokers, while monotherapy with vitamin C alone is ineffective" - See iHerb or Vitacost vitamin E products.
• Mediterranean Diet Lowers C-reactive Protein Levels - Medscape, 11/11/03 - "For each 10-point increase in diet score, there was a corresponding 0.22 mg/dL reduction in C-reactive protein levels, a 0.21 pg/ml reduction in interleukin-6, a 12.5 mg/dL decrease in fibrinogen, and a 0.87 mmol/L decrease in homocysteine levels (P < .05), he said. Also, white blood cell count decreased significantly"
• Plasma interleukin-6 is associated with psychological coronary risk factors: Moderation by use of multivitamin supplements - Brain Behav Immun. 2003 Aug;17(4):296-303 - "Plasma IL-6 was independently associated with anger, hostility, and severity of depressive symptoms ... Multivitamin use was associated with lower plasma IL-6 levels, but only among men with high composite factor scores ... These data suggest that plasma IL-6 is elevated among healthy men characterized by a propensity for anger, a hostile disposition, and greater severity of depressive symptoms and that multivitamin supplements could ameliorate plasma IL-6 levels among these men"
• Omega-3 Fatty Acid Reduces Pro-Inflammatory Cytokines In Heart Transplant Patients - Doctor's Guide, 4/11/02 - "gave 25 stable heart transplant patients two capsules of omega-3 fatty acid daily - each capsule contained 500 mg of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ... The results suggest that omega-3 fatty acid supplementation increased concentrations of the anti-inflammatory interleukin (IL)-10, from 119 to 268 pg/mL (p=0.00008). There were reductions in systemic levels of pro-inflammatory IL-12, from 473 to 376 pg/mL (p=0.001), and IL-6, from 695 to 569 pg/mL (p<0.0001)"

Other News:

• Scientists Develop Nasal Spray That Improves Memory - Science Daily, 10/1/09
• Potential Treatment To Prevent Diabetes And Obesity Using Interleukin-6 - Science Daily, 10/17/08
• Inflammatory Markers and Albuminuria Independently Predict Heart Failure - Medscape, 5/2/08 - "Interleukin (IL)-6, C-reactive protein, and macroalbuminuria are significant predictors of congestive heart failure, independent of obesity and other established risk factors" - Also see my inflammation page for ways to reduce it.
• Elevated IL-6 Levels Associated With Increased Atrial Fibrillation Risk - Medscape, 2/26/08 - "a doubling of IL-6 level was independently associated with a 49% increase in the odds of developing AF"
• Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta A Randomized Cross-Over Study - J Am Coll Cardiol. 2008 Feb 19;51(7):742-749 - "Ramipril reversed the impaired endothelial function and decreased the expression of proinflammatory cytokine IL-6, sCD40L, and adhesion molecules in normotensive subjects with SCR. These findings imply that ramipril treatment may have antiatherogenic effects in subjects with SCR, even in the absence of arterial hypertension" - Note:  Ramipril was my first line choice for combo therapy.
• Mild Depression Tied to Bone Loss - WebMD, 11/26/07 - "Even mild depression may significantly increase a woman's risk for developing osteoporosis ... An inflammatory protein that has specifically been linked to bone loss -- interleukin-6 -- was found to be significantly elevated in the women with depression"
• The role of interleukin-6 in insulin resistance, body fat distribution and energy balance - Obes Rev. 2007 Oct 23 - "Its quantitative release from adipose tissue results in a subclinical, systemic elevation of IL-6 plasma levels with increasing body fat content, which may be implicated in the proinflammatory state leading to insulin resistance. On the other hand, IL-6 produced in the working muscle during physical activity could act as an energy sensor by activating AMP-activated kinase and enhancing glucose disposal, lipolysis and fat oxidation. In addition, both impaired IL-6 secretion and action are risk factors for weight gain"
• Human C-reactive Protein Regulates Myeloma Tumor Cell Growth And Survival - Science Daily, 9/15/07 - "CRP protects myeloma cells from apoptosis induced by chemotherapy drugs and stimulates myeloma cells to secrets more IL-6, which in turn provides additional protection to myeloma from apoptosis and stimulates liver cells to secrete more CRP. Thus, CRP could be a therapeutic target for breaking the vicious circle of myeloma to improve the therapeutic efficacy of currently available treatments"
• Why Liver Cancer Is More Prevalent In Males Than In Females - Science Daily, 7/5/07 - "By eliminating IL-6, we reduced the incidence of liver cancer in the males by close to 90%"
• The Role of IL-6 in Inflammatory Diseases - Medscape, 6/4/07
• Two Markers Strongly Linked To Prostate Cancer Incidence And Mortality Almost A Decade Prior To Diagnosis - Science Daily, 11/14/06 - "Increased levels of two markers of inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), are significantly associated with prostate cancer incidence and mortality almost a decade prior to diagnosis"
• Cytokines Play Role in Sleep Disorders, Obesity - Clinical Psychiatry News, 10/06 - "Interventions to reduce or neutralize proinflammatory cytokines may be novel treatments in patients with sleep disorders and obesity ... Three inflammation-associated cytokines—tumor necrosis factor-α (TNF-α, interleukin-1 (IL-1), and IL-6—are elevated in obese and sleep-deprived patients, and may mediate excessive daytime sleepiness and fatigue"
• Researchers Find Added Benefit of Statins in Those at High Risk for Heart Disease, Diabetes - Doctor's Guide, 9/13/06 - "found marked reductions in two pivotal biomarkers of inflammation: C-reactive protein (CRP) and interleukin-6. While these markers are typically elevated in insulin resistance, a condition that precedes the development of diabetes, statin therapy reduced these levels by 36% and 44%, respectively"
• Chemical can slow memory - USA Today, 3/1/06 - "The team discovered that people with the highest IL-6 levels had the worst scores. These low performers didn't have scores that signaled Alzheimer's, but they had a less-than-stellar ability to multi-task or to remember new information"
• Is Interleukin-6 The "Holy Grail" Of Exercise Mediation? - Science Daily, 10/11/04
• Interleukin-6 stimulates lipolysis and fat oxidation in humans - J Clin Endocrinol Metab. 2003 Jul;88(7):3005-10
• Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart Failure - Doctor's Guide, 11/20/02 - "At six-month follow-up, sub-antimicrobial dose doxycyline significantly reduced CRP levels by 45.8 percent compared to baseline values (p<0.05). The drug was also associated with a 33.5 percent reduction in interleukin-6 and a 50 percent reduction in metalloproteinase ... The findings are exciting, since research is now showing that CRP is both a key marker of inflammation leading to future acute coronary events, but also that CRP itself may contribute to the initiation and progression of atherosclerosis"
• C-Reactive Protein, IL-6 Levels Tied to Heart Disease in Postmenopausal Women - Doctor's Guide, 8/28/02 - "Baseline levels of the inflammatory biomarkers C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with a two-fold increase in risk of healthy postmenopausal women developing coronary heart disease (CHD)"
• Another Study Suggests Inflammation May Trigger Diabetes - WebMD, 7/17/01 - "The immune system and inflammation may be factors causing type 2 diabetes ... women who had high levels of immune system substances called C-reactive protein or interleukin-6, or both, in their blood were more likely to develop type 2 diabetes ... Both C-reactive protein, called CRP, and interleukin-6, or IL-6, are considered indicators for inflammation"

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