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Recent Longevity News for the week ending 5/4/16 Vitamin stops the aging process of organs - Science Daily, 4/28/16 - "As mice, like all mammals, age, the regenerative capacity of certain organs (such as the liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging ... We gave nicotinamide riboside to 2-year-old mice, which is an advanced age for them ... This substance, which is close to vitamin B3, is a precursor of NAD+, a molecule that plays a key role in mitochondrial activity. And our results are extremely promising: muscular regeneration is much better in mice that received NR, and they lived longer than the mice that didn't get it ... Parallel studies have revealed a comparable effect on stem cells of the brain and skin ... So far, no negative side effects have been observed following the use of NR, even at high doses" - See nicotinamide riboside at Amazon.com.
Eating
chocolate each day could reduce heart disease, diabetes risk - Science
Daily, 4/28/16 - "Data of 1,153 people aged 18-69 years
old who were part of the Observation of Cardiovascular Risk in Luxembourg
(ORISCAV-LUX) study were analysed. It was found that those who ate 100 g of
chocolate a day -- equivalent to a bar -- had reduced insulin resistance and
improved liver enzymes. Insulin sensitivity is a well-established risk factor to
cardiovascular disease" - See Ghirardelli Chocolate Intense Dark Squares, Midnight Reverie, 4.12 oz.,
86% Cacao (Pack of 4) at Amazon.com Probiotics stop menopause-like bone loss in mice - Science Daily, 4/27/16 - "treated female mice twice a week with Lactobacillus rhamnosus GG (LGG) ... A month after ovary removal, mice that were not treated with probiotic bacteria had lost half of their bone density. But the bone density in probiotic-treated mice stayed the same ... In mice that did not have their ovaries removed, probiotic treatment actually led to an increase in bone density" - Note: Lactobacillus rhamnosus is one of the bacterial in the Garden of Life Primal Defense ULTRA I take. Cholesterol levels, not statins, influence colorectal cancer risk - Science Daily, 4/27/16 - "They confirmed findings from previous studies that showed a decreased risk of colorectal cancer in statin users compared to non-users. However, they found that the difference in the risk of colorectal cancer was not significantly different between those patients who continued statin therapy and those who discontinued (OR, 0.98; 95% CI, 0.79-1.22). Furthermore, for every 1 mmol/L (~38.6 mg/dl) increase in total cholesterol level, authors observed a 10 percent decreased risk of colorectal cancer ... Additionally, they observed that decreases in total serum cholesterol (>1 mmol/L) at least a year before the cancer diagnosis were associated with 1.25-fold and 2.36-fold increased risk of colorectal cancer in users and nonusers, respectively" Nutrient supplements can give antidepressants a boost - Science Daily, 4/26/16 - "Omega 3 fish oils, S-adenosylmethionine (SAMe), methylfolate (bioactive form of folate) and Vitamin D, were all found to boost the effects of medication ... They reported mixed results for zinc, vitamin C and tryptophan (an amino acid). Folic acid didn't work particularly well, nor did inositol" - Note: For people who want an increase in energy and mood with anti-aging effects to boot, I’d skip the antidepressants and go with a combination of deprenyl, lithium (the over-the-counter supplement form), GH-3 and beta-arginine. On the beta-arginine, it will weird you out if you don’t start slow and take it with food if possible. Build yourself up to 3200 mg per day. Don’t take more than 800 mg per three or four hour period. Check with a doctor first on all of that. Also, see methylfolate at Amazon.com. Abstracts from this week: Combination of aspartic acid and glutamic acid inhibits tumor cell proliferation - Biomed Res. 2016;37(2):153-9 - "Placental extract contains several biologically active compounds, and pharmacological induction of placental extract has therapeutic effects, such as improving liver function in patients with hepatitis or cirrhosis ... Active molecules were separated by chromatographic analysis, and their antiproliferative activities were determined by a colorimetric assay. We identified aspartic acid and glutamic acid to possess the antiproliferative activity against human hepatoma cells. Furthermore, we showed that the combination of aspartic acid and glutamic acid exhibited enhanced antiproliferative activity, and inhibited Akt phosphorylation. We also examined in vivo tumor inhibition activity using the rabbit VX2 liver tumor model. The treatment mixture (emulsion of the amino acids with Lipiodol) administered by hepatic artery injection inhibited tumor cell growth of the rabbit VX2 liver. These results suggest that the combination of aspartic acid and glutamic acid may be useful for induction of tumor cell death, and has the potential for clinical use as a cancer therapeutic agent" - See aspartic acid at Amazon.com and glutamic acid at Amazon.com.
The Effect
of Coenzyme Q10 Supplementation on Pro-Inflammatory Factors and Adiponectin in
Mildly Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled
Trial - Int J Vitam Nutr Res. 2015;85(3-4):156-64 -
"Sixty mildly hypertensive patients were randomly divided into two groups:
placebo (PG, n = 30) and coenzyme Q10 (QG, n = 30).
The QG was given 1 capsule containing 100 mg Q10 per day ... The mean
enhancement in adiponectin of QG was
significantly higher than PG (from 21.1 ± 14.5 to 24.2 ± 15.5 ng/ml, P = 0.04).
Significant declines in the median of IL6
(from 23 to 16 pg/ml, P = 0.001) and in the mean of
hs-CRP were also observed in QG after
intervention (from 3.53 ± 3.36 to 2.62 ± 2.51 mg/L, P = 0.03)" - See
ubiquinol products at Amazon.com
Combined
1,25-Dihydroxy-vitamin D and Resveratrol: A Novel Therapeutic Approach to
Ameliorate Ischemia Reperfusion-Induced Myocardial Injury - Int J Vitam Nutr
Res. 2015;85(3-4):174-84 - "Our study showed that
combination of a non-hypotensive dose of 1,25 D
and resveratrol can be a novel and effective
strategy for protecting against ischemia" - See Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules
at Amazon.com
Cannabis, Psychosis, and Mortality: A Cohort Study of 50,373 Swedish Men - Am J Psychiatry. 2016 Apr 22 - "Subjects with a baseline history of heavy cannabis use had a significantly higher risk of death (hazard ratio=1.4" Health Focus (Head & Neck Cancer):
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