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Recent Longevity News for the seven days ending 10/1/08. You should consult your doctor if you are taking any medications. Novel Approaches To Heart Disease And Inflammation - Science Daily, 9/30/08 - "the immune system's role in heart disease is a relatively recent finding, with the first inklings of its importance discovered in the early 1980s. Prior to that time, scientists believed that atherosclerosis, a blockage in the arteries and the underlying cause of most heart problems, was due to plaque formation caused solely by cholesterol buildup ... inflammatory T cells not only contributed to plaque formation, but they also played a key role in the rupture of the artery wall, which produces a heart attack"
Vitamin C May Prevent Hyperuricemia, Gout - Medscape, 9/26/08 -
"Hyperuricemia is
considered a precursor of gout, which is the most
common inflammatory arthritis in adult men ... An association was observed
between greater vitamin C intake and lower
prevalence of hyperuricemia defined as > 6 mg/dL. The multivariable odds ratio
for hyperuricemia for the highest intake of vitamin C (>1000 mg/d) compared to
the lowest (<90 mg/d) was 0.34 ... These findings support a potential role of
vitamin C in the prevention of hyperuricemia and gout" - See
vitamin C products at Amazon.com
Vitamin D again linked to breast cancer protection - Nutra USA, 9/26/08 -
"Increased intakes of the
vitamin were associated with a 24 per cent reduction in the risk of
developing ER+ and PR+ tumours" - [Abstract]
- See
vitamin D at Amazon.com Ingredient in Chinese Herb Acts as a Natural Viagra - WebMD, 9/26/08 - "the main compound in horny goat weed, called icariin, acted the same way that Viagra does" - See horny goat weed products at iHerb.
Vitamin D Linked to Genetic and Environmental Risk for MS - Medscape,
9/26/08 - "Everyone who has examined this from the
National Academy of Sciences to the dietary committee of the European Union to a
variety of professional organizations all agree pretty much that the amount of
vitamin D that people are getting is too low"
- See
vitamin D at Amazon.com Differences Between People And Animals On Calorie Restriction - Science Daily, 9/24/08 - "In the majority of the animal models of longevity, extended lifespan involves pathways related to a growth factor called IGF-1 (insulin-like growth factor-1), which is produced primarily in the liver. Production is stimulated by growth hormone and can be reduced by fasting or by insensitivity to growth hormone. In calorie-restricted animals, levels of circulating IGF-1 decline between 30 percent and 40 percent ... For years, we have been following a cohort of people from the CR Society who have been on long-term calorie restriction. We found no difference in IGF-1 levels between people on calorie restriction and those who are not ... The CR Society members, who call themselves CRONies (Calorie Restriction with Optimal Nutrition), had been on a calorie-restriction diet for an average of seven years when Fontana did the measurements, but their IGF-1 levels were virtually identical to sedentary people who ate a standard, Western diet ... there are two major influences on IGF-1 levels: calorie intake and protein intake ... His team has been following a population of strict vegans for several years. They tend to eat less protein than the CRONies from the CR Society, so he compared IGF-1 levels between the two groups ... The vegans had significantly less circulating IGF-1 ... The strict vegans took in about 10 percent of their total calories from protein, whereas those on calorie restriction tended to get about 23 or 24 percent of calories from protein ... If our research is on the right track, maybe humans don't need to be so calorie restricted. Limiting protein intake to .7 or .8 grams per kilogram per day might be more effective" Eating Fish in Infancy Lowers Eczema Risk - WebMD, 9/24/08 - "Babies in a newly published study whose diets included fish before the age of 9 months were 24% less likely to develop eczema by their first birthdays than babies who did not eat fish" Isoflavone Dietary Supplement Improves Functioning Of Arteries In Stroke Patients - Science Daily, 9/23/08 - "A dietary supplement containing isoflavone – a chemical found in soybeans, chickpeas, legumes and clovers – can improve artery function in stroke patients ... 12 weeks of isoflavone supplement, at a dose of 80 mg a day, significantly improved brachial FMD and, therefore, vascular endothelial dysfunction in patients who had suffered an ischaemic stroke (a stroke caused by blood clots or other obstructions)" Plant Antioxidant May Protect Against Radiation Exposure - Science Daily, 9/23/08 - "Resveratrol, the natural antioxidant commonly found in red wine and many plants, may offer protection against radiation exposure ... Currently there are no drugs on the market that protect against or counteract radiation exposure" Antioxidant Deficiency Linked To Pulmonary Hypertension - Science Daily, 9/23/08 - "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes" Association of ACE Inhibitors and Angiotensin Receptor Blockers With Keratinocyte Cancer Prevention in the Randomized VATTC Trial - oncologystat.com, 9/3/08 - "squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) ... Time to new BCC was 2.5 years for ACE inhibitor or ARB users and 2.2 years for nonusers. The absolute incidence rate of BCCs per 1000 patient-years was lower among ACE inhibitor/ARB users than nonusers (154 vs 233; unadjusted incidence rate ratio [IRR] = 0.66 ... Time to new SCC was 2.9 years for ACE inhibitor or ARB users and 2.6 years for nonusers. The absolute incidence rate of BCCs per 1000 patient-years was lower among ACE inhibitor/ARB users than nonusers (83 vs 141; unadjusted IRR = 0.58" Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top): Optimal protein intake in the elderly - Clin Nutr. 2008 Sep 24 - "It appears that an intake of 1.5g protein/kg/day, or about 15-20% of total caloric intake, is a reasonable target for elderly individuals wishing to optimize protein intake in terms of health and function"
Effects of grape seed-derived polyphenols on amyloid beta -protein self-assembly
and cytotoxicity - J Biol Chem. 2008 Sep 24 - "Alzheimer's
disease (AD) ... studies showed that a commercially-available
grape seed polyphenolic extract,
MegaNatural-AZ (MN), significantly attenuated AD-type cognitive deterioration
and reduced cerebral amyloid deposition" - See
grape seed extract at Amazon.com Fatigue Predicts Mortality in Older Adults - J Am Geriatr Soc. 2008 Sep 22 - "Mortality rates at 10 years were 59% (123/210) for older adults with fatigue, versus 38% (106/282) for those without fatigue"
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