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Home > Health
Conditions > Pulmonary Hypertension
Pulmonary Hypertension
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Attenuating effect of
magnesium on pulmonary arterial calcification in rodent models of pulmonary
hypertension - J Hypertens 2022 Oct 1 - "Vascular
calcification has been considered as a potential therapeutic target in
pulmonary hypertension. Mg2+ has a protective role against calcification ...
Monocrotaline (MCT)-induced and chronic hypoxia-induced pulmonary
hypertension ... Mg2+ supplement is a powerful strategy to treat pulmonary
hypertension by mitigating pulmonary arterial calcification as the
calcification triggered physiological and pathological changes to PASMCs"
- See magnesium supplements at Amazon.com.
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SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and
Normalizes Pulmonary Hypertension Associated with Heart Failure with
Preserved Ejection Fraction (PH-HFpEF) - Circulation. 2016 Jan 26 -
"These studies validate a rodent model of metabolic
syndrome and PH-HFpEF, suggesting a potential role of nitrite and metformin
as a preventative treatment for this disease" - See
metformin at The Antiaging Store.
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Genistein, a Soy Phytoestrogen, Reverses Severe Pulmonary Hypertension and
Prevents Right Heart Failure in Rats - Hypertension. 2012 Jul 2 -
"PH was induced in male rats by 60 mg/kg of
monocrotaline. After 21 days, when PH was well established, rats received
daily injection of genistein (1 mg/kg per day) for 10 days or were left
untreated to develop RHF by day 30. Effects of genistein on human pulmonary
artery smooth muscle cell and endothelial cell proliferation and neonatal
rat ventricular myocyte hypertrophy were assessed in vitro. Severe PH was
evident 21 days after monocrotaline, as peak systolic right ventricular
pressure increased to 66.35+/-1.03 mm Hg and right ventricular ejection
fraction reduced to 41.99+/-1.27%. PH progressed to RHF by day 30 (right
ventricular pressure, 72.41+/-1.87 mm Hg; RV ejection fraction,
29.25+/-0.88%), and mortality was ≈75% in RHF rats. Genistein therapy
resulted in significant improvement in lung and heart function as right
ventricular pressure was significantly reduced to 43.34+/-4.08 mm Hg and
right ventricular ejection fraction was fully restored to 65.67+/-1.08%
similar to control. Genistein reversed PH-induced pulmonary vascular
remodeling in vivo and inhibited human pulmonary artery smooth muscle cell
proliferation by ≈50% in vitro likely through estrogen receptor-β. Genistein
also reversed right ventricular hypertrophy (right ventricular hypertrophy
index, 0.35+/-0.029 versus 0.70+/-0.080 in RHF), inhibited neonatal rat
ventricular myocyte hypertrophy, and restored PH-induced loss of capillaries
in the right ventricle. These improvements in cardiopulmonary function and
structure resulted in 100% survival by day 30. Genistein restored PH-induced
downregulation of estrogen receptor-β expression in the right ventricle and
lung. In conclusion, genistein therapy not only rescues preexisting severe
PH but also prevents the progression of severe PH to RHF" - See
genistein at Amazon.com.
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Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats
- Hypertension. 2009 Jul 13 - "Pulmonary
hypertension was associated with an upregulation of NAD(P)H oxidase in small
pulmonary arteries, which was significantly attenuated by resveratrol
treatment. Our studies show that resveratrol exerts anti-inflammatory,
antioxidant, and antiproliferative effects in the pulmonary arteries, which
may contribute to the prevention of pulmonary hypertension" - See
resveratrol products at Amazon.com.
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Can 2 Garlic Cloves a Day Keep the Doc Away? - WebMD, 4/4/05 -
"Ku's team recently found that allicin -- a compound
found in garlic -- prevents a mild form of pulmonary hypertension in rats.
Now they find that the garlic compound prevents a much more severe form of
pulmonary hypertension in rats"
News & Research:
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Endothelin Drugs Benefit Those With Pulmonary Hypertension - Science
Daily, 9/10/09
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FDA Approves Tadalafil Tablets for Pulmonary Arterial Hypertension -
Doctor's Guide, 5/26/09
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Antioxidant Deficiency Linked To Pulmonary Hypertension - Science Daily,
9/23/08 - "Antioxidant augmentation in patients
might be used to increase nitric oxide vasodilator effects, reduce pulmonary
artery pressures and potentially improve clinical outcomes"
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Serum Sodium Predicts Mortality 10 Times Higher In PAH Patients -
Science Daily, 6/13/08
- Most Common Cause
of Pulmonary Hypertension - Medscape, 2/5/07
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Pulmonary Hypertension May Indicate Hemoglobinuria - Doctor's Guide,
12/15/05
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Drug May Ease Pulmonary Hypertension - WebMD, 11/16/05
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Ongoing and Completed Clinical Trials in Pulmonary Hypertension Are Driving
the Need for New Practice Guidelines - Doctor's Guide, 11/4/05
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Combination Therapy with Inhaled Iloprost and Bosentan Effective in
Pulmonary Arterial Hypertension - Doctor's Guide, 11/3/05
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Sildenafil Use in Pulmonary Hypertension Appears Useful; Raises Controversy
- Doctor's Guide, 11/3/05
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First Report Of Cancer Drug Gleevec As New Target Therapy For Pulmonary
Hypertension - Doctor's Guide, 9/30/05
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FDA Approves Revatio (Sildenafil Citrate) As Treatment for Pulmonary
Arterial Hypertension - Doctor's Guide, 6/6/05
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FDA Grants Orphan Drug Status to PulmoLAR, Treatment for Pulmonary Arterial
Hypertension - Doctor's Guide, 5/12/05
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Medical Researchers Say Statins, Other Cholesterol-Depleting Agents Affect
Hypertension - Science Daily, 4/12/05
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FDA Approves Ventavis (Iloprost) for Treatment of Pulmonary Arterial
Hypertension - Doctor's Guide, 12/29/04
- Pulmonary
Hypertension, November 2004 - Medscape, 12/20/04
- Sildenafil May Be
Effective for Pulmonary Arterial Hypertension - Medscape, 10/28/04
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FDA Grants Orphan Drug Designation for Ambrisentan, Treatment for Pulmonary
Arterial Hypertension - Doctor's Guide, 8/3/04
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New Pulmonary Hypertension Guideline Challenges Use of Calcium Channel
Blockers - Doctor's Guide, 7/13/04
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Significant Benefit With Sildenafil in Primary Pulmonary Hypertension -
Doctor's Guide, 4/28/04
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Inhaled Iloprost Demonstrates Long-term Benefit In Pulmonary Hypertension
- Doctor's Guide, 10/6/03
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Fasudil Beneficial for Pulmonary Hypertension Patients - Doctor's Guide,
10/1/03
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Medical Therapy for Pulmonary Arterial Hypertension Increases Need for Early
Detection - Doctor's Guide, 7/14/03
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Potential New Treatment For Pulmonary Hypertension In Sickle Cell Patients
- Intelihealth, 6/26/03
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Oral Beraprost Sodium May Improve Survival in Chronic Thromboembolic
Pulmonary Hypertension - Doctor's Guide, 6/11/03
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No Impact On Ocular Health With High-Dose Sildenafil For Pulmonary
Hypertension - Doctor's Guide, 5/7/03
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Primary Pulmonary Hypertension Abnormalities Correlate With Disease Severity
- Doctor's Guide, 4/3/03
- Intravascular
Ultrasound Best to Identify Pulmonary Hypertension - Medscape, 3/25/03
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Pulmonary Endarterectomy Can Be Curative for Primary Pulmonary Hypertension
- Doctor's Guide, 2/2/03
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Additional Remodulin (Treprostinil) Efficacy and Safety Data Published -
Doctor's Guide, 1/24/03
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Primary Pulmonary Hypertension Improves with Chronic Trepostinil -
Doctor's Guide, 11/22/02
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Monitor Liver Functioning In Pulmonary Arterial Hypertension Patients Taking
Bosentan - Doctor's Guide, 11/5/02
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Viagra (Sildenafil) May Improve Exercise Tolerance in Patients with
Pulmonary Hypertension - Doctor's Guide, 9/20/02
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Sildenafil Alleviates Pulmonary Hypertension - Doctor's Guide, 9/19/02
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Severe Pulmonary Hypertension Responds Well To Inhaled Iloprost -
Doctor's Guide, 8/1/02
- Inhaled Iloprost
Relieves Symptoms of Severe Pulmonary Hypertension - Medscape, 8/1/02
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Sildenafil (Viagra) Effective In Treating Pulmonary Hypertension -
Doctor's Guide, 6/10/02
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Valve Surgeries: Inhaled Prostacyclin Aids Pulmonary Hypertension -
Doctor's Guide, 3/21/02
- Intravascular Ultrasound
Helps to Pinpoint Pulmonary Emboli - Doctor's Guide, 1/24/02
- Tracleer (Bosentan), Oral
Treatment For Pulmonary Arterial Hypertension, Available In US -
Doctor's Guide, 12/5/01
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FDA Approves Important New Therapy For Rare But Fatal Disorder -
Intelihealth, 11/21/01
- FDA Approves Tracleer
(Bosentan) Tablets for Pulmonary Arterial Hypertension - Doctor's Guide,
11/21/01
- Treprostinil (Remodulin)
Improves Quality Of Life In Some Patients With Pulmonary Arterial
Hypertension - Doctor's Guide, 11/19/01
- Hepatopulmonary Syndrome
And Portopulmonary Hypertension - Doctor's Guide, 11/12/01
- First Oral Drug
[bosentan] for Deadly Lung Disease - WebMD, 10/5/01
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Dual Antagonist Promising In Pulmonary Hypertension - Doctor's Guide,
10/5/01
- Viagra (Sildenafil) Used
to Treat Pulmonary Hypertension - Doctor's Guide, 9/25/01
- FDA Advisory Committee
Recommends Approval of Remodulin For Pulmonary Arterial Hypertension -
Doctor's Guide, 8/10/01
- Prostacyclin (Iloprost)
Aerosol Feasible Option For Children With Pulmonary Hypertension -
Doctor's Guide, 5/31/01
- British Doctors Use Viagra
(Sildenafil) to Treat Pulmonary Hypertension - Doctor's Guide, 5/31/01
- Sildenafil (Viagra) May
Help Patients With Pulmonary Hypertension - Doctor's Guide, 5/23/01 -
"sildenafil (Viagra), given intravenously, causes
pulmonary vasodilation while reducing pulmonary vascular resistance and
increasing cardiac output"
- Transplantation Remains
Valuable Option For End-Stage Pulmonary Hypertension - Doctor's Guide,
1/30/01
- Bosentan Increases
Exercise Function In Patients With Pulmonary Hypertension - Doctor's
Guide, 11/14/00
- Hearing Loss A Threat To
Children Who Survive Persistent Pulmonary Hypertension - Doctor's Guide,
8/14/00
- Increased Use Of
Fenfluramine Linked To Increased Pulmonary Hypertension - Doctor's
Guide, 3/15/00
- Surgery Benefits Chronic
Thromboembolic Pulmonary Hypertension Patients - Doctor's Guide, 8/20/99
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