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Phytoestrogen

• phytoestrogens at Amazon.com

Related Topics:

• isoflavones / red clover / bioflavonoids / phytochemicals / estrogen / aromatization / DIM / I3C / cruciferous vegetables / antioxidants / soy / carotenoids

News & Research:

• Selective Estrogen Receptor Modulators for BPH - Medscape, 10/17/13 - "Many epidemiological and experimental researches have shown that dietary estrogens are beneficial to men's health.[29,31,32] This may be evident from the fact that men living in Western nations have higher incidence of prostate cancer and BPH, plausibly because of their lower dietary phytoestrogen intake, as compared with their counterparts in Asian countries.[33–35] Many of these phytoestrogens are found to display ERβ receptor selectivity, especially compounds whose core structures have isoflavone or flavones group. Genistein, a naturally occurring SERM which shows 22-fold selectivity for ERβ, is an isoflavone usually found in soy ... Our in vivo studies in rat[3] indicated that irrespective of the molecular structure and mechanism of action, the SERMs universally and significantly reduce prostate weight. This response was better in combination with a 5α-reductase inhibitor, finasteride. We found that the ventral prostate of adult mature rats receiving tamoxifen, BP and ormeloxifene each at 1.0 mg kg−1 dose for 21 days regressed significantly by 37%, 32%, 36% respectively" - Note:  It's a nine page article.  I was disappointed that it didn't get in to aromatase inhibitors such as Femara (letrozole).  See genistein at Amazon.com.
  • Letrozole - Steroidal.com - "Letrozole (Femara) belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as selective estrogen receptor modulators (SERMs), such as Nolvadex and Clomid. AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control"
• Soy-based formula? Neonatal plant estrogen exposure leads to adult infertility in female mice - Science Daily, 5/2/12 - "A paper published May 2 in Biology of Reproduction describes the effects of brief prenatal exposure to plant estrogens on the mouse oviduct, modeling the effects of soy-based baby formula on human infants. The results suggest that exposure to estrogenic chemicals in the womb or during childhood has the potential to affect a woman's fertility as an adult, possibly providing the mechanistic basis for some cases of unexplained female infertility ... part of the National Institutes of Health, previously demonstrated that neonatal exposure to the plant estrogen genistein results in complete infertility in female adult mice. Causes of infertility included failure to ovulate, reduced ability of the oviduct to support embryo development before implantation, and failure of the uterus to support effective implantation of blastocyst-stage embryos ... The team now reports that neonatal exposure to genistein changes the level of immune response in the mouse oviduct, known as mucosal immune response. Some of the immune response genes were altered beginning from the time of genistein treatment, while others were altered much later, when the mouse was in early pregnancy. Together, those changes led to harmfully altered immune responses and to compromised oviduct support for preimplantation embryo development, both of which would likely contribute to infertility ... estrogenic chemical exposure to the female fetus, infant, child, and adolescent all have potential impacts on mucosal immunity in the reproductive tract and, therefore, on adult fertility. The authors present the view that limiting such exposures, including minimizing use of soy-based baby formula, is a step toward maintaining female reproductive health"
• Plant compound reduces breast cancer mortality, study suggests - Science Daily, 9/13/11 - "The most important type of phytoestrogens in our Western diet are lignans, which are contained in seeds, particularly flaxseeds, as well as in wheat and vegetables. In the bowel, these substances are turned into enterolactone, which is absorbed by the mucous tissue and which was determined by the Heidelberg researchers as a biomarker in the patients' blood ... Compared to the study subjects with the lowest enterolactone levels, the women with the highest blood levels of this biomarker had an approximately 40 percent lower mortality risk ... Another observation that may be interpreted in this direction is that Asian women are less frequently affected by breast cancer. Their soy-rich diet contains large amounts of another type of phytoestrogens, isoflavones. On the other hand, scientists fear that isoflavones might imitate the growth-promoting properties of real hormones and, thus, accelerate hormone-dependent tumors such as breast cancer and prostate cancer. "It has not yet been finally determined whether lignans in the body imitate the hormone effect or, on the contrary, counteract it,""
• Plant Estrogen May Cut Breast Cancer - WebMD, 3/20/07 - "A diet rich in estrogen-like compounds found in flaxseed, tea, and many plants may help curb breast cancer after menopause ... Women with the highest lignan intake were 17% less likely to be diagnosed with breast cancer during the study than those with the lowest intake"
• More support for soy's protection against prostate cancer - Nutra USA, 2/13/06 - "High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The odds ratio (OR) [the risk compared to a standard of 1.00] comparing the highest to the lowest quartile of intake was 0.74"
• Veggies in Diet May Cut Lung Cancer Risk - WebMD, 9/27/05 - "the people who consumed the highest amount of phytoestrogens from food had nearly half the lung cancer risk as those with the lowest phytoestrogen intake from food" [Abstract]
• Supplements for Menopausal Symptoms (Soy and Red Clover Isoflavones, Black Cohosh, and Progesterone Cream) review - ConsumerLab.com, 8/2/05
• Phytoestrogens May Not Prevent Breast Cancer - WebMD, 2/4/04
• Phytoestrogens May Shield Against Endometrial Cancer - Natural Foods Merchandiser, 11/03
• Phytoestrogen review - ConsumerLab.com, 7/16/02
• Soy and Health: What's the Scoop? Most Recent Addition to Soy Research Shows Lower Breast Cancer Risk - WebMD, 12/21/00
• Phytochemicals: Nutrients Whose Time Has Come - Nutrition Science News, 7/00

Abstracts:

• Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress - Phytother Res. 2019 Nov 20 - "Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant-derived molecules possessing various degrees of estrogen-like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism" - See phytoestrogens at Amazon.com.
• Breast development in the first 2 years of life: an association with soy-based infant formulas - J Pediatr Gastroenterol Nutr. 2008 Feb;46(2):191-5 - "We suggest that phytoestrogens impose a preserving effect on breast tissue that is evolved in early infancy, leading eventually to a slower waning of infantile breast tissue"
• Exposure to the phytoestrogen daidzein attenuates apomorphine-induced penile erection concomitant with plasma testosterone level reduction in dose and time-related manner in adult rats - Urology. 2007 Sep;70(3):613-7 - "The phytoestrogen daidzein has the potential to adversely affect erectile function in a dose and time-related manner that is at least partly attributable to androgen deficiency. These findings implicate that phytoestrogens, especially isoflavones, if overconsumed for a long period, might be a novel risk factor for erectile dysfunction"
• Phytoestrogens and indicators of breast cancer prognosis - Nutr Cancer. 2006;56(1):3-10 - "In women with higher intakes of phytoestrogens, there was a 32% reduction in the odds of being diagnosed with any stage of cancer other than stage 1 (95% confidence interval, CI = 0.49-0.93; P = 0.02), a 38% reduction in odds of being diagnosed with positive lymphovascular invasion (95% CI = 0.40-0.95; P = 0.03), and a 66% increase in the odds of being diagnosed with a positive progesterone receptor"
• Dietary Phytoestrogen Intake Is Associated with Reduced Colorectal Cancer Risk - J Nutr. 2006 Dec;136(12):3046-3053 - "Dietary lignan intake was associated with a significant reduction in colorectal cancer risk [OR (T3 vs. T1) = 0.73; 95% CI: 0.56, 0.94], as was isoflavone intake [OR (T3 vs. T1) = 0.71"
• Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer - Prostate. 2006 Aug 18 - "Our study provides strong evidence that high intake of phytoestrogens substantially reduce prostate cancer risk among men with specific polymorphic variation in the promoter region of the estrogen receptor-beta gene"
• Dietary phytoestrogens and lung cancer risk - JAMA. 2005 Sep 28;294(12):1493-504
• Phytoestrogen supplement use by women - J Nutr 2003 Jun;133(6):1983S-6S - "Until safety with respect to breast cancer is established, phytoestrogen supplements should not be recommended, particularly for women at high risk of breast cancer"