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Home > Anti-aging Research > Phytoestrogen


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  • Selective Estrogen Receptor Modulators for BPH - Medscape, 10/17/13 - "Many epidemiological and experimental researches have shown that dietary estrogens are beneficial to men's health.[29,31,32] This may be evident from the fact that men living in Western nations have higher incidence of prostate cancer and BPH, plausibly because of their lower dietary phytoestrogen intake, as compared with their counterparts in Asian countries.[33–35] Many of these phytoestrogens are found to display ERβ receptor selectivity, especially compounds whose core structures have isoflavone or flavones group. Genistein, a naturally occurring SERM which shows 22-fold selectivity for ERβ, is an isoflavone usually found in soy ... Our in vivo studies in rat[3] indicated that irrespective of the molecular structure and mechanism of action, the SERMs universally and significantly reduce prostate weight. This response was better in combination with a 5α-reductase inhibitor, finasteride. We found that the ventral prostate of adult mature rats receiving tamoxifen, BP and ormeloxifene each at 1.0 mg kg−1 dose for 21 days regressed significantly by 37%, 32%, 36% respectively" - Note:  It's a nine page article.  I was disappointed that it didn't get in to aromatase inhibitors such as Femara (letrozole).  See genistein at Amazon.com.
    • Letrozole - Steroidal.com - "Letrozole (Femara) belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as selective estrogen receptor modulators (SERMs), such as Nolvadex and Clomid. AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control"
  • Soy-based formula? Neonatal plant estrogen exposure leads to adult infertility in female mice - Science Daily, 5/2/12 - "A paper published May 2 in Biology of Reproduction describes the effects of brief prenatal exposure to plant estrogens on the mouse oviduct, modeling the effects of soy-based baby formula on human infants. The results suggest that exposure to estrogenic chemicals in the womb or during childhood has the potential to affect a woman's fertility as an adult, possibly providing the mechanistic basis for some cases of unexplained female infertility ... part of the National Institutes of Health, previously demonstrated that neonatal exposure to the plant estrogen genistein results in complete infertility in female adult mice. Causes of infertility included failure to ovulate, reduced ability of the oviduct to support embryo development before implantation, and failure of the uterus to support effective implantation of blastocyst-stage embryos ... The team now reports that neonatal exposure to genistein changes the level of immune response in the mouse oviduct, known as mucosal immune response. Some of the immune response genes were altered beginning from the time of genistein treatment, while others were altered much later, when the mouse was in early pregnancy. Together, those changes led to harmfully altered immune responses and to compromised oviduct support for preimplantation embryo development, both of which would likely contribute to infertility ... estrogenic chemical exposure to the female fetus, infant, child, and adolescent all have potential impacts on mucosal immunity in the reproductive tract and, therefore, on adult fertility. The authors present the view that limiting such exposures, including minimizing use of soy-based baby formula, is a step toward maintaining female reproductive health"
  • Plant compound reduces breast cancer mortality, study suggests - Science Daily, 9/13/11 - "The most important type of phytoestrogens in our Western diet are lignans, which are contained in seeds, particularly flaxseeds, as well as in wheat and vegetables. In the bowel, these substances are turned into enterolactone, which is absorbed by the mucous tissue and which was determined by the Heidelberg researchers as a biomarker in the patients' blood ... Compared to the study subjects with the lowest enterolactone levels, the women with the highest blood levels of this biomarker had an approximately 40 percent lower mortality risk ... Another observation that may be interpreted in this direction is that Asian women are less frequently affected by breast cancer. Their soy-rich diet contains large amounts of another type of phytoestrogens, isoflavones. On the other hand, scientists fear that isoflavones might imitate the growth-promoting properties of real hormones and, thus, accelerate hormone-dependent tumors such as breast cancer and prostate cancer. "It has not yet been finally determined whether lignans in the body imitate the hormone effect or, on the contrary, counteract it,""
  • Plant Estrogen May Cut Breast Cancer - WebMD, 3/20/07 - "A diet rich in estrogen-like compounds found in flaxseed, tea, and many plants may help curb breast cancer after menopause ... Women with the highest lignan intake were 17% less likely to be diagnosed with breast cancer during the study than those with the lowest intake"
  • More support for soy's protection against prostate cancer - Nutra USA, 2/13/06 - "High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The odds ratio (OR) [the risk compared to a standard of 1.00] comparing the highest to the lowest quartile of intake was 0.74"
  • Veggies in Diet May Cut Lung Cancer Risk - WebMD, 9/27/05 - "the people who consumed the highest amount of phytoestrogens from food had nearly half the lung cancer risk as those with the lowest phytoestrogen intake from food" [Abstract]
  • Supplements for Menopausal Symptoms (Soy and Red Clover Isoflavones, Black Cohosh, and Progesterone Cream) review - ConsumerLab.com, 8/2/05
  • Phytoestrogens May Not Prevent Breast Cancer - WebMD, 2/4/04
  • Phytoestrogens May Shield Against Endometrial Cancer - Natural Foods Merchandiser, 11/03
  • Phytoestrogen review - ConsumerLab.com, 7/16/02
  • Soy and Health: What's the Scoop? Most Recent Addition to Soy Research Shows Lower Breast Cancer Risk - WebMD, 12/21/00
  • Phytochemicals: Nutrients Whose Time Has Come - Nutrition Science News, 7/00