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Anti-aging Research > Huperzine A
Huperzine A/Huperzia
Specific Recommendations:
News and Research:
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Huperzine A provides seizure protection in genetic epilepsy models - Science
Daily, 11/10/16 - "In particular, huperzine A shows
potential for protecting against febrile seizures, which are a feature of both
Dravet syndrome, a severe form of childhood epilepsy, and a related condition,
GEFS+ (genetic epilepsy with febrile seizures plus ... The protection observed
in normal mice suggest huperzine A might also increase seizure resistance in
other forms of treatment-resistant epilepsy. While these results are
encouraging, further research will be required to determine suitability of using
huperzine A as a clinical treatment for epilepsy ... Huperzine A is thought to
work, in part, by inhibiting the enzyme acetylcholinesterase, which breaks down
the neurotransmitter acetylcholine. Thus, huperzine A can increase the levels of
acetylcholine in the brain" - See
Huperzine at Amazon.com
 .
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Natural
Alzheimer's-fighting compound created inexpensively in lab - Science Daily,
8/25/11 - "Until now, researchers have only been able to
derive small amounts of the compound directly from the Huperzia serrata plant,
or had to resort to lengthy and cumbersome methods to synthesize it in the lab
... Now researchers at Yale have developed a practical and cost-effective method
to synthesize huperzine A in the lab. The process requires just eight steps and
produces a yield of 40 percent. Previously, the best synthetic techniques had
required twice as many steps and achieved yields of only two percent ... In
addition, the Herzon lab and the firm are working with the U.S. Army, which is
interested in huperzine A's potential in blocking the effects of chemical
warfare agents ... Other Alzheimer's treatments based on enzyme inhibitors are
currently prescribed in the U.S., but huperzine A binds better, is more easily
absorbed by the body and last longer in the body than other treatments ... We
believe huperzine A has the potential to treat a range of neurologic disorders
more effectively than the current options available"
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Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's
Disease - Science Daily, 4/17/08 - "Existing
evidence suggests that patients with Alzheimer's disease who have taken
Huperzine A have improved general cognitive function, global clinical
status, functional performance and reduced behavioural disturbance compared
to patients taking placebos"
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There's Hope in the Drug Pipeline [for Alzheimer's] - US News, 12/11/06
- "A compound called huperzine A seems to combine
some memory-saving effects of drugs like Aricept and Namenda with an ability
to protect neurons from beta amyloid. It's currently being tested for safety
and effectiveness in people"
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Ginkgo Biloba
and Huperzine A -- Memory Enhancers - ConsumerLab.com, 12/5/05 -
"CL found significant amounts of lead in supplements
made with a form of ginkgo, while those made with another form did not"
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Complementary and
Integrative Approaches to Dementia - Medscape, 7/5/05 -
"Huperzine A is a potent plant-based alkaloid with
reversible acetylcholinesterase-inhibitory"
- Ginkgo Biloba
Analysis: Few Pills Pass Quality Test - WebMD, 4/21/03 -
"ConsumerLab
also tested four off-the-shelf brands of
huperzine A ... One of these products --
Solaray Dietary Supplement -- contained unacceptably high levels of lead"
- Using Complementary
Treatments - PsychiatricTimes.com, 11/15/02 -
"Research has shown huperzine A to be a selective
and reversible inhibitor of acetylcholinesterase. It also has been shown to
lessen neuronal toxicity caused by glutamate. Initial small investigations
reported improvement in cognitive functions of subjects with AD"
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The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his recommendations includes
lycopene, gamma tocopherol,
Huperzine, SAMe,
folic acid,
carnosine, glutathione, DMAE,
Huperzine A, probiotics, MSM,
secretagogues,
arginine pyroglutamate, IP-6,
bioflavonoid formulas and grape skin/seed
extracts"
Abstracts:
- Evaluation of the
in vitro and in vivo metabolic pathway and cytochrome P450
inhibition/induction profile of Huperzine A - Biochem Biophys Res Commun.
2016 Oct 15 - "Huperzine A (HupA), one of the
reversible and selective acetylcholinesterase inhibitors derived from
Chinese herb Huperzia Serrata, possesses affirmative action of ameliorating
cognitive dysfunction of Alzheimer's disease. Up to now, the effects of HupA
on human cytochrome P450s (CYPs) have not been fully elucidated ... These
results suggest that HupA is substantially excreted by kidney unchanged
rather than metabolized by human liver, and is unlikely to cause clinically
relevant drug-drug interaction (DDI) when co-administrated with drugs that
are metabolized by CYP isoenzyme system" - See
huperzine at Amazon.com.
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Alleviation of chronic pain following rat spinal cord compression injury
with multimodal actions of huperzine A - Proc Natl Acad Sci U S A. 2013
Feb - "Compared with controls, HUP-A treatment
demonstrates significant analgesic effects in both regimens. SCI rats
manifested no drug tolerance following repeated bolus i.p. or chronic
intrathecal HUP-A dosing. The pain-ameliorating effect of HUP-A is
cholinergic dependent. Relative to vehicle treatment, HUP-A administration
also reduced neural inflammation, retained higher numbers of
calcium-impermeable GluR2-containing AMPA receptors, and prevented Homer1a
up-regulation in dorsal horn sensory neurons. Therefore, HUP-A may provide
safe and effective management for chronic postneurotrauma pain by
reestablishing homeostasis of sensory circuits"
- The
anti-inflamm-aging and hepatoprotective effects of huperzine A in
D-galactose-treated rats - Mech Ageing Dev. 2013 Jan 8 -
"Oxidative stress contributes to a chronic inflammatory process referred to
as "inflamm-aging". Acetylcholinesterase inhibitors (AChEI) can enhance
cholinergic transmission and act as anti-inflammatory agents via
immunocompetent cells expressing α-7 acetylcholine receptors (AChR) ...
Huperzine A exhibited protective effects against D-gal-induced
hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the
activation of the cholinergic anti-inflammatory pathway. The huperzine A
mechanism might be involved in the inhibition of DAMPs-mediated NF-κB
nuclear localization and activation"
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Role of
Huperzine A in the Treatment of Alzheimer's Disease - Ann Pharmacother.
2009 Feb 24 - "AD is a progressive neurodegenerative
brain disorder for which there is no cure; available therapies only decrease
cognitive decline. Huperzine A, an alkaloid derived from Chinese club moss
(H. serrata), acts as a selective inhibitor of acetylcholinesterase and may
also display neuroprotective properties. Preliminary data suggest that
huperzine A may improve cognition; studies ranging from 8 to 12 weeks have
found improvements in the Mini-Mental State Examination score of 1-5 points
... Although use of huperzine A has shown promising results in patients with
AD, data supporting its use are limited by weak study design"
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