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Home > Anti-aging Research > Huperzine A

Huperzine A/Huperzia

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News and Research:

  • Huperzine A provides seizure protection in genetic epilepsy models - Science Daily, 11/10/16 - "In particular, huperzine A shows potential for protecting against febrile seizures, which are a feature of both Dravet syndrome, a severe form of childhood epilepsy, and a related condition, GEFS+ (genetic epilepsy with febrile seizures plus ... The protection observed in normal mice suggest huperzine A might also increase seizure resistance in other forms of treatment-resistant epilepsy. While these results are encouraging, further research will be required to determine suitability of using huperzine A as a clinical treatment for epilepsy ... Huperzine A is thought to work, in part, by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. Thus, huperzine A can increase the levels of acetylcholine in the brain" - See Huperzine at Amazon.com.
  • Natural Alzheimer's-fighting compound created inexpensively in lab - Science Daily, 8/25/11 - "Until now, researchers have only been able to derive small amounts of the compound directly from the Huperzia serrata plant, or had to resort to lengthy and cumbersome methods to synthesize it in the lab ... Now researchers at Yale have developed a practical and cost-effective method to synthesize huperzine A in the lab. The process requires just eight steps and produces a yield of 40 percent. Previously, the best synthetic techniques had required twice as many steps and achieved yields of only two percent ... In addition, the Herzon lab and the firm are working with the U.S. Army, which is interested in huperzine A's potential in blocking the effects of chemical warfare agents ... Other Alzheimer's treatments based on enzyme inhibitors are currently prescribed in the U.S., but huperzine A binds better, is more easily absorbed by the body and last longer in the body than other treatments ... We believe huperzine A has the potential to treat a range of neurologic disorders more effectively than the current options available"
  • Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's Disease - Science Daily, 4/17/08 - "Existing evidence suggests that patients with Alzheimer's disease who have taken Huperzine A have improved general cognitive function, global clinical status, functional performance and reduced behavioural disturbance compared to patients taking placebos"
  • There's Hope in the Drug Pipeline [for Alzheimer's] - US News, 12/11/06 - "A compound called huperzine A seems to combine some memory-saving effects of drugs like Aricept and Namenda with an ability to protect neurons from beta amyloid. It's currently being tested for safety and effectiveness in people"
  • Ginkgo Biloba and Huperzine A -- Memory Enhancers - ConsumerLab.com, 12/5/05 - "CL found significant amounts of lead in supplements made with a form of ginkgo, while those made with another form did not"
  • Complementary and Integrative Approaches to Dementia - Medscape, 7/5/05 - "Huperzine A is a potent plant-based alkaloid with reversible acetylcholinesterase-inhibitory"
  • Ginkgo Biloba Analysis: Few Pills Pass Quality Test - WebMD, 4/21/03 - "ConsumerLab also tested four off-the-shelf brands of huperzine A ... One of these products -- Solaray Dietary Supplement -- contained unacceptably high levels of lead"
  • Using Complementary Treatments - PsychiatricTimes.com, 11/15/02 - "Research has shown huperzine A to be a selective and reversible inhibitor of acetylcholinesterase. It also has been shown to lessen neuronal toxicity caused by glutamate. Initial small investigations reported improvement in cognitive functions of subjects with AD"
  • The Wizard is Oz - Life Extension Magazine, 11/01 - "Best-selling author and nutritional guru to the rich and famous, Oz Garcia is singing the praises of the Life Extension Foundation and its products in his newest book, The Healthy High Tech Body, published in September 2001 ... Supplements at the top of Garcia's list of recommendations ... DHA ... NADH ... Alpah Lipoic Acid ... Acetyl-L-Carnitine ... An expanded list of his recommendations includes lycopene, gamma tocopherol, Huperzine, SAMe, folic acid, carnosine, glutathione, DMAE, Huperzine A, probiotics, MSM, secretagogues, arginine pyroglutamate, IP-6, bioflavonoid formulas and grape skin/seed extracts"


  • Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A - Biochem Biophys Res Commun. 2016 Oct 15 - "Huperzine A (HupA), one of the reversible and selective acetylcholinesterase inhibitors derived from Chinese herb Huperzia Serrata, possesses affirmative action of ameliorating cognitive dysfunction of Alzheimer's disease. Up to now, the effects of HupA on human cytochrome P450s (CYPs) have not been fully elucidated ... These results suggest that HupA is substantially excreted by kidney unchanged rather than metabolized by human liver, and is unlikely to cause clinically relevant drug-drug interaction (DDI) when co-administrated with drugs that are metabolized by CYP isoenzyme system" - See huperzine at Amazon.com.
  • Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A - Proc Natl Acad Sci U S A. 2013 Feb - "Compared with controls, HUP-A treatment demonstrates significant analgesic effects in both regimens. SCI rats manifested no drug tolerance following repeated bolus i.p. or chronic intrathecal HUP-A dosing. The pain-ameliorating effect of HUP-A is cholinergic dependent. Relative to vehicle treatment, HUP-A administration also reduced neural inflammation, retained higher numbers of calcium-impermeable GluR2-containing AMPA receptors, and prevented Homer1a up-regulation in dorsal horn sensory neurons. Therefore, HUP-A may provide safe and effective management for chronic postneurotrauma pain by reestablishing homeostasis of sensory circuits"
  • The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats - Mech Ageing Dev. 2013 Jan 8 - "Oxidative stress contributes to a chronic inflammatory process referred to as "inflamm-aging". Acetylcholinesterase inhibitors (AChEI) can enhance cholinergic transmission and act as anti-inflammatory agents via immunocompetent cells expressing α-7 acetylcholine receptors (AChR) ... Huperzine A exhibited protective effects against D-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation"
  • Role of Huperzine A in the Treatment of Alzheimer's Disease - Ann Pharmacother. 2009 Feb 24 - "AD is a progressive neurodegenerative brain disorder for which there is no cure; available therapies only decrease cognitive decline. Huperzine A, an alkaloid derived from Chinese club moss (H. serrata), acts as a selective inhibitor of acetylcholinesterase and may also display neuroprotective properties. Preliminary data suggest that huperzine A may improve cognition; studies ranging from 8 to 12 weeks have found improvements in the Mini-Mental State Examination score of 1-5 points ... Although use of huperzine A has shown promising results in patients with AD, data supporting its use are limited by weak study design"