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magnesium is inversely associated with coronary artery calcification in the
Genetics of Atherosclerotic Disease (GEA) study - Nutr J. 2016 Mar
1;15(1):22 - "After full adjustment, subjects in the
highest quartile of serum magnesium had 48 % lower odds of hypertension (p =
0.028), 69 % lower odds of DM2 (p = 0.003), and 42 % lower odds of CAC score > 0
(p = 0.016) compared to those with the lowest serum magnesium. The analyses also
showed that a 0.17 mg/dL (1SD) increment in serum magnesium was independently
associated with 16 % lower CAC" - [Nutra
USA] - See
Jarrow Formulas, MagMind at Amazon.com.
magnesium is associated with coronary artery calcification in a Korean
population at low risk for cardiovascular disease - Nutr Metab Cardiovasc
Dis. 2015 Aug 13 - "low < 1.9 mg/dL (n = 931), normal =
1.9-2.3 mg/dL (n = 32,341), and high > 2.3 mg/dL ... The odds ratio for CAC in
the low serum magnesium group compared to the normal group was 2.10 (1.40-3.15,
P < 0.001) ... CONCLUSION: Low serum magnesium level is associated with CAC in a
Korean population at low risk for cardiovascular disease. Further studies are
needed to generalize this finding and to verify the causal relationship between
low serum magnesium and CAC" - See
magnesium supplements at Amazon.com.
Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine
Model of Extraosseous Calcification - Nutrients. 2015 Aug 18 - "MK-7
supplementation inhibited cardiovascular calcification and decreased aortic
alkaline phosphatase tissue concentrations. Furthermore, MK-7 supplementation
increased aortic MGP messenger ribonucleic acid (mRNA) expression (10-fold; p <
0.05). CKD-induced arterial hypertension with secondary myocardial hypertrophy
and increased elastic fiber breaking points in the arterial tunica media did not
change with MK-7 supplementation. Our results show that high-dose MK-7
supplementation inhibits the development of cardiovascular calcification. The
protective effect of MK-7 may be related to the inhibition of secondary
mineralization of damaged vascular structures" - See MK-7 at Amazon.com.
Vitamin D Inadequacy Accelerates Calcification and Osteoblast-Like Cell
Formation in the Vascular System of LDL Receptor Knockout and Wild-Type Mice
- J Nutr. 2014 Mar 19 - "Vitamin D insufficiency is
highly associated with cardiovascular morbidity and mortality. We have
demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR-/-)
mice fed a diet low in vitamin D ... Collectively, the findings imply low
vitamin D status as a causal factor for vascular calcification and
atherosclerosis" - See
vitamin D at Amazon.com.
concentrations of serum phosphorus within the normal range could be associated
with less calcification of the coronary artery in Koreans with normal renal
function - Am J Clin Nutr. 2011 Oct 26 - "Serum
phosphorus concentrations are associated with an increased risk of
cardiovascular disease (CVD) and mortality in patients with renal insufficiency.
This association has also been reported in Western individuals without chronic
kidney disease (CKD) ... Compared with the group with a serum phosphorus
concentration ≤3.3 mg/dL, the OR of an Agatston score >100 in individuals with a
serum phosphorus concentration >3.6 to ≤3.9 mg/dL was 3.89 (95% CI: 1.43, 10.63;
P = 0.008) and in those with a serum phosphorus concentration >3.9 mg/dL was
3.17 (95% CI: 1.19, 8.41; P = 0.021) ... A lower concentration of serum
phosphorus within the normal range could be associated with less calcification
of the coronary artery in Koreans with normal renal function"
Deficiency and Coronary Artery Calcification in Subjects with Type 1 Diabetes
- Diabetes Care. 2010 Oct 26 - "Vitamin D deficiency
independently predicts prevalence and development of coronary calcification, a
marker of coronary artery plaque burden, in individuals with type 1 diabetes"
vitamin D at Amazon.com.
Long-Term Marathon Running Linked With Increased Coronary Calcification
- Medscape, 3/22/10 - "Compared with controls,
marathoners had significantly more calcified plaque volume--274 mm3 for the
marathoners and 169 mm3 for the controls--and higher calcium scores and
noncalcified plaque volumes, although the latter two measures did not reach
Study strengthens Vitamin K1's heart benefits - Nutra USA, 5/26/09 -
"Subjects receiving a daily vitamin K1 plus
multivitamin supplement experienced 6 per cent less progression of coronary
artery calcification (CAC), or hardening of the arteries that leads to
atherosclerosis and cardiovascular disease" - [Abstract]
vitamin K at Amazon.com.
ahead, sleep in — it’s good for the heart - msnbc.com, 12/23/08 -
"About 12 percent of the people in the study
developed artery calcification during the five-year study period. Among
those who had slept less than five hours a night, 27 percent had developed
artery calcification ... That dropped to 11 percent among those who slept
five to seven hours, and to 6 percent among those who slept more than seven
hours a night"
Vitamin K2 linked to better heart health - NutraUSA, 9/10/08 -
"When the intakes of K1 and K2 were divided into
four groups from the lowest to highest, no association was found between K1
intakes and calcification. However, high consumption of K2 (about 45
micrograms per day) was associated with 20 per cent decreased coronary
calcification, compared with low consumption of K2 (about 18micrograms per
day)" - See
vitamin K at Amazon.com.
Vitamin K may reverse arterial calcification - Nutra USA, 4/3/07 -
"using 10-week old male Wistar Kyoto rats ...
high-vitamin K intake (both K1 and K2) not only blocked the progress of
further calcium accumulation but also lead to a greater than 37 per cent
reduction of previously accumulated arterial calcium precipitates within six
News & Research:
Inflammation behind heart valve disease, research suggests - Science
Daily, 3/15/11 - "immune cells and a group of
inflammatory substances called leukotrienes can be found in calcified heart
valves. The most significant inflammation was seen in patients with the
narrowest valves on ultrasound examination. The researchers have also shown
in cell cultures that leukotrienes stimulate the calcification of heart
valve cells ... There are similarities between atherosclerosis
(calcification of the arteries) and aortic stenosis. However, lipid-lowering
medicines known as statins which are capable of preventing atherosclerosis
have proved ineffective in preventing calcification of the aortic valve ...
anti-inflammatory medication could be a future treatment for aortic
stenosis, and it would mean a lot to these patients, most of whom are
elderly, if we could slow the disease to the extent that they do not need
surgery" - See the "Alternative News" sections of my
Inflammation page and my C-Reactive
Protein page for ways to reduce it.
established between erectile dysfunction and calcified coronary arteries
- Science Daily, 6/1/10 - "men with ED had a 54
percent greater likelihood of having a high-risk CACS than men without ED.
The increased risk was similar to that of patients with a history of
hypertension and smoking"
Small Increases In Phosphorus Mean Higher Risk Of Heart Disease -
Science Daily, 115/09 - "Higher levels of phosphorus
in the blood are linked to increased calcification of the coronary arteries
-- a key marker of heart disease risk ... Even small increases in the blood
level of phosphorus predicted an increased risk of progressive CAC in these
apparently healthy adults ... The phosphorus-related increase in CAC was
comparable to that seen with traditional heart disease risk factors like
high blood pressure and high cholesterol"
Adiponectin Regulates Arterial Calcification - J Bone Miner Res. 2009
Mar 3 - "adiponectin inhibited osteoblastic
differentiation of CVSMCs via AdipoR1/p38 signaling pathway ... Our findings
firstly demonstrated that Adiponectin(-/-) mice developed arterial
calcification, and this could be attributed to the loss of inhibitory action
of adiponectin on osteoblastic differentiation of CVSMCs. It suggested that
adiponectin play a protective role against arterial calcification"
ACE-I/ARB treatment in type 1 diabetes patients with albuminuria is
associated with lower odds of progression of coronary artery calcification
- J Diabetes Complications. 2007 Sep-Oct;21(5):273-9 -
"coronary artery calcification (CAC) ... In backward
logistic regression, presence of albuminuria at baseline predicted
progression of CAC among subjects not treated with ACE-I/ARB [odds
ratio=4.06 ... Among the subjects with albuminuria, the odds of progression
was 62% lower (95% CI=88% decrease to 23% increase; P=.106) in those treated
with ACE-I/ARB ... Albuminuria is a significant independent risk factor for
CAC progression in young type 1 diabetes patients asymptomatic for CAD, and
ACE-I/ARB treatment is associated with substantially lower odds of CAC
- Shock Therapy
for Rotator Cuff - WebMD, 11/20/03
First Report of Calcification on Lateral Collateral Ligament - Doctor's
Cardiac Valve Calcification Predicts Mortality In Dialysis Patients -
Doctor's Guide, 1/16/03
Polycystic Ovaries Can Lead To Coronary Artery Calcification, Says
University Of Pittsburgh - Doctor's Guide, 4/29/02
- Study Says
Hormones May Be Heart Healthy - WebMD, 4/4/02
Hormone Replacement May Halve Rate of Breast Arterial Calcification -
Doctor's Guide, 4/4/02
Statins May Inhibit Calcium Growth on Aortic Valve in Elderly - Doctor's
Guide, 3/29/02 -
"People who take statins may have at least 60
percent less aortic valve calcium than people who do not take statins"
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