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Recent Longevity News for the week ending 1/24/18

Women run faster after taking newly developed supplement, study finds - Science Daily, 1/18/18 - "women who took a specially prepared blend of minerals and nutrients for a month saw their 3-mile run times drop by almost a minute ... DiSilvestro is working toward developing and selling a supplement, based on this and previous research. It's expected to cost between $35 and $40 for a month's supply. The study was supported by the Gatorade Sports Science Institute, but the company is not involved in the commercialization efforts ... The minerals in the study included forms of iron, copper and zinc along with two other nutrients -- carnitine (derived from an amino acid) and phosphatidylserine (made up of fatty acids and amino acids.)"

Prebiotics in infant formula could improve learning and memory and alter brain chemistry - Science Daily, 1/17/18 - "Starting on the second day of life, piglets were given a cow's milk-based infant formula supplemented with polydextrose (PDX), a synthetic carbohydrate with prebiotic activity, and galactooligosaccharide (GOS), a naturally occurring prebiotic. When the piglets were 25 days old, Fleming took them through several learning, memory, and stress tests. After 33 days, blood, brain, and intestinal tissues were collected for analysis ... Pigs fed PDX and GOS spent more time playing with new objects than pigs who didn't receive the prebiotic supplements. The preference for novel objects, an indication of natural curiosity, is a sign of healthy brain development and points towards positive development of learning and memory" - See probiotic products at Amazon.com.

Cycling Won't Sabotage a Man's Sex Life: Study - WebMD, 1/17/18 - "high-intensity cyclists logged better erectile function scores than low-intensity cyclists ... Also notably, cyclists did experience more than twice the incidence of scarring or narrowing in the urethra -- a condition known as urethral strictures -- compared to swimmers or runners. The condition can affect the flow of urine from the body. But cyclists' sexual and urinary health was comparable overall to the other athletes ... Urethral strictures "are such an uncommon event that I wouldn't keep people from riding," Breyer said"

Cycling Won't Sabotage a Man's Sex Life: Study - WebMD, 1/17/18 - "high-intensity cyclists logged better erectile function scores than low-intensity cyclists ... Also notably, cyclists did experience more than twice the incidence of scarring or narrowing in the urethra -- a condition known as urethral strictures -- compared to swimmers or runners. The condition can affect the flow of urine from the body. But cyclists' sexual and urinary health was comparable overall to the other athletes ... Urethral strictures "are such an uncommon event that I wouldn't keep people from riding," Breyer said"

A high-salt diet produces dementia in mice - Science Daily, 1/16/18 - "We discovered that mice fed a high-salt diet developed dementia even when blood pressure did not rise ... The scientists discovered that an impaired ability of cells lining blood vessels, called endothelial cells, reduced the production of nitric oxide, a gas normally produced by the endothelial cells to relax blood vessels and increase blood flow. To see if the biological effects of a high-salt diet could be reversed, Dr. Iadecola and colleagues returned some mice to a regular diet for four weeks and found that cerebral blood flow and endothelial function returned to normal"

Can Muesli help against arthritis? - Science Daily, 1/12/18 - 'We were able to show that a bacteria-friendly diet has an anti-inflammatory effect, as well as a positive effect on bone density' explains Dr. Mario Zaiss, who is leading the team behind the study. 'Our findings offer a promising approach for developing innovative therapies for inflammatory joint diseases as well as for treating osteoporosis, which is often suffered by women after the menopause. We are not able to give any specific recommendations for a bacteria-friendly diet at the moment, but eating muesli every morning as well as enough fruit and vegetables throughout the day helps to maintain a rich variety of bacterial species.' - See muesli at Amazon.com and probiotic products at Amazon.com.

Chronic inflammation causing loss of muscle mass - Science Daily, 1/11/18 - "Their findings show that CRP affects muscle cells' protein synthesis, that is, the generation of new proteins taking place in all living cells ... Muscles are our main protein depots. We saw that CRP interferes with the protein synthesis in the muscle cells, hence contributing to the loss of muscle mass ... A mechanism which explains the connection is of great significance for both preventive measures and drug development. What is interesting is that inflammaging is a process quietly at work. If we can tackle inflammaging in time, are we then able to postpone the development of a number of chronic diseases" - Note:  See my CRP and inflammation pages for ways to reduce it.

Mediterranean diet may help protect older adults from becoming frail - Science Daily, 1/11/18 - "a diet emphasizing primarily plant-based foods -- such as fruits and vegetables, whole grains, legumes, and nuts -- may help keep people healthy and independent as they age ... People who followed a Mediterranean diet the most were overall less than half as likely to become frail over a nearly four-year period compared with those who followed it the least ... Although older people who followed a Mediterranean diet had a lower risk of becoming frail, it's unclear whether other characteristics of the people who followed this diet may have helped to protect them"

Common pain reliever use during pregnancy linked to language delay in girls - Science Daily, 1/10/18 - "researchers from the Icahn School of Medicine at Mount Sinai found an elevated rate of language delay in girls at 30 months old born to mothers who used acetaminophen during pregnancy, but not in boys ... those who took acetaminophen more than six times in early pregnancy -- were nearly six times more likely to have language delay than girls born to mothers who did not take acetaminophen. These results are consistent with studies reporting decreased IQ and increased communication problems in children born to mothers who used more acetaminophen during pregnancy"

Green Leafy Vegetables Linked to Slower Cognitive Decline - Medscape, 1/8/18 - "The rate of decline among those who consumed 1 to 2 servings per day was the equivalent of being 11 years younger compared with those who rarely or never consumed green leafy vegetables ... Investigation of the nutrients for which green leafy vegetables are a rich or primary source indicated that higher food intakes of folate, phylloquinone, and lutein were each linearly associated with slower cognitive decline and appeared to account for the protective correlation of green leafy vegetables to cognitive change."

Female night shift workers may have increased risk of common cancers - Science Daily, 1/8/18 - "Overall, long-term night shift work among women increased the risk of cancer by 19 percent. When analyzing specific cancers, the researchers found that this population had an increased risk of skin (41 percent), breast (32 percent), and gastrointestinal cancer (18 percent) compared with women who did not perform long-term night shift work"

Repeated influenza vaccination helps prevent severe flu in older adults - Science Daily, 1/8/18 - "Repeated vaccination for influenza was highly effective in preventing severe and fatal infection caused by influenza in older adult ... The prevention of severe and fatal infection caused by influenza was observed mainly in patients who were vaccinated in both the current and previous seasons, which reinforces the recommendation of annual vaccination for influenza in older adults"

Abstracts from this week:

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension - Eur J Nutr. 2018 Jan 12 - "Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels" - [Nutra USA] - See chlorogenic acid at Amazon.com.

Vitamin B-6 and depressive symptomatology, over time, in older Latino adults - Nutr Neurosci. 2018 Jan 16:1-12 - "Suboptimal plasma PLP is associated with higher depressive symptomatology in older Hispanic of Puerto Rican descent and this appears to persist over time. Our data suggest that identification and treatment of vitamin B-6 deficiency may be a useful preventive approach in this population" - See Best Naturals Vitamin B-6 25 mg 250 Tablets at Amazon.com

Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders - Nutr Neurosci. 2018 Jan 16:1-11 - "We found that children with autism have more VA and VD deficiencies than control children, and VA and VD co-deficiency may exacerbate the symptoms of children with ASD"

Declining Health-Related Quality of Life in the U.S. - Am J Prev Med. 2018 Jan 12 - "variable proportions of this decline were attributable to medical (21.9%; obesity, cardiac disease, hypertension, arthritis, medical injury), economic (15.6%; financial crisis, job loss), substance use (15.3%; substance use disorder or marijuana use), mental health (13.1%; depression and anxiety disorders), and social (11.2%; partner, neighbor, or coworker problems) risks"

Association of Serum 25(OH) D Levels with Infarct Volumes and Stroke Severity in Acute Ischemic Stroke - J Nutr Health Aging. 2018;22(1):97-102 - "NIH Stroke Scale (NIHSS) score ... In conclusion, reduced serum 25(OH) D levels in acute ischemic stroke are an early predictor of larger volumes of ischemic tissue and worse neurological deficit (assessed by the NIHSS)" - See vitamin D at Amazon.com

Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial - J Am Coll Nutr. 2018 Jan 9:1-11 - "Significant reductions in weight (by 1.1%) and BMI were found in the resveratrol group compared to the placebo group" - See Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.

Docosahexaenoic acid prevents resistance to antiepileptic drugs in two animal models of drug-resistant epilepsy - Nutr Neurosci. 2018 Jan 16:1-9 - "lamotrigine (LTG) ... phenytoin (PHT) ... DHA removes the 'inherent resistance' of 6-Hz seizures to PHT and LTG, and prevents the development of pharmacodynamic tolerance to LTG in LTG-resistant kindled rats. DHA might have potential to be used as add-on therapy in patients with refractory epilepsy" - See docosahexaenoic acid at Amazon.com.

Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats - Brain Behav Immun. 2017 Oct;65:33-42 - "Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities ... Our findings suggest that MDD may hold a dysmetabolic component that responds to probiotic treatment. This finding has wide implications owing to the high metabolic comorbidity in MDD. Furthermore, the close association between depressive-like behaviour and cerebral T cell populations demonstrate lymphocyte-brain interactions as a promising future research area in the field of psychoneuroimmunology" - [Nutra USA] - See probiotic products at Amazon.com.

Neat Tech Stuff / "How 's":

Bonavita Metropolitan 8-Cup brewer - CNET, 1/21/18 - "The Bonavita Metropolitan might have a modest price but it makes surprisingly good coffee"

Health Focus (Cayenne/Capsicum):