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Recent Longevity News for the seven days ending 10/31/07. You should consult your doctor if you are taking any medications. San Diego is still standing but we took a serious hit. Over 25% of the county burned, over a half million people were evacuated and over 2,000 homes and businesses were destroyed. I was in an advisory evacuation area not a mandatory evacuation area. Rancho Bernardo was the hardest hit. I don't know where the Rancho Bernardo line starts but it has to be within a half mile of my house. My mail goes through the Rancho Bernardo post office. Seems like everyone I know knows someone that has lost a home. Several people I know were forced to evacuate their homes and went to friends houses miles away just to be forced to evacuate from there. Last Wednesday the news said we passed Katrina. I don't know if that makes it the largest disaster in US history or not. Despite closing down major sections of the major interstates and not having any reasonable detours, things went fairly smoothly. Seven people that died. Not to undermine their deaths but that seems low. Two of the deaths were a couple found in a burned home in Poway. It doesn't seem possible that they didn't get the reverse 911, their neighbors didn't notify them, they didn't see the fire coming, their smoke detectors didn't work, they didn't notice the smoke and they couldn't get out of the house. Most of the California homes have a balcony door or window in every room that you can exit from plus the way I remember it, it was plastered on the news a full day before it hit Poway. I'm wondering if it was a suicide. The reverse 911 probably saved a lot of lives. Four of the seven deaths were migrates living in a canyon were the reverse 911 would not have helped. Some people didn't get reverse 911 calls because they used a PO Box for the address on their phone bill. That's something to think about if you do that. The reverse 911 system cost the county $300,000 to implement but it was worth it. If your area doesn't have it you might want to get after your government officials. They need to work on increasing the bandwidth on the emergency websites though. They were worthless because they were overloaded and crashed. The TV stations and TV websites could have been better at telling people what they needed to know instead of sensationalizing the fire. The TV websites were overloaded also and would not load half the time. Qualcomm Stadium was the major evacuation area. They had more volunteers than evacuees and they started turning away donations because they had so much. My friend went to see her burned home on Sunday and found out that when her house started burning, her neighbor and a cameraman broke into her house and salvaged her purse, which contained her credit cards and driver's license, some antique china and some pictures. The firemen were so overwhelmed that I don't think they even made it there. The only thing she was able to salvage from the ashes were some Christmas tree ornaments that her nephews had painted. The paint was gone but she says she'll have them paint them again. Someone put a sign on a burned home that said "No More Termites". They definitely won their battle with the termites. At least one of the fires was started by arson(s). We have the Terminator (Arnold Schwarzenegger) for governor. He talks like him when he talks about going after the arson(s). He has stayed in San Diego the entire time. There's a $300,000 reward for information on the arson(s) the last time I heard. That amount has been increasing from $50,000.
Chemical
In Red Wine, Fruits And Vegetables May Stop Cancer, Heart Disease, Depending On
The Dose - Science Daily, 10/30/07 - "very high
doses of antioxidant polyphenols shut down and
prevent cancerous tumors by cutting off the
formation of new blood vessels needed for tumor growth ... the same polyphenols
play a beneficial role for those with diseased hearts and circulatory systems by
facilitating blood vessel growth ... the amount of polyphenols necessary to
obtain an anti-cancer effect is the equivalent of drinking about a bottle of red
wine each day" - See
grape seed extract at Amazon.com Drug Commonly Used To Treat Bipolar Disorder Dramatically Increases Lifespan In Worms - Science Daily, 10/30/07 - "Nematode worms treated with lithium show a 46 percent increase in lifespan, raising the tantalizing question of whether humans taking the mood affecting drug are also taking an anti-aging medication" - See lithium products at OffshoreRx1.com or iHerb. TZDs May Reduce Lung Cancer Risk - Physician's Weekly, 10/29/07 - "A 33% reduction in lung cancer risk was found among TZD users" Statins May Fight Prostate Cancer - WebMD, 10/29/07 - "Overall, 76% of men who took statins were alive and without cancer 10 years after treatment vs. 66% of those who didn’t" Very Low LDL Cholesterol Produces Greatest Decrease in Risk - Medscape, 10/27/07 - "The researchers found that there was a highly significant reduction in the risk of major cardiovascular events with descending levels of LDL cholesterol. The lowest risk was seen in patients who had achieved levels below 64 mg/dL" Drugs For Hypertension May Help Prevent And Treat Alzheimer's Disease - Science Daily, 10/26/07 - "mice genetically determined to develop Alzheimer's disease beta-amyloid production and subsequent cognitive deterioration, significantly benefit from the treatment with the anti-hypertensive agent Valsartan, found to pharmacologically prevent beta-amyloid production in the brain even when delivered to Alzheimer's disease mice at doses 3-4 fold lower than the minimal equivalent dose prescribed for the treatment of hypertension in humans. Other anti-hypertension drugs with beneficial results included Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and Hydralazine HCI" - Note: I'm big on Micardis (telmisartan). Valsartan and losartan (generic names so they shouldn't have been capitalized) are also ARBs. I'm wondering if telmisartan was in the study considering that it's not that popular yet. Canola Oil Increases Compliance With Dietary Recommendations For Fatty Acids - Science Daily, 10/26/07 - "switching to canola-based products 100 percent of the time would decrease adults' saturated fatty acid intake by up to 9.4 percent; increase their intake of monounsaturated fatty acid by 27.6 percent; and increase their alpha-linolenic acid intakes by73 percent" Drinking Alcohol May Protect Lungs - WebMD, 10/25/07 - "people who drank fewer than two alcoholic drinks per day were 18% less likely to show signs of lung disease than abstainers. Those who drank three to five drinks per day had a 10% lower risk of lung disease, but heavy drinkers who drank more than six drinks per day had a 9% increased risk of lung disease"
Omega-3 to cut colon cancer: meta-analysis - Nutra USA, 10/25/07 -
"the highest consumption of
fish oil was associated with 12 per cent
reduction in the incidence of colorectal cancer"
- [Abstract]
- See Mega Twin EPA at Amazon.com
Mesalamine, Folic Acid Each Cut Colorectal Cancer in Patients With Inflammatory
Bowel Disease - oncologystat.com, 10/24/07 -
"Patients who took at least 1 mg of folic acid
daily also had about a 90% cut in their CRC
incidence during follow-up, compared with the controls" - See
folic acid at Amazon.com Statin Use Linked to Better Blood Pressure Control - Medscape, 10/23/07 - "After adjustment for demographics, body mass index, diabetes, smoking, exercise, low-salt diet, and antihypertensive medications, the odds ratio for having blood pressure under control was 1.46 for statin users compared with nonusers" Insulin Linked to Colonic Polyps, Neoplasia - oncologystat.com, 10/23/07 - "those with poorly controlled diabetes, identified by a high serum level of hemoglobin A 1c (HbA 1c ), were significantly more likely to have advanced colonic adenomatous polyps, compared with diabetic patients with better glycemic control ... patients with poorly controlled diabetes were more than sixfold as likely to have advanced polyps and nearly sixfold as likely to have right-sided polyps, compared with patients who had better glycemic control. The average number of polyps found in poorly controlled patients was 5.5; in better-controlled patients, the average was 2.5 polyps per patient. Results from a third study reported at the meeting showed that having three or more polyps was the strongest predictor of risk for recurrent advanced neoplasia in the colon" Low Calcium May Spur Breast Cancer Spread - oncologystat.com, 10/19/07 - "The study involved implanting breast cancer cells into mice and feeding them a low-calcium diet. The mice experienced a high bone turnover and showed a 43% increase in bone destruction, a 24% increase in tumor area, and a 24% increase in tumor cell proliferation compared to a control group" Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds: Renoprotection provided by losartan in combination with pioglitazone is superior to renoprotection provided by losartan alone in patients with type 2 diabetic nephropathy - Kidney Blood Press Res. 2007;30(4):203-11 - "Renoprotection conferred by losartan combined with pioglitazone is superior to that conferred by losartan alone in subjects with type 2 diabetic nephropathy. The combination is generally well tolerated" Rosiglitazone Reduces Liver Fat and Insulin Requirements While Improving Hepatic Insulin Sensitivity And Glycemic Control In Patients With Type 2 Diabetes Requiring High Insulin Doses - J Clin Endocrinol Metab. 2007 Oct 23 - "During rosiglitazone, HbA1c decreased from 8.9+/-0.4% to 7.8+/-0.3% (p=0.007) and insulin requirements from 218+/-22 to 129+/-20 IU/day (p=0.002). Liver fat content decreased by 46+/-9% from 20+/-3% to 11+/-3% (p=0.0002). Hepatic insulin sensitivity, measured from the % suppression of endogenous glucose production by insulin, increased from -40+/-7% to -89+/-12% (p=0.001). The % change in liver fat correlated with the % decrease in HbA1c (r=0.53, p=0.06), insulin dose (r=0.66, p=0.014), and suppression of endogenous glucose production (r=0.76, p=0.003)" Differences in Free Estradiol and Sex Hormone Binding Globulin in Women with and without Premenstrual Dysphoric Disorder - J Clin Endocrinol Metab. 2007 Oct 23 - "Overall means for LH, progesterone, E2, peak E2, and free E2 were not different between groups. Across the menstrual cycle, overall %free E2 was significantly lower and SHBG significantly greater in the PMDD group compared to controls (1.39+/- 0.26 vs. 1.50+/- 0.28 vs. p= 0.03; 61.4+/- 25.1 vs. 52.4 +/- 21.3 nmol/L, p=0.046, respectively). During the luteal phase, free E2 was significantly lower in the PMDD group compared to controls (PMDD 7.6 +/- 7.0 vs. controls 8.9 +/- 8.4 pmol/L, p=0.032). For both follicular and luteal phases, SHBG was significantly higher in the PMDD group (follicular phase 60.5+/- 31.7 vs. 51.4+/- 38.2 nmol/L, p= 0.047; luteal phase 65.1 +/- 32.3 vs. 55.1+/- 38.9 nmol/L, p=0.03). In both groups, SHBG significantly increased from the follicular to luteal phase" Growth Hormone Replacement Therapy in Adults with Growth Hormone Deficiency Improves Maximal Oxygen Consumption (VO2 Max) Independently of Dosing Regimen or Physical Activity - J Clin Endocrinol Metab. 2007 Oct 23 - "GH replacement therapy in GH-deficient adults improved VO2 max similarly with both dosing regimens, without any influence of physical activity. There was no effect on submaximal exercise performance" The role of interleukin-6 in insulin resistance, body fat distribution and energy balance - Obes Rev. 2007 Oct 23 - "Its quantitative release from adipose tissue results in a subclinical, systemic elevation of IL-6 plasma levels with increasing body fat content, which may be implicated in the proinflammatory state leading to insulin resistance. On the other hand, IL-6 produced in the working muscle during physical activity could act as an energy sensor by activating AMP-activated kinase and enhancing glucose disposal, lipolysis and fat oxidation. In addition, both impaired IL-6 secretion and action are risk factors for weight gain" - See my IL-6 page for ways to reduce it. Glycemic index, glycemic load and thyroid cancer risk - Ann Oncol. 2007 Oct 19 - "Compared with the lowest tertile, the ORs in subsequent tertiles were 1.68 and 1.73 for GI, and 1.76 and 2.17 for GL. The OR for highest tertile of GI compared with lowest one was 1.70 for papillary and 1.57 for follicular thyroid cancer. The ORs for GL were 2.17 for papillary and 3.33 for follicular thyroid cancer ... Our study shows that high dietary levels of GI and GL are associated with thyroid cancer risk"
Quercetin reduces blood pressure in hypertensive subjects - J Nutr. 2007
Nov;137(11):2405-11 - "730 mg
quercetin/d for 28 d vs. placebo ...
reductions in (P < 0.01) systolic (-7 +/- 2 mm Hg), diastolic (-5 +/- 2 mm Hg),
and mean arterial pressures (-5 +/- 2 mm Hg)
were observed in stage 1 hypertensive patients after quercetin treatment"
- See
quercetin at Amazon.com
A case-control study on the dietary intake of mushrooms and breast cancer risk
among Korean women - Int J Cancer. 2007 Oct 17 -
"Both the daily intake (5th vs. 1st quintile, OR = 0.48, 95% CI = 0.30-0.78, p
for trend 0.030) and the average consumption frequency of mushrooms (4th vs. 1st
quartile, OR = 0.54, 95% CI = 0.35-0.82, p for trend 0.008) were inversely
associated with breast cancer risk" - See
Maitake
products at iHerb
and
shiitake mushroom supplements at Amazon.com Health Focus (Deprenyl/Selegiline):
Deprenyl Abstracts:
Affiliates (I could sure use some sales. You can drag the links onto your desktop and use them so that I get credit for the sale. Click here for more stores):
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