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Anti-aging Research > Cholesterol Absorption Inhibitors.
Cholesterol Absorption Inhibitors & other non-statins
Related Topics:
News & Research:
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Elevated cholesterol levels: No clear benefit of ezetimibe, report suggests
- Science Daily, 9/14/11
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Cholesterol-lowering drug shrinks enlarged prostates in hamster model -
Science Daily, 10/21/10 - "Ezetimibe reduced
prostatic enlargement in aged hamsters as effectively as finasteride and
combining the two drugs worked better than either one alone ... finasteride
caused atrophy of the hamster prostate while ezetimibe did not"
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Niacin Tops Zetia in Cutting Artery Plaque - WebMD, 11/16/09 -
"The question is whether ezetimibe works at all ...
Niacin has been around for 50 years. It's a well-understood drug, and in
this trial it was clearly superior ... Ultrasound images of neck arteries
showed that Niaspan reduced artery plaque by about 2%. Zetia did not slow
plaque buildup, although it did lower cholesterol" - See
niacin at Amazon.com
 .
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ARBITER 6-HALTS: HDL Raising With Niacin Superior to Ezetimibe -
Medscape, 11/16/09 - "Adding extended-release niacin
(Niaspan, Abbott) to statin therapy results in a significant regression of
atherosclerosis as measured by carotid intima-media thickness (IMT), whereas
the addition of ezetimibe (Zetia, Merck/Schering-Plough) to statin therapy
did not, according to an eagerly anticipated study" - See
niacin at Amazon.com.
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Consumption of
fish/fish oil associated with specific heart-rate variability parameters
- theheart.org, 2/21/08 - "fish and omega-3
fatty-acid consumption are associated with "more optimal" values of various
heart-rate variability (HRV) indices" - [Abstract]
- See Mega Twin EPA at Amazon.com.
-
Dietary Fish and {omega}-3 Fatty Acid Consumption and Heart Rate Variability
in US Adults - Circulation. 2008 Feb 19 -
"Habitual tuna/other fish and marine omega-3 consumption are associated with
specific HRV components in older adults, particularly indices of vagal
activity, baroreceptor responses, and sinoatrial node function"
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Cholesterol Drug Has No Benefit in Trial - New York Times, 1/14/08 -
"About 70 percent of patients who take Zetia do so
in the form of Vytorin, which combines Zetia with the cholesterol drug Zocor
... the plaques actually grew somewhat faster in patients taking Zetia along
with Zocor than in those taking Zocor alone. Patients in the trial who took
the combination of Zetia and Zocor were receiving it in the form of Vytorin
pills ... Patients should not be prescribed Zetia unless all other
cholesterol drugs have failed"
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Biggest LDL-C Reduction Ever Shown in Patients Is Achieved With
Rosuvastatin/Ezetimibe Combination - Doctor's Guide, 6/20/06
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New Cholesterol Drug Poised for U.S. Market - WebMD, 7/22/04 -
"The drug, called Vytorin, is the first of its kind,
combining a popular drug, Zocor, from a class known as statins, with a
non-statin medication, Zetia, in a single pill"
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Ezetimibe May Improve Cholesterol in High-Risk Groups - Doctor's Guide,
6/22/04
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Ezetimibe Plus Simvastatin Effective Treatment for Diabetics with Increased
LDL-Cholesterol Levels - Doctor's Guide, 6/7/04
- Lipid-Lowering
Combination May Be More Effective Than High-Dose Atorvastatin -
Medscape, 3/12/04 -
"The coadministration of ezetimibe plus
simvastatin provided additional improvements in lipid profiles across a
wide range of doses compared with titration of
atorvastatin monotherapy"
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Simvastatin/Ezetimibe Combination Outperforms High Dose Atorvastatin in
Lowering Cholesterol - Doctor's Guide, 3/9/04
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Ezetimibe Plus Simvastatin Reduces C-Reactive Protein Levels - Doctor's
Guide, 11/14/03
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Zetia (Ezetimibe) Plus Simvastatin Provided More than Twice the Reduction of
C-reactive protein in Patients with High Cholesterol Compared to Simvastatin
Alone - Doctor's Guide, 11/13/03 - "CRP
is considered an emerging risk marker for CHD ... Zetia with
simvastatin reduced levels of the marker CRP by 33.3 percent compared to
simvastatin administered alone (14.3 percent ... In addition, patients
taking Zetia co-administered with simvastatin experienced an LDL cholesterol
(LDL-C) reduction of 45 to 60 percent across the dosage range, compared to a
reduction of 31 to 44 percent in patients taking simvastatin alone"
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Combination Treatment of Ezetimibe and Simvastatin Safe and Effective -
Doctor's Guide, 10/3/03 -
"The combined administration of ezetimibe 10 mg/dL
and simvastatin 5 mg to
80 mg/dL is well tolerated and effective in allowing patients with primary
hypercholesterolaemia to attain the recommended low-density lipoprotein
(LDL) cholesterol levels ... ezetimibe is a cholesterol absorption inhibitor
that blocks the transport of dietary and biliary cholesterol across the
intestinal wall"
- Adverse Drug Reaction
Seen With Repaglinide and Gemfibrozil - Medscape, 9/29/03
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Ezetimibe may complement statins and other lipid-lowering drugs -
Doctor's Guide, 9/28/03
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Ezetimibe Helps Achieve LDL- Cholesterol Goals in Hypercholesterolemics With
or Without Diabetes - Doctor's Guide, 8/26/03
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Gemfibrozil Contraindicated in Diabetics Patients Taking Rosiglitazone -
Doctor's Guide, 8/19/03
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Ezetimibe Safe and Effective in Patients With Hypercholesterolaemia -
Doctor's Guide, 7/28/03
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Ezetrol (Ezetimibe), First Of A New Class Of Cholesterol-Lowering Drugs In
15 Years, Approved By Health Canada - Doctor's Guide, 6/19/03
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Ezetimibe-Statin Combination Lowers Cholesterol Safely and Effectively in
the Elderly - Doctor's Guide, 5/17/03
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Repaglinide Potency Greatly Increased When Combined With Gemfibrozil -
Doctor's Guide, 4/24/03
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Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High
Cholesterol - Doctor's Guide, 4/4/03 -
"C-reactive protein
is considered an emerging risk factor and risk marker for coronary heart
disease ... the levels of C-reactive protein were about halved when the
pooled ezetimibe plus simvastatin results were
compared with simvastatin alone. The combination produced about a 34.8%
reduction compared to an 18.2% reduction if the statin was used as
monotherapy"
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Ezetimibe Plus Lovastatin Offers New Treatment Option For
Hypercholesterolemia - Doctor's Guide, 2/20/03
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Ezetimibe Plus Simvastatin Safely Improves Lipid Profile - Doctor's
Guide, 1/17/03 -
"Ezetimibe and simvastatin given together reduced
low-density lipoprotein cholesterol by 44
to 57%, reduced triglycerides by 20 to 28%
and raised high-density lipoprotein cholesterol by
8 to 11%, depending on the simvastatin dose"
-
Gemfibrozil Reduces Cardiovascular Events In Male Diabetics With Coronary
Heart Disease - Doctor's Guide, 12/23/02
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Lopid (Gemfibrozil) May Increase Low-density Lipoprotein Levels in Some
Patients - Doctor's Guide, 12/16/02
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New Cholesterol Absorption Inhibitor [Ezetimibe] Appears Safe, Effective for
Hypercholesterolemia - Doctor's Guide, 11/29/02
- New Type of Drug
Lowers Cholesterol - WebMD, 3/18/02
- Drug
[Lopid®/gemfibrozil] Lowers Heart Disease by Increasing Good Cholesterol,
and More - WebMD, 3/27/01
- Gemfibrozil-Niacin
Combination Greatly Increases Good Cholesterol - Doctor's Guide, 3/10/00
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