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Aricept(TM) (donepezil hydrochloride)

Related Topics:

• Alzheimer's / Reminyl® (Galantamine hydrobromide) / Seroquel® (quetiapine) / Aricept™ (donepezil hydrochloride) / Exelon (rivastigmine tartrate) / Axura (memantine) / Procaine HCl

News & Research:

• Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats - Nutr Neurosci. 2016 Jul 1:1-8 - "Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits ... Memory impairment was induced by 15% w/v ethanol (2 g/kg, i.g.) administration for 30 days. RA (8, 16, and 32 mg/kg, i.g.) or donepezil (2 mg/kg, i.g.) was administered 30 minutes before ethanol ... RA 32 mg/kg had comparable effects with donepezil in prevention of acquisition and retention memory impairment. The higher doses of RA not only prevented increased lipid peroxidation and nitrite content but also decreased SOD, CAT, GSH, and FRAP levels in alcoholic groups and exerted antioxidant effects in non-alcoholic rats ... RA represents a potential therapeutic option against chronic ethanol-induced amnesia which deserves consideration and further examination" - See rosmarinic acid at Amazon.com.  Note that it shows rosemary extract but if you look at the label they're standardized to a percentage of rosmarinic acid.
• Cholinesterase Inhibition Combined With Antioxidants May Help Alzheimer's Disease Outcomes - Doctor's Guide, 3/17/09 - "Addition of a defined antioxidants formulation (Formula F) to donepezil treatment of patients with mild Alzheimer's disease (AD) substantially reduces oxidative stress and provides significant benefits over treatment with donepezil alone"
• Alzheimer's Drug May Help Mild Memory Loss, Imaging Study Suggests - Science Daily, 8/3/08
• Small But Significant Improvements With Donepezil in Patients With Mild Cognitive Impairment - Doctor's Guide, 3/3/08
• Donepezil Misses Primary End Point in CADASIL Treatment Trial - Medscape, 2/26/08
• Alzheimer's Agitation: Aricept No Help? - WebMD, 10/3/07
• Donepezil Effective, Safe in Late-Stage Alzheimer's Disease - Medscape, 8/3/07
• Drug Improves Symptoms Of Severe Alzheimer's Disease - Science Daily, 7/30/07
• There's Hope in the Drug Pipeline [for Alzheimer's] - US News, 12/11/06 - "A compound called huperzine A seems to combine some memory-saving effects of drugs like Aricept and Namenda with an ability to protect neurons from beta amyloid. It's currently being tested for safety and effectiveness in people" - See iHerb or Vitacost huperzine A products.
• FDA Broadens Use of Alzheimer's Drug - WebMD, 10/17/06
• FDA Approves Expanded Use of Treatment for Patients With Severe Alzheimer's Disease - Doctor's Guide, 10/13/06
• Treatment Benefits Are Ongoing When Patients With Moderate to Severe Alzheimer's Disease Receive Memantine While Continuing Donepezil - Doctor's Guide, 10/12/06
• Behavior Problems in Moderate to Severe Alzheimer's Disease Improved With Combined Memantine and Donepezil - Doctor's Guide, 10/10/06
• Donepezil Improves Cognition in Severe Alzheimer's Disease Patients - Doctor's Guide, 9/7/06
• MRIs Show Drug Treatment Slows Brain Deterioration on Road to Alzheimer's Disease - Doctor's Guide, 7/17/06
• Donepezil Provide Potential Benefits for Severe Alzheimer's Disease - Doctor's Guide, 4/24/06
• Drug May Fight Severe Alzheimer's - WebMD, 3/22/06
• Drug Helps Cognitive Function In Brain Tumor Patients After Radiation - Science Daily, 3/18/06
• 11 Aricept Deaths in Clinical Trial - WebMD, 3/17/06
• Donepezil for Alzheimer's Dementia - Clinical Psychiatry News, 3/06
• Trio of Drugs May Improve Alzheimer's - WebMD, 1/25/06
• Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials - BMJ. 2005 Aug 6;331(7512):321-327 - "Because of flawed methods and small clinical benefits, the scientific basis for recommendations of cholinesterase inhibitors for the treatment of Alzheimer's disease is questionable"
• Drug May Delay Onset of Alzheimer's - WebMD, 6/8/05
• Convenient New Formulation of Aricept (Donepezil) Now Available for Treatment of Mild-To-Moderate Alzheimer's Disease - Doctor's Guide, 6/7/05
• Donepezil Fails to Stop Progression to Alzheimer's - Clinical Psychiatry News, 5/05
• Drug Holds Off Alzheimer's Disease - WebMD, 4/13/05
• Aricept Appears to Demonstrate Significant Treatment Benefits in Patients Exclusively With Early-Stage Alzheimer's Disease - Doctor's Guide, 12/14/04
• Donepezil May Help Behavioral Responses in AD - Clinical Psychiatry News, 12/04
• Aricept May Help Memory in Multiple Sclerosis - WebMD, 11/8/04
• FDA Approves Orally Disintegrating Tablet Formulation of Aricept (Donepezil) for Treatment of Mild to Moderate Alzheimer's Disease - Doctor's Guide, 10/18/04
• Long-Term Donepezil May Hold Other Benefits - Clinical Psychiatry News, 10/04
• Donepezil May Delay Alzheimer's by 18 Months - Clinical Psychiatry News, 9/04
• Treatment Causes Short-term, Modest Delay In Alzheimer's Onset In Patients With Mild Cog Impairment - Science Daily, 7/20/04
• Alzheimer's Drug Slows Progression - WebMD, 7/19/04
• Donepezil May Have Short-Term Benefit For Mild Cognitive Impairment - Doctor's Guide, 7/19/04
• Study: Drug May Delay Alzheimer's Onset - Intelihealth, 7/19/04
• For Some Alzheimer's Patients, Donepezil Is Best - Clinical Psychiatry News, 7/04
• Alzheimer's Drug Treats Stroke-Related Dementia - HealthDay, 6/27/04
• Long-Term Donepezil Not Associated with Reduced Institutionalisation or Progress of Disability in Patients with Alzheimer's Disease - Doctor's Guide, 6/25/04
• Alzheimer's Drug Shows Little Benefit - WebMD, 6/24/04 - "During the first two years of the study, patients taking Aricept did slightly better in tests gauging thinking and functional ability. But those improvements waned and were no different than placebo"
• Switch Safe from Donepezil to Galantamine - Doctor's Guide, 5/19/04
• Alzheimer's Drug May Help Memory in MS Patients - Medscape, 4/27/04
• Donepezil Benefits Alzheimer's Patients With Comorbidities - Doctor's Guide, 2/5/04
• Memantine More Effective Than Placebo for Treatment of Alzheimer Disease in Patients Receiving Donepezil - Doctor's Guide, 1/21/04
• Drug Combo Slows Alzheimer's Disease - WebMD, 1/20/04
• Alzheimer's Drug May Slow Disease - WebMD, 11/5/03
• Donepezil Beneficial For Severe Dementia and Neuropsychiatric Symptoms in Elderly - Doctor's Guide, 11/4/03
• Drug Interactions with Cholinesterase Inhibitors: a Review - Doctor's Guide, 10/23/03
• Patients With Dementia Following Stroke Improved When Treated With Aricept (Donepezil) - Doctor's Guide, 8/26/03
• Memantine Plus Donepezil Effective for Severe AD - Clinical Psychiatry News, 8/03
• Persistent Therapy With Aricept (Donepezil HCl Tablets) Associated With Delayed Nursing Home Placement For Alzheimer's Patients - Doctor's Guide, 7/1/03
• Start Cholinesterase Inhibitor Immediately After Alzheimer's Dx - Clinical Psychiatry News, 6/03
• Vascular Dementia Patients Benefit from Donepezil Treatment - Doctor's Guide, 5/26/03
• Memantine Adds Benefits to Donepezil Therapy in Alzheimer's Patients - Doctor's Guide, 5/21/03
• Antipsychotics Effective for Elderly Patients With Dementia - Psychiatric News, 4/18/03 - "atypical antipsychotics have been used to alleviate deteriorating behavioral symptoms in dementia patients, such as agitation and aggression. New research that she cited shows some atypical antipsychotics can actually improve cognition through activating the release of acetylcholine in the cortex. Clozapine, olanzapine, and risperidone, she reported, robustly increased acetylcholine release in the cortex, while ziprasidone only moderately increased levels, compared with haloperidol and thioridazine, which did not elevate acetylcholine levels at all ... atypical antipsychotics increase cortical dopamine and cholinesterase inhibitors at the very least increase cortical acetylcholine action, leading to an improvement in memory and thinking, as well as improvement in psychosis and behavior"
• First Cholinesterase Inhibitor for Mild Cognitive Impairment - Medscape, 4/7/03
• Donepezil Effective in Patients with Vascular Dementia - Doctor's Guide, 3/7/03
• Patients With Vascular Dementia Tolerate Donepezil With Few Cardiovascular Complications - Doctor's Guide, 2/18/03
• Alzheimer’s Drugs May Offer Psychiatric Benefits - psychiatryonline.org, 2/7/03
• Drug Update: Alzheimer's Disease - Clinical Psychiatry News, 2/03
• Alzheimer's Drugs Help More Than Memory - WebMD, 1/7/03 - "Four such drugs have been approved by the FDA for use in the U.S. -- Reminyl, approved in 2001; Exelon, approved in 2000; Aricept, approved in 1996; and Cognex, approved in 1993, but rarely used now because it can cause liver problems ... treatment with one of these drugs for at least one month slowed the worsening of functional skills such as the ability to dress, bathe and shop. And it improved psychiatric symptoms including depression, hallucinations, delusions, anxiety, and apathy"
• Donepezil Improves The Behavioural And Psychologic Symptoms Of Alzheimer's Disease - Doctor's Guide, 12/16/02
• Donepezil Effective and Well Tolerated in Alzheimer Patients - Doctor's Guide, 11/18/02
• Donepezil (Aricept) May Improve Executive Functioning in ADHD - Doctor's Guide, 10/28/02
• Rivastigmine, Donepezil Produce Sustained Benefit in Alzheimer's Patients - Doctor's Guide, 10/14/02
• In a Newly Published Study, More Alzheimer's Disease Patients Were Able to Benefit from ARICEPT® (donepezil) Treatment than Exelon® (rivastigmine) - Doctor's Guide, 8/6/02
• In A Newly Published Study More Alzheimer's Disease Patients Were Able To Benefit From Aricept (Donepezil HCl Tablets) Treatment Than Exelon (Rivastigmine Tartrate) - Doctor's Guide, 7/31/02
• Gender, Apolipoprotein E Genotype Do Not Predict Response to Donepezil - Doctor's Guide, 7/31/02
• Sustained Donepezil Lowers Healthcare Cost, Savings Increase with Length of Treatment - Doctor's Guide, 7/22/02
• Rivastigmine, Donepezil Combination Well Tolerated and Efficacious - Doctor's Guide, 7/22/02
• Cognitive Decline Rapid and not Regained Following Discontinuation of Acetylecholinesterase Inhibitors - Doctor's Guide, 7/22/02
• Donepezil Improves Cognitive Performance in Healthy Pilots - Medscape, 7/12/02
• Switch from Donepezil to Rivastigmine Well Tolerated in Elderly Patients with Alzheimer's Disease - Doctor's Guide, 5/15/02
• Study Confirms Patients With Moderate Stage Alzheimer's Disease Benefit From Treatment With Aricept® (Donepezil Hcl Tablets) - Doctor's Guide, 5/13/02
• Alzheimer's Patients Who Fail On Aricept (Donepezil) May Benefit From Exelon (Rivastigmine) - Doctor's Guide, 5/2/02
• Acetylcholinesterase Inhibitors Improve Behavior - Clinical Psychiatry News, 4/02
• Aricept (Donepezil) Improves Cognition/Function in Vascular Dementia Caused by Stroke - Doctor's Guide, 4/17/02
• Aricept Wins First Head-to-Head Match-Up Against Reminyl - WebMD, 4/12/02
• Aricept (Donepezil) Significantly Improves Cognition/Daily Living over Reminyl (Galantamine) in Alzheimer's Disease - Doctor's Guide, 4/4/02
• Donepezil Cuts Alzheimer's Health Care Costs - Clinical Psychiatry News, 4/02
• Aricept (Donepezil) Improves Cognition/Function in Vascular Dementia - Doctor's Guide, 2/26/02
• Aricept (Donepezil) Produces Cognitive/Functional Benefits in Vascular Dementia - Doctor's Guide, 1/25/02
• Aricept Shows Promise For Autism Spectrum Disorder - Doctor's Guide, 10/3/01
• Aricept (Donepezil), Shows Significant Benefits In Moderate/Severe Alzheimer's Disease - Doctor's Guide, 8/28/01
• Aricept (Donepezil) Helps Alzheimer's Patients Maintain Daily Activities Longer - Doctor's Guide, 8/14/01
• Keeping Life Normal With Alzheimer's - WebMD, 8/13/01 - "What it shows is that patients treated with [Aricept] are much less likely to experience a significant loss of function over a period of at least a year"
• Donepezil Preferred To Rivastigmine For Physician Convenience In Alzheimer's Treatment - Doctor's Guide, 6/18/01
• Donepezil and Rivastigmine May Be Combined In Alzheimer's Patients - Doctor's Guide, 5/12/01
• Donepezil Better Tolerated Than Rivastigmine, Efficacy Comparable - Doctor's Guide, 5/11/01 - "both drugs to provide effective cognitive improvement in patients with Alzheimer’s dementia, but donepezil to have fewer cholinergic side effects"
• Rapid Switching From Aricept (Donepezil) to Exelon (Rivastigmine) Well Tolerated in Alzheimer's - Doctor's Guide, 5/11/01
• Donepezil Provides Cognitive Benefit in Alzheimer's Disease - Doctor's Guide, 4/24/01 - "significant cognitive improvements were shown by mean increases in MMSE scores from baseline at week 4 (+1.31) and week 12 (+1.79)"
• Alzheimer’s Drug Aricept (Donepezil) May Delay Need For Nursing Home Placements - Doctor's Guide, 4/4/01
• Donepezil Better Tolerated Than Rivastigmine In Alzheimer’s Patients - Doctor's Guide, 2/26/01
• Donepezil Effective For Mild-To-Moderate Alzheimer’s Disease - Doctor's Guide, 2/19/01
• Aricept (Donepezil HCl) Better Tolerated Than Exelon (Rivastigmine Tartrate) In Mild And Moderate Alzheimer’s - Doctor's Guide, 9/27/00
• Aricept (Donepezil) Improves Cognition, Global Function In Alzheimer's Patients - Doctor's Guide, 7/11/00
• Donepezil showed to delay function decline in Alzheimer's - Doctor's Guide, 5/5/00
• Alzheimer's patients taking Aricept (donepezil) maintained daily activities longer - Doctor's Guide, 5/5/00
• Different Measurements Used To Show Efficacy Of Alzheimer's Treatments - Doctor's Guide, 4/10/00
• Aricept Leading Therapy For Alzheimer's Disease - Doctor's Guide, 4/7/00
• Nursing Home Residents With AD Respond To Aricept (Donepezil) - Doctor's Guide, 3/16/00
• Donepezil Helps Alzheimer Patients To Function Normally - Doctor's Guide, 9/27/99
• Longest Term Effects To Date Shown In Latest Donepezil Studies - Doctor's Guide, 9/23/99
• Aricept Effective In Long-Term Treatment Of Alzheimer's - Doctor's Guide, 8/18/99
• Aricept Reduces Memory Loss From MS - Doctor's Guide, 4/20/99
• Donepezil And Metrifonate Effective In Alzheimer's Patients - Doctor's Guide, 4/29/98
• Patients With Early Alzheimer's More Likely To Choose Drug Treatment - Doctor's Guide, 6/3/98 - "Donepezil is a very good treatment for some patients"
• Donepezil Preserves Functional Status In Alzheimer's Patients - Doctor's Guide, 3/15/98
• Donepezil Improves Alzheimer's Patients' Ability To Function - Doctor's Guide, 1/22/98