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Recent Longevity News for the week ending 7/27/16

Antibiotics weaken Alzheimer's disease progression through changes in the gut microbiome - Science Daily, 7/24/16 - "Two of the key features of Alzheimer's disease are the development of amyloidosis, accumulation of amyloid-ß (Aß) peptides in the brain, and inflammation of the microglia, brain cells that perform immune system functions in the central nervous system. Buildup of Aß into plaques plays a central role in the onset of Alzheimer's, while the severity of neuro-inflammation is believed to influence the rate of cognitive decline from the disease ... For this study, Sisodia and his team administered high doses of broad-spectrum antibiotics to mice over five to six months. At the end of this period, genetic analysis of gut bacteria from the antibiotic-treated mice showed that while the total mass of microbes present was roughly the same as in controls, the diversity of the community changed dramatically. The antibiotic-treated mice also showed more than a two-fold decrease in Aß plaques compared to controls, and a significant elevation in the inflammatory state of microglia in the brain. Levels of important signaling chemicals circulating in the blood were also elevated in the treated mice" - Note:  It would seem like changing the microbe balance via probiotics would be the way to go, not taking antibiotics.  See probiotic products at Amazon.com.

Plant compounds give '1-2' punch to colon cancer - Science Daily, 7/22/16 - "The combination of two plant compounds that have medicinal properties -- curcumin and silymarin -- holds promise in treating colon cancer ... The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death" - See curcumin products at Amazon.com and silymarin at Amazon.com.

Which Diabetes Drug Is Best? - WebMD, 7/19/16 - "Metformin, in the absence of contraindications or intolerability, should be the first-line agent to treat patients with type 2 diabetes"

New link between periodontal and cerebrovascular diseases - Science Daily, 7/18/16 - "We observed that people diagnosed with periodontal disease had about a 4-fold increased risk of developing lacunar stroke compared with those without periodontitis"

Abstracts from this week:

Zeaxanthin-based dietary supplement and topical serum improve hydration and reduce wrinkle count in female subjects - J Cosmet Dermatol. 2016 Jun 17 - "Subjects were divided into three groups: two tests (skin formula 1 - oral product alone (ZO-1), skin formula 2- oral product with topical product (ZO-2 + ZT)), and one placebo control ... A statistically significant difference was observed between mean differences from baseline scores for total wrinkle count at week 4 for the combination active groups compared to placebo. A statistically significant difference from baseline scores for fine lines count was also observed at the week 4 visit compared to placebo for both active groups. Statistically significant differences from baseline scores for average wrinkles severity were seen for week 12 visit for both active groups compared to placebo" - [Nutra USA] - Note:  I couldn't find any serums with zeaxanthin at Amazon.  For facial serums, I've tried several.  Here's my pick: InstaNatural Vitamin C Skin Clearing Serum - Anti Aging Formula with Retinol & Hyaluronic Acid - Natural & Organic Wrinkle, Acne, Dark Spot, Fine Line & Hyperpigmentation Defying Facial Product

Curcumin AntiCancer Studies in Pancreatic Cancer - Nutrients. 2016 Jul 16;8(7) - "Several preclinical studies have demonstrated that curcumin, a naturally occurring polyphenolic compound, has anticancer effects against different types of cancer, including PC, by modulating many molecular targets. Regarding PC, in vitro studies have shown potent cytotoxic effects of curcumin on different PC cell lines including MiaPaCa-2, Panc-1, AsPC-1, and BxPC-3. In addition, in vivo studies on PC models have shown that the anti-proliferative effects of curcumin are caused by the inhibition of oxidative stress and angiogenesis and are due to the induction of apoptosis" - See curcumin products at Amazon.com.

L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial - Endocr J. 2016 Jul 16 - "Hypothyroid patients experience fatigue-related symptoms despite adequate thyroid hormone replacement ... 60 patients (age 50.0 ± 9.2 years, 3 males, 57 females) who still experienced fatigue (fatigue severity scale [FSS] score ≥ 36) were given L-carnitine (n = 30, 990 mg L-carnitine twice daily) or placebo (n = 30) for 12 weeks. After 12 weeks, although neither the FSS score nor the physical fatigue score (PFS) changed significantly, the mental fatigue score (MFS) was significantly decreased by treatment with L-carnitine compared with placebo (from 4.5 ± 1.9 to 3.9 ± 1.5 vs. from 4.2 ± 1.8 to 4.6 ± 1.6, respectively; P < 0.01). In the L-carnitine group, 75.0%, 53.6%, and 50.0% of patients showed improvement in the FSS score, PFS, and MFS, respectively, but only 20.0%, 24.0%, and 24.0%, respectively, did so in the placebo group (all P < 0.05). Both the PFS and MFS were significantly improved in patients younger than 50 years and those with free T3 ≥ 4.0 pg/mL by treatment with L-carnitine compared with placebo" - See L-carnitine at Amazon.com.

Protective effects of chronic treatment with a standardized extract of Ginkgo biloba L. in the prefrontal cortex and dorsal hippocampus of middle-aged rats - Behav Brain Res. 2016 Jul 13 - "prefrontal cortex (PFC) and dorsal hippocampus (DH) ... Behavioural data showed that EGb treatment improved short-term memory. Neither an anti-anxiety effect nor a change in locomotor activity was observed. Twenty-four hours after the behavioural tests, the rats were decapitated, and the PFC and DH were quickly dissected out and prepared for the comet assay. The levels of DNA damage in the PFC were significantly lower in rats that were treated with 1.0g.kg-1 EGb. Both doses of EGb decreased H2O2-induced DNA breakage in cortical cells, whereas the levels of DNA damage in the EGb-treated animals were significantly lower than those in the control animals ... Altogether, our data provide the first demonstration that chronic EGb treatment improved the short-term memory of middle-aged rats, an effect that could be associated with a reduction in free radical production in the PFC. These data suggest that EGb treatment might increase the survival of cortical neurons and corroborate and extend the view that EGb has protective and therapeutic properties" - See Ginkgo biloba at Amazon.com.

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