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Home > Anti-aging Research > Piperine


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News and Research:

  • Unmasking black pepper's secrets as a fat fighter - Science Daily, 5/2/12 - "piperine also can block the formation of new fat cells ... piperine interferes with the activity of genes that control the formation of new fat cells. In doing so, piperine may also set off a metabolic chain reaction that helps keep fat in check in other ways"
  • Curcumin and Piperine Prevent Remodeling of Aorta - Medscape, 12/26/11 - "N-nitro-L-arginine-methylester (L-NAME) is a nonspecific inhibitor of all three NO synthase (NOS) isoforms (neuronal - nNOS; inducible - iNOS; endothelial - eNOS) and causes an increase of blood pressure in a dose-dependent manner when administered to the experimental animals ... Administration of piperine or curcumin to animals with L-NAME-induced hypertension lead to a decrease of blood pressure, curcumin causing a more significant drop. Similar hypertension reducing effect of curcumin has been reported recently by Nakmreong et al.[34] Another study[25] registered a significant decrease of blood pressure after intravenous piperine administration. Piperine treatment was effective also in lowering blood pressure in rats with L-NAME-induced experimental hypertension described by Kumar et al.[36] The combination of curcumin and piperine in our experiment did not cause a statistically significant blood pressure decrease (with the exception of the third week) but it is apparent that it copies the course of the piperine graph curve. These differences in the results are probably related to different mechanisms of effect by the spices on blood pressure"
  • The Doctor's Remedy: Turmeric for Joint Pain - NYTimes.com, 10/19/11 - "Physician: Dr. Minerva Santos, director of integrative medicine at Northern Westchester Hospital in New York ... Recommended Remedy: Turmeric for joint pain ... What the Doctor Says: ... She recommends a dose of 1,000 milligrams a day. The benefit of buying it in a bottle, she said, is that it’s usually combined with a compound called piperine, which aids absorption"
  • Resveratrol bioavailability boosted by piperine: Study - Nutra USA, 8/16/11 - "Using mice, Prof Ahmad and his co-workers analyzed the level of exposure and maximum blood levels of resveratrol achieved by combining 100 milligrams of resveratrol per kilogram of animal with 10 mg/kg of piperine ... Compared to resveratrol alone, combination with piperine was found to increase the degree of exposure to 229 percent, and the maximum levels in the blood by a whopping 1,544 percent" - [Abstract] - See resveratrol products at Amazon.com.
  • Spices may boost breast health: Study - Nutra USA, 12/9/09 - "curcumin, found in turmeric, and piperine, found in black peppers, decreased the number of stem cells while having no effect on normal differentiated cells ... If we can limit the number of stem cells, we can limit the number of cells with potential to form tumours ... normal, non-cancerous stem cells were unaffected by the compounds, which appeared to selectively target the cancer stem cells" - [Abstract]
  • Monthly Updates - Hair Loss Research, 10/01 - "While finasteride (Propecia/Proscar) decreases serum DHT, it also is thought to increase estrogen which suggests that men over 35 may want to consider using it in conjunction with a systemic aromatase inhibitor such as Chrysin/Piperine (Super Miraforte), Arimidex, or stinging nettle extract, to maximize its hair growth effects and minimize potential side effects (that are listed in the PDR) such as Gynocaemastia (breast enlargement in males), sexual side effects, and an increase in fat deposition. These compounds have been reliably shown to increase testosterone and reduce excess estrogen, resulting in a youthful hormone profile that optimizes immune function and to some degree, body composition"


  • Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial - Complementary Therapies in Medicine, Aug 2017 - "In this 12-week randomized double-blind placebo-controlled trial, subjects with T2D (n = 118) were assigned to curcuminoids (1000 mg/day plus piperine 10 mg/day) or placebo plus standard of care for T2D ... Between-group comparison of change in the study parameters revealed significant reductions in serum levels of TC (−21.86 ± 25.78 versus −17.06 ± 41.51, respectively; p = 0.023), non-HDL-C (−23.42 ± 25.13 versus −16.84 ± 41.42, respectively; p = 0.014) and Lp(a) (−1.50 ± 1.61 versus −0.34 ± 1.73, respectively; p = 0.001) and elevations in serum HDL-C levels (1.56 ± 4.25 versus −0.22 ± 4.62, respectively; p = 0.048) in the curcuminoids group as compared with the placebo group (p < 0.05)" - [Nutra USA] - See curcumin products at Amazon.com and piperine extract at Amazon.com.
  • Piperine Triggers Apoptosis of Human Oral Squamous Carcinoma Through Cell Cycle Arrest and Mitochondrial Oxidative Stress - Nutr Cancer. 2017 Apr 20:1-9 - "Piperine induced significant (P < 0.01) dose-related increment in ROS production and nuclear condensation. Moreover, piperine stimulated cell death by inducing loss of MMP, and caspase-3 activation. Cell cycle study revealed that piperine arrested the cells in G2/M phase and decreased the DNA content. Findings of this study suggest the efficacy of piperine in inducing cell death via the decrease in MMP and ROS liberation followed by caspase-3 activation and cell cycle arrest" - See piperine extract at Amazon.com.
  • Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity - Appl Physiol Nutr Metab. 2016 Jan;41(1):26-32 - "Physical inactivity reduces, and exercise training increases, mitochondrial capacity ... Sixteen healthy young adults were randomly assigned in a double-blind fashion to consume either placebo or 500 mg of resveratrol plus 10 mg of piperine, a bioenhancer to increase bioavailibilty and bioefficacy of resveratrol ... Changes in mitochondrial capacity from baseline to post-testing indicated significant differences between the resveratrol+piperine-trained arm and the placebo-trained arm (p = 0.02), with the resveratrol+piperine group increasing about 40% from baseline (Δk = 0.58), while the placebo group increased about 10% from baseline (Δk = 0.13). Neither the placebo group nor the resveratrol+piperine group exhibited changes in mitochondrial capacity in the untrained arm" - [Nutra USA] - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com and piperine extract at Amazon.com.
  • Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis - Clin Nutr. 2015 Jan 7 - "Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: -2.20 mg/L; 95% confidence interval [CI]: -3.96, -0.44; p = 0.01). This effect was robust in sensitivity analysis"
  • Piperine inhibits the growth and motility of triple-negative breast cancer cells - Cancer Lett. 2014 Nov 13 - "Taken together, these findings suggest that piperine may be useful in the treatment of TNBC"
  • Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder - Phytother Res. 2014 Aug 4 - "One hundred and eleven subjects were assigned to standard antidepressive therapy plus curcuminoids-piperine combination (1000-10 mg/day; n = 61) or standard antidepressive therapy alone (n = 50) for a period of 6 weeks ... Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory II (BDI-II) ... There were significantly greater reductions in total HADS score and subscales of anxiety and depression in the curcuminoids versus control group (p < 0.001). Likewise, reductions in BDI-II total score and scores of somatic and cognitive subscales were found to be greater in the curcuminoids compared with control group" - See curcumin products at Amazon.com and piperine extract at Amazon.com.
  • Targeting breast stem cells with the cancer preventive compounds curcumin and piperine - Breast Cancer Res Treat. 2009 Nov 7 - "Both curcumin and piperine inhibited mammosphere formation, serial passaging, and percent of ALDH+ cells by 50% at 5 muM and completely at 10 muM concentration in normal and malignant breast cells. There was no effect on cellular differentiation. Wnt signaling was inhibited by both curcumin and piperine by 50% at 5 muM and completely at 10 muM. Curcumin and piperine separately, and in combination, inhibit breast stem cell self-renewal but do not cause toxicity to differentiated cells. These compounds could be potential cancer preventive agents. Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials"
  • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers - Planta Med. 1998 May;64(4):353-6 - "Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects"
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