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Home > Health Conditions > Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS or Lou Gerhig's Disease)

Alternative News:

  • Gut microbiome influences ALS outcomes - Science Daily, 5/13/20 - "mice with a common ALS genetic mutation, changing the gut microbiome using antibiotics or fecal transplants could prevent or improve disease symptoms ... he findings provide a potential explanation for why only some individuals carrying the mutation develop ALS. They also point to a possible therapeutic approach based on the microbiome ... The gut-brain axis has been implicated in a range of neurological conditions, including Parkinson's disease and Alzheimer's disease. Our results add weight to the importance of this connection" - See probiotic supplements at Amazon.com.
  • Gut microbes may affect the course of ALS - Science Daily, 7/22/19 - "To reveal the mechanism by which Akkermansia may be producing its effect, the scientists examined thousands of small molecules secreted by the gut microbes. They zeroed in on one molecule called nicotinamide (NAM): Its levels in the blood and in the cerebrospinal fluid of ALS-prone mice were reduced following antibiotic treatment and increased after these mice were supplemented with Akkermansia, which was able to secrete this molecule. To confirm that NAM was indeed a microbiome-secreted molecule that could hinder the course of ALS, the scientists continuously infused the ALS-prone mice with NAM. The clinical condition of these mice improved significantly. A detailed study of gene expression in their brains suggested that NAM improved the functioning of their motor neurons" - Note:  See previous newsletters.  Akkermansia is the one that may help with weight control.
  • Omega-3s in Diet May Help Ward Off Lou Gehrig's Disease - WebMD, 7/15/14 - "For the study, Fitzgerald's team looked at the association between ALS and these fatty acids among almost 1,000 ALS patients ... People ranked in the top 20 percent in terms of their omega-3 fatty acid intake cut their odds of developing ALS by a third, compared to those in the bottom 20 percent" - See fish oil supplements at Amazon.com.
  • Vitamin D confers protection to motoneurons and is a prognostic factor of amyotrophic lateral sclerosis - Neurobiol Aging. 2013 Nov 13 - "Amyotrophic lateral sclerosis (ALS) is an incurable paralytic disorder primarily typified by the selective and progressive degeneration of motoneurons in the brain and spinal cord. ALS causes muscle wasting and atrophy, resulting eventually in respiratory failure and death within 3-5 years of diagnosis. Vitamin D is a potent secosteroid hormone with diverse biological functions that include protection against neuronal damage ... Here we found that the biologically active form of vitamin D significantly potentiated the effect of neurotrophic factors and prevented motoneurons from a Fas-induced death, while electrophysiological properties of motoneurons were not affected. In ALS patients, we report that a severe vitamin D deficiency accelerates by 4 times the rate of decline and were associated with a marked shorter life expectancy. Our findings support a neuroprotective function of vitamin D on motoneurons and propose vitamin D as a reliable prognostic factor of ALS" - See vitamin D at Amazon.com.
  • Melatonin Delays ALS Symptom Onset and Death in Mice - Science Daily, 4/25/13 - "Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, the research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death ... Our experiments show for the first time that a lack of melatonin and melatonin receptor 1, or MT1, is associated with the progression of ALS ... We saw similar results in a Huntington's disease model in an earlier project, suggesting similar biochemical pathways are disrupted in these challenging neurologic diseases" - See melatonin at Amazon.com.
  • Eating Bright-Colored Fruits and Vegetables May Prevent or Delay Amyotrophic Lateral Sclerosis - Science Daily, 1/29/13 - "Using data from five prospective groups: the National Institutes of Health (NIH)–AARP Diet and Health Study, the Cancer Prevention Study II-Nutrition Cohort, the Multiethnic Cohort, the Health Professionals Follow-up Study, and the Nurses’ Health Study, researchers investigated more than one million participants for the present study ... subjects with diets high in beta-carotene and lutein—found in dark green vegetables—had a lower risk ALS risk" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • Lithium profoundly prevents brain damage associated with Parkinson's disease, mouse study suggests - Science Daily, 6/24/11 - "lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals" - See lithium supplements at Amazon.com.
  • Long-Term Vitamin E Intake Linked to Reduced ALS Risk - Medscape, 3/29/11 - "For dietary vitamin E intake, the adjusted RR comparing the highest quartile with the lowest was 0.79" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • High Polyunsaturated Fat And Vitamin E Intake May Halve Motor Neurone Disease Risk - Science Daily, 4/30/06
  • Diet May Slow Lou Gehrig's Disease - WebMD, 4/21/06
  • Lou Gehrig's Disease Not treatable With Creatine - WebMD, 3/24/03
  • Fat Abnormalities Hold Gehrig's Clue - Intelihealth, 9/16/02 - "Free radicals have long been thought to play a role in ALS, and some ALS specialists advise taking antioxidant vitamins in hopes of curbing them. In Mattson's experiment, published in this month's Annals of Neurology, free radicals caused ceramides to rise inside those crucial nerve cells ... Indeed, doctors like Newman expect medications, not diet, to ultimately hold the key. For now, Newman advises patients just to eat the moderate-fat diet the government already recommends for a healthy heart and take antioxidants such as vitamin E as a precaution"
  • DA Grants Orphan Drug Status to Creatine for Amyotrophic Lateral Sclerosis - Doctor's Guide, 3/26/02 - "Creatine is a critical element in cellular energy production and modulation. It is the substrate of the creatine kinase system, which helps prolong cellular life and protect against cell injury and death ... We have seen, and continue to see, encouraging results among ALS patients, as measured by muscle strength and a decreased rate of deterioration. Additionally, creatine has a long history of safe use, and is well tolerated by patients in the study"

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