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Adenosine Triphosphate (ATP)

Specific Recommendations:

• ATP supplements at Amazon.com
• ribose / creatine / coenzyme Q10 / NADH

New & Research:

• Tired of bring tired? - IAS/James South MA
• CLA may protect against elderly muscle loss - Nutra USA, 7/24/09 - "Supplementation with conjugated linoleic acid (CLA) prevented age-related muscle loss in mice ... After six months the researchers note that both the trans-10 cis-12 and CLA-mix showed “significantly higher muscle mass, as compared to corn oil and cis-9 trans-11 CLA groups” ... Both groups also exhibited increased cellular energy production (ATP), as well as higher levels of the antioxidant enzymes catalase and glutathione peroxidase in the muscles, compared to the corn oil and cis-9 trans-11 CLA groups" - See conjugated linoleic acid at Amazon.com.
• Blocking Key Energy Protein Kills Cancer Cells, First Evidence Provided - Science Daily, 3/31/08
• Muscle DNA Damage Initiates Physical Aging - Science Daily, 4/12/05 - "Mitochondrial DNA is critical for the production of a form of chemical energy known as ATP (adenosine triphosphate), which is needed by all cells for all bodily functions. When ATP is reduced, so is muscle endurance -- and thus begins the slide toward age-related muscle weakness, loss of muscle mass and onset of many diseases of old age"
• Muscle DNA Damage Initiates Physical Aging - Science Daily, 4/12/05 - "Mitochondrial DNA is critical for the production of a form of chemical energy known as ATP (adenosine triphosphate), which is needed by all cells for all bodily functions. When ATP is reduced, so is muscle endurance -- and thus begins the slide toward age-related muscle weakness, loss of muscle mass and onset of many diseases of old age"
• ATP, The Energy Currency - Nutrition Science News, 3/01
• Ribose Recovery - Nutrition Science News, 3/01 - "ribose, is the sugar that begins the metabolic process for ATP production. ATP is a nucleotide made of adenosine coupled to three phosphate molecules. Adenosine is made up of adenine and ribose ... On average, increased power output was 9 to 9.9 percent higher with ribose administration ...By the end of four weeks, the ribose group experienced a significant increase (+29.8 percent ribose vs. +7.4 percent placebo) in the number of total repetitions performed for the 10 sets to muscular failure ... ribose must be used during and immediately after exercise. Ingesting it more than one-half to one hour from the time of exercise is expected to have little effect. Manufacturers and scientific consensus indicate using 3­5 g at the start of exercise and 3­5 g right after exercise. During long-term, high-intensity exercise, such as competitive sports and those activities indicated in the previous studies, 3­5 g can be taken every hour with a sports drink ... the exercise needs to be intense and long—as befitting multiple reps—and have anaerobic bouts in order to expect ribose to have a significant effect. If a person is doing exercise that is at a training rather than intense level, one would not expect them to see a benefit"
• Does Ribose Matter? - Nutrition Science News, 5/99
• Adenosine Triphosphate, basic energy - By Phil Micans PharmB, International Anti-aging Systems

Abstracts:

• A Single Dose Of Oral Atp Supplementation Improves Performance And Physiological Response During Lower Body Resistance Exercise In Recreational Resistance Trained Males - J Strength Cond Res. 2017 Oct 16 - "ATP supplement condition (ATP=400mg) or a placebo condition ... The total weight lifted were higher for the ATP condition compared to placebo (Placebo= 3995.7+/-1137.8, ATP= 4967.4+/-1497.9 Kg; p= 0.005)" - [Nutra USA] - See ATP supplements at Amazon.com.
• Oral Adenosine-5'-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout - J Am Coll Nutr. 2017 Jan 12:1-7 - "In a double-blind, placebo-controlled, randomized design, 42 healthy male individuals were given either 400 mg of ATP as disodium salt or placebo for 2 weeks prior to an exercise bout ... ATP significantly increased Wingate peak power in later bouts compared to baseline" - [Nutra USA]
• Effects of oral adenosine-5'-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men - Nutr Metab (Lond). 2013 Sep 22;10(1):57 - "oral ATP supplementation may enhance muscular adaptations following 12-weeks of resistance training, and prevent decrements in performance following overreaching"