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Home > Anti-aging Research > Prebiotics

Prebiotics

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  • Prebiotics reduce body fat in overweight children - Science Daily, 6/7/17 - "Participants were randomly assigned to groups given either the prebiotic fiber -- oligofructose-enriched inulin -- or a placebo, once daily for 16 weeks. The prebiotic was provided as a white powder, mixed in water ... Powdered fiber, mixed in a water bottle, taken once a day is all we asked the children to change, and we got, what we consider, some pretty exciting results -- it has been fantastic ... Based on four-month intervention data, the annual projected body weight increase in the prebiotic group would be 3 kilograms (6.6 pounds), within the expected healthy range, whereas the projected increase in the placebo group was 8 kilograms (17.6 pounds), almost triple the expected yearly weight increase. Thus, supplementation with the prebiotic improved outcomes in children who were overweight or obese. Importantly, the researchers show that the prebiotic induced specific gut bacterial shifts compared to placebo" - [Abstract] - Note:  17.6 - 6.6 = 11 pounds difference or about a pound per month.  The abstract says they used 8 grams per day.  See inulin at Amazon.com.
  • Dietary prebiotics improve sleep, buffer impacts of stress, says study - Science Daily, 2/25/17 - "Prebiotics are dietary fibers found naturally in foods like chicory, artichokes, raw garlic, leeks and onions. When beneficial bacteria digest prebiotic fiber, they not only multiply, improving overall gut health, but they also release metabolic byproducts. Some research suggests these byproducts can influence brain function ... the rats on the prebiotic diet spent more time in non-rapid-eye-movement (NREM) sleep, which is restful and restorative, than those on the non-prebiotic diet ... After being exposed to a stressor, the rats on the prebiotic diet also spent more time in rapid-eye-movement (REM) sleep. REM sleep is believed to be critical for promoting recovery from stress, with research showing that those who get more REM sleep post-trauma are less likely to suffer from post-traumatic stress disorder" - See prebiotic supplements at Amazon.com.
  • Prebiotics may help to cope with stress - Science Daily, 2/10/17 - "regular intake of prebiotics may promote beneficial gut bacteria and recovery of normal sleep patterns after a stressful episode"
  • Gut microbial mix relates to stages of blood sugar control - Science Daily, 3/5/15 - "men whose blood sugar control stayed normal over the year had more gut bacteria that are considered beneficial for metabolic health, whereas those who stayed prediabetic had fewer beneficial bacteria and more harmful bacteria ... she said it is possible that changing one's gut bacteria could prevent diabetes" - See  probiotic products at Amazon.com and prebiotic supplements at Amazon.com.
  • A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity - Clin Nutr. 2014 Oct 20 - "Thirteen trials, representing 513 adult participants with Body Mass Index ≥25 kg/m² were included. Prebiotic supplementation reduced plasma total cholesterol (SMD -0.25; 95% CI -0.48, -0.02) and LDL-c (SMD -0.22; 95% CI -0.44, -0.00) concentrations in overall analysis, and reduced triglycerides (SMD -0.72; 95% CI -1.20, -0.23) and increased HDL-c (SMD 0.49; 95% CI 0.01, 0.97) concentrations in diabetic trials. Synbiotic supplementation reduced plasma fasting insulin (SMD -0.39; 95% CI -0.75, -0.02) and triglycerides (SMD -0.43; 95% CI -0.70, -0.15) concentrations"
  • Effect of Dietary Prebiotic Supplementation in Pre-diabetes - Medscape, 10/1/14 - "Thirty adults with pre-diabetes (Impaired Glucose Tolerance or Impaired Fasting Glucose) aged between 40–60 years will be randomly assigned to receive either 10 grams of prebiotic (inulin/oligofructose) daily or 10 grams placebo (maltodextrin) daily for 12 weeks ... Supplementation of the diet with bifidogenic prebiotic fibres (such as inulin) may reduce or retard the accumulation of AGEs in individuals at risk of developing type 2 diabetes. Prebiotics have been shown to improve and restore optimal microbial balance within the gastrointestinal tract, potentially reducing AGE absorption and/or production by the human host. Preliminary investigations indicate that consuming a high-AGE diet is sufficient to favour the proliferation of potentially pathogenic colonic bacteria over more beneficial species. Consumption of glycated proteins,[34] fried meats[61] and toasted wheat flakes[62] encouraged the preferential growth of greater numbers of detrimental gram negative and sulphate-reducing colonic micro-organisms when compared to control diets. Short Chain Fatty Acids (SCFAs) produced as a bacterial by-product of prebiotic fermentation act to lower the intestinal pH, inhibiting the growth of protein-degrading micro-organisms capable of producing potentially toxic metabolites. SCFAs also stimulate colonic smooth muscle contractions, speeding intestinal transit and limiting the time available for protein fermentation and putrefaction to occur in the gut.[63] Therapeutic manipulation of the gut microbiota with prebiotics may restore gut normobiosis and reduce AGE accumulation in humans at risk for type 2 diabetes development by the following mechanisms"

Abstracts:

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