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Home > Anti-aging Research > Prebiotics

Prebiotics

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News & Research:

  • Anxiety might be alleviated by regulating gut bacteria - Science  Daily, 5/20/19 - "People who experience anxiety symptoms might be helped by taking steps to regulate the microorganisms in their gut using probiotic and non-probiotic food and supplements ... Of the 14 studies that had used probiotics as the intervention, more than a third (36%) found them to be effective in reducing anxiety symptoms, while six of the remaining seven studies that had used non-probiotics as interventions found those to be effective -- a 86% rate of effectiveness ... Some studies had used both the IRIF (interventions to regulate intestinal microbiota) approach and treatment as usual ... The authors say one reason that non-probiotic interventions were significantly more effective than probiotic interventions was possible due to the fact that changing diet (a diverse energy source) could have more of an impact on gut bacteria growth than introducing specific types of bacteria in a probiotic supplement ... There are two kinds of interventions (probiotic and non-probiotic interventions) to regulate intestinal microbiota, and it should be highlighted that the non-probiotic interventions were more effective than the probiotic interventions" - See probiotic products at Amazon.com and prebiotic supplements at Amazon.com.
  • Prebiotics reduce body fat in overweight children - Science Daily, 6/7/17 - "Participants were randomly assigned to groups given either the prebiotic fiber -- oligofructose-enriched inulin -- or a placebo, once daily for 16 weeks. The prebiotic was provided as a white powder, mixed in water ... Powdered fiber, mixed in a water bottle, taken once a day is all we asked the children to change, and we got, what we consider, some pretty exciting results -- it has been fantastic ... Based on four-month intervention data, the annual projected body weight increase in the prebiotic group would be 3 kilograms (6.6 pounds), within the expected healthy range, whereas the projected increase in the placebo group was 8 kilograms (17.6 pounds), almost triple the expected yearly weight increase. Thus, supplementation with the prebiotic improved outcomes in children who were overweight or obese. Importantly, the researchers show that the prebiotic induced specific gut bacterial shifts compared to placebo" - [Abstract] - Note:  17.6 - 6.6 = 11 pounds difference or about a pound per month.  The abstract says they used 8 grams per day.  See inulin at Amazon.com.
  • Dietary prebiotics improve sleep, buffer impacts of stress, says study - Science Daily, 2/25/17 - "Prebiotics are dietary fibers found naturally in foods like chicory, artichokes, raw garlic, leeks and onions. When beneficial bacteria digest prebiotic fiber, they not only multiply, improving overall gut health, but they also release metabolic byproducts. Some research suggests these byproducts can influence brain function ... the rats on the prebiotic diet spent more time in non-rapid-eye-movement (NREM) sleep, which is restful and restorative, than those on the non-prebiotic diet ... After being exposed to a stressor, the rats on the prebiotic diet also spent more time in rapid-eye-movement (REM) sleep. REM sleep is believed to be critical for promoting recovery from stress, with research showing that those who get more REM sleep post-trauma are less likely to suffer from post-traumatic stress disorder" - See prebiotic supplements at Amazon.com.
  • Prebiotics may help to cope with stress - Science Daily, 2/10/17 - "regular intake of prebiotics may promote beneficial gut bacteria and recovery of normal sleep patterns after a stressful episode"
  • Gut microbial mix relates to stages of blood sugar control - Science Daily, 3/5/15 - "men whose blood sugar control stayed normal over the year had more gut bacteria that are considered beneficial for metabolic health, whereas those who stayed prediabetic had fewer beneficial bacteria and more harmful bacteria ... she said it is possible that changing one's gut bacteria could prevent diabetes" - See  probiotic products at Amazon.com and prebiotic supplements at Amazon.com.
  • A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity - Clin Nutr. 2014 Oct 20 - "Thirteen trials, representing 513 adult participants with Body Mass Index ≥25 kg/m² were included. Prebiotic supplementation reduced plasma total cholesterol (SMD -0.25; 95% CI -0.48, -0.02) and LDL-c (SMD -0.22; 95% CI -0.44, -0.00) concentrations in overall analysis, and reduced triglycerides (SMD -0.72; 95% CI -1.20, -0.23) and increased HDL-c (SMD 0.49; 95% CI 0.01, 0.97) concentrations in diabetic trials. Synbiotic supplementation reduced plasma fasting insulin (SMD -0.39; 95% CI -0.75, -0.02) and triglycerides (SMD -0.43; 95% CI -0.70, -0.15) concentrations"
  • Effect of Dietary Prebiotic Supplementation in Pre-diabetes - Medscape, 10/1/14 - "Thirty adults with pre-diabetes (Impaired Glucose Tolerance or Impaired Fasting Glucose) aged between 40–60 years will be randomly assigned to receive either 10 grams of prebiotic (inulin/oligofructose) daily or 10 grams placebo (maltodextrin) daily for 12 weeks ... Supplementation of the diet with bifidogenic prebiotic fibres (such as inulin) may reduce or retard the accumulation of AGEs in individuals at risk of developing type 2 diabetes. Prebiotics have been shown to improve and restore optimal microbial balance within the gastrointestinal tract, potentially reducing AGE absorption and/or production by the human host. Preliminary investigations indicate that consuming a high-AGE diet is sufficient to favour the proliferation of potentially pathogenic colonic bacteria over more beneficial species. Consumption of glycated proteins,[34] fried meats[61] and toasted wheat flakes[62] encouraged the preferential growth of greater numbers of detrimental gram negative and sulphate-reducing colonic micro-organisms when compared to control diets. Short Chain Fatty Acids (SCFAs) produced as a bacterial by-product of prebiotic fermentation act to lower the intestinal pH, inhibiting the growth of protein-degrading micro-organisms capable of producing potentially toxic metabolites. SCFAs also stimulate colonic smooth muscle contractions, speeding intestinal transit and limiting the time available for protein fermentation and putrefaction to occur in the gut.[63] Therapeutic manipulation of the gut microbiota with prebiotics may restore gut normobiosis and reduce AGE accumulation in humans at risk for type 2 diabetes development by the following mechanisms"

Abstracts:

  • Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome - Mol Psychiatry. 2019 May 16 - "Male middle age is a transitional period where many physiological and psychological changes occur leading to cognitive and behavioural alterations, and a deterioration of brain function. However, the mechanisms underpinning such changes are unclear. The gut microbiome has been implicated as a key mediator in the communication between the gut and the brain, and in the regulation of brain homeostasis, including brain immune cell function ... Male young adult (8 weeks) and middle-aged (10 months) C57BL/6 mice received diet enriched with a prebiotic (10% oligofructose-enriched inulin) or control chow for 14 weeks. Prebiotic supplementation differentially altered the gut microbiota profile in young and middle-aged mice with changes correlating with faecal metabolites. Functionally, this translated into a reversal of stress-induced immune priming in middle-aged mice. In addition, a reduction in ageing-induced infiltration of Ly-6Chi monocytes into the brain coupled with a reversal in ageing-related increases in a subset of activated microglia (Ly-6C+) was observed. Taken together, these data highlight a potential pathway by which targeting the gut microbiome with prebiotics can modulate the peripheral immune response and alter neuroinflammation in middle age. Our data highlight a novel strategy for the amelioration of age-related neuroinflammatory pathologies and brain function" - [Nutra USA] - See oligofructose at Amazon.com.
  • Gut microbiota in common elderly diseases affecting activities of daily living - World J Gastroenterol. 2018 Nov 14 - "Gut microbiota are involved in the development or prevention of various diseases such as type 2 diabetes, fatty liver, and malignancy such as colorectal cancer, breast cancer and hepatocellular carcinoma. Alzheimer's disease, osteoporosis, sarcopenia, atherosclerotic stroke and cardiovascular disease are major diseases associated with decreased activities of daily living (ADL), especially in elderly people. Recent analyses have revealed the importance of gut microbiota in the control of these diseases. The composition or diversity of these microbiota is different between patients with these conditions and healthy controls, and administration of probiotics or prebiotics has been shown effective in the treatment of these diseases. Gut microbiota may affect distant organs through mechanisms that include regulating the absorption of nutrients and/or the production of microbial metabolites, regulating and interacting with the systemic immune system, and translocating bacteria/bacterial products through disrupted mucosal barriers. Thus, the gut microbiota may be important regulators in the development of diseases that affect ADL" - [Nutra USA] - See probiotic products at Amazon.com.
  • Feeding the developing brain: Juvenile rats fed diet rich in prebiotics and bioactive milk fractions exhibit reduced anxiety-related behavior and modified gene expression in emotion circuits - Neurosci Lett. 2018 Jun 11;677:103-109 - "These data demonstrate that early life diets containing prebiotics and bioactive milk fractions can adaptively alter genes in neural circuits underlying emotion regulation and impact anxiety-related behavior" - [Nutra USA]
  • Longevity extension in Drosophila through gut-brain communication - Scientific Reportsvolume 8, Article number: 8362 (2018), 30 May 2018 - "With age, the body become less efficient at handling environmental stresses leading to a myriad of physiological imbalances including elevated inflammation, oxidative stress, metabolic dysregulation and mitochondrial damage. There will never be a single therapeutic or dietary solution to manage the mounting chronic diseases associated with aging; however, maintaining a healthy gut microbiota through the use probiotic and prebiotic supplements can delay chronic disease onset and promote longevity by simultaneously affecting each of the main triggers of aging" - [Nutra USA] - See prebiotics and probiotics at Amazon.com.
  • Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Nutrients. 2017 Oct 27;9(11) - "Participants who took probiotics or prebiotics showed significant improvements in the H1N1 strain seroprotection rate (with an odds ratio (OR) of 1.83 and a 95% confidence interval (CI) of 1.19-2.82, p = 0.006, I² = 0%), the H3N2 strain seroprotection rate (OR = 2.85, 95% CI = 1.59-5.10, p < 0.001, I² = 0%), and the B strain seroconversion rate (OR = 2.11, 95% CI = 1.38-3.21, p < 0.001, I² = 0%). This meta-analysis suggested that probiotics and prebiotics are effective in elevating immunogenicity by influencing seroconversion and seroprotection rates in adults inoculated with influenza vaccines"
  • Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study - Am J Clin Nutr. 2014 Jan 8 - "52 patients with NAFLD were supplemented twice daily for 28 wk with either a synbiotic or a placebo capsule ... Synbiotic supplementation in addition to lifestyle modification is superior to lifestyle modification alone for the treatment of NAFLD, at least partially through attenuation of inflammatory markers in the body" - See prebiotic supplements at Amazon.com and probiotic products at Amazon.com.
    • Synbiotics - Wikipedia - "Synbiotics refer to nutritional supplements combining probiotics and prebiotics in a form of synergism, hence synbiotics"