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Anti-aging Research > Pectin
News & Research:
Apple fibres may boost immune health: Study - Nutra USA, 3/3/10 -
"fed low-fat diets supplemented with either soluble
(pectin, 10 per cent of the diet) or insoluble fibre (cellulose, 5 or 10 per
cent of the diet) for six weeks. At the end of this period the mice were
challenged with an endotoxin to induce sickness ... Two hours after
[entotoxin] injection, the mice fed soluble fibre were only half as sick as
the other group, and they recovered 50 per cent sooner. And the differences
between the groups continued to be pronounced all the way out to 24 hours"
- [Abstract] [Science
Pectin Power: Why Fruits And Vegetables May Protect Against Cancer's Spread
- Science Daily, 10/13/08 - "They have shown that a
fragment released from pectin, found in all fruits and vegetables, binds to
and is believed to inhibit galectin 3 (Gal3), a protein that plays a role in
all stages of cancer progression"
Pectin shows potential against prostate cancer - Nutra USA, 8/22/07 -
"The new study looked at the effect of different
forms of pectin - commercially available fractionated pectin powder (FPP),
citrus pectin (CP), and pH-modified CP (PectaSol) - on hormone- (androgen)
responsive and androgen-independent human prostate cancer cells ... the FPP
induced apoptosis (programmed cell death) by about 40 fold, compared to
non-treated cells, for both types of cancer cell" - [Abstract]
- Citrus Nutrient
Helps Slow Prostate Cancer - WebMD, 12/16/03 -
"Every day, patients took 18 capsules of pectin:
Each contained 14 grams of pectin, equaling 800 mg a day ... Fourteen months
later, 70% of the men had significant increases in the time it took to
produce PSA -- it took longer for prostate cells to produce a doubling of
blood PSA levels"
Pectin Regulates the Levels of Inflammatory Cytokines and Immunoglobulins in
Interleukin-10 Knockout Mice - J Agric Food Chem. 2010 Oct 14 -
"Pectin has protective, anti-inflammatory effects on
inflammatory bowel disease (IBD), but the exact mechanism is unknown ... Pectin
treatment reduced expression of TNF-α and GATA-3, an important transcription
factor for the Th2 immune response. These mice also expressed lower levels of
IgE in the spleen and Peyer's patches (PP) and lower IgG and IgM expression in
PP. Interestingly, IL-10 deficiency resulted in lower CD4(+) and CD8(+)
populations in the spleen, mesenteric lymph node (MLN), and PP; however, pectin
counteracted these declines in the MLN and PP. Therefore, dietary pectin
downregulates the inflammatory response in the colon by moderating the
production of proinflammatory cytokines and immunoglobulins"
induced by endotoxin can be mitigated by the dietary soluble fiber, pectin,
through up-regulation of IL-4 and Th2 polarization - Brain Behav Immun.
2010 Feb 6 -
"We show that a diet rich in soluble fiber protects
mice from endotoxin-induced sickness behavior by polarizing mice Th2 when
compared to a diet containing only insoluble fiber. Mice fed soluble fiber
became less sick and recovered faster from endotoxin-induced sickness
behaviors than mice fed insoluble fiber ... These data show that a diet rich
in soluble fiber protects against endotoxin-induced sickness behavior by
polarizing mice Th2 and promoting alternative activation of macrophages"
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