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Anti-aging Research > Licorice
Specific Recommendations from my affiliates:
News & Research:
Licorice manufacturers encouraged to state daily limit of consumption -
Science Daily, 3/2/15 - "The boy also complained of
a bad headache and had high blood pressure ... he had been eating at least
20 licorice sweets each day for the past four months. This resulted in the
consumption of 2.88 mg/kg of glycyrrhizic acid (one of the active
ingredients of licorice), well above the World Health Organization's
recommended maximum of 2 mg/kg"
acid in liquorice--evaluation of health hazard - Food Chem Toxicol.
1993 Apr;31(4):303-12 - "Glycyrrhizic acid is
hydrolysed in the intestine to the pharmacologically active compound
glycyrrhetic acid, which inhibits the enzyme 11 beta-hydroxysteroid
dehydrogenase (in the direction of cortisol to cortisone) as well as
some other enzymes involved in the metabolism of corticosteroids.
Inhibition of 11 beta-hydroxysteroid dehydrogenase leads to increased
cortisol levels in the kidneys and in other mineralocorticoid-selective
Licorice extract protects the skin from UV-induced stress - Science
Daily, 2/18/15 - "the antioxidant active
Licochalcone A, which is the main component of the root extract of the plant
Glycyrrhiza inflata (Chinese Licorice), is able to protect the skin from
subsequent UV irradiation damage from within by strengthening the skin's own
defense systems. Thus plant extracts with the described profile are able to
provide a protective shield from sun exposure supporting and going beyond
the action of sunscreens regarding sun protection"
Liquorice root found to contain anti-diabetic substance - Science Daily,
Eating Licorice In Pregnancy May Affect A Child's IQ And Behavior -
Science Daily. 10/6/09 - "Expectant mothers who eat
excessive quantities of licorice during pregnancy could adversely affect
their child's intelligence and behavior ... They were also more likely to
have poor attention spans and show disruptive behavior such as ADHD
(attention deficit hyperactivity disorder) ... It is thought that a
component in licorice called glycyrrhizin may impair the placenta, allowing
stress hormones to cross from the mother to the baby"
Effects of Herbal
Supplements on the Kidney - Medscape, 11/14/05 -
"Licorice root (Glycyrrhiza glabra), especially when
used at high doses and for prolonged periods, has a well-known
pseudoaldosterone-like effect on the reabsorption of sodium and potassium"
Licorice Licks Herpes Virus Infection - Science Daily, 3/14/05
- Licorice Root
May Keep Mental Skills Sharp - WebMD, 3/29/04
Drug May Fight SARS - WebMD, 2/12/03
Antimicrobial Properties Of Licorice Extract - Intelihealth, 5/13/02
Ask Dr. J - Dr. Janson, 4/02 - "Chewing a
licorice extract, called deglycyrrhizinated licorice (DGL) can soothe the
symptoms of heartburn by coating the mucosa"
- Expectant Moms,
Pass on the Licorice - WebMD, 6/13/01
- Could Licorice
Help You Get Lean? - WebMD, 7/14/00
- Herbs for Kids:
What's Safe, What's Not - WebMD, 6/26/00
And the Good Herb Taketh Away - Nutrition Science News, 10/99
What preventive measures can I suggest during flu season?
- Nutrition Science News, 3/99
Immune Enhancers - Nutrition Science News, 2/99
- Licorice May Prevent
Cholesterol Build-Up - Doctor's Guide, 4/16/97
Involvement of BID Translocation in Glycyrrhetinic Acid and 11-Deoxy
Glycyrrhetinic Acid-Induced Attenuation of Gastric Cancer Growth - Nutr
Cancer. 2014 Feb 18 - "Glycyrrhetinic acid (GA), the
main chemical constituents of licorice, has shown remarkable anticancer
activity. However, the side effects limit its widespread use. 11-DOGA is
produced through reduction of GA 11-carbonyl to 11-hydroxyl to reduce its
side effects, although its anticancer activities are largely unknown. Here,
we report that the functional mechanisms of GA and 11-DOGA in gastric
cancers, as well as the comparison between these two drugs' pharmacological
potential. Firstly, we found that GA and 11-DOGA significantly inhibits the
viabilities of gastric cancer cells in dose- and time-dependent manners.
Both GA and 11-DOGA induce gastric cancer cells apoptosis and cell cycle
arrest in G2 phase by upregulation of p21 and downregulation of cdc2 and
cyclin B1. Further studies show that GA and 11-DOGA-induced apoptosis in
gastric cancer cells is associated with BID translocation from nucleus to
mitochondria. Moreover, GA and 11-DOGA could effectively inhibit tumor
formation of gastric cancer cells in nude mice" -
Note: One of those side effects is
that licorice increases cortisol which is not good for most people.
licorice supplements at Amazon.com.
Grapefruit juice and liquorice increase cortisol availability in patients
with Addison's disease - Eur J Endocrinol. 2011 Sep 6 -
"Compared to the ordinary treatment, the median AUC
for serum cortisol increased with liquorice (53783 vs. 50882, p<0.05) and
GFJ (60661 vs. 50882, p<0.05). Cortisol levels in serum were also elevated
2.6h after tablet ingestion (liquorice 223 vs. 186 nmol/L, p<0.05; GFJ 337
vs. 186 nmol/L, p<0.01). Liquorice increased the median urinary
cortisol/cortisone-ratio (0.43 vs 0.21, p<0.00001), whereas GFJ increased
the (aTHF+THF)/THE-ratio (0.55 vs 0.43, p<0.05)" - Note: From my
readings, most have too much cortisol already. I've read where licorice
increases it. Licorice and grapefruit juice sounds like an unlikely
combination but people might want to be aware of it.
The old lady who liked liquorice: hypertension due to chronic intoxication
in a memory-impaired patient - Neth J Med. 2005 Apr;63(4):149-50
Licorice consumption and serum testosterone in healthy man
- Exp Clin Endocrinol Diabetes. 2003 Sep;111(6):341-3 -
"The mean testosterone values decreased by 26 %
after one week of treatment"
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