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Home > Anti-aging Research > Inulin

Inulin

Specific Recommendations:

News & Research:

  • Inulin - Wikipedia, the free encyclopedia - "Inulins are a group of naturally occurring polysaccharides produced by many types of plants"
  • Rats fed a dietary fiber supplement had better weight control - Science Daily, 4/8/15 - "Despite having constant access to food high in fat and sugar, rats given supplemental oligofructose fibre gained about one third less weight than the control group ... microbiota in obese rats given oligofructose were changed to be more similar to those of lean animals. Gut hormones were also affected by the oligofructose, including an increase of a hormone that helps control the sensation of satiety -- the feeling of being full ... In a 2009 human study that she led, adults receiving supplements of oligofructose lost on average one kilogram over a 12 week period -- and perhaps more importantly, didn't continue to gain weight" - See oligosaccharide at Amazon.com.
  • Effect of Dietary Prebiotic Supplementation in Pre-diabetes - Medscape, 10/1/14 - "Thirty adults with pre-diabetes (Impaired Glucose Tolerance or Impaired Fasting Glucose) aged between 40–60 years will be randomly assigned to receive either 10 grams of prebiotic (inulin/oligofructose) daily or 10 grams placebo (maltodextrin) daily for 12 weeks ... Supplementation of the diet with bifidogenic prebiotic fibres (such as inulin) may reduce or retard the accumulation of AGEs in individuals at risk of developing type 2 diabetes. Prebiotics have been shown to improve and restore optimal microbial balance within the gastrointestinal tract, potentially reducing AGE absorption and/or production by the human host. Preliminary investigations indicate that consuming a high-AGE diet is sufficient to favour the proliferation of potentially pathogenic colonic bacteria over more beneficial species. Consumption of glycated proteins,[34] fried meats[61] and toasted wheat flakes[62] encouraged the preferential growth of greater numbers of detrimental gram negative and sulphate-reducing colonic micro-organisms when compared to control diets. Short Chain Fatty Acids (SCFAs) produced as a bacterial by-product of prebiotic fermentation act to lower the intestinal pH, inhibiting the growth of protein-degrading micro-organisms capable of producing potentially toxic metabolites. SCFAs also stimulate colonic smooth muscle contractions, speeding intestinal transit and limiting the time available for protein fermentation and putrefaction to occur in the gut.[63] Therapeutic manipulation of the gut microbiota with prebiotics may restore gut normobiosis and reduce AGE accumulation in humans at risk for type 2 diabetes development by the following mechanisms" - See prebiotic supplements at Amazon.com.
  • What are fructooliogosaccharides and how do they provide digestive, immunity and bone health benefits? - Science Daily, 7/16/13 - "Fructooliogosaccharides are naturally found in chicory, onions, asparagus, wheat, tomatoes and other fruits, vegetables and grains. They also can be derived from cane sugar and seaweed for use as a low-calorie (1.5 -- 2 Kcal/g) food sweetener and supplement. As scFOS provides approximately 30-to-50 percent of the sweetness of regular sugar, it can be used to enhance flavor and lower the amount of sugar in a food product ... In addition, scFOS are considered prebiotics. After they are consumed, fructooliogosaccharides move to the large intestine to stimulate the production of microbiota in the colon and gastrointestinal track ... The regular addition of scFOS to the diet is "ideal for maintaining mineral density and (bone) strength ... Most Americans, including many formula-fed infants and children, do not get enough scFOS"
  • Inulin plus resistant starch could be super-prebiotic - Nutra USA, 6/29/10 - "the combination of the ingredients not only boosted levels of lactobacilli and bifidobacteria in the animals’ intestine, but also improved intestinal function"
  • Artificial Sweetener May Lower Blood Pressure - WebMD, 11/20/09 - "Systolic blood pressure dropped an average of 6.9 points in the OFS group, compared with 3.5 in the placebo group ... Diastolic blood pressure decreased an average of 7.3 points in the OFS group vs. 2.3 in the placebo group ... Levels of total cholesterol, low-density lipoprotein ( LDL or “bad” cholesterol), and triglycerides also dropped more in participants given OFS than in those who took placebo tablets" - See:

    • Fructooligosaccharide - Wikipedia, the free encyclopedia - "Fructooligosaccharides (FOS) also sometimes called oligofructose or oligofructan, is a class of oligosaccharides used as an artificial or alternative sweetener. FOS exhibits sweetness levels between 30 and 50 percent of sugar in commercially-prepared syrups. [1] Its use emerged in the 1980s in response to consumer demand for healthier and calorie-reduced foods. The term oligosaccharide refers to a short chain of sugar molecules (in the case of FOS, fructose molecules). Oligo means few, and saccharide means sugar"
    • See inulin at Amazon.com.
  • Lifelong prebiotic supplements may enhance survival: rat study - Nutra USA, 4/24/08 - "In terms of survival, at 18 months of age, all the animals in the prebiotic group were still alive, compared to 76 per cent in the control group. After 24 months, 81 per cent of the rats in the prebiotic group were alive, compared to only 52 per cent of controls" - [Abstract]
  • Functional Foods & Nutraceuticals - Nutrition Science News, 7/00 - "Plasma total cholesterol was reduced by 7.9 percent and total triglycerides by 21.2 percent in young men consuming a 50 g serving of a breakfast cereal fortified with 18 percent inulin for four weeks during a study conducted at the University of Milan, Italy"

Abstracts:

  • Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity - Obesity (Silver Spring). 2017 Mar;25(3):510-513 - "Participants were randomized to 21 g of oligofructose (n = 20; BMI 30.4 kg/m2 ) or a maltodextrin placebo (n = 17; BMI 29.5 kg/m2 ) for 12 weeks ... plasminogen activator inhibitor-1 (PAI-1) ... Lipopolysaccharide (LPS) ... Plasma LPS concentrations were reduced by 40% in the oligofructose group over 12 weeks compared to a 48% increase in the placebo group ... Oligofructose reduces metabolic endotoxemia and PAI-1. Incorporating prebiotics into the diet through supplements or functional foods may help mitigate some markers of obesity-associated inflammation" - [Nutra USA] - See oligofructose at Amazon.com.
  • The effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes: a randomised, double-blind, placebo-controlled trial - Br J Nutr. 2016 Sep 29:1-8 - "Patients in the synbiotic group received a daily capsule that contained three viable and freeze-dried strains: Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum (2×109 colony-forming units/g each) plus 800 mg inulin for 6 weeks ... After 6 weeks of intervention, compared with the placebo, synbiotic supplementation led to a significant decrease in serum insulin levels (-1·5 (sd 5·9) v. +4·8 (sd 11·5) µIU/ml, P=0·005), homoeostatic model assessment for insulin resistance (-0·4 (sd 1·3) v. +1·1 (sd 2·7), P=0·003) and homoeostatic model assessment for β cell function (-5·1 (sd 24·2) v. +18·9 (sd 45·6), P=0·008) and a significant increase in quantitative insulin sensitivity check index (+0·01 (sd 0·01) v. -0·007 (sd 0·02), P=0·02). In addition, synbiotic intake significantly decreased serum TAG (-14·8 (sd 56·5) v. +30·4 (sd 37·8) mg/dl, P<0·001) and VLDL-cholesterol concentrations (-3·0 (sd 11·3) v. +6·1 (sd 7·6) mg/dl, P<0·001) compared with the placebo" - [Nutra USA] - See synbiotic products at Amazon.com, probiotic products at Amazon.com and inulin at Amazon.com.
  • Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study - Br J Nutr. 2014 May 22:1-8 - "placebo-controlled pilot study on thirty-eight subjects with the metabolic syndrome; they were supplemented with either synbiotic capsules containing 200 million of seven strains of friendly bacteria plus fructo-oligosaccharide or placebo capsules twice a day for 28 weeks ... After 28 weeks of treatment, the levels of fasting blood sugar and insulin resistance improved significantly in the G1 group"
  • Transcriptional response of HT-29 intestinal epithelial cells to human and bovine milk oligosaccharides - Br J Nutr. 2013 May 28:1-11 - "The present study suggests that milk oligosaccharides contribute to the development and maturation of the intestinal immune response and that bovine milk may be an attractive commercially viable source of oligosaccharides for such applications"
  • Prebiotics to Fight Diseases: Reality or Fiction? - Phytother Res. 2012 Dec 27 - "This review focuses on the short-chain low-digestible carbohydrates (LDCs) which are metabolized by gut microbiota serving as energy source, immune system enhancers or facilitators of mineral uptake. Intake of foods containing LDCs can improve the state of health and may prevent diseases as for example certain forms of cancer. Given the large number of different molecules belonging to LDCs, we focused our attention on fructans (inulin, fructo-oligosaccharides), galacto-oligosaccharides and resistant starches and their therapeutic and protective applications. Evidence is accumulating that LDCs can inhibit bacterial and viral infections by modulating host defense responses and by changing the interactions between pathogenic and beneficial bacteria. Animal studies and studies on small groups of human subjects suggest that LDCs might help to counteract colorectal cancer, diabetes and metabolic syndrome. The action mechanisms of LDCs in the human body might be broader than originally thought, perhaps also including reactive oxygen species scavenging and signaling events"
  • Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus - Lipids Health Dis. 2012 Feb 22;11:29 - "A randomized, double-blind, placebo-controlled study was conducted on twenty volunteers (ten for placebo group and ten for symbiotic group), aged 50 to 60 years ... Over a total test period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of 200 mL of a symbiotic shake containing 10(8) UFC/mL Lactobacillus acidophilus, 10(8) UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other volunteers (the placebo group) drank daily the same amount of a shake that did not contain any symbiotic bacteria ... The results of the symbiotic group showed a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a significant increase (P < 0.05) in HDL cholesterol and a significant reduction (P < 0.05) in fasting glycemia. No significant changes were observed in the placebo group"
  • Beneficial effects of catechin-rich green tea and inulin on the body composition of overweight adults - Br J Nutr. 2011 Oct 28:1-6 - "The aim of the present study was to investigate whether the effect of catechin-rich green tea in combination with inulin affects body weight and fat mass in obese and overweight adults. A total of thirty subjects were divided into a control group and an experimental group who received 650 ml tea or catechin-rich green tea plus inulin. A reduction of body weight ( - 1.29 (sem 0.35) kg) and fat mass (0.82 (sem 0.27) kg) in the experimental group was found after 6 weeks, and no adverse effects were observed. After refraining from consumption for 2 weeks, sustained effects on body weight and fat mass were observed. We conclude that continuous intake of catechin-rich green tea in combination with inulin for at least 3 weeks may be beneficial for weight management" - Note: 1.29 kg is 2.8 pounds.  See inulin products at Amazon.com and green tea extract at Amazon.com.
  • Dietary fructo-oligosaccharides improve insulin sensitivity along with the suppression of adipocytokine secretion from mesenteric fat cells in rats - Br J Nutr. 2011 Jun 2:1-8 - "Short-chain fructo-oligosaccharides (FOS) are known to have beneficial effects on health. However, the effects of FOS on insulin resistance have not been fully clarified. We observed the effects of FOS feeding on insulin sensitivity and adipocytokine release from abdominal adipocytes in weaning rats. Male Sprague-Dawley rats, 3 weeks old, were divided into three groups and fed a sucrose-based American Institute of Nutrition (AIN)-93 growth diet (control), the control diet containing 5 % FOS for 5 weeks (FOS-5wk) or the control diet for 2 weeks followed by the 5 % FOS diet for 3 weeks (FOS-3wk). Tail blood was collected after fasting for 9 h on day 33 of feeding, and glucose and insulin levels were measured. On the last day, rats were anaesthetised and killed after the collection of aortic blood. Small- and large-intestinal mesenteric fat tissues were immediately excised, and the release of adiponectin, leptin and TNF-α was evaluated from the subsequently isolated adipocytes. The weight of the large-intestinal mesenteric fat, fasting blood insulin level and homeostatic model assessment for insulin resistance decreased in a time-dependent manner, and were much lower in the FOS-5wk group than in the control group. These values were correlated with aortic blood leptin levels. The secretion rate of leptin from the isolated mesenteric adipocytes in the small intestine, but not in the large intestine, was lower in the FOS-fed groups than in the control group. In conclusion, FOS feeding improved insulin sensitivity accompanied by the reduction in large-intestinal fat mass and leptin secretion from the mesenteric adipocytes of the small intestine"
  • Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan - Br J Nutr. 2008 Apr 11;:1-8 - "a diet with 10 % of an oligofructose-enriched inulin (Synergy1) ... During the whole intervention period, male rats receiving Synergy1 (SYN1-M) displayed lower body weight, cholesterol and plasma triacylglycerolaemia compared with the controls (Cont-M). The survival rate at 24 months of age of SYN1-M rats was 35.3 % greater than that of Cont-M rats. In female rats, the Synergy1 supplementation (SYN1-F) group also reduced body weight, cholesterol and triacylglycerolaemia levels, but results were less consistent over the experiment. The survival rate at 24 months of age in SYN1-F rats was 33.3 % greater compared with that of the control (Cont-F) group. To conclude, lifelong intervention with Synergy1 improved biological markers during ageing and survival rate (lifespan) of rats"
  • Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans - Am. J. of Clin. Nutri, 3/03
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