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Home > Anti-aging Research > Synergism


  • Plant compounds give '1-2' punch to colon cancer - Science Daily, 7/22/16 - "The combination of two plant compounds that have medicinal properties -- curcumin and silymarin -- holds promise in treating colon cancer ... The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death" - See curcumin products at Amazon.com and silymarin at Amazon.com.
  • Regular use of vitamin and mineral supplements could reduce the risk of colon cancer, study suggests - Science Daily, 2/3/12 - "Rats fed a high-fat plus low-fibre diet and exposed to carcinogens developed pre-cancerous lesions; whereas, rats undergoing similar treatment, but provided with daily multivitamin and mineral supplements, showed a significant (84%) reduction in the formation of pre-cancerous lesions and did not develop tumours ... The authors conclude that "multivitamin and mineral supplements synergistically contribute to the cancer chemopreventative potential"
  • Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients - Adv Ther. 2011 Nov 21 - "containing berberine 500 mg, policosanol 10 mg, red yeast rice 200 mg, folic acid 0.2 mg, coenzyme Q10 2.0 mg, and astaxanthin 0.5 mg) or placebo ... There was a statistically significant reduction in total cholesterolemia (-20%), LDL-C (-31%), and insulin resistance (-10%) with nutraceutical treatment. No significant changes were detected for plasma high-density lipoprotein cholesterol (HDL-C). Furthermore, no statistical differences were found between baseline and end-study safety parameters. Medication compliance and tolerability were high" - Note: I’m been promoting synergy and talking lower doses of everything proven in specific areas like this for some time.
  • DSM builds olive extract IP with energy & exercise performance patent - Nutra USA, 4/7/11 - "According to European Patent EP2009/063492, the invention refers to hydroxytyrosol in combination with at least one other ingredient, including the likes of CoQ10, resveratrol, B vitamins, and EGCG from green tea ... Hydroxytyrosol is thought to be the main antioxidant compound in olives, and believed to play a significant role in the many health benefits attributed to olive oil. Previous research has linked the compound to cardiovascular benefits, with reductions in LDL or 'bad' cholesterol. Data has also suggested the compound may boost eye health and reduce the risk of against macular degeneration ... Hydroxytyrosol significantly increased the running distance to exhaustion in mice and so improved endurance in prolonged exercise ... hydroxytyrosol promotes mitochondrial activity and mitochondrial biogenesis leading to an enhancement of mitochondrial function and cellular defense system" - See olive leaf extract at Amazon.com.  As far as the synergy, I would think that most would be already taking the CoQ-10, resveratrol, B-vitamins and green tea.
  • Curcumin-soy formulation may boost absorption 60-fold: Indena study - Nutra USA, 4/6/11 - "Curcumin has been a sort of ‘forbidden fruit’ for biomedical research, since its poor oral bioavailability has substantially hampered clinical development, despite the very promising indications of the preclinical research ... The volunteers received five (low-dose - 209 mg total curcuminoids) or nine (high-dose - 376 mg total curcuminoids) hard-shell capsules of either the soybean-based phospholipid-curcumin formulation (Meriva) or five capsules of a non-formulated curcuminoid mixture containing 1799 mg of curcuminoids ... Total curcuminoid absorption was about 29-fold higher for Meriva than for its corresponding unformulated curcuminoid mixture, but only phase-2 metabolites could be detected, and plasma concentrations were still significantly lower than those required for the inhibition of most anti-inflammatory targets of curcumin ... the major plasma curcuminoid after administration of Meriva was not curcumin, but demethoxycurcumin, a more potent analogue in many in vitro anti-inflammatory assays" - [Abstract]
  • Synergistic, Additive, and Antagonistic Effects of Food Mixtures on Total Antioxidant Capacities - J Agric Food Chem. 2011 Jan 11 - "When foods are consumed together, the total antioxidant capacity of food mixtures may be modified via synergistic, additive, or antagonistic interactions among these components, which may in turn alter their physiological impacts ... The results indicated that within the same food category, 13, 68, and 21% of the combinations produced synergistic, additive, and antagonistic interactions, respectively, while the combinations produced 21, 54, and 25% synergistic, additive, and antagonistic effects, respectively, across food categories. Combining specific foods across categories (e.g., fruit and legume) was more likely to result in synergistic antioxidant capacity than combinations within a food group. Combining raspberry and adzuki bean extracts demonstrated synergistic interactions in all four chemical-based assays. Compositional changes did not seem to have occurred in the mixture. Results in this study suggest the importance of strategically selecting foods or diets to maximum synergisms as well as to minimum antagonisms in antioxidant activity"
  • Squeezing maximum health benefits out of the orange in your stocking - Science Daily, 12/20/10 - "We're looking for synergistic effects ... Cases where the effect of two or more antioxidants together was stronger than the sum of them separately ... In conclusion, they identified several combinations of antioxidants that were the most synergistic -- the compounds hesperidin and naringenin, in particular, appeared to contribute the most punch in the combinations"
  • TED 2010: Halting Blood Vessels Key to New Cancer Treatment; Possibly Obesity - wired.com, 2/10/10 - "What he found was that nature has laced a large number of foods, beverages and herbs with naturally occurring inhibitors of angiogenesis ... He and his researchers built a simulator to test the effect different foods (see list of foods at right) would have on blood vessels at concentrations that are available through eating, rather than concentrated, encapsulated forms. The tests showed that an extract of resveratrol, found in red grapes and red wine, would inhibit abnormal angiogenesis by 60 percent. Extracts from strawberries and soybeans had similar benefits ... They also tested four teas — a Chinese jasmine tea, Japanese sencha, Earl Gray and a blend of the Chinese jasmine and Japanese sencha teas. The teas varied in their potencies. The Chinese Jasmine and Japanese sencha teas were each less potent than the Earl Grey tea. But when they combined the two teas, the combination was more potent than either one alone or than the Earl Grey tea. This means there’s food synergy, Li said, and that foods likely work best in combination to create benefits"
  • Highlights from TED 2010, Wednesday: "We can eat to starve cancer" - boingboing.net, 2/10/10 - "Angiogenesis means the growth of blood vessels. Your body usually knows how to regulate the growth of blood vessels, but sometimes there are defects in blood growing and pruning. Too little angiogenesis can lead to things like wounds that won't heal, heart attack, and other diseases. Too much angiogenesis leads to other bad things such as blindness, arthritis. It's is a common denominator of many diseases. It's also the "hallmark of every type of cancer." ... In autopsies of people who died in car accidents, doctors have found microscopic cancers in 40% of woman (breast) and 40% of men (prostate). Something like 70% of older people have microcancers in their thyroid. But the cancer is harmless -- "cancer without disease." If you block angiogenesis the cancer can't grow. "It's a tipping point between harmless cancer and deadly one.""
  • Putting Antioxidants To Use In Functional Formulas - Functional Foods & Nutraceuticals, 5/02 - "Lester Packer, PhD, an antioxidant expert and professor emeritus at the University of California, Berkeley, coined the term 'antioxidant network' to convey the interactivity and interdependence of multiple antioxidants. For example, when an antioxidant, such as vitamin E, donates an electron to quench a hazardous free radical, it becomes a weak free radical itself. But vitamin E can be restored back to its full antioxidant strength when vitamin C donates an electron to it"
  • Combining Antibiotics May Boost Their Bacteria-Killing Ability - Doctor's Guide, 5/6/97