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Home > Health Conditions > Lymphoma

Non-Hodgkin's Lymphoma

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  • Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK and AKT Phosphorylation - Biol Pharm Bull. 2019;42(12):2109-2112 - "Primary effusion lymphoma (PEL) ... Sulforaphane (SFN), a natural compound found in cruciferous vegetables and broccoli sprouts, modulates signaling pathways and epigenetic gene expression ... Our data and previous literature indicate that SFN represses the phosphorylation of p38MAPK and AKT, which results in PEL cell apoptosis" - See sulforaphane at Amazon.com.
  • Improved Survival in Cancer Patients With High Vitamin D - Medscape, 5/1/14 - "overall survival for colorectal and breast cancer patients in the highest quartile of circulating 25-hydroxyvitamin D [25(OH)D] levels was significantly better than it was for those in the lowest quartile of 25(OH)D levels ... Overall survival was also significantly better for lymphoma patients in the highest 25(OH)D quartile compared with those in the lowest quartile ... Considering that vitamin D deficiency is widespread around the world, our suggestion is to ensure everyone has sufficient levels of this important nutrient — that is, circulating 25(OH)D levels — greater than 75 nmol/L ... when investigators compared 25(OH)D levels in the range of 40 to 70 nmol/L to levels <19 nmol/L, they found that a 10-nmol/L increase in circulating vitamin D levels upon cancer diagnosis was associated with a 4% reduction in all-cause mortality among all cancer patients in whom a dose-response relationship was assessed" - See vitamin D at Amazon.com.
  • Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine - Lipids Health Dis. 2013 Mar 16;12(1):36 - "N-3's are promising chemo-sensitizing agents for the treatment of CLL. Selective enhancement of chemo-sensitivity of EHEB, JVM-2 and MEC-2 to drugs by n-3 that is not dependent on increased lipid peroxidation and ROS generation indicates alternative mechanisms by which n-3 enhances chemo-sensitivity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • trans Fatty Acid Intake Is Associated with Increased Risk and n3 Fatty Acid Intake with Reduced Risk of Non-Hodgkin Lymphoma - J Nutr. 2013 Mar 13 - "diets high in TFAs, processed meats, and higher fat dairy products were positively associated with NHL risk, whereas diets high in n3 fatty acids and total seafood were inversely associated with risk" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Fruits and vegetables consumption and risk of non-Hodgkin's lymphoma: A meta-analysis of observational studies - Int J Cancer. 2012 Dec 13 - "searched on PubMed database from January 1966 through September 2012 to indentify case-control and cohort studies ... For vegetables, the summary relative risks (RRs) of NHL for high vs low intake for case-control, cohort and all studies were 0.75 (95% CI, 0.60-0.94; N=8), 0.90 (95% CI, 0.81-1.00; N=5) and 0.81 (95%CI, 0.71-0.92; N=13) ; and the corresponding RRs for intake of 1 serving per day were 0.88 (95% CI, 0.80-0.96; N=8), 0.96 (95% CI, 0.92-1.00; N=5) and 0.92 (95%CI, 0.87-0.96; N=13). For fruits and vegetables combined, the summary RR for high vs low intake was 0.78 (95%CI, 0.66-0.92; N=4), and for intake of 1 serving per day was 0.95 (95%CI, 0.91-1.00; N=4) ... Fruits intake was generally not associated with total NHL, or any histological subtypes. Our findings suggest that intakes of vegetables, and fruits and vegetables combined, but not fruits alone, significantly reduce risk of NHL"
  • Insufficient vitamin D levels in chronic lymphocytic leukemia patients linked to cancer progression and death - Science Daily, 11/3/10 - "patients with insufficient levels of vitamin D when their leukemia was diagnosed progressed much faster and were about twice as likely to die as were patients with adequate levels of vitamin D ... They also found solid trends: increasing vitamin D levels across patients matched longer survival times and decreasing levels matched shortening intervals between diagnosis and cancer progression ... Other studies have suggested that low vitamin D levels at diagnosis may be associated with poorer outcomes in colorectal, breast, melanoma and lung cancers, as well as lymphoma ... Vitamin D insufficiency, in general, is widespread" - See vitamin D at Amazon.com.
  • Vitamin D Insufficiency and Prognosis in Non-Hodgkin's Lymphoma - J Clin Oncol. 2010 Aug 16 - "event-free survival (EFS) and overall survival (OS) ... 25(OH)D insufficient patients with diffuse large B-cell lymphoma (DLBCL) had inferior EFS (hazard ratio [HR], 1.41; 95% CI, 0.98 to 2.04) and OS (HR, 1.99; 95% CI, 1.27 to 3.13); 25(OH)D insufficient patients with T-cell lymphoma also had inferior EFS (HR, 1.94; 95% CI, 1.04 to 3.61) and OS (HR, 2.38; 95% CI, 1.04 to 5.41). There were no associations with EFS for the other NHL subtypes. Among patients with DLBCL and T-cell lymphoma, higher 1,25(OH)(2)D levels were associated with better EFS and OS, suggesting that any putative tumor 1-alpha-hydroxylase activity did not explain the 25(OH)D associations. CONCLUSION 25(OH)D insufficiency was associated with inferior EFS and OS in DLBCL and T-cell lymphoma. Whether normalizing vitamin D levels in these patients improves outcomes will require testing in future trials" - See vitamin D at Amazon.com.
  • Vitamin K may cut lymph cancer risk: US study - Nutra USA, 4/21/10
  • Vitamin K may protect against developing non-Hodgkin's lymphoma, say Mayo Clinic researchers - Science Daily, 4/19/10 - "the risk of developing Non-Hodgkin lymphoma was approximately 45 percent lower for participants who had vitamin K intakes in the top quartile of intake in the study (>108 ug/day), compared to participants who had intakes in the bottom quartile (<39 ug/day). This association remained after accounting for other factors such as age, sex, education, obesity, smoking, alcohol use and intake of foods with high amounts of antioxidants"
  • Vitamin D May Boost Lymphoma Survival - WebMD, 12/7/09
  • Vitamin D levels associated with survival in lymphoma patients - Science Daily, 12/5/09 - "Patients with deficient vitamin D levels had a 1.5-fold greater risk of disease progression and a twofold greater risk of dying, compared to patients with optimal vitamin D levels after accounting for other patient factors associated with worse outcomes"
  • Green Tea Extract Shows Promise In Leukemia Trials - Science Daily, 5/26/09 - "We found not only that patients tolerated the green tea extract at very high doses, but that many of them saw regression to some degree of their chronic lymphocytic leukemia ... majority of individuals who entered the study with enlarged lymph nodes saw a 50 percent or greater decline in their lymph node size" - See green tea extract at Amazon.com.
  • Drinking Wine May Increase Survival Among Non-Hodgkin's Lymphoma Patients - Science Daily, 4/21/09 - "those who drank wine had a 76 percent five-year survival compared with 68 percent for non-wine drinkers. Further research found five-year, disease-free survival was 70 percent among those who drank wine compared with 65 percent among non-wine drinkers"
  • Grape Extracts May Be Effective Against Harmful Gut Bacteria - Science Daily, 3/4/09 - "H. pylori is the bacterial agent most commonly associated with peptic ulcers, gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric cancer ... The antibacterial effects of extracts from red, white, black and muscadine grapes as well as the pure compounds resveratrol, ellagic acid, and myricetin were tested for anti-H. pylori activity using agar dilution, laser scanning microscopy and cell proliferation. Following 24 hour treatment, results showed that muscadine grape skin extract had the highest anti-H. pylori effect, followed by muscadine grape synergy and seed extract. Additionally, two of the three compounds, resveratrol and ellagic acid, also inhibited H. pylori" - See grape seed extract at Amazon.com and resveratrol products at Amazon.com.
  • Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells - Int J Cancer. 2008 Apr 3 - "Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL" - See curcumin products at Amazon.com.
  • Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk - Cancer Causes Control. 2008 Jan 17 - "For the GSTM3 3-base insertion and higher total vegetable intake, the risk was 0.56 (0.35-0.92, p interaction = 0.03); for GSTP1 A114V and higher cruciferous vegetable intake, the risk was 0.52 (0.34-0.81, p interaction = 0.02); for OGG1 S326C and higher daily zinc intake, the risk was 0.71 (0.47-1.08, p interaction = 0.04) and for XRCC3 T241M and higher green leafy vegetable intake, the risk was 0.63"
  • Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma - Cancer Causes Control. 2007 Jul 25 - "Our results suggest that the inverse association between UV exposure and NHL risk may be mediated by the vitamin D pathway"
  • Carotenoids linked to lower risk of non-Hodgkin lymphoma - Nutra USA, 6/12/06 - "High daily intakes of the carotenoids lutein and zeaxanthin, as well as vegetables in general, could reduce the risk of non-Hodgkin lymphoma by almost 50 per cent"
  • Getting Some Sun May Fight Blood Cancer - WebMD, 3/31/04 - "women and men who got the most sun exposure during their off-work hours had the lowest risk of non-Hodgkin's lymphoma ... What might be causing it? The obvious answer is that vitamin D synthesized in the skin from sun exposure is causing this effect. There is increasing evidence that vitamin D has protective effects against many cancers. The evidence for colorectal cancer protection is pretty solid"
  • Diet Linked to Non-Hodgkin's Lymphoma - WebMD, 3/9/04 - "if a person has a higher intake of animal protein, they will have a higher risk of non-Hodgkin's lymphoma ... And people who have a higher intake of saturated fat have an increased risk. On the other hand, if you have higher-than-average intake of dietary fiber -- particularly if you frequently eat vegetables and fruits with a high fiber content -- you have a reduced risk of non-Hodgkin's lymphoma"
  • What role, if any, does Cox-2 inhibition play in the case of lymphoma? - Life Extension Magazine, 1/02
  • Fish Oil Slows Lymphoma - Life Extension Magazine, 9/00

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