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Garcinia Cambogia (-HCA)

Related Topics:

• Hydroxycitric Acid (HCA) / Diabetes / Syndrome X / Weight Control

Specific Recommendations:

• Garcinia cambogia at Amazon.com

News & Research:

• Hydroxycitric Acid - The Natural Pharmacist
• Hydroxycitric Acid Slows Glucose Uptake, Cuts Insulin Peaks/Valleys A La South Beach Diet - Science Daily, 5/23/05 - "sugar that is normally absorbed rather quickly -- within about 20 minutes -- took over 2 hours after HCA ingestion. This delay is good because it reduces the high peaks of glucose, which otherwise would require the body to produce a lot of insulin to deal with the 'meal.' ... we don't know how this will translate into humans ... Fast sugar is worse for you; slower is better"
• HCA, better than ephedra? - Nutra USA, 2/4/04 - "study’s principal investigator, Dr Harry Preuss of Georgetown University Medical Center ... Super CitriMax performed a function not noted in ephedra however - it significantly increased serum serotonin levels (a mechanism of appetite control and eating behavior) and lowered serum leptin levels, a biomarker of the gene that regulates obesity"

Abstracts:

• Garcinia Cambogia Improves High-Fat Diet-Induced Glucose Imbalance By Enhancing Calcium/CaMKII/AMPK/GLUT4-Mediated Glucose Uptake In Skeletal Muscle - Mol Nutr Food Res 2022 Feb 25 - "Garcinia cambogia (G. cambogia) is known to have antiobesity effects ... In an HFD-induced diabetes mouse model, G. cambogia administration resulted in significant blood glucose-lowering effects ... These findings provide new insights into the mechanism by which G. cambogia regulates glucose homeostasis in obesity-induced diabetes" - See Garcinia cambogia at Amazon.com.
• Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated From Triple Negative Breast Cancer Cell Line MDA-MB-231 - Nutr Cancer 2020 Jun 1;1-11 - "Development of therapy resistance is a major clinical issue in breast cancer treatments. Breast cancer stem cells (bCSCs) have a clearly defined role in the development of breast cancer therapy resistance and tumor recurrence. Therefore, discovery of new treatment strategies to circumvent cancer therapy resistance and tumor recurrence by targeting bCSCs is desperately needed. Fruits of many Garcinia species are edible and, possess a range of health benefits. Garcinia quaesita, a species in the genus Garcinia, is endemic to Sri Lanka. Dried fruits of G. quaesita are commonly used to flavor dishes in Sri Lanka. The present study assessed the potential anticancer and apoptotic properties of G. quaesita fruit extracts in bCSCs using WST-1 cell proliferation assay, sphere formation assay, caspase 3/7 assay, real-time PCR and fluorescent and phase-contrast microscopy. DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (Ferric Reducing Anti-oxidant Power) assays were used as anti-oxidant assays. The hexane extract of G. quaesita fruits was found to mediate cytotoxicity in bCSCs through induction of apoptosis. Furthermore, the hexane extract showed free radical scavenging ability. This pilot investigation provides a rationale to consume G. quaesita fruits as an anticancer dietary supplement for breast cancer patients"