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Home > Anti-aging Research > Wild Yam

Wild Yam (Dioscorea villosa)

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News & Research:

Abstracts:

  • DA-9801, a standardized Dioscorea extract, improves memory function via the activation of nerve growth factor-mediated signaling - Nutr Neurosci. 2020 Mar 27 - "Nerve growth factor (NGF) is a neurotrophin that plays a critical role in mammalian learning and memory functions ... Nerve growth factor (NGF) is a neurotrophin that plays a critical role in mammalian learning and memory functions. NGF also regulates neuronal cell differentiation and neurite outgrowth by activating ERK/CREB signaling. This present study examined the effects of a standardized Dioscorea extract (DA-9801) ... Mice were orally treated with DA-9801 (10 and 100 mg/kg/day) once daily for 7 days. They were subjected to passive avoidance test to evaluate memory functions ... DA-9801 treatment increased the NGF contents and neurite length, respectively. Mice with DA-9801 administration showed memory enhancement in the passive avoidance test. DA-9801 also increased newborn cell differentiation, neurite length, NGF secretion, and ERK/CREB phosphorylation in the mouse hippocampus" - See Dioscorea extract at Amazon.com.