To address the growing use of ad blockers we now use affiliate links to sites like Amazon.com, streaming services, and others. Affiliate links help sites like QualityCounts.com stay open. Affiliate links cost you nothing but help me support my family. We do not allow paid reviews on this site. As an Amazon Associate I earn from qualifying purchases.  Also, you can donate  to ben@qualitycounts.com via Zelle or PayPal.  Click here for the PayPal QR.  Click here for Bitcoin QR code or Bitcoin address: 39muDw6WpQV8j6EdA8eUBvT5iFDiVpVpiE
Home ReliableRXPharmacy Past Newsletters Amazon.com Contact
 Sign-up for newsletter 
 Newsletter Archive
 Newsletter via RSS Feed
 Research on Supplements
 Health Conditions
 Anti-aging Recommendations
 Insulin and Aging
 QualityCounts.com in Time
 Longevity Affiliates:

Home > Anti-aging Research > Thunder God Vine

Thunder God Vine

Specific Recommendations:

News & Research:



  • Thunder God Vine: A Powerful Discovery for Pancreatic Cancer Patients - National Foundation for Cancer Research, 11/10/21 - "The key ingredient of the thunder god vine is called triptolide. Triptolide makes up a molecule called Minnelide, which appears to attack pancreatic cancer cells. It also attacks the tumor’s stroma or outer layer that shields it from the body’s immune system" - See Thunder of God Vine at Amazon.com.
  • Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation - Onco Targets Ther. 2021 - "Celastrol, a quinone methide triterpenoid, is a natural product extracted from Tripterygium wilfordii Hook F. (“Thunder of God Vine”) plant and is used widely in TCM (traditional Chinese medications). The biological activities of celastrol have been extensively explored; it has been documented that celastrol has anticancer activity against various tumors, including leukemia, melanoma glioma, and prostate cancer.19–28 The celastrol anticancer activity was owed to its capability to compromise different cellular mechanisms in cancer cells. Celastrol is found to suppress tumor necrotic factor (TNF) induced cancer cells metastasis, nuclear factor (NF)-kB signaling, heat shock protein (HSP) 90, extracellular signal-regulated kinase (ERK), proteasome, and modulates TRAIL-induced apoptosis ... Celastrol inhibited pancreatic cancer proliferation through affecting several signaling pathways. The celastrol’s inhibitory effects on pancreatic cancer was basically attributed to DDIT3 and ATF3 activation and suppression of RRM2 and MCM4 genes" - See Thunder of God Vine at Amazon.com.
  • Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro - Chin J Cancer 2010 Apr - "Leukemia is a malignant tumor highly dependent on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), which is relevant for the occurrence, metastasis, proliferation, apoptosis, and drug resistance of tumor cells. Research has confirmed that the NF-kappaB family is one of the target genes in the Notch signaling pathway. This study investigated the effects of Celastrol on the apoptosis of U937 cells and the expression levels of Notch1 and NF-kappaB in these cells ... Celastrol inhibited cell proliferation and induced apoptosis in U937 cells in a concentration-dependent manner. The possible mechanism might be involved in the regulation of a survival signaling pathway, such as Notch or NF-kappaB"
  • Thunder God Vine - NIH - "Thunder god vine may have side effects, including digestive problems, abnormal heart rates, high blood pressure, less blood cell production, kidney problems, decreased bone mineral content (with long-term use), infertility, menstrual cycle changes, rashes, diarrhea, headache, and hair loss"