|
|
|
Home >
Anti-aging Research > Thunder God Vine
Thunder God Vine
Specific Recommendations:
News & Research:
Abstracts:
-
Thunder God Vine: A Powerful Discovery for Pancreatic Cancer Patients -
National Foundation for Cancer Research, 11/10/21 -
"The key ingredient of the thunder god vine is called triptolide. Triptolide
makes up a molecule called Minnelide, which appears to attack pancreatic
cancer cells. It also attacks the tumor’s stroma or outer layer that shields
it from the body’s immune system" - See Thunder of God Vine at Amazon.com.
-
Celastrol
Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic
Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation
- Onco Targets Ther. 2021 - "Celastrol, a quinone
methide triterpenoid, is a natural product extracted from Tripterygium
wilfordii Hook F. (“Thunder of God Vine”) plant and is used widely in TCM
(traditional Chinese medications). The biological activities of celastrol
have been extensively explored; it has been documented that celastrol has
anticancer activity against various tumors, including leukemia, melanoma
glioma, and prostate cancer.19–28 The celastrol anticancer activity was owed
to its capability to compromise different cellular mechanisms in cancer
cells. Celastrol is found to suppress tumor necrotic factor (TNF) induced
cancer cells metastasis, nuclear factor (NF)-kB signaling, heat shock
protein (HSP) 90, extracellular signal-regulated kinase (ERK), proteasome,
and modulates TRAIL-induced apoptosis ... Celastrol inhibited pancreatic
cancer proliferation through affecting several signaling pathways. The
celastrol’s inhibitory effects on pancreatic cancer was basically attributed
to DDIT3 and ATF3 activation and suppression of RRM2 and MCM4 genes"
- See Thunder of God Vine at Amazon.com.
-
Effects of Celastrol on
growth inhibition of U937 leukemia cells through the regulation of the
Notch1/NF-kappaB signaling pathway in vitro - Chin J Cancer 2010 Apr -
"Leukemia is a malignant tumor highly dependent on nuclear factor
kappa-light-chain-enhancer of activated B cells (NF-kappaB), which is
relevant for the occurrence, metastasis, proliferation, apoptosis, and drug
resistance of tumor cells. Research has confirmed that the NF-kappaB family
is one of the target genes in the Notch signaling pathway. This study
investigated the effects of Celastrol on the apoptosis of U937 cells and the
expression levels of Notch1 and NF-kappaB in these cells ... Celastrol
inhibited cell proliferation and induced apoptosis in U937 cells in a
concentration-dependent manner. The possible mechanism might be involved in
the regulation of a survival signaling pathway, such as Notch or NF-kappaB"
-
Thunder God Vine
- NIH - "Thunder god vine may have side effects,
including digestive problems, abnormal heart rates, high blood pressure,
less blood cell production, kidney problems, decreased bone mineral content
(with long-term use), infertility, menstrual cycle changes, rashes,
diarrhea, headache, and hair loss"
|
|
