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Home > Health Conditions > Sickle Cell

Sickle Cell

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  • Real-World data on efficacy of L-glutamine in preventing sickle cell disease-related complications in pediatric and adult patients - Front Med (Lausanne) 2022 Aug 1 - "L-glutamine has been shown to play an important role in the regulation of oxidative stress which is one of the key contributors to the pathophysiology of sickle cell disease (SCD). In a Phase 3 clinical trial, L-glutamine demonstrated a significant reduction in SCD-related complications including vaso-occlusive crises (VOCs), hospitalizations, and acute chest syndrome (ACS) compared to placebo in patients with SCD ... Compared to baseline, patients had significantly fewer pain crises (median change from 3.0 to 0.0; P < 0.00001), hospitalizations (median change from 3.0 to 0.0; P < 0.00001), days of hospitalization (median change from 15.0 to 0.0; P < 0.00001), and blood transfusions (median change from 3.0 to 0.0; P < 0.00001) at 24, 48, and 72 weeks following L-glutamine therapy. Moreover, there was a drastic decrease in the number of ACS events during this time. A significant increase was observed in mean hemoglobin levels and hematocrit proportions from baseline to 72 weeks (P < 0.001). Conversely, compared to baseline, mean reticulocyte counts and lactate dehydrogenase (LDH) levels were considerably lower at follow-up time points (P = 0.003 and P < 0.001, respectively). No patient reported treatment-related adverse events" - See L-glutamine at Amazon.com.
  • Oral Arginine Emerges as Potential Adjuvant for Vaso-Occlusive Crisis Management - Medscape, 12/11/19 - "Oral arginine supplementation significantly increased plasma arginine levels and improved acute pain-related outcomes in Nigerian children with sickle cell disease ... Low plasma arginine levels are associated with acute pain requiring hospitalization in Nigerian children with sickle cell disease, and have also been shown in a prior study in the United States to predict pediatric vaso-occlusion ... Despite similar baseline Numerical Pain Scale (PS) scores (8.7 and 8.4 on a 0–10 scale), day 5 pain scores were 1.2 vs. 2.0, and the mean daily rate of decline was 1.5 vs. 1.1 cm/day ... By day 5, 54% of patients on arginine were already home, as compared with just 24% in the placebo arm" - See L-arginine products at Amazon.com.
  • Supplement May Ease Sickle Cell Pain - WebMD, 7/18/18 - "Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell patients' number of acute pain crises by 25 percent compared with a placebo ... In addition, the supplement reduced hospitalizations by one-third" - See l-glutamine at Amazon.com.
  • Arginine Therapy Shows Promise for Sickle Cell Pain - Science Daily, 9/16/13 - "A deficiency of nitric oxide, a potent vasodilator, has been identified in sickle cell disease and may contribute to episodes of blocked vessels and pain. Since arginine is a building block of nitric oxide, researchers hypothesized that arginine could be a beneficial treatment for pain related to sickle cell disease ... a randomized, double blind placebo control clinical trial of 38 children with sickle cell disease hospitalized for 56 episodes of pain. The research team discovered a 54 percent reduction in the use of opioid pain medication and significantly lower pain scores at hospital discharge in those treated with arginine over those receiving placebo" - See L-arginine products at Amazon.com.
  • Effect of omega-3 (n-3) fatty acid supplementation in patients with sickle cell anemia: randomized, double-blind, placebo-controlled trial - Am J Clin Nutr. 2012 Nov 28 - "Blood cell aggregation and adherence to vascular endothelium and inflammation play a central role in vaso-occlusive crisis in sickle cell disease. The antiaggregatory, antiadhesive, antiinflammatory, and vasodilatory omega-3 (n-3) fatty acids (DHA and EPA) are significantly reduced in patients with the disease ... One hundred forty patients recruited from a single center in Sudan were randomly assigned and received, daily, 1 (age 2-4 y), 2 (age 5-10 y), 3 (age 11-16), or 4 (age ≥17 y) omega-3 capsules containing 277.8 mg DHA and 39.0 mg EPA or placebo for 1 y ... Omega-3 treatment reduced the median rate of clinical vaso-occlusive events (0 compared with 1.0 per year, P < 0.0001), severe anemia (3.2% compared with 16.4%; P < 0.05), blood transfusion (4.5% compared with 16.4%; P < 0.05), white blood cell count (14.4 +/- 3.3 compared with 15.6 +/- 4.0 ×10(3)/μL; P < 0.05), and the OR of the inability to attend school at least once during the study period because of illness related to the disease to 0.4 ... The findings of this trial, which need to be verified in a large multicenter study, suggest that omega-3 fatty acids can be an effective, safe, and affordable therapy for sickle cell anemia" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Arginine Supplements May Help Treat Pulmonary Hypertension in Sickle Cell - Medscape, 6/30/03
  • Zinc Helps Sickle Cell Kids Grow - WebMD, 1/24/02
  • Growth Benefits Of Zinc In Children With Sickle Cell Disease - Intelihealth, 1/22/02
  • Zinc Plays Significant Role in Growth of Children with Sickle Cell Disease - Doctor's Guide, 1/22/02
  • African Herbal Remedy Alleviates Pain Associated With Sickle Cell Anemia - Intelihealth, 8/23/01
  • Antioxidants Quell Sickle-Cell - Nutrition Science News, 4/01

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