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Peroxisome Proliferator-activated Receptors (PPARs))

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News & Research:

• A Pill to make Exercise Obsolete - The New Yorker, 11/6/17 - "Iron Julius still takes 516, although lately he has noticed a decrease in the drug’s quality. “I’m a volunteer firefighter so stamina at times is very important,” he explained. “If you research, many police and firefighters are on some form of performance-enhancing substance as the jobs are sometimes physically demanding.” Iron Julius told me that around a third of the people he sees at the gym are using 516, without any side effects that he’s heard about. When I asked whether he would recommend it, his response was, “Hell yeah man, try it. It don’t mess with hormones and it increases performance.” ... So I ordered some. A few weeks later, a twenty-milligram bottle of 516 arrived, taped into a sealed Tyvek envelope. It was about the size of the complimentary shampoo you get in hotels and contained a cloudy white liquid with a faint smell of nail-polish remover. A label instructed me to “see accompanying information”—there wasn’t any—for dosage instructions. Below that were two contradictory phrases: “Rx only” and “Not for human consumption. ... ”I called Tim Willson, the drug’s designer, to ask whether he would take it. “No,” he said, without hesitation. I contacted the other researchers and found that none of them had ever taken an exercise pill, in any form. I put the bottle to one side of my desk while I pondered not only the advisability of ingesting a likely carcinogen but also the fact that I actually enjoy exercise and get plenty of it. Since then, the bottle has sat on my desk, undisturbed. During the past month, its contents appear to have developed a faint, yellowish tinge."
• Molecular 'switch' contributes to cellular aging process: Discovery suggests new treatments for metabolic diseases - Science Daily, 11/30/10 - "in older animals SMRT acts like a "switch," turning off the protective cellular activities of proteins known as peroxisome proliferator-activated receptors (PPARs). PPARs help regulate genes that promote fat burning to maintain lipid (blood fat) balance and reduce oxidative stress. The researchers were able to reduce the negative effects of oxidative stress by giving antioxidants or drugs known to turn the protective activities of PPARs back on ... PPAR drugs have been used to increase insulin sensitivity and lower blood lipid levels ... we believe SMRT is one of the key players that causes age-dependent decline in mitochondrial function by blocking PPAR activity, and we've found a way to boost the body's ability to better handle metabolic and oxidative stress" - Note: There are several PARR receptor activators such as the blood pressure drug telmisartan and the diabetes medication Actos (some doctors have criticized me for years for taking it for anti-aging).  When I get a chance I'll search my site and put the articles on it.