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Home > Anti-aging Research > Nicotinamide riboside

Nicotinamide riboside

Specific Recommendations:

News & Research:

  • Mohs Surgeons Favor Nicotinamide for Chemoprevention in Survey - Medscape, 4/20/21 - "Approximately three-quarters of Mohs surgeons recommended nicotinamide for prevention of keratinocyte carcinoma" -  See nicotinamide at Amazon.com.
  • NAD+ can restore age-related muscle deterioration, research finds - Science Daily, 1/20/21 - "Although aggregated proteins have been suggested to contribute to brain aging, this is the first time that they have been shown to contribute to muscle aging and to directly damage mitochondria. "These abnormal proteotoxic aggregates could serve as novel biomarkers for the aging process, beyond the brain and muscle," says Auwerx ... the researchers fed worms the vitamin nicotinamide riboside and the antitumor agent Olaparib, both of which boost the levels of nicotinamide adenine dinucleotide (NAD+), a biomolecule that is essential for maintaining mitochondrial function, and whose levels decline during aging ... The encouraging results led the researchers to test nicotinamide riboside in aged mice. The treatment also activated the mitochondrial defense systems and reduced the number and size of amyloid aggregates in different skeletal muscle tissues ... Drugs that boost mitochondrial quality control could therefore be tested in the clinic to reverse these age-related proteotoxic aggregates and rejuvenate tissues" - See nicotinamide riboside at Amazon.com.
  • Supplement makes (mouse) moms' milk better; pups benefit for life - Science Daily, 1/22/19 - "Mother mice given the NR supplement lost weight faster and produced more milk than mothers not fed NR. In addition to increasing the quantity of milk the moms produced, NR supplementation also increased the quality of the milk, which contained higher levels of a protein factor that promotes brain development ... The advantages to the pups being nursed by NR-supplemented moms were striking and long-lasting. The pups were bigger and had better metabolic health than pups nursed by non-supplemented moms. As adults, they also had better motor coordination, better learning and memory, and were less anxious and more resilient to stress ... NR-supplementation in mice returned liver levels of NAD back to or above normal, and supercharged lactation, so that NR-fed moms produced more milk and the milk contained higher levels of a growth factor called brain-derived neurotrophic factor (BDNF) that enhances brain development"
  • Dietary supplement shows promise for reversing cardiovascular aging - Science Daily, 3/29/18 - "a new University of Colorado Boulder study published today indicates that when people consume a natural dietary supplement called nicotinomide riboside (NR) daily, it mimics caloric restriction, aka "CR," kick-starting the same key chemical pathways responsible for its health benefit ... Supplementation also tends to improve blood pressure and arterial health ... it is well tolerated and appears to activate some of the same key biological pathways that calorie restriction does ... Half were given a placebo for six weeks, then took a 500 mg twice-daily dose of nicotinamide riboside (NR) chloride (NIAGEN). The other half took NR for the first six weeks, followed by placebo ... The researchers found that 1,000 mg daily of NR boosted levels of another compound called nicotinamide adenine dinucleotide (NAD+) by 60 percent. NAD+ is required for activation of enzymes called sirtuins, which are largely credited with the beneficial effects of calorie restriction ... in 13 participants with elevated blood pressure or stage 1 hypertension (120-139/80-89 mmHg), systolic blood pressure was about 10 points lower after supplementation. A drop of that magnitude could translate to a 25 percent reduction in heart attack risk"
  • Vitamin nicotinamide riboside protects mice from diabetes complications - Science Daily, 5/27/16 - "As had been shown in previous studies, NR greatly protected the prediabetic and T2D mice from weight gain due to the high-fat diet. But the new study also showed that NR had other beneficial effects on whole body metabolism in the prediabetic and T2D mice. It protected high-fat fed mice from hepatic steatosis -- the build-up of fat globules in the liver -- which was severe in the prediabetic and T2D mice that did not receive NR. NR also reduced liver damage in the mice on high-fat diets, and greatly improved blood sugar levels in the prediabetic and T2D mice ... NR also protected against peripheral nerve damage, or neuropathy, a common, serious complication of prediabetes and T2D ... about 60 to 70 percent of people with diabetes have some form of neuropathy. Peripheral neuropathy is a leading cause of diabetic foot ulcers and limb amputation in people with T2D" - See See nicotinamide riboside at Amazon.com.
  • Vitamin stops the aging process of organs - Science Daily, 4/28/16 - "As mice, like all mammals, age, the regenerative capacity of certain organs (such as the liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging ... We gave nicotinamide riboside to 2-year-old mice, which is an advanced age for them ... This substance, which is close to vitamin B3, is a precursor of NAD+, a molecule that plays a key role in mitochondrial activity. And our results are extremely promising: muscular regeneration is much better in mice that received NR, and they lived longer than the mice that didn't get it ... Parallel studies have revealed a comparable effect on stem cells of the brain and skin ... So far, no negative side effects have been observed following the use of NR, even at high doses" - See nicotinamide riboside at Amazon.com.
  • Beyond Resveratrol: The Anti-Aging NAD Fad - Scientific American, 3/11/15 - "A prominent theory of aging holds that decaying of mitochondria is a key driver of aging. While it's not clear why our mitochondria fade as we age, evidence suggests that it leads to everything from heart failure to neurodegeneration, as well as the complete absence of zipping around the supper table ... NAD boosters might work synergistically with supplements like resveratrol to help reinvigorate mitochondria and ward off diseases of aging. Elysium is banking on this potential synergy—its NR-containing supplement includes a resveratrol-like substance called pterostilbene (pronounced tero-STILL-bean), which is found in blueberries and grapes ... Why pterostilbene instead of resveratrol? ... While resveratrol has hogged the anti-aging spotlight over the past decade, unsung researchers in places like Oxford, Miss., have quietly shown that pterostilbene is a kind of extra-potent version of resveratrol. The pterostilbene molecule is nearly identical to resveratrol's except for a couple of differences that make it more "bioavailable" (animal studies indicate that about four times as much ingested pterostilbene gets into the bloodstream as resveratrol). Test-tube and rodent studies also suggest that pterostilbene is more potent than resveratrol when it comes to improving brain function, warding off various kinds of cancer and preventing heart disease." - Note: This was a year old article that showed up on my Facebook. I read some of the reviews on Amazon. Nothing gets my goat more that people who think something that delays aging has to give you a buzz such as caffeine. That said, some of the reviews for nicotinamide riboside said it negatively affected their sleep and made them for fatigued and depressed. The negative reviews for Niagen seems to be from those that think it has to give you a buzz (err!!).  I'm sticking with this for now: Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.  Also see Niagen at Amazon.com.

Abstracts:

  • NAD + and NAFLD - Caution, Causality, and Careful Optimism - J Physiol 2021 May 1 - "The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide, and new treatments are direly needed. Nicotinamide adenine dinucleotide (NAD+ ) has been proposed as a potential target to prevent and reverse NAFLD. NAD+ is an important redox factor for energy metabolism and is used as a substrate by a range of enzymes, including sirtuins (SIRT), which regulates histone acetylation, transcription factor activity and mitochondrial function. NAD+ is also a precursor for reduced nicotinamide adenine dinucleotide phosphate (NADPH), which is an important component of the antioxidant defense system. NAD+ precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are available as over-the-counter dietary supplements, and oral supplementation with these precursors increases hepatic NAD+ levels and prevent hepatic lipid accumulation in pre-clinical models of NAFLD. Moreover, NAD+ precursors were found to improve hepatic mitochondrial function and decrease oxidative stress in pre-clinical NAFLD models. NAD+ repletion also prevents NAFLD progression to non-alcoholic steatohepatitis (NASH), as NAD+ precursor supplementation is associated with decreased hepatic stellate cell activation, and decreased fibrosis. However, initial clinical trials have only shown modest effects when NAD+ precursors were administrated to people with obesity. We review the available pre-clinical investigations of NAD+ supplementation for targeting NAFLD, and discuss how data from the first clinical trials can be reconciled with observations from preclinical research" - See nicotinamide adenine dinucleotide at Amazon.com.
  • Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans - Am J Clin Nutr. 2020 Apr 22 - "A randomized, double-blinded, placebo-controlled, crossover intervention study was conducted in 13 healthy overweight or obese men and women. Participants received 6 wk NR (1000 mg/d) and placebo supplementation ... NR increased body fat-free mass (62.65% ± 2.49% compared with 61.32% ± 2.58% in NR and placebo, respectively; change: 1.34% ± 0.50%, P = 0.02) and increased sleeping metabolic rate. Interestingly, acetylcarnitine concentrations in skeletal muscle were increased upon NR (4558 ± 749 compared with 3025 ± 316 pmol/mg dry weight in NR and placebo, respectively; change: 1533 ± 683 pmol/mg dry weight, P = 0.04) and the capacity to form acetylcarnitine upon exercise was higher in NR than in placebo (2.99 ± 0.30 compared with 2.40 ± 0.33 mmol/kg wet weight; change: 0.53 ± 0.21 mmol/kg wet weight, P = 0.01). However, no effects of NR were found on insulin sensitivity, mitochondrial function, hepatic and intramyocellular lipid accumulation, cardiac energy status, cardiac ejection fraction, ambulatory blood pressure, plasma markers of inflammation, or energy metabolism"
  • Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome - NPJ Aging Mech Dis. 2020 Jan 7;6:1 - "In this study, we report that NAD+ levels are reduced in the cochlea of CSB m/m mice and that short-term treatment (10 days) with the NAD+ precursor nicotinamide riboside (NR), prevents hearing loss, restores outer hair cell loss, and improves cochlear health in CSB m/m mice. Similar, but more modest effects were observed in CSA -/- mice. Remarkably, we observed a reduction in synaptic ribbon counts in the presynaptic zones of inner hair cells in both CSA -/- and CSB m/m mice, pointing to a converging mechanism for cochlear defects in CS. Ribbon synapses facilitate rapid and sustained synaptic transmission over long periods of time. Ribeye, a core protein of synaptic ribbons, possesses an NAD(H) binding pocket which regulates its activity. Intriguingly, NAD+ supplementation rescues reduced synaptic ribbon formation in both CSA -/- and CSB m/m mutant cochleae. These findings provide valuable insight into the mechanism of CS- and ARHL-associated hearing loss, and suggest a possible intervention" - [Nutra USA]
  • Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload - J Am Coll Cardiol. 2019 Apr 16;73(14):1795-1806 - " Boosting the UPRmt with nicotinamide riboside (which augments NAD+ pools) in cardiomyocytes in vitro or hearts in vivo significantly mitigated the reductions in mitochondrial oxygen consumption induced by these stresses. In mice subjected to pressure overload, nicotinamide riboside reduced cardiomyocyte death and contractile dysfunction. Myocardial tissue from patients with aortic stenosis also showed evidence of UPRmt activation, which correlated with reduced tissue cardiomyocyte death and fibrosis and lower plasma levels of biomarkers of cardiac damage (high-sensitivity troponin T) and dysfunction (N-terminal pro–B-type natriuretic peptide)." - [Nutra USA]
  • NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency - Proc Natl Acad Sci U S A. 2018 Feb 20 - "NR-treated 3xTgAD/Polβ+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain. NR improved cognitive function in multiple behavioral tests and restored hippocampal synaptic plasticity in 3xTgAD mice and 3xTgAD/Polβ+/- mice. In general, the deficits between genotypes and the benefits of NR were greater in 3xTgAD/Polβ+/- mice than in 3xTgAD mice. Our findings suggest a pivotal role for cellular NAD+ depletion upstream of neuroinflammation, pTau, DNA damage, synaptic dysfunction, and neuronal degeneration in AD. Interventions that bolster neuronal NAD+ levels therefore have therapeutic potential for AD" - [Nutra USA]
  • Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration - FASEB J. 2017 Aug 21 - "NAD+ depletion is a common phenomenon in neurodegenerative pathologies ... Taken together, our findings demonstrate that NR is a better neuroprotective agent than NAD+ in excitotoxicity-induced AxD and that axonal protection involves defending intracellular NAD+ homeostasis"
  • Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice - Sci Rep. 2016 May 27;6:26933 - "NR improved glucose tolerance, reduced weight gain, liver damage and the development of hepatic steatosis in prediabetic mice while protecting against sensory neuropathy. In T2D mice, NR greatly reduced non-fasting and fasting blood glucose, weight gain and hepatic steatosis while protecting against diabetic neuropathy. The neuroprotective effect of NR could not be explained by glycemic control alone ... Quantitative metabolomics established that hepatic NADP(+) and NADPH levels were significantly degraded in prediabetes and T2D but were largely protected when mice were supplemented with NR" - [Nutra USA]