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Anti-aging Research > Hydrangea
Hydrangea
Specific Recommendations:
News & Research:
Abstracts:
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Effect of Standardized
Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat
Reduction in Overweight or Obese Humans: A Randomized Double-Blind
Placebo-Controlled Study - Nutrients 2022, 14(1), 208 -
"A total of 93 healthy overweight or obese males and
females, aged 19–65 years, with body mass indexes (BMIs) ≥ 25 and <32 kg/m2,
were recruited and received either an oral administration of 600 mg of WHS, or
placebo tablets for 12 weeks. Daily supplementation with WHS decreased body
weights, body fat masses, and BMIs compared with the placebo-treated group. The
hip circumferences, visceral fat areas, abdominal fat areas, and
visceral-to-subcutaneous ratios decreased after WHS supplementation. No
significant side effects were observed during or after the 12 weeks of WHS
intake. In conclusion, WHS, which has beneficial effects on body weight and body
fat reduction, could be a promising antiobesity supplement that does not produce
any side effects" - [Nutra USA] - See
hydrangea supplements at Amazon.com.
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Discovery of Natural
Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches
- Nutrients 2021 Jan 17;13(1):254 - "Alzheimer's disease
(AD) is a neurodegenerative disease conceptualized as a clinical-biological
neurodegenerative construct where amyloid-beta pathophysiology is supposed to
play a role. The loss of cognitive functions is mostly characterized by the
rapid hydrolysis of acetylcholine by cholinesterases including
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Moreover, both
enzymes are responsible for non-catalytic actions such as interacting with
amyloid β peptide (Aβ) which further leads to promote senile plaque formation.
In searching for a natural cholinesterase inhibitor, the present study focused
on two isocoumarines from hydrangea, thunberginol C (TC) and hydrangenol
8-O-glucoside pentaacetate (HGP). Hydrangea-derived compounds were demonstrated
to act as dual inhibitors of both AChE and BChE. Furthermore, the compounds
exerted selective and non-competitive mode of inhibition via hydrophobic
interaction with peripheral anionic site (PAS) of the enzymes. Overall results
demonstrated that these natural hydrangea-derived compounds acted as selective
dual inhibitors of AChE and BChE, which provides the possibility of potential
source of new type of anti-cholinesterases with non-competitive binding property
with PAS"
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